29 results about "Coccidia" patented technology

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The invention relates to the technical field of intelligent breeding, bioinformatics and artificial intelligence crossing, provides a chicken coccidiosis early warning method, device and equipment, a storage medium and a program product, and has relatively high anti-interference capability during chicken coccidiosis early warning. The voiceprint feature vector and the posture feature vector of the chicken are obtained according to the sound wave data and the video data in the current time window, so that the disease posterior probability and the group infection index are obtained; inputting the group infection index into a preset chicken coccidiosis SIR-Coccidia propagation dynamical model to carry out epidemic situation evolution simulation of a future time step; and when the epidemic situation evolution simulation result exceeds a preset safety threshold, generating a preliminary prevention and control strategy based on a multi-objective optimization algorithm, performing compliance matching processing on the preliminary prevention and control strategy and a preset veterinary prevention and control knowledge base, obtaining a corrected prevention and control strategy, performing risk prediction, and generating a target early warning instruction set.

The application discloses a phytosterol and phytosterol ester complex agent and application thereof, wherein the complex agent comprises phytosterol and phytosterol ester with a mass ratio of 1:10. The application aims to improve the water solubility and bioavailability of phytosterol, realize synergistic effect by compounding phytosterol and phytosterol ester, interfere with the lipid acquisition of coccidia from multiple targets, up-regulate the expression of cecal tight junction protein to repair the intestinal barrier, inhibit the release of serum and cecal pro-inflammatory factors to relieve inflammatory reaction, regulate the expression of genes related to lipid synthesis and fatty acid oxidation to remodel lipid metabolism homeostasis, and then effectively inhibit the growth and development of coccidia, and significantly improve the growth performance of broilers infected with coccidia.

This invention discloses a method for constructing and analyzing a genome-scale metabolic network model of *Paragonimus denitrifyingus*, belonging to the field of systems biology. The method includes: whole-genome annotation; obtaining global metabolic response data of *Paragonimus denitrifyingus*; automatically retrieving genomic information and constructing Model 1 based on the species code and genome annotation results of *Paragonimus denitrifyingus* in the KEGG database; constructing Model 2 by identifying homologous proteins in the *Paragonimus denitrifyingus* genome through homology searching of proteins in the target organism based on a pre-trained Hidden Markov Model; and integrating Model 1 and Model 2. This invention allows for the efficient design and modification of denitrification engineering, achieving precise control of nitrogen degradation processes. Compared to existing metabolic engineering methods, this invention effectively reduces the workload of exploratory experiments and greatly advances a deeper understanding of the nitrogen degradation characteristics of *Paragonimus denitrifyingus*.

The invention discloses a feed additive for replacing antibiotics to treat chicken necrotic enteritis and application of the feed additive, and belongs to the technical field of feed. The effective component of the feed additive is the tannin extract from chestnut trees, and animal experiments prove that the tannin extract from chestnut trees can improve the production performance of broiler chickens with necrotic enteritis to a certain extent, improve the intestinal morphology and immune function of the broiler chickens with necrotic enteritis and improve the immunity of the broiler chickens with necrotic enteritis. Therefore, the chestnut tree tannin extract can replace antibiotics and has a good treatment effect on broiler intestinal inflammation caused by clostridium perfringens and coccidiosis.

The invention belongs to the technical field of microorganisms, and in particular relates to enterococcus faecalis ZJUIDS-C010 with calcium enrichment capacity and application of the enterococcus faecalis ZJUIDS-C010. The invention discloses enterococcus faecalis ZJUIDS-C010, and the preservation number of the enterococcus faecalis ZJUIDS-C010 is CGMCC (China General Microbiological Culture Collection Center) NO. 34467. The invention also provides an application of the enterococcus faecalis ZJUIDS-C010 in increasing the utilization rate of calcium / enriching calcium at the same time. The enterococcus faecalis ZJUIDS-C010 can be used for preparing a product for promoting calcium absorption of intestinal tracts of pets.

The application discloses a dog-derived Enterococcus faecalis ZJUIDS-D016 with anti-aging effect and application, the dog-derived Enterococcus faecalis ZJUIDS-D016 is classified and named as (Enterococcus faecalis) Enterococcus faecalis ), and the preservation number is CGMCC 27038.The strain of the application is isolated from the intestinal tract of a healthy dog, has acid resistance, bile salt resistance and broad-spectrum antibacterial activity, and is sensitive to chloramphenicol, erythromycin and penicillin.The strain of the application has strong host adaptability, can colonize in the intestinal tract of a dog and secrete organic acids and bacteriocins, significantly inhibits the proliferation of common pathogenic bacteria such as dog pathogenic escherichia coli, effectively improves the intestinal health of pets and delays aging, and is suitable for preparing pet probiotic products.

The invention discloses enterococcus durans BHDY002 and application thereof in preparation of products for promoting animal growth, and belongs to the technical field of microorganisms. The strain is preserved in the Guangdong Microbial Culture Collection Center on November 21, 2025, the preservation address is the 5th floor of the building 59, No.100 Courtyard, Xianlie Middle Road, Guangzhou, and the preservation number is GDMCC No: 67336. According to the invention, enterococcus durans with excellent tolerance is successfully screened from excrement samples of wild birds of wild angoraeae, and the probiotic potential and safety of enterococcus durans are verified through morphological observation, physiological and biochemical characteristic analysis, molecular biological identification and comprehensive evaluation of probiotic performance. The research widens the screening source of high-quality probiotic resources, widens the understanding of biological functions of enterococcus durans, and provides theoretical basis and strain resources for developing probiotic preparations for promoting animal growth, antagonizing pathogenic bacteria and regulating intestinal microecology.

This invention relates to the field of biodetection technology, specifically disclosing a CPA kit, primers, applications, and methods for detecting Eimeria coccidia and Cryptosporidium micrococcidia. The CPA kit for detecting Eimeria coccidia and Cryptosporidium micrococcidia of this invention includes the primer combinations shown in SEQ ID No. 1-12. Using the method of this invention, high sensitivity and high specificity detection of Eimeria coccidia and Cryptosporidium micrococcidia can be achieved within 15-45 minutes.

The present invention relates to methods for controlling or preventing infestation of plants by a phytopathogenic microorganism of the genus Pseudopyrenochaeta, comprising applying to a crop of plants, the locus thereof, or propagation material thereof, the compound of formula (I) or a pesticidal composition comprising the compound.

The invention discloses a compound traditional Chinese medicine and application thereof in preparing a medicine for resisting eimeria tenella or treating coccidiosis, and relates to the technical field of livestock breeding. The compound traditional Chinese medicine comprises the following raw materials in parts by mass: 5-20 parts of hesperidin and 1-10 parts of citric acid. According to the invention, chicks are taken as experimental subjects, a chick coccidiosis model is established, and the effect of the compound traditional Chinese medicine on the chick coccidiosis is researched from the aspects of general conditions of the chicks, bloody stool conditions, coccidiocyst discharge conditions, cecum tissue lesion conditions, pathological detection, serum biochemistry, oxidation resistance detection and the like. The compound traditional Chinese medicine achieves a good anti-coccidiosis drug level, the required raw materials are low in cost, convenient to use and free of hormones and antibiotics, no toxic or side effect is caused to chickens, drug resistance cannot be caused, a new choice is provided for replacing chemical drugs for preventing and treating coccidiosis, and addition of anti-coccidiosis drugs in chicken feed is expected to be reduced or replaced.

The invention relates to the technical field of biology, and particularly discloses pediococcus pentosaceus SUM0411 with bacteriostatic, anti-inflammatory and antioxidant functions, the pediococcus pentosaceus SUM0411 is preserved in China Center for Type Culture Collection on November 20, 2025, the preservation number is CCTCC NO: M20252634, the pediococcus pentosaceus SUM0411 is obtained by being separated from feces of Jianyang big-ear sheep, the pediococcus pentosaceus SUM0411 has the effects of enhancing the immune function and the antioxidant capacity of animals, and the pediococcus pentosaceus SUM0411 can be used for preparing a medicine for preventing and treating diseases such as the animal diseases. The feed additive has the capabilities of improving daily gain, maintaining intestinal barriers, relieving intestinal inflammation and the like, can be used as a novel probiotic additive, and can be applied to feeds.

The present invention provides combinations of microbial flora selected from the group consisting of Phascolactobacterium faecium, Phascolactobacterium succinatus, Dialister succinatus, Dialister propionysifaciens, Bifidobacterium bifidum, and Lactobacillus intestinalis for use in succinate consumption, processes for producing such combinations, their compositions, and uses.

The invention relates to the technical field of chicken flock immunization, and provides a method for promoting coccidiosis immune cycle by controlling the humidity of padding. The method comprises the following steps: laying a drip irrigation humidity control device; mixed padding is prepared, and the drip irrigation humidity control device is placed in the mixed padding; a water outlet hole of the drip irrigation humidity control device is arranged to be in direct contact with the ground, and the water outlet amount of the drip irrigation humidity control device is controlled, so that the humidity of the mixed padding is 20-30%. According to the method, the humidity of the mixed padding can be rapidly adjusted, and the humidity of each area of the padding is uniform. Besides, when the humidity of the padding is adjusted to be within the range, the sporulation rate of coccidiosis is superior to that of other padding humidity, secondary circulation of tender and toxic oocysts can be effectively guaranteed, and the tender and toxic immune protection effect is improved.

The application relates to the technical field of cross technology of intelligent breeding, bioinformatics and artificial intelligence, and provides a chicken coccidiosis early warning method, device, equipment, storage medium and program product, which has strong anti-interference capability in chicken coccidiosis early warning. According to sound wave data and video data in a current time window, soundprint feature vectors and body state feature vectors of chickens are obtained to obtain a disease posterior probability and a group infection index; the group infection index is input into a preset chicken coccidiosis SIR-Coccidia transmission dynamics model to simulate epidemic evolution in a future time step; when the epidemic evolution simulation result exceeds a preset safety threshold, a preliminary prevention and control strategy is generated based on a multi-objective optimization algorithm, the preliminary prevention and control strategy is subjected to compliance matching processing with a preset veterinary prevention and control knowledge base, a corrected prevention and control strategy is obtained and risk prediction is carried out, and a target early warning instruction set is generated.

The invention relates to an agricultural pest biological control technology, and aims to provide a rhodococcus strain and application thereof to degradation of insecticides and enhancement of parasitic wasp resistance. The strain is preserved in the China Center for Type Culture Collection, the preservation name is Fanqing Sheng Rhodococcus IT-1, the classification name of Latin is Rhodococcus qingshengii, and the preservation number is CCTCC NO: M 20252461. The 16S rRNA gene sequence of the strain is as shown in SEQ ID NO: 1. The strain is unique in source and broad in function spectrum; biological control can be enhanced, and the effect is remarkable; the strain is supplemented back into the parasitic wasp body in a feeding mode, the endurance capacity of the parasitic wasp to imidacloprid and thiamethoxam can be remarkably improved, and the strain has great significance in maintaining and enhancing the biological control function of an agricultural ecosystem and reducing dependence of chemical pesticides.

This invention relates to the field of feed technology, specifically to an anticoccidial plant extract, additives, and their applications. The anticoccidial plant extract of this invention is an aqueous extract of a combination of plant raw materials, including *Dichroa febrifuga*, *Portulaca oleracea*, *Cirsium japonicum*, *Platycladus orientalis* leaves, *Paeonia lactiflora*, *Astragalus membranaceus*, and licorice. This invention also proposes additives containing this plant extract, including feed additives and drinking water additives. This invention uses natural plant extracts to prevent and treat coccidiosis in poultry, exhibiting green and safe characteristics. Through the synergistic effect of the extracted components, it improves the growth performance of poultry infected with coccidia and reduces the number of coccidia oocysts in feces.

The present invention relates to animal feed or animal feed additive comprising a polypeptide having protease activity and uses thereof. Specifically, the protease is a serine S1 protease from the genera Microspora, Terracoccus and Knoellia, all belonging to the family Microbacteriaceae of the suborder Micrococineae. These proteases have high activity over a broad pH range (pH 3-7) and are thus highly active during the entire passage through the digestive tract. It further relates to methods for producing these proteases as well as using the proteases to improve animal performance and the nutritional value of animal feed.

The invention discloses an application of onion appendages and extracts thereof in preparation of veterinary drugs or feed additives for resisting parasitic diseases. A treatment test on chicken infected with coccidiosis proves that the coccidiosis resisting index of the onion skin extract can reach an efficient level close to 180 and is almost equivalent to that of a chemical medicine diclazuril, and pathological diseases show that the onion skin extract has remarkable effects of relieving cecum thickening and chicken bloody stool and improving intestinal tract pathological injury. The onion skin extract is prepared into a medicine feed additive, the medicine feed additive and feed are used for feeding sick chickens together, the chicken coccidiosis can be effectively prevented and treated, the effect is remarkable, and the market application and popularization value is achieved.

Conjugates of amphotericin B and gold nanoparticles stabilized with thiohexoses or thiopentoses, and a method to produce said nanoparticles are described. As the conjugates of amphotericin B to the stabilized gold nanoparticles show several advantages over amphotericin B alone, pharmaceutical compositions comprising said nanoparticles, and to their use for treat fungal and leishmanial infection are described. These amphotericin B stabilized gold nanoparticles are dispersible in water and are not toxic for mammalian cells differently from free amphotericin B and other currently used amphotericin B preparations. Importantly, the conjugates of amphotericin B and stabilized gold nanoparticles are more efficacious in treating all forms of Cryptococcal infections (planktonic, intracellular and biofilms) than amphotericin B.

The invention discloses a pellet feed for laboratory mice and a preparation method of the pellet feed. The feed consists of the following raw materials in percentage by weight: 42-50% of corn, 8-12% of fermented soybean meal, 4-8% of insect protein (hermetia illucens larva powder), 2-4% of maltodextrin, 1-2% of inulin, 0.5-2% of inactivated enterococcus faecalis, 1.5-3% of a vitamin premix, 3-5% of a mineral premix, 0.3-0.8% of xylooligosaccharide, 2-4% of vegetable oil, 1-3% of cellulose and the balance of auxiliary materials. The method has the advantages that heavy metal and micro-plastic pollution are avoided, allergens are removed, and the survival rate of laboratory mice is increased by 20%; active ingredients of the inactivated enterococcus faecalis are reserved through a spraying process, and the number of beneficial bacteria in the intestinal tract is increased by 25-35% compared with a contrast; the feed conversion rate is increased by 21-32%, the weight gain is stable, and the fluctuation of experimental data is reduced.

The invention discloses functional probiotics for relieving nutrition metabolism disorder of aquatic animals and application of the functional probiotics, and relates to the technical field of aquaculture, the functional probiotics are Lactococcus lactis GCL-1, the Lactococcus lactis GCL-1 is preserved in the China General Microbiological Culture Collection Center on January 7, 2026, and the preservation number is CGMCC NO.37318. The invention further discloses a preparation method of the functional probiotics for relieving the nutrition metabolism disorder of the aquatic animals and application of the functional probiotics for relieving the nutrition metabolism disorder of the aquatic animals. After the lactococcus lactis GCL-1 provided by the invention is applied to an aquatic animal feed, the growth performance of the aquatic animal can be improved, liver oxidative stress, inflammation and lipid metabolism disorder induced by a high cottonseed meal feed can be relieved, meanwhile, the intestinal health is improved, and the physiological health of the aquatic animal is improved.

This invention discloses a strain of *Pediococcus lactis* GBW9011 and its preparation as a solid microbial preparation for preventing diarrhea in weaned rabbits, belonging to the field of microbial preparations. This invention provides a strain of *Pediococcus lactis* GBW9011, with the preservation number CGMCC No. 34454. This invention utilizes *Pediococcus lactis* GBW9011 to ferment and enrich inorganic zinc ions, preparing zinc-rich lactic acid bacteria powder. This powder is then mixed with a compound enzyme preparation, fructooligosaccharides, and compound vitamins to prepare a solid microbial preparation. This solid microbial preparation can prevent diarrhea in weaned rabbits, exerting a synergistic effect through "inhibiting pathogens, strengthening the barrier, aiding digestion, and resisting stress," significantly reducing the incidence of diarrhea in weaned rabbits, increasing weight gain and survival rates, improving digestive enzyme activity, and improving intestinal flora structure. This has significant implications for animal husbandry, including rabbits.

The invention provides a probiotic composition for improving chicken production performance and a preparation method and application thereof, and relates to the technical field of microecological preparations. The probiotic composition comprises lactobacillus plantarum HM-05, lactobacillus casei HM-09 and pediococcus acidilactici PA-19, the preservation number of the lactobacillus plantarum HM-05 is CGMCC (China General Microbiological Culture Collection Center) NO.6739, the preservation number of the lactobacillus casei HM-09 is CGMCC NO.6736, and the preservation number of the pediococcus acidilactici PA-19 is CGMCC NO.19881; the ratio of the viable bacteria of the lactobacillus plantarum HM-05 to the viable bacteria of the lactobacillus casei HM-09 to the viable bacteria of the pediococcus acidilactici PA-19 is (1-5): (0.5-2): (1-10), and the probiotic composition obtained by compounding the viable bacteria of the lactobacillus plantarum HM-05, the viable bacteria of the lactobacillus casei HM-09 and the viable bacteria of the pediococcus acidilactici PA-19 can well inhibit breeding of pathogenic bacteria, improve balance of beneficial microbial communities in intestinal tracts and prevent diseases; the production performance and the health level of the bred chickens are effectively improved.

The application discloses a kind of recombinant lactococcus solid fermentation medium, fermentation and its application.The medium provided by the application comprises the following components by weight: 85~93 parts of soybean meal, 2~5 parts of glucose, 1~2 parts of calcium carbonate, 2~4 parts of radix astragali, 1~3 parts of atractylodes, 1 part of sanguisorba officinalis.The application also discloses a method for preparing recombinant lactococcus solid fermentation using the medium, and the prepared solid fermentation.The experiments verify that the atractylodes and sanguisorba officinalis added in the medium of the application can synergistically promote the proliferation of lactococcus, significantly increase the solid fermentation viable count;The obtained recombinant lactococcus solid fermentation can increase the level of intestinal mucosa sIgA, significantly reduce the cecal lesion score of coccidiosis infected chicken, reduce the amount of oocyst discharge, and improve growth performance.The application provides a new technical solution for the green and safe prevention and control of coccidiosis, and has good application prospect.

This invention discloses a quadruple PCR primer set and kit for detecting chicken coccidiosis, belonging to the field of chicken coccidiosis biodetection technology. Compared with the prior art, this invention can simultaneously obtain detection results for four types of chicken coccidiosis, greatly shortening the detection and identification time and providing a guarantee for timely prevention of the spread of chicken coccidiosis. Furthermore, the coccidia oocyst lysis buffer provided by this invention can quickly obtain DNA templates for quadruple PCR detection. The quadruple PCR primers provided by this invention have high detection specificity, low detection limit, good repeatability, and reliable results.

The invention relates to the technical field of livestock breeding, in particular to an intestinal biomarker for predicting residual feed intake of calves and application of the intestinal biomarker. Comprising intestinal microorganisms and / or characteristic metabolites; the enteric microorganisms comprise one or more of enterococcus, enterococcus hisei and enterococcus faecium; the characteristic metabolites comprise one or more of linoleic acid metabolites, bile acid metabolites and lipid metabolites. The intestinal biomarker can be used for simply and quickly predicting the residual feed intake of the calves, so that early-stage accurate breeding of the calves with high feed efficiency is realized, the feeding cost is remarkably reduced, and lasting economic benefits are brought. The screening method is scientific and rigorous, and the reliability and stability of the biomarker are ensured through 16S rDNA sequencing and LC-MS metabonomics combined analysis in combination with a machine learning algorithm. By detecting the biomarker, the calf RFI level can be preliminarily identified in a short time, and the market implementation feasibility is high.

The invention relates to the technical field of aquaculture microorganisms, in particular to enterococcus faecalis, low-temperature probiotic compound bacteria as well as a preparation method and application of the enterococcus faecalis and the low-temperature probiotic compound bacteria. The low-temperature probiotics used in the invention can keep good growth ability and functional activity in a low-temperature environment. The low-temperature probiotic compound bacteria are added into the feed for feeding, so that the intestinal health of cultured objects in a low-temperature culture environment can be effectively improved, and the abundance of pathogenic bacteria such as vibrio, salmonella and edwardsiella can be effectively reduced. The probiotic compound bacteria can effectively increase the protein content in the cultured objects, and compared with cultured objects without probiotics, the protein content in fish meat of the cultured objects can be increased by 8.4% when the cultured objects are continuously fed with the probiotic compound bacteria for 40 days.