34 results about "Intestinal motility" patented technology

The application discloses a postoperative gastrointestinal motility closed-loop management system and belongs to the technical field of postoperative gastrointestinal motility nursing, which comprises the following: a wireless distributed sensing node attached to key acupoints on the abdomen for collecting borborygmus, gastrointestinal slow wave, abdominal tension and IMU motion posture; an edge computing control terminal running an adaptive multi-modal fusion algorithm, calculating a gastrointestinal motility index MI(t) by dynamically updating weights through Kalman filtering or variational Bayesian inference; a two-stage safety execution module containing software logic fusing (stopping when the algorithm judges an abnormality) and hardware physical fusing (MOSFET relay forced power-off); and a cloud monitoring platform supporting remote visual monitoring, data tracing, OTA upgrading and adopting AES-256 hardware encryption; the system realizes a four-layer closed-loop architecture from sensing, decision-making, execution and monitoring. The application significantly shortens the postoperative gastrointestinal function recovery time and reduces the incidence of complications through non-invasive multi-modal monitoring and closed-loop feedback.

This invention provides the application of Liu Mo Tang freeze-dried powder in the preparation of products regulating intestinal flora imbalance, belonging to the field of biomedical technology. The Liu Mo Tang freeze-dried powder provided by this invention effectively improves intestinal flora imbalance, particularly in constipation-predominant irritable bowel syndrome (IBS). Constipation-predominant IBS leads to a decrease in butyrate-producing bacteria, reduced butyrate production capacity, impaired intestinal barrier function, increased permeability, and weakened intestinal motility, accompanied by pathogenic bacterial proliferation. After administration of Liu Mo Tang, the abundance of butyrate-producing bacteria is upregulated, and the increase of abnormal bacteria is inhibited, which helps restore intestinal butyrate supply, improves intestinal barrier function, and promotes the recovery of intestinal motility. By reshaping the balance between butyrate-producing bacteria and pro-inflammatory bacteria, it effectively improves intestinal flora imbalance in IBS.

The application provides application of Lactobacillus paracasei K56 in preparation of products for improving intestinal peristalsis and promoting defecation, and relates to the technical field of biotechnology. The application comprises application of Lactobacillus paracasei K56 in preparation of products containing at least one efficacy of improving small intestinal propulsion rate of a subject, promoting intestinal peristalsis of the subject and promoting defecation of the subject, wherein the products comprise a fermentation product fermented by using a fermenting agent containing Lactobacillus paracasei K56, and the fermentation substrate contains milk; and the application comprises increasing the proportion of the number of dead Lactobacillus paracasei K56 cells in the fermented product relative to the total number of Lactobacillus paracasei K56 cells. The application alleviates the technical problem that inactivation of bacteria in a fermented product causes the probiotic function to be affected.

The application provides a probiotic preparation and application thereof. The probiotic preparation comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavenging bacteria, organic acid producing bacteria and space-occupying bacteria; the oxygen scavenging bacteria are Weizmannia bacteria, the organic acid producing bacteria are lactobacillus or lactobacillus plantarum, and the space-occupying bacteria are bifidobacterium; the water activity of the probiotic preparation is less than or equal to 0.3, preferably 0.04-0.3, further preferably 0.04-0.2, and more preferably 0.04-0.15. The probiotic preparation has high live bacteria stability when stored at room temperature. Moreover, the probiotic preparation can effectively improve functional gastrointestinal diseases and has bidirectional regulation function, and is suitable for different intestinal motility disorders, such as diarrhea and constipation.

The invention provides a traditional Chinese medicine external application composition for treating gastroparesis after brain injury and a preparation method thereof. The traditional Chinese medicine external application composition is prepared from the following components: rhizoma acori graminei, paederia scandens, radix polygoni multiflori preparata, aloe, gastrodia elata, semen aesculi, phyllanthus emblica, stephania tetrandra, turmeric, radix fici simplicissimae, fructus piperis longi, swertia pseudochinensis, rhizoma nardostachyos, lily, ginkgo leaves and cynanchum paniculatum. Dual mechanisms of neuroprotection and gastrointestinal motility regulation are creatively fused, central nervous injury can be improved through components such as rhizoma acori graminei and radix polygoni multiflori preparata, gastrointestinal hormone secretion and slow-wave pace-making functions can be synchronously regulated through components such as paederia scandens and turmeric, and compared with a conventional single-target treatment means, the traditional Chinese medicine composition is more suitable for a complex pathological mechanism of gastric paralysis after brain injury. Meanwhile, the preparation process is simple, the cost is low, external application avoids aggravation of gastrointestinal burdens, common western medicine side effects such as arrhythmia are avoided, clinical operation is convenient, patient tolerance is good, the gastric emptying recovery time is remarkably shortened, and the risk of complications such as aspiration pneumonia is reduced.

This application discloses a nutritional meal recommendation system, method, equipment, and medium for post-gynecological surgery, relating to the field of digital health management technology and applied to a computer device. It includes: an association matrix acquisition module, used to construct dynamic physiological signs by combining the patient's hormone levels and blood loss after gynecological surgery, and splicing them according to time sequence and the nutritional ratio of candidate ingredients to generate a nutritional metabolism association matrix; an evolution matrix acquisition module, used to perform first-order differentiation and normalization of the matrix in the time dimension to construct a metabolic nutritional evolution feature matrix; a node sequence construction module, used to split feature vectors, construct a heterogeneous graph using gastrointestinal dynamic impedance, and use a graph attention network to screen ingredient nodes to form a sequence of nodes with absorption potential; and a meal plan generation module, used to calculate the nutritional difference in the sequence, extract decreasing topological fragments, and generate an individualized nutritional meal plan adapted to the patient's dynamic physiology and gastrointestinal capacity.

The present application belongs to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating children's functional dyspepsia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: Fructus Aurantii Immaturus 5-20 parts, Magnolia officinalis 5-20 parts, Forsythia suspensa 5-30 parts, Dendrobium 5-30 parts, Atractylodes macrocephala 5-20 parts, and Glycyrrhiza 5-30 parts. The pharmacological experiment results show that the traditional Chinese medicine composition has the effects of improving gastrointestinal motility and regulating gastrointestinal hormone secretion, has a significant therapeutic effect on children's functional dyspepsia, has stable curative effect, and has a small dosage. Meanwhile, the present application has the advantages of simple process operation, low cost, good controllability and stability, and is suitable for industrialized mass production.

The application discloses a lactobacillus rhamnosus capable of significantly increasing the number of enteric neurons and neuroglial cells and an application thereof, and belongs to the field of microorganisms.The lactobacillus rhamnosus CCFM1360 has good activity, certain acid and alkali resistance and adhesion, can significantly increase the number of enteric neurons and neuroglial cells, repair intestinal barrier function, increase the content of SCFAs in colon contents, increase the number of Treg cells in mesenteric lymph nodes, reduce the expression level of inflammatory factors in colon tissues, reduce the intestinal inflammation level, and relieve the weakened intestinal motility disorder.

The invention provides a lactobacillus kunkeeei H09 and an application of the lactobacillus kunkeeei H09. The lactobacillus kunkeeei H09 is prepared from lactobacillus kunkeeei H09 and lactobacillus kunkeeei H09, the preservation number of the lactobacillus kkaike H09 provided by the invention in the China General Microbiological Culture Collection Center is CGMCC (China General Microbiological Culture Collection Center) NO.31250. According to the application, the lactobacillus kkaike H09 is applied to food intake regulation, intestinal development regulation, intestinal motility regulation and immunity regulation, and experimental results show that the lactobacillus kkaike H09 can remarkably improve the food intake of bees, increase the intestinal development length of the bees, promote the intestinal motility of the bees and improve the immunity of the bees, and has probiotic potential.

The present invention is directed to a balloon-based system and method for measuring gastrointestinal motility. The balloon can be a stand-alone balloon with pressure sensing capabilities or the balloon can be deployed as a component of a catheter-based system. The balloon can be deployed in an uninflated state and can be inflated with fluid such as air, water, or other biocompatible fluid while disposed within the gastrointestinal tract. The pressure sensor can take the form of a pressure sensor disposed within the balloon or disposed on a surface of the balloon. Additional, sensors can also be applied to monitor other conditions, function, or disease state.

This invention discloses the application of Rehmannia glutinosa exosomes in the preparation of drugs for the prevention of colitis, belonging to the field of plant exosome technology. The Rehmannia glutinosa exosomes extracted using the specific process of this invention not only significantly reduced the DAI score of a colitis model to below 2.0 and restored TNF-α to normal levels, but also unexpectedly improved intestinal motility disorders associated with colitis by bidirectionally regulating gastrointestinal hormones (inhibiting VIP / ET-1 and promoting MTL / SP). This effect is significantly superior to that of traditional water and alcohol extracts of Rehmannia glutinosa.

1. Name of the product in this design: Gastrointestinal motility therapy device. 2. Purpose of this design: For the treatment of gastrointestinal motility disorders and functional diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses a pet feed additive for enhancing gastrointestinal peristalsis. A double-layer embedding structure is adopted, wherein the outer layer is a pH response type compound formed by chitosan and sodium alginate, and the effects of stomach protection and intestinal tract targeted slow release are achieved; the core of the inner layer is a compound of resveratrol and inulin and selenium-enriched yeast prepared through biotransformation. The composition has the synergistic effect through multiple target points: the resveratrol is used for regulating intestinal nerves and resisting inflammation, the inulin is used as prebiotics for promoting proliferation of beneficial bacteria, and the organic selenium is used for enhancing the oxidation resistance of intestinal mucosa, so that the gastrointestinal tract peristalsis is comprehensively and safely promoted. Experiments show that the additive can significantly improve the defecation condition, shorten the gastrointestinal transmission time, optimize the intestinal flora and reduce inflammation, and is suitable for being added to pet food needing to improve gastrointestinal motility.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving anorexia and a medicinal preparation. The traditional Chinese medicine composition comprises radix pseudostellariae, rhizoma atractylodis, fried hawthorn, raw malt, Chinese yam, endothelium corneum gigeriae galli, pericarpium citri reticulatae, fried rice sprout, fried semen raphani, liquorice and rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition provided by the invention has the effects of strengthening the spleen and the stomach, improves gastrointestinal motility by regulating gastrointestinal hormone secretion, and can improve spleen functions and relieve spleen and stomach injuries, so that the food intake and the body weight of anorexia patients are effectively improved, and anorexia symptoms are remarkably improved.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

The application discloses a gastric electrical monitoring and evaluation method, comprising the following steps: determining a monitoring original signal and a lead signal corresponding to maximum power according to a power spectrum of a gastric electrical original signal; performing filtering processing to obtain a pretreated first signal and a pretreated second signal; determining amplitude phase information and artifact information according to the pretreated first signal and the pretreated second signal; determining a target analytical phase and a target gastric electrical signal according to the amplitude phase information, the pretreated second signal and the artifact information; determining a signal time-frequency domain index, a slow wave propagation direction and a gastric electrical slow wave phase coupling degree according to the target analytical phase and the target gastric electrical signal; and determining a gastrointestinal motility evaluation result according to the signal time-frequency domain index, the slow wave propagation direction and the gastric electrical slow wave phase coupling degree. The application further provides a gastric electrical monitoring and evaluation system. The application monitors from a time-frequency domain feature of a signal and a time-space feature of a stomach, obtains monitoring data for gastric evaluation, and improves the accuracy of gastric state evaluation.

This invention discloses a traditional Chinese medicine composition for regulating calcium ion homeostasis in the stomach, belonging to the field of traditional Chinese medicine technology. It is made from calcined oyster shell, calcined abalone shell, dried plum, poria cocos, and jujube seed in a specific weight ratio. This invention selects highly efficient calcium sources, calcined oyster shell and calcined abalone shell, in equal proportions, avoiding the deficiency of insufficient calcium content in traditional calcined dragon bone. It targets and supplements local calcium ions in the stomach, enhances the stabilizing effect of calcium ions on potassium ion channels, inhibits abnormal potassium ion leakage, and improves gastrointestinal smooth muscle tone. At the same time, it eliminates unsuitable medicinal materials such as Codonopsis pilosula, Astragalus membranaceus, Eucommia ulmoides, and Lycium barbarum. It uses Prunus mume to inhibit the proliferation of harmful bacteria in the small intestine and reduce fermentation and gas production, Poria cocos to supplement gastrointestinal trace elements, and Ziziphus jujuba var. spinosa to stabilize potassium ion channels, restore the calcium-potassium ion balance in the stomach, improve gastrointestinal motility rhythm, and alleviate problems such as small intestinal bacterial overgrowth, insufficient gastrointestinal motility, and abdominal distension. This composition does not contain sucrose, maltodextrin, chemical additives, or irritating excipients. It is fully decocted and suitable for people with fragile gastrointestinal barriers and immune sensitivity. The raw materials are safe and readily available, the preparation method is simple, and it has broad application prospects in gastrointestinal conditioning.

The application discloses a bifidobacterium that can significantly improve the expression of BDNF of a host and an application thereof, and belongs to the technical field of microorganisms. The bifidobacterium CCFM1359 provided by the application can effectively improve the levels of BDNF and its specific receptor TrkB in the colon of a mouse, can also increase the number of enteric glial cells, improve the content of excitatory neurotransmitter Ach in the colon, down-regulate the content of inhibitory neurotransmitter NO, and repair the enteric nervous system. Moreover, the bacteria can down-regulate the gene expression levels of TLR2 and TNF-alpha, up-regulate the gene expression level of IL-10, reduce the inflammation level in the colon, and regulate the intestinal motility. Therefore, in the future, a more personalized treatment scheme can be adopted for patients with damaged enteric nerves (including but not limited to intestinal motility disorders), and the application prospect is very considerable.

The application discloses a lactobacillus paracasei for repairing intestinal nerves and an application thereof, and belongs to the field of microorganisms. The lactobacillus paracasei CCFM1321 provided by the application can significantly increase the number of intestinal nerve glial cells, improve the level of glial cell-derived neurotrophic factor GDNF and the expression of its receptor GFR alpha 1 / RET, and repair the damaged intestinal nervous system of mice. The lactobacillus paracasei can down-regulate the over-activation of Toll-like receptor 2 (TLR2), reduce the expression of inhibitory neurotransmitters, increase the expression of serotonin 5-HT and its receptor 5-HT 2B , and has the effect of protecting the intestinal nervous system. Moreover, the lactobacillus paracasei can reduce the inflammation level in the colon tissue caused by the damage of intestinal nerves, improve the pathological damage of the colon tissue, and relieve the intestinal motility disorder. Therefore, a more personalized treatment scheme can be adopted for gastrointestinal diseases caused by the abnormal intestinal nervous system, and the application prospect is considerable.

This invention provides a bridging drainage system for a gastric tube and a urostomy bag, belonging to the field of medical equipment technology. It includes: a stoma baseplate with a stoma opening for attaching to the stoma; a hollow annular drainage assembly with its bottom detachably connected to the stoma baseplate; a urostomy bag, one end of which is fixedly fitted onto the annular drainage assembly; a drainage bag connected to the other end of the urostomy bag via a drainage tube; an infusion dilution assembly connected to the annular drainage assembly via an infusion tube to provide diluent; and a first dilution sleeve disposed inside the urostomy bag. This bridging drainage system provides multiple dilution points inside and outside the stoma, successfully resolving stoma outlet obstruction, fecal hardening in stoma patients, and defecation difficulties caused by insufficient intestinal motility by diluting and collecting feces.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a pharmaceutical composition for treating simple obesity of spleen deficiency and dampness retention type and its application. This pharmaceutical composition is prepared based on seven traditional Chinese medicines listed in the Food and Drug Catalogue: Codonopsis pilosula, Poria cocos, Coix lacryma-jobi, Dioscorea opposita, Nelumbo nucifera, Lilium brownii, and Ziziphus jujuba. The pharmaceutical composition provided by this invention improves the condition of swollen, pale, and white-coated tongue in rats with simple obesity of spleen deficiency and dampness retention type, and improves abnormal lipid metabolism; it can effectively regulate abnormalities in serum BUN, UA, MTL, VIP, and other indicators in rats with simple obesity of spleen deficiency and dampness retention type, improve gastrointestinal emptying, enhance gastrointestinal motility, and increase the calcium content of myocardial cell membranes. 2+ -ATPase, Na + -K + - It increases ATPase activity, improves cellular energy metabolism, and reduces the risk of cardiovascular disease caused by obesity; it inhibits the expression levels of BUN and UA, which can treat obesity-induced hyperuricemia and improve renal metabolism. It also exerts a therapeutic effect on simple obese rats with spleen deficiency and dampness retention.

This invention provides a *Hydroxystoma coagulans* strain and its uses. This *Hydroxystoma coagulans* strain was deposited on November 3, 2025, at the China General Microbiological Culture Collection Center (CGMCC), with accession number CGMCC No. 36494. The *Hydroxystoma coagulans* strain provided by this invention has multiple functions: it can enhance whole intestinal motility, accelerating small intestinal propulsion and promoting colonic emptying; it can soften stool, significantly increasing stool water content, thus fundamentally improving constipation.

The present application provides a probiotic preparation and its use. The probiotic preparation of the present application comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavengers, organic acid producers and place holders; the adjuvants comprise flavoring agents, oligosaccharides and other additives; wherein the oligosaccharides are not lactulose, stachyose, raffinose, oligogentiobiose and oligochitosan, and the other additives are not theaflavins, ethylenediaminetetraacetic acid disodium salt and sorbic acid. The present application effectively promotes the metabolic activity of probiotics through a specific combination of adjuvants, rather than just providing physical protection or nutritional support. Experimental data show that the adjuvant combination of the present application can significantly and continuously improve the oxidation-reduction potential and Na + K + ATPase activity of probiotics. Moreover, the probiotic preparation of the present application can effectively improve functional gastrointestinal diseases and has a bidirectional regulation function, which is suitable for different intestinal motility disorders, such as diarrhea and constipation.

The invention provides a lactobacillus meliiflora P18 and a preparation method of the lactobacillus meliiflora P18. The lactobacillus meliiflora P18 is prepared from lactobacillus meliiflora P18 and an application of the lactobacillus meliiflora P18. The preservation number of the lactobacillus melisii mengbu P18 provided by the invention is CGMCC (China General Microbiological Culture Collection Center) NO.31263 in the General Microbiological Culture Collection Center of the China Committee for Culture Collection of Microorganisms. According to the application, the lactobacillus melisii P18 is applied to food intake regulation, intestinal motility regulation and immunity regulation, and experimental results show that the lactobacillus melisii P18 can significantly improve food intake, promote intestinal motility and improve immunity, and has probiotic potential.

The invention relates to application of bifidobacterium longum subspecies infantis C-3 in preparation of a product with the efficacy of relieving constipation or promoting intestinal tract movement. The classification name of the bifidobacterium longum subspecies infantis C-3 is Bifidobacterium longum subspecies infantis C-3, and the preservation number of the bifidobacterium longum subspecies infantis C-3 is GDMCC No: 64541. The bifidobacterium longum subsp. Infantis C-3 can enhance intestinal motility through multiple ways and promote normal secretion of gastrointestinal hormones, and provides a new idea and basis for constipation regulation.

The application discloses a kind of pelvic fracture postoperative intestinal function recovery methods based on multi-modal evaluation, it is related to medical postoperative rehabilitation evaluation technical field, including collecting patient postoperative gastrointestinal motility related physiological indexes, pelvic cavity imaging data, clinical manifestation text record and so on multi-modal data, pre-processing is extracted multi-modal evaluation characteristics;Characteristics are input into coevolution network, each evaluation branch parallel processing corresponding modal characteristics, through shared intermediate representation layer completes feature exchange and weight mutual adjustment, combined with the adaptive contribution degree of branch exchange after intermediate representation and own state vector calculation, weighted fusion obtains comprehensive intestinal function recovery state score, compares threshold value and determines recovery stage and matches output rehabilitation intervention suggestion.The method can realize the linkage processing of multi-modal characteristics, dynamically adapt each modal evaluation weight, improve the accuracy of intestinal function recovery evaluation, output and patient recovery stage adapt to rehabilitation intervention scheme.

An orally swallowable, immediate release tablet, comprising itopride or a pharmaceutically acceptable salt thereof as an active ingredient, characterized in that the tablet comprises granules containing the active ingredient, mannitol and optionally at least one additional pharmaceutically acceptable excipient, wherein the tablet does not contain lactose. Said tablet for use in prevention or treatment of gastrointestinal motility disorders. A method for manufacturing the orally swallowable, immediate release tablet according to any of the preceding claims, comprising: a) granulating itopride or a pharmaceutically acceptable salt thereof with mannitol and optionally at least one additional pharmaceutically acceptable excipient, b) optionally blending the granules obtained in step a) with at least one extra-granular pharmaceutically acceptable excipient, and c) compressing the granules from step a) or the blend from step b) into tablets.

The application relates to a kind of intestinal power detection devices with fixing function for veterinary, including bottom plate, tail limiting mechanism is arranged on the bottom plate, injection mechanism is connected with the tail limiting mechanism;The tail limiting mechanism includes turnover component, clamping component is arranged on the turnover component;The injection mechanism includes sliding part, and the sliding part is slidably connected with the bottom plate;It also includes injection part arranged in the sliding part;The injection part includes sleeve, medical lubricant is contained in the sleeve, one end of the sleeve close to the tail limiting mechanism is provided with insertion part, the insertion part is made of silica gel material, the sleeve is detachably connected with steel ball containing part, the steel ball containing part is communicated with the sleeve and the insertion part, the sleeve is slidably connected with push part, the push part extends out of the sleeve from the other end of the sleeve, and injection work is facilitated on the intestine of mouse.