12 results about "Human astrovirus" patented technology

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory diseases, autoimmune diseases, and microbial and bacterial infections; and non-complement-mediated diseases, such cystic fibrosis and various acute diseases. The invention is directed to modifications of a synthetic peptide of 15 amino acids from the Polar Assortant (PA) peptide, which is a scrambled peptide derived from human Astrovirus protein. In some embodiments, the invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of PA (e.g., sarcosine derivatives) having, for example, internal peptide substitutions, and modifications, including PEGylation at the N-terminus and C-terminus. The invention further provides methods of selecting at least one synthetic peptide for treating various conditions.

The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage.

The present invention provides synthetic peptides, compositions containing synthetic peptides, and methods for modifying the complement system. [Solution] The present invention relates to the modification of a 15-amino acid synthetic peptide from polar assortant (PA) peptides, which are scrambled peptides derived from human astrovirus protein. In some embodiments, the present invention relates to peptides that are modified PAs, which are stapled and / or have D-enantiomer substitutions of certain amino acids, and which include sarcosine substitutions at certain amino acid positions. The present invention further provides a method for selecting at least one synthetic peptide to treat various conditions.

The invention discloses a recombinant vector containing a human astrovirus nucleic acid fragment, which is obtained by inserting an exogenous nucleotide sequence into a prokaryotic expression vector skeleton, and the exogenous nucleotide sequence is formed by sequentially connecting the following gene sequences: an SUMO fusion tag DNA sequence, an SAP gene sequence, an MS2 phage related DNA sequence and a human astrovirus sequence fragment. The tail end of the prepared human astrovirus pseudovirus particle contains a stem-loop structure, so that the human astrovirus pseudovirus particle is not easily degraded by nuclease, and the stability of virus nucleic acid RNA (Ribonucleic Acid) is improved; meanwhile, a human astrovirus conservative RNA gene sequence is wrapped by the phage MS2 coat protein, so that the phage MS2 coat protein has relatively high ribonuclease and deoxyribonuclease resistance, and the long-term stability of virus nucleic acid RNA is enhanced. And the stability problem of the virus RNA quality control product in the production and use processes is solved.

1. Name of the product in this design: Packaging Box (Human Astrovirus Detection Kit). 2. Purpose of this design: for packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The present invention provides peptide compounds that regulate the complement system and methods of using these compounds. The invention is an isolated, purified peptide of 30 amino acids derived from human astrovirus protein, called CP1. The invention is directed to peptide compounds that are peptide mimetics, peptide analogs and / or synthetic derivatives of CP1 having, for example, internal peptide deletions and substitutions, deletions and substitutions at the N-terminus and C-terminus, and that are able to regulate complement activation. The invention further provides pharmaceutical compositions of therapeutically effective amounts of the peptide compounds and a pharmaceutically acceptable carrier, diluent, or excipient for treating a disease or condition associated with complement-mediated tissue damage.

The invention discloses a composition for detecting seven foodborne viruses and an RT-PCR (reverse transcription-polymerase chain reaction) kit thereof, and belongs to the technical field of foodborne virus detection. The detected food-borne viruses specifically comprise a norovirus GI gene group, a norovirus GII gene group, a hepatitis A virus, a hepatitis E virus, a group A rotavirus, a human astrovirus and a human sapovirus, grouping detection is performed, and at least three food-borne viruses are detected in each group; preferably, the norovirus GI gene group, the norovirus GII gene group, the hepatitis A virus and the rotavirus A are taken as a first group, and the hepatitis E virus, the human astrovirus and the human sapovirus are taken as a second group. The method can rapidly and efficiently detect the food-borne viruses in the food, can effectively save rare samples and reagents, has high sensitivity and specificity, is simple in result judgment and convenient to apply, can be applied to rapid detection of the specificity of the food-borne viruses in the food, and provides technical support for guaranteeing food safety and protecting human health.

The invention relates to the technical field of virus detection, in particular to a human astrovirus multiplex fluorescent quantitative PCR detection primer probe set based on long sequence analysis, a kit, a detection method and application. For typical, MLB and VA genomes of HAstV, long sequence analysis is carried out, primers and probes are designed, experimental screening optimization is carried out on a plurality of pairs of designed primer and probe combinations to obtain an optimal primer and probe combination, and a triple real-time fluorescent PCR detection method is established, so that the contents of typical, MLB and VA HAstV in a sample to be detected can be qualitatively and quantitatively detected in real time at the same time; the kit is high in sensitivity, strong in specificity and good in repeatability, and provides technical support for diagnosis, prevention and control of epidemic situations.

We provide peptide-based inhibitors for different pathways in the complement system. [Solution] The present invention provides synthetic peptides. The present invention relates to the modification of a 15-amino acid synthetic peptide from polar assortant (PA) peptides, which are scrambled peptides derived from human astrovirus protein. In some embodiments, the present invention relates to peptides that are modified PAs, which are stapled and / or have D-enantiomer substitutions of certain amino acids, and which include sarcosine substitutions at certain amino acid positions. The present invention further provides a method for selecting at least one synthetic peptide to treat various conditions.

The invention provides a primer composition and a kit for detecting infectious diarrhea type pathogens. Staphylococcus aureus, escherichia coli, klebsiella pneumoniae, proteus mirabilis, listeria monocytogenes, pseudomonas aeruginosa, salmonella enteritidis, clamping film bacillus aerogenes, vibrio cholerae, clostridium difficile, aeromonas capora, yersinia enterocolitica, plesiomonas shigelloides, vibrio parahaemolyticus, campylobacter jejuni, candida albicans and aspergillus fumigatus are detected at the same time. The kit can be one or any combination of Aspergillus flavus, entamoeba histolytica, human adenovirus A, human adenovirus B, human adenovirus C, human adenovirus F, human bocavirus, rotavirus, norovirus, fiveleaf virus and human astrovirus, and has the advantages of short time consumption, high resolution, high flux, high sensitivity and the like.

The invention provides a primer probe combination for detecting diarrhea viruses through quadruple TaqMan qPCR and application of the primer probe combination, and belongs to the technical field of diarrhea virus detection. The primer probe combination for detecting the diarrhea virus through quadruple TaqMan qPCR provided by the invention comprises primer probes for detecting rotavirus, norovirus, human astrovirus and adenovirus respectively. The primer probe combination provided by the invention has the advantages of high sensitivity, stability, specificity and the like when being used for quadruple TaqMan fluorescent quantitative PCR detection.