5 results about "Pneumococcal Diseases" patented technology

The present invention relates to multivalent immunogenic compositions comprising one or more Streptococcus pneumoniae polysaccharide protein conjugates wherein each of the conjugates comprises a polysaccharide from a Streptococcus pneumoniae serotype conjugated to a carrier protein wherein the serotype of the Streptococcus pneumoniae is as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed from a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed from a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering to the patient the multivalent immunogenic composition of the invention. The multivalent immunogenic composition is used to provide protection against Streptococcus pneumoniae infection and / or pneumococcal disease caused by Streptococcus pneumoniae. The compositions of the invention are also useful as part of a therapeutic regimen that provides supplemental protection for patients who have been vaccinated with a multivalent vaccine for the prevention of pneumococcal disease.

The present disclosure is drawn to an endolysin protein against Streptococcus pneumoniae (Spn), designated SP-CHAP. The disclosure provides methods of treating diseases in a subject resulting from infection with pneumococcal bacteria, said diseases including but not limited to pneumonia, invasive pneumococcal disease, meningitis and sepsis. Such treatment methods include administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising SP-CHAP polypeptide, polypeptide fragments, SP-CHAP encoding nucleic acids (RNA / DNA) or variants thereof.

The invention is related to 26-valent immunogenic compositions comprising 26 different S. pneumoniae polysaccharide carrier protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. The 26-valent immunogenic compositions are useful for providing protection against S. pneumoniae infection and / or pneumococcal diseases caused by S. pneumoniae including pneumococcal pneumoniae, invasive pneumococcal disease and acute otitis media.

The invention is related to 26-valent immunogenic compositions comprising 26 different S. pneumoniae polysaccharide carrier protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. The 26-valent immunogenic compositions are useful for providing protection against S. pneumoniae infection and / or pneumococcal diseases caused by S. pneumoniae including pneumococcal pneumoniae, invasive pneumococcal disease and acute otitis media.

An immunogenic composition comprising bacterial membrane vesicles (MVs) comprising a streptococcal MalX antigen and / or a streptococcal PrsA antigen, characterized in that the MVs do not comprise an immunogenic amount of a streptococcal PspA antigen. The membrane vesicles may be artificial membrane particles. Medical uses of the composition in particular for immunization against pneumococcal disease, and methods of manufacturing the composition.