3 results about "A serotype" patented technology

Disclosed herein are methods for detecting the presence of a plurality of adeno-associated viruses (AAVs) or adenoviruses (Ad) in a sample. Methods for determining multiple serotypes of AAV or Ad virus in a sample are also described. Further disclosed are methods for detecting the presence of a heteroviral capsid protein in a sample comprising a serotype of AAV or Ad. Also disclosed is the use of LC-MS for detecting the presence of a plurality of AAVs or Ad in a sample; or a use for determining a plurality of serotypes of a plurality of AAVs or Ad in a sample; or to detect the presence of a heteroviral capsid protein in a sample comprising a serotype of AAV or Ad.

This invention provides a serotyping method, a serotyping PCR kit, and a primer pair for Mannhemia haemolitica, enabling simple and rapid serotyping of the species. [Solution] For the 12 serotypes of Mannhemia haemolitica (A1, A2, A5, A6, A7, A8, A9, A12, A13, A14, A16, A17), 11 specific capsule-coding genes are targeted, with serotypes A14 and A16 having homologous capsule-coding genes.

The present invention relates to the field of chemical synthesis, and disclosed is a chemical synthesis method for a serotype O5 O-antigen oligosaccharide of pseudomonas aeruginosa. In the present invention, a D-glucuronic acid building block and a D-fucosamine building block are used to construct an O-antigen trisaccharide, wherein the stereoselective synthesis of a D-fucosamine 1,2-α-cis-glycosidic bond relies on remote acyl participation and reagent regulation, and the synthesis of two 2,3-diaminomannuronic acid 1,2-β-trans glycosidic bonds is realized by means of SN2 nucleophilic substitution of a C2 azido group; and by means of selective assembly of protecting groups, orthogonal modification of modifying groups, and regulation of the reactivity of glycosyl donors and acceptors, the preparation of a multifunctionally modified O-antigen target trisaccharide is successfully completed. The method of the present invention is characterized in that raw materials are cheap and easily available and the preparation method is simple and easy to repeat, and has good prospects of application in the development of vaccines against pseudomonas aeruginosa.