7results about How to "Reduce tissue damage" patented technology

The invention provides application of a traditional Chinese medicine composition in preparation of medicines for preventing and / or treating influenza A and related diseases thereof. The traditional Chinese medicine composition comprises the following components or is prepared from the following raw material medicines in parts by weight: 20-40 parts of gypsum, 10-30 parts of wild buckwheat rhizome, 10-30 parts of herba houttuyniae, 3-15 parts of roasted herba ephedrae, 3-15 parts of fried semen armeniacae amarae, 3-15 parts of bulbus fritillariae cirrhosae, 5-25 parts of herba ardisiae japonicae, 3-15 parts of folium eriobotryae, 3-15 parts of fried fructus perillae and 3-15 parts of roasted radix glycyrrhizae. The traditional Chinese medicine composition disclosed by the invention has a relatively good inhibition effect on influenza A viruses, is low in toxicity and high in safety, also has a good anti-influenza A virus infection effect, and can provide a basis for clinically treating pulmonary infection caused by the influenza A viruses.

The application provides an antibacterial neural electrode based on a high-surface-potential zirconium oxide layer and a preparation method thereof. The electrode comprises, from bottom to top, a bottom zirconium oxide film layer, a first insulating layer, a metal layer, a second insulating layer, a top zirconium oxide film layer and an electrode modification layer. A distal end of the metal layer is partially exposed to form an electrode point, and the electrode modification layer covers the electrode point. The bottom zirconium oxide film layer and the top zirconium oxide film layer are subjected to high-surface-potential treatment and exhibit a positive surface potential in a physiological environment. The positive surface potential can destroy the cell membranes of bacteria with negative charges through electrostatic action after the neural electrode is implanted in vivo, and inhibit the formation of microglial cells and astrocytes. The damage to the membranes of mammalian cells (such as neurons) with neutral electricity is extremely small. The application realizes active antibacterial function through the high-surface-potential zirconium oxide film layer, ensures long-term effective contact between the electrode and neurons, and thus realizes high-quality, long-term stable electrophysiological recording and stimulation function of the neural electrode.

The present invention discloses an expandable percutaneous puncture needle, belonging to the technical field of medical devices, comprising a needle core and a syringe, wherein the needle core is a solid needle, and the syringe is wrapped around the outer periphery of the needle core, the needle core is a cylinder, the inner hole diameter of the syringe is equal to the outer circle diameter of the needle core, and teeth are symmetrically arranged on both sides of the needle core, the teeth are in the shape of a triangular prism, and the syringe is composed of two semicircular barrel walls, the teeth pass through the gap of the syringe and a part of the teeth are exposed outside the syringe, and the teeth arranged on the needle core expand the range in the bone when the needle core is rotated, and the two barrel walls are driven to separate from each other by a connecting driving mechanism to achieve the same size as the outer diameter of the outer sheath of a conventional expansion sleeve, so as to realize the expansion of the puncture needle and replace the function of the expansion sleeve, thereby eliminating the insertion process of the guide needle and the expansion sleeve, making the surgical operation simpler and safer, reducing the difficulty and risk of the surgery, and reducing the pain and tissue damage caused to the patient by the secondary insertion of the sleeve.

The invention relates to an abdominal wall fat tissue minimally invasive biopsy and anesthesia integrated device and a using method and application thereof.The device comprises an anesthesia injection and fat sampling integrated sterile needle, the anesthesia injection and fat sampling integrated sterile needle comprises a puncture needle, a needle head connecting part, a compressible cavity and a pressing head which are sequentially connected, and the pressing head is provided with a connecting hole communicated with the compressible cavity; a detachable sealing piece is arranged at the top of the connecting hole, anesthesia injection is contained in the compressible cavity, and a sealing cover arranged on the outer side of an opening of the puncture needle in a sleeving mode is arranged at the bottom of the puncture needle. The device further comprises a surface anesthesia application, a miniature negative pressure pump, tweezers, a sample split charging small tube and a disinfection cotton swab. According to the device, the surface anesthesia application, the anesthesia injection and fat sampling integrated sterile needle are matched for use, so that the preparation is simple, and the fat tissue collection step is simplified; the related biopsy method adopts a minimally invasive technology, so that tissue damage and postoperative recovery time are reduced; the device can also be integrated into a kit for direct detection of adipose tissue.

The invention provides a malt type acupuncture needle based on a new material. The 316 stainless steel wires are selected as raw materials, and the 316 stainless steel wires are medical-grade materials containing molybdenum elements and have good biocompatibility, corrosion resistance and mechanical strength. Although the 316 stainless steel wire contains molybdenum, the performance can be improved by adjusting the molybdenum content. A molybdenum-rich protective layer is formed on the surface of the acupuncture needle through a chemical vapor deposition (CVD) technology, so that the corrosion resistance of the acupuncture needle is further improved. Besides, according to the malt-type acupuncture needle prepared by the invention, a painless needle tip is formed by adopting a modern cutting process and reserving a manual multi-grinding process of a traditional acupuncture needle, so that the friction force and tissue damage during insertion are reduced, and the pain of a patient is greatly relieved. Meanwhile, the malt-shaped acupuncture needle designed by the invention can effectively solve the problems of safety and sanitation during clinical operation of a conventional acupuncture needle, and the therapeutic effect of acupuncture is enhanced.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

A kind of positioning device of intraductal lesion, the positioning device includes positioning catheter and breast ductoscope sheath cooperating with positioning catheter, breast ductoscope sheath includes mirror sheath body, hollow guide sleeve, first connector, second connector, third connector, one end of hollow guide sleeve is connected with the inside of mirror sheath body, first connector, second connector, third connector are communicated with the inside of hollow guide sleeve by mirror sheath body, positioning catheter includes intermediate pipeline and outer pipeline, outer pipeline is sleeved on the outside of intermediate pipeline, the outside of outer pipeline is equipped with the scale mark distributed along the axial direction, one end of intermediate pipeline is equipped with the liquid injection hole that can inject methylene blue.The utility model discloses by breast ductoscope sheath sends into the lesion position of breast duct with positioning catheter, and injects methylene blue, improves the accuracy of intraductal lesion position positioning and checking, reduces unnecessary resection the pain and tissue damage brought to patient.