3results about How to "Reduce tissue damage" patented technology

The application provides an antibacterial neural electrode based on a high-surface-potential zirconium oxide layer and a preparation method thereof. The electrode comprises, from bottom to top, a bottom zirconium oxide film layer, a first insulating layer, a metal layer, a second insulating layer, a top zirconium oxide film layer and an electrode modification layer. A distal end of the metal layer is partially exposed to form an electrode point, and the electrode modification layer covers the electrode point. The bottom zirconium oxide film layer and the top zirconium oxide film layer are subjected to high-surface-potential treatment and exhibit a positive surface potential in a physiological environment. The positive surface potential can destroy the cell membranes of bacteria with negative charges through electrostatic action after the neural electrode is implanted in vivo, and inhibit the formation of microglial cells and astrocytes. The damage to the membranes of mammalian cells (such as neurons) with neutral electricity is extremely small. The application realizes active antibacterial function through the high-surface-potential zirconium oxide film layer, ensures long-term effective contact between the electrode and neurons, and thus realizes high-quality, long-term stable electrophysiological recording and stimulation function of the neural electrode.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

A kind of positioning device of intraductal lesion, the positioning device includes positioning catheter and breast ductoscope sheath cooperating with positioning catheter, breast ductoscope sheath includes mirror sheath body, hollow guide sleeve, first connector, second connector, third connector, one end of hollow guide sleeve is connected with the inside of mirror sheath body, first connector, second connector, third connector are communicated with the inside of hollow guide sleeve by mirror sheath body, positioning catheter includes intermediate pipeline and outer pipeline, outer pipeline is sleeved on the outside of intermediate pipeline, the outside of outer pipeline is equipped with the scale mark distributed along the axial direction, one end of intermediate pipeline is equipped with the liquid injection hole that can inject methylene blue.The utility model discloses by breast ductoscope sheath sends into the lesion position of breast duct with positioning catheter, and injects methylene blue, improves the accuracy of intraductal lesion position positioning and checking, reduces unnecessary resection the pain and tissue damage brought to patient.