9 results about "Chronic constipation" patented technology

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

This invention relates to a method for donor-recipient matching in intestinal microbiota transplantation for chronic constipation based on multidimensional microbiota characteristics and machine learning, and its application. By collecting 16S rRNA intestinal microbiota data of donors and recipients before intestinal microbiota transplantation (FMT) treatment, as well as retrospective data on the clinical efficacy of FMT, the invention calculates characteristics such as differences in microbiota abundance, metabolic pathway activity, enzyme activity, and species diversity between donors and recipients. Principal component analysis is used to select high-contribution features that can explain 90% of the variance. A random forest machine learning model is used to select feature markers related to treatment efficacy, and the weights of these markers in the model are calculated. Finally, the optimal donor is selected by weighted scoring and ranking of the microbiota characteristics of each donor.

The present invention describes a dietary supplement consisting of a first plurality of daily doses of a laxative composition (A) comprising Psyllium, MgO, and fennel dry extract.; and a second plurality of daily doses of a probiotic and prebiotic composition (B) comprising B. lactis, B. longum, and FOS. Subject-matter of the present invention is therefore also a food supplement as described above for use in the treatment of constipation, linked to the intake of drugs, constipation-predominant IBS, chronic constipation, or acute constipation, characterized in that the plurality of doses of composition (B) are taken sequentially to a number of doses of composition (A).

The invention belongs to the field of traditional Chinese medicine preparations, and relates to spleen-warming dampness-dissipating paste and a preparation method thereof. The formula comprises radix aconiti lateralis preparata, raw rhubarb, rhizoma zingiberis, cinnamon, fructus evodiae, ginseng, honey-fried licorice root, angelica sinensis, coptis chinensis and compound of glauber-salt and liquorice. The process comprises the following steps: adding water to decoct twice, combining decoctions, concentrating under reduced pressure, and adding mirabilitum dehydratum to obtain an extracting solution. In the formula, monkshood and rhubarb are monarch drugs for warming yang and relaxing bowels; the rhizoma zingiberis, the cortex cinnamomi and the fructus evodiae help the monarch to warm Ginseng, angelica sinensis and honey-fried licorice root reinforce qi, nourish blood and strengthen vitality; the coptis chinensis has the effects of clearing heat and purging, the compound of glauber-salt and liquorice has the effects of moistening the lower part and the honey-fried licorice root has the effect of conductant The whole formula realizes the effects of warming yang as the root, relaxing bowels as the symptom, strengthening primordial qi and preventing change, is suitable for chronic constipation, abdominal obesity, intolerance of cold, fat tongue body, white and greasy fur and the like caused by insufficiency of spleen yang and dysfunction of transportation and transformation, and has the advantages of reasonable formula, exact effect, scientific process and the like.

The present application relates to a kind of regulating gastrointestinal function of the composition of food and medicine and its preparation method and application.The present application uses the medicinal material of food and medicine, such as Cistanche, Cassia seed, Codonopsis, hawthorn, immature fruit of Citrus aurantium, angelica and licorice, reasonable compatibility as main effective component, further can increase seasoning, functional auxiliary material black sesame, walnut, Chinese yam, jujube, dietary fiber or honey, and be made into suitable product of taste.The efficacy application result verifies that the composition has good spleen and kidney, blood and qi, moistening intestine and defecation effect, can significantly regulate gastrointestinal function, improve the treatment effect on acute constipation and chronic constipation;After increasing functional auxiliary material, not only have the effect of preparation forming and improving taste, but also have the function of significantly improving intestinal peristalsis, secretory water, reducing the adverse effects of long-term use of emodin-containing traditional Chinese medicine, etc.The regulating gastrointestinal function of the composition of food and medicine of the present application is suitable for long-term constipation population, especially suitable for weak old people.

Provided herein are compounds that inhibit phosphodiesterase 5 (PDE5) and methods of use thereof. In some forms, the compounds can have a structure according to Formula I:Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating gastrointestinal diseases and disorders such as intestinal cancers, chronic constipation, and inflammatory bowel disease.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

The present disclosure relates to a dry food composition for use in a method for treating chronic constipation in a feline in need thereof, wherein the said dry food composition includes: - from about 50g / Mcal to about 100g / Mcal of protein; - from about 25g / Mcal to about 55g / Mcal of fat; - from about 10g / Mcal to about 25g / Mcal of Ash; and - from about 15g / Mcal to about 35g / Mcal of Total Dietary Fibers (TDF), wherein the dry food composition comprises, on a dry matter basis, from about 5% to about 12% by weight of psyllium.