50 results about "Coccidia" patented technology

Disclosed are novel pharmaceutical, animal feed compositions and methods of treating non-human animals comprising at least one component selected from the extract(s), fraction(s), active compound(s) and phytochemical(s), or mixtures thereof, derived from non-woody plants of the genus Hesperaloe. Animal feed compositions may comprise a basal animal feed and water soluble solids extracted from Hesperaloe and comprising at least one saponin. The water soluble solids may comprise from about 5 to about 30 wt % saponin. The compositions of the present invention can be used for the treatment of non-human animals, such as poultry and more particularly for preventing and treating coccidiosis. An embodiment provides an immunological composition useful for inducing the production of antibodies to an antigen in a non-human animal comprising an antigen, preferably a coccidia, and a saponin composition extracted from Hesperaloe. The saponins extracted from Hesperaloe biomass may comprise 25(27)-dehydrofucreastatin, 5(6),25(27)-disdehydroyuccaloiside C, 5(6)-disdehydroyuccaloiside C, furcreastatin and yuccaloiside C.

The invention relates to the technical field of intelligent breeding, bioinformatics and artificial intelligence crossing, provides a chicken coccidiosis early warning method, device and equipment, a storage medium and a program product, and has relatively high anti-interference capability during chicken coccidiosis early warning. The voiceprint feature vector and the posture feature vector of the chicken are obtained according to the sound wave data and the video data in the current time window, so that the disease posterior probability and the group infection index are obtained; inputting the group infection index into a preset chicken coccidiosis SIR-Coccidia propagation dynamical model to carry out epidemic situation evolution simulation of a future time step; and when the epidemic situation evolution simulation result exceeds a preset safety threshold, generating a preliminary prevention and control strategy based on a multi-objective optimization algorithm, performing compliance matching processing on the preliminary prevention and control strategy and a preset veterinary prevention and control knowledge base, obtaining a corrected prevention and control strategy, performing risk prediction, and generating a target early warning instruction set.

The application discloses a phytosterol and phytosterol ester complex agent and application thereof, wherein the complex agent comprises phytosterol and phytosterol ester with a mass ratio of 1:10. The application aims to improve the water solubility and bioavailability of phytosterol, realize synergistic effect by compounding phytosterol and phytosterol ester, interfere with the lipid acquisition of coccidia from multiple targets, up-regulate the expression of cecal tight junction protein to repair the intestinal barrier, inhibit the release of serum and cecal pro-inflammatory factors to relieve inflammatory reaction, regulate the expression of genes related to lipid synthesis and fatty acid oxidation to remodel lipid metabolism homeostasis, and then effectively inhibit the growth and development of coccidia, and significantly improve the growth performance of broilers infected with coccidia.

The invention provides pediococcus pentosaceus Su and application thereof, and belongs to the technical field of microorganisms. According to the invention, intestinal contents of horses and donkeys are screened to obtain a strain, the strain is identified as pediococcus pentosaceus, and the strain is mixed with lactobacillus plantarum to obtain the microbial inoculum. The microbial agent obtained by the invention can be used as an additive to improve the lactation yield of postpartum female donkeys and the nutritional quality of breast milk, increase the content of fat and improve the immunocompetence of donkey foals; the microbial inoculum can serve as a leavening agent to be fermented with motherwort, the obtained fermented motherwort serves as an additive, the optimized female donkey feed is obtained by optimizing a feed formula, the feed is used for feeding female donkeys, and the action effect of the microbial inoculum fermented motherwort in animal bodies is preliminarily understood.

This invention discloses a method for constructing and analyzing a genome-scale metabolic network model of *Paragonimus denitrifyingus*, belonging to the field of systems biology. The method includes: whole-genome annotation; obtaining global metabolic response data of *Paragonimus denitrifyingus*; automatically retrieving genomic information and constructing Model 1 based on the species code and genome annotation results of *Paragonimus denitrifyingus* in the KEGG database; constructing Model 2 by identifying homologous proteins in the *Paragonimus denitrifyingus* genome through homology searching of proteins in the target organism based on a pre-trained Hidden Markov Model; and integrating Model 1 and Model 2. This invention allows for the efficient design and modification of denitrification engineering, achieving precise control of nitrogen degradation processes. Compared to existing metabolic engineering methods, this invention effectively reduces the workload of exploratory experiments and greatly advances a deeper understanding of the nitrogen degradation characteristics of *Paragonimus denitrifyingus*.

The invention discloses a feed additive for replacing antibiotics to treat chicken necrotic enteritis and application of the feed additive, and belongs to the technical field of feed. The effective component of the feed additive is the tannin extract from chestnut trees, and animal experiments prove that the tannin extract from chestnut trees can improve the production performance of broiler chickens with necrotic enteritis to a certain extent, improve the intestinal morphology and immune function of the broiler chickens with necrotic enteritis and improve the immunity of the broiler chickens with necrotic enteritis. Therefore, the chestnut tree tannin extract can replace antibiotics and has a good treatment effect on broiler intestinal inflammation caused by clostridium perfringens and coccidiosis.

A method for preparing a drug for treating bovine cholecystitis belongs to the field of biological veterinary medicine. The present invention utilizes the original ecological pathogens of bovine cholecystitis, and further adds bovine blood, trace elements, and freeze-dried Escherichia coli powder, freeze-dried enterococcus powder, freeze-dried Pseudomonas aeruginosa powder, and lecithin. Weak ultrasound is used in a buffer solution to activate the activity of various pathogens, and in the intelligent cultivation process, the corresponding antimicrobial peptides and antimicrobial proteins are strongly induced in the body of the big-headed golden fly larvae. The antimicrobial peptides and antimicrobial proteins have the characteristics of high biological activity and broad spectrum of action. Clinical treatment results show that the drug prepared by the present invention has good efficacy and high efficiency. The production process of the present invention is easy to industrialize and control, the product consistency is good, energy is saved, and it is suitable for large-scale production.

The invention discloses application of epicoccum nigrum Z01 in preparation of a carrier for preventing and treating saprolegnia dogwood infection in the technical field of microorganisms. The preservation number of the Epicoccum nigrum Z01 is CCTCC (China Center For Type Culture Collection) NO: M2024967, and the Epicoccum nigrum Z01 can be applied to preparation of a carrier for treating or preventing saprolegnia multifida infection so as to prevent and inhibit the pathogenic bacterium saprolegnia in freshwater aquaculture from infecting aquatic animals.

The invention belongs to the technical field of microorganisms, and in particular relates to enterococcus faecalis ZJUIDS-C010 with calcium enrichment capacity and application of the enterococcus faecalis ZJUIDS-C010. The invention discloses enterococcus faecalis ZJUIDS-C010, and the preservation number of the enterococcus faecalis ZJUIDS-C010 is CGMCC (China General Microbiological Culture Collection Center) NO. 34467. The invention also provides an application of the enterococcus faecalis ZJUIDS-C010 in increasing the utilization rate of calcium / enriching calcium at the same time. The enterococcus faecalis ZJUIDS-C010 can be used for preparing a product for promoting calcium absorption of intestinal tracts of pets.

The application discloses a dog-derived Enterococcus faecalis ZJUIDS-D016 with anti-aging effect and application, the dog-derived Enterococcus faecalis ZJUIDS-D016 is classified and named as (Enterococcus faecalis) Enterococcus faecalis ), and the preservation number is CGMCC 27038.The strain of the application is isolated from the intestinal tract of a healthy dog, has acid resistance, bile salt resistance and broad-spectrum antibacterial activity, and is sensitive to chloramphenicol, erythromycin and penicillin.The strain of the application has strong host adaptability, can colonize in the intestinal tract of a dog and secrete organic acids and bacteriocins, significantly inhibits the proliferation of common pathogenic bacteria such as dog pathogenic escherichia coli, effectively improves the intestinal health of pets and delays aging, and is suitable for preparing pet probiotic products.

The application relates to the technical field of veterinary traditional Chinese medicines, in particular to an anticoccidial combined extract, an anticoccidial composite additive and a preparation method and application thereof, and an anticoccidial product. The anticoccidial combined extract contains Terminalia chebula extract and Saussurea costus extract in a specific mass ratio, has a remarkable anticoccidial effect without other components, can significantly inhibit the activity of dihydroorotate dehydrogenase (DHODH), improve an anticoccidial index (ACI), reduce the oocyst production of coccidia, and reduce the degree of intestinal lesions of chickens caused by coccidia; meanwhile, the anticoccidial combined extract can significantly improve the daily weight gain and daily feed intake of broilers, reduce the feed-meat ratio, and has a double effect of “disease prevention + yield increase”.

The invention discloses enterococcus durans BHDY002 and application thereof in preparation of products for promoting animal growth, and belongs to the technical field of microorganisms. The strain is preserved in the Guangdong Microbial Culture Collection Center on November 21, 2025, the preservation address is the 5th floor of the building 59, No.100 Courtyard, Xianlie Middle Road, Guangzhou, and the preservation number is GDMCC No: 67336. According to the invention, enterococcus durans with excellent tolerance is successfully screened from excrement samples of wild birds of wild angoraeae, and the probiotic potential and safety of enterococcus durans are verified through morphological observation, physiological and biochemical characteristic analysis, molecular biological identification and comprehensive evaluation of probiotic performance. The research widens the screening source of high-quality probiotic resources, widens the understanding of biological functions of enterococcus durans, and provides theoretical basis and strain resources for developing probiotic preparations for promoting animal growth, antagonizing pathogenic bacteria and regulating intestinal microecology.

This invention relates to the field of biodetection technology, specifically disclosing a CPA kit, primers, applications, and methods for detecting Eimeria coccidia and Cryptosporidium micrococcidia. The CPA kit for detecting Eimeria coccidia and Cryptosporidium micrococcidia of this invention includes the primer combinations shown in SEQ ID No. 1-12. Using the method of this invention, high sensitivity and high specificity detection of Eimeria coccidia and Cryptosporidium micrococcidia can be achieved within 15-45 minutes.

The invention provides heat-resistant pediococcus acidilactici and application of the heat-resistant pediococcus acidilactici in pellet feed production. The heat-resistant pediococcus acidilactici is named as pediococcus acidilactici YJ and is preserved in the China Center for Type Culture Collection on May 19, 2025, and the preservation number of the heat-resistant pediococcus acidilactici is CCTCC (China Center for Type Culture Collection) NO: M 20251096. The strain YJ has heat-resistant and extrusion-resistant functions, and can be added into a feed production process before particle forming to obtain a feed product with high viable count and uniform addition, so that the growth and intestinal development of chicks are promoted, intestinal injury is repaired, and the production performance of the chicks is improved. The strain YJ can tolerate the high temperature of 90 DEG C, and can be directly added in a mixing stage, so that the strain YJ can be uniformly added in powdery, hard pellet feed and expanded pellet feed, meanwhile, the magnitude order of viable count can reach 107 cfu / g feed, and meanwhile, the variable coefficient of mixing uniformity is less than 5.0%.

The present invention relates to methods for controlling or preventing infestation of plants by a phytopathogenic microorganism of the genus Pseudopyrenochaeta, comprising applying to a crop of plants, the locus thereof, or propagation material thereof, the compound of formula (I) or a pesticidal composition comprising the compound.

The invention discloses an artificial feed for fragrant snails containing a natural attractant. The artificial feed for fragrant snails contains chicken meat powder, Methylococcus capsulatus protein powder, Clostridium ethanolate protein powder and Candida utilis powder instead of existing proteins such as shrimp meat powder, soybean meal and fish meal. The artificial feed for fragrant snails is prepared by coordinating Nannochloropsis algae powder, Schizochytrium ruthenicum powder, soybean oil, chitosan oligosaccharide, microcrystalline cellulose, complex vitamins, complex minerals and a natural attractant prepared by mixing a protein hydrolysate of river mussels and a carbon dioxide supercritical extraction product of Ruditapes philippinarum. The artificial feed for fragrant snails can significantly improve the feeding behavior of fragrant snails and increase the food intake of fragrant snail larvae, promote the rapid growth of the conches in a relatively short period of time, and effectively solve the problems of the palatability of feed for fragrant snail larvae and the slow growth of artificial feed. More importantly, the artificial feed for fragrant snails can significantly improve the quality of conch meat, save breeding costs, reduce water pollution and improve breeding efficiency.

The invention discloses a compound traditional Chinese medicine and application thereof in preparing a medicine for resisting eimeria tenella or treating coccidiosis, and relates to the technical field of livestock breeding. The compound traditional Chinese medicine comprises the following raw materials in parts by mass: 5-20 parts of hesperidin and 1-10 parts of citric acid. According to the invention, chicks are taken as experimental subjects, a chick coccidiosis model is established, and the effect of the compound traditional Chinese medicine on the chick coccidiosis is researched from the aspects of general conditions of the chicks, bloody stool conditions, coccidiocyst discharge conditions, cecum tissue lesion conditions, pathological detection, serum biochemistry, oxidation resistance detection and the like. The compound traditional Chinese medicine achieves a good anti-coccidiosis drug level, the required raw materials are low in cost, convenient to use and free of hormones and antibiotics, no toxic or side effect is caused to chickens, drug resistance cannot be caused, a new choice is provided for replacing chemical drugs for preventing and treating coccidiosis, and addition of anti-coccidiosis drugs in chicken feed is expected to be reduced or replaced.

The invention relates to the technical field of biology, and particularly discloses pediococcus pentosaceus SUM0411 with bacteriostatic, anti-inflammatory and antioxidant functions, the pediococcus pentosaceus SUM0411 is preserved in China Center for Type Culture Collection on November 20, 2025, the preservation number is CCTCC NO: M20252634, the pediococcus pentosaceus SUM0411 is obtained by being separated from feces of Jianyang big-ear sheep, the pediococcus pentosaceus SUM0411 has the effects of enhancing the immune function and the antioxidant capacity of animals, and the pediococcus pentosaceus SUM0411 can be used for preparing a medicine for preventing and treating diseases such as the animal diseases. The feed additive has the capabilities of improving daily gain, maintaining intestinal barriers, relieving intestinal inflammation and the like, can be used as a novel probiotic additive, and can be applied to feeds.

The invention belongs to the technical field of natural composition preparation, and particularly relates to earthworm polypeptide oral liquid and a preparation method thereof. According to the invention, 15-20 parts of earthworm peptide powder and 5-8 parts of conch peptide powder are specifically combined, and the earthworm peptide powder in the composition is beneficial to promoting the utilization of sugar by muscles, so that the glycemic index is reduced; the conch peptide powder can regulate starvation hormone, reduce the proportion of pathogenic bacteria in intestinal tracts and improve the abundance of beneficial bacteria. Therefore, when the polypeptide composition is used for preparing the earthworm polypeptide oral liquid for resisting sugar and inhibiting harmful intestinal flora, the anti-sugar effect can be achieved, meanwhile, the increase of the number of enterobacter and / or enterococcus in the intestinal tract is effectively inhibited, and the occurrence of intestinal inflammation is reduced. Therefore, according to the technical scheme, the application range of the earthworms is enriched, and the application value of the market is widened.

The present invention provides combinations of microbial flora selected from the group consisting of Phascolactobacterium faecium, Phascolactobacterium succinatus, Dialister succinatus, Dialister propionysifaciens, Bifidobacterium bifidum, and Lactobacillus intestinalis for use in succinate consumption, processes for producing such combinations, their compositions, and uses.

The present invention relates to the field of genetic engineering technology, and specifically provides a site for the site-specific integration of exogenous genes in Eimeria tenella and its application. The present invention relates to the screening of a site-specific integration of exogenous genes in transgenic Eimeria tenella, plasmid construction and its application. The present invention discloses information on an efficient integration site for Eimeria tenella, and after the exogenous gene is integrated into the site, it can not only be stably inherited but also improve the reproductive capacity of the transgenic coccidia to a certain extent. The present invention also provides a plasmid vector, comprising: a homologous left arm of the site-specific integration site, an exogenous gene and a homologous right arm of the site-specific integration site. The vector is designed based on the CRISPR / Cas9 targeting system, and the plasmid vector can accurately introduce the exogenous gene into a specific site in the coccidia genome, thereby solving the problems of random integration of exogenous genes in coccidia transgenic technology and loss of exogenous genes in transgenic coccidia.

The invention relates to the technical field of microorganisms, in particular to application of lactobacillus salivarius PC114 in preparation of a product for removing drug-resistant bacteria in intestinal tracts, and the preservation number of the lactobacillus salivarius PC114 is CGMCC (China General Microbiological Culture Collection Center) NO.23518. The invention further relates to a preparation method of the lactobacillus salivarius PC114. The lactobacillus salivarius PC114 has the effects of reducing the number of vancomycin-resistant enterococcus, improving the diversity and uniformity of intestinal community, regulating the composition of intestinal flora, improving intestinal barrier injury and the like, and can be applied to preparation of products for removing intestinal drug-resistant bacteria.

The invention relates to the technical field of biological detection, in particular to a primer probe composition for a fungal infection detection system, which comprises an upstream primer, a downstream primer and a fluorescent probe designed aiming at candida auricula, and an upstream primer, a downstream primer and a fluorescent probe designed aiming at cryptococcus gattii (cryptococcus neoformans). The upstream primer, the downstream primer and the fluorescent probe are designed aiming at histoplasma capsulatum, the upstream primer, the downstream primer and the fluorescent probe are designed aiming at trichosporon crassiforme, and the upstream primer, the downstream primer and the fluorescent probe are designed aiming at paracoccus brazilii; the invention also relates to a method for simultaneously detecting and quantifying five clinical important yeast-like pathogenic fungi by combining a fluorescent quantitative polymerase chain reaction (qPCR) and a digital polymerase chain reaction (dPCR). Therefore, the problem that multiple pathogenic fungi cannot be detected at the same time during single pathogen detection is solved; or although multiple detection is carried out, accurate quantification is difficult, and the like.

The invention relates to the technical field of chicken flock immunization, and provides a method for promoting coccidiosis immune cycle by controlling the humidity of padding. The method comprises the following steps: laying a drip irrigation humidity control device; mixed padding is prepared, and the drip irrigation humidity control device is placed in the mixed padding; a water outlet hole of the drip irrigation humidity control device is arranged to be in direct contact with the ground, and the water outlet amount of the drip irrigation humidity control device is controlled, so that the humidity of the mixed padding is 20-30%. According to the method, the humidity of the mixed padding can be rapidly adjusted, and the humidity of each area of the padding is uniform. Besides, when the humidity of the padding is adjusted to be within the range, the sporulation rate of coccidiosis is superior to that of other padding humidity, secondary circulation of tender and toxic oocysts can be effectively guaranteed, and the tender and toxic immune protection effect is improved.

The invention relates to the technical field of feed additives, and particularly discloses a compound feed additive as well as a preparation method and application thereof. The compound feed additive provided by the invention comprises the following components in parts by weight: 1-8 parts of a saw palmetto extract, 1-5 parts of an inonotus obliquus extract, 0.5-2.5 parts of a rhizoma dioscoreae nipponicae extract, 20-30 parts of a raspberry extract, 3-5 parts of a cortex erythrinae extract, 3-5 parts of compound bacteria and 10-30 parts of a carrier, furthermore, the compound bacteria are selected from enterococcus faecium, bacillus laterosporus, acetobacter ollani, lactobacillus acidophilus and lactobacillus rhamnosus; the invention also provides an animal feed prepared from the compound feed additive. The compound feed additive provided by the invention can improve the growth performance of animals from multiple aspects of enhancing animal immunity, improving animal intestinal microbe balance, increasing the feed conversion rate and the like, so that the breeding benefits of the livestock and poultry breeding industry are improved.

The invention relates to a primer probe composition for detecting chicken coccidiosis oocysts based on RAA-LFD and application of the primer probe composition. The specific primer and the probe are designed according to the specific sequence of the chicken coccidiosis 18S rRNA gene, and the chicken coccidiosis 18S rRNA gene in a chicken manure sample can be qualitatively detected. Firstly, a target gene is subjected to isothermal amplification through an RAA method, then a lateral flow chromatography test strip is combined, finally, an amplification product is subjected to visual analysis, and the purpose of rapid detection can be achieved. The method has the advantages of being simple and convenient to operate, rapid in reaction, high in sensitivity, good in specificity, visual in reaction result and the like, is suitable for rapid diagnosis of clinical samples and laboratories, and has a good application prospect in prevention and control of chicken coccidiosis.

A compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, for use in the treatment of a patient infected with pathogenic organisms; wherein X and Y are each independently selected from C, N, O and S, provided at least one of X and Y is N, O or S; wherein R1 and R2 are each independently selected from an optionally substituted C1-C8 alkyl, C1-C8 alkenyl, aryl, heteroaryl or alkylaryl group; and wherein Z is selected from H, —CN, —NO2, —NR3R4, —NR5(CO)R6; C1-C4 alkyl, C1-C4 alkoxy, —(CO)WR12, hydroxy, amino, thiol, chloro, fluoro, CF3, CHF2 or CH2F groups. The compounds may be effective in treating patients / animals infected with parasites selected from Schistosoma, Haemonchus, Eimeria, Echinococcus, Dirofilaria, Fasciola or Plasmodium parasites. Additionally or alternatively, the compounds of formula (I) may be effective in treating patients infected with pathogenic bacteria selected from S. aureus, MRSA and Enterococcus faecalis.

The application relates to the technical field of cross technology of intelligent breeding, bioinformatics and artificial intelligence, and provides a chicken coccidiosis early warning method, device, equipment, storage medium and program product, which has strong anti-interference capability in chicken coccidiosis early warning. According to sound wave data and video data in a current time window, soundprint feature vectors and body state feature vectors of chickens are obtained to obtain a disease posterior probability and a group infection index; the group infection index is input into a preset chicken coccidiosis SIR-Coccidia transmission dynamics model to simulate epidemic evolution in a future time step; when the epidemic evolution simulation result exceeds a preset safety threshold, a preliminary prevention and control strategy is generated based on a multi-objective optimization algorithm, the preliminary prevention and control strategy is subjected to compliance matching processing with a preset veterinary prevention and control knowledge base, a corrected prevention and control strategy is obtained and risk prediction is carried out, and a target early warning instruction set is generated.

The invention relates to an agricultural pest biological control technology, and aims to provide a rhodococcus strain and application thereof to degradation of insecticides and enhancement of parasitic wasp resistance. The strain is preserved in the China Center for Type Culture Collection, the preservation name is Fanqing Sheng Rhodococcus IT-1, the classification name of Latin is Rhodococcus qingshengii, and the preservation number is CCTCC NO: M 20252461. The 16S rRNA gene sequence of the strain is as shown in SEQ ID NO: 1. The strain is unique in source and broad in function spectrum; biological control can be enhanced, and the effect is remarkable; the strain is supplemented back into the parasitic wasp body in a feeding mode, the endurance capacity of the parasitic wasp to imidacloprid and thiamethoxam can be remarkably improved, and the strain has great significance in maintaining and enhancing the biological control function of an agricultural ecosystem and reducing dependence of chemical pesticides.