15 results about "Chronic constipation" patented technology

The invention discloses a traditional Chinese medicine composition for treating chronic constipation and a preparation method thereof.The traditional Chinese medicine composition is prepared from eucommia ulmoides, radix clematidis, aster, rhizoma atractylodis macrocephalae, mangnolia officinalis, poria cocos, codonopsis pilosula, immature bitter orange, cynomorium songaricum, cistanche deserticola, semen cassiae and glycyrrhiza uralensis. The traditional Chinese medicine composition has the functions of warming and tonifying liver and kidney, tonifying kidney and strengthening essence, diffusing and lowering lung qi, invigorating spleen and replenishing qi, eliminating dampness and promoting diuresis and the like, so that body fluid is generated, intestines are moistened and nourished, qi movement is smooth, large intestine conduction is recovered, and constipation, especially chronic constipation of old people or people with deficiency of qi and blood, is effectively treated.

To provide a system and a method for easily and accurately detecting a defecation event and acquiring defecation event data.SOLUTION: A system 100 and a method facilitate detection and recording of a defecation event of a target such as a participant of a clinical test for treating a digestive system disease such as an irritable bowel syndrome (IBS), an inflammatory bowel disease (IBD), and chronic coprostasis. The system 100 and the method can be used by individual patients for detecting and recording a defecation event, and resultant data can be checked in detail by a medical treatment provider at the time of evaluating health and / or treatment of the gastrointestinal of the patient.SELECTED DRAWING: Figure 1

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

This invention relates to a method for donor-recipient matching in intestinal microbiota transplantation for chronic constipation based on multidimensional microbiota characteristics and machine learning, and its application. By collecting 16S rRNA intestinal microbiota data of donors and recipients before intestinal microbiota transplantation (FMT) treatment, as well as retrospective data on the clinical efficacy of FMT, the invention calculates characteristics such as differences in microbiota abundance, metabolic pathway activity, enzyme activity, and species diversity between donors and recipients. Principal component analysis is used to select high-contribution features that can explain 90% of the variance. A random forest machine learning model is used to select feature markers related to treatment efficacy, and the weights of these markers in the model are calculated. Finally, the optimal donor is selected by weighted scoring and ranking of the microbiota characteristics of each donor.

The present invention describes a dietary supplement consisting of a first plurality of daily doses of a laxative composition (A) comprising Psyllium, MgO, and fennel dry extract.; and a second plurality of daily doses of a probiotic and prebiotic composition (B) comprising B. lactis, B. longum, and FOS. Subject-matter of the present invention is therefore also a food supplement as described above for use in the treatment of constipation, linked to the intake of drugs, constipation-predominant IBS, chronic constipation, or acute constipation, characterized in that the plurality of doses of composition (B) are taken sequentially to a number of doses of composition (A).

The invention relates to the technical field of health-care food, in particular to multi-element composite plant nutrition powder and a preparation method thereof. The multi-element composite plant nutrition powder is prepared from the following raw materials in parts by mass: 41 to 44 parts of maltodextrin, 24 to 27 parts of lactitol, 12 parts of comprehensive vegetable and fruit enzyme powder, 10 parts of semen plantaginis husk powder, 7 to 8 parts of fructo-oligosaccharide, 1 part of semen cassiae powder, 1 part of fructus cannabis, 1 part of bunge cherry seed, 0.002 to 0.003 part of vitamin B1, 0.01 to 0.02 part of vitamin B2 and 0.03 to 0.04 part of vitamin B6. The formula disclosed by the invention integrates lubrication, motivation, prebiotics regulation, enzyme assistance and nutrition support, is suitable for people with poor dietary fiber, old people with weakened intestinal motility and people with chronic constipation needing long-term conditioning, not only is quick and reliable in bowel relaxing, but also pays attention to overall maintenance of intestinal health, and has remarkable comprehensive advantages.

The invention belongs to the field of traditional Chinese medicine preparations, and relates to spleen-warming dampness-dissipating paste and a preparation method thereof. The formula comprises radix aconiti lateralis preparata, raw rhubarb, rhizoma zingiberis, cinnamon, fructus evodiae, ginseng, honey-fried licorice root, angelica sinensis, coptis chinensis and compound of glauber-salt and liquorice. The process comprises the following steps: adding water to decoct twice, combining decoctions, concentrating under reduced pressure, and adding mirabilitum dehydratum to obtain an extracting solution. In the formula, monkshood and rhubarb are monarch drugs for warming yang and relaxing bowels; the rhizoma zingiberis, the cortex cinnamomi and the fructus evodiae help the monarch to warm Ginseng, angelica sinensis and honey-fried licorice root reinforce qi, nourish blood and strengthen vitality; the coptis chinensis has the effects of clearing heat and purging, the compound of glauber-salt and liquorice has the effects of moistening the lower part and the honey-fried licorice root has the effect of conductant The whole formula realizes the effects of warming yang as the root, relaxing bowels as the symptom, strengthening primordial qi and preventing change, is suitable for chronic constipation, abdominal obesity, intolerance of cold, fat tongue body, white and greasy fur and the like caused by insufficiency of spleen yang and dysfunction of transportation and transformation, and has the advantages of reasonable formula, exact effect, scientific process and the like.

The present application relates to a kind of regulating gastrointestinal function of the composition of food and medicine and its preparation method and application.The present application uses the medicinal material of food and medicine, such as Cistanche, Cassia seed, Codonopsis, hawthorn, immature fruit of Citrus aurantium, angelica and licorice, reasonable compatibility as main effective component, further can increase seasoning, functional auxiliary material black sesame, walnut, Chinese yam, jujube, dietary fiber or honey, and be made into suitable product of taste.The efficacy application result verifies that the composition has good spleen and kidney, blood and qi, moistening intestine and defecation effect, can significantly regulate gastrointestinal function, improve the treatment effect on acute constipation and chronic constipation;After increasing functional auxiliary material, not only have the effect of preparation forming and improving taste, but also have the function of significantly improving intestinal peristalsis, secretory water, reducing the adverse effects of long-term use of emodin-containing traditional Chinese medicine, etc.The regulating gastrointestinal function of the composition of food and medicine of the present application is suitable for long-term constipation population, especially suitable for weak old people.

The invention relates to a medicinal and edible composition for regulating gastrointestinal functions as well as a preparation method and application of the medicinal and edible composition. Medicinal and edible medicinal materials such as cistanche, semen cassiae, codonopsis pilosula, hawthorn, immature bitter orange, angelica sinensis and liquorice are reasonably combined to serve as main functional components, seasoning and functional auxiliary materials such as black sesame, walnuts, Chinese yam, Chinese dates, dietary fibers or honey can be further added, and a finished product with proper taste is prepared. Pharmacodynamic application results prove that the composition has good effects of invigorating spleen and tonifying kidney, nourishing blood and regulating qi, and moistening intestines and relaxing bowel, and can obviously regulate gastrointestinal functions and improve treatment effects on acute constipation and chronic constipation; after the functional auxiliary materials are added, the effects of forming the preparation and improving the taste are achieved, and meanwhile the functions of obviously improving intestinal tract movement and secreting water on constipation, reducing the adverse effect of long-term use of the emodin-containing traditional Chinese medicine and the like are achieved. The medicinal and edible composition for regulating the gastrointestinal function is suitable for people with long-term constipation, especially for weak old people.

The invention discloses vegetable juice capable of promoting reproduction of probiotics and a preparation method of the vegetable juice, and belongs to the technical field of diet conditioning, in the vegetable juice, dietary fibers and intestinal flora are fully reserved through wall breaking treatment instead of squeezing, and then sufficient food is obtained for mass reproduction. Organic vegetables are used, no bactericide is used, toxic food is not provided, more dietary fibers are provided, low-temperature sterilization is used in the whole process, more dietary fibers are reserved, and the shelf life is longer after ultrahigh pressure treatment; vegetables such as carrots, beet roots, kohlrabi and the like in the formula are subjected to scientific proportioning and a wall breaking process, and high-concentration dietary fibers, active enzymes and natural prebiotics components are released. Dietary fibers form small particles after wall breaking, water absorption is enhanced, intestinal wall villus movement is stimulated, intestinal tract movement is accelerated, and metabolic waste discharge is accelerated. Active enzymes such as amylase and protease directly participate in food decomposition, the intestinal burden is reduced, and after long-term drinking, the intestinal barrier function can be repaired, and chronic constipation, abdominal distension and inflammatory response can be relieved.

Provided herein are compounds that inhibit phosphodiesterase 5 (PDE5) and methods of use thereof. In some forms, the compounds can have a structure according to Formula I:Also provided are pharmaceutical compositions and medicaments that include the compounds described herein as well as methods of treating gastrointestinal diseases and disorders such as intestinal cancers, chronic constipation, and inflammatory bowel disease.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

The present disclosure relates to a dry food composition for use in a method for treating chronic constipation in a feline in need thereof, wherein the said dry food composition includes: - from about 50g / Mcal to about 100g / Mcal of protein; - from about 25g / Mcal to about 55g / Mcal of fat; - from about 10g / Mcal to about 25g / Mcal of Ash; and - from about 15g / Mcal to about 35g / Mcal of Total Dietary Fibers (TDF), wherein the dry food composition comprises, on a dry matter basis, from about 5% to about 12% by weight of psyllium.

The invention relates to a chronic constipation intestinal flora transplantation donor-receptor matching method based on multidimensional flora characteristics and machine learning and application of the chronic constipation intestinal flora transplantation donor-receptor matching method. 16s rRNA intestinal flora data of a donor and a receptor before FMT treatment and retrospective data of FMT clinical treatment effect are collected; the characteristics of flora abundance difference, metabolic pathway activity difference, enzyme activity difference, species diversity difference and the like between a donor and a receptor are calculated, the characteristics are selected through principal component analysis, and high-contribution characteristics capable of explaining 90% variance are screened out. According to the method, a random forest machine learning model is used for screening out characteristic markers related to the treatment effect, the weights of the markers in the model are calculated, and finally the optimal donor is screened out by performing weighted scoring and sorting on the flora characteristics of each donor.