93 results about "Intestinal motility" patented technology

The invention belongs to the technical field of probiotics, and particularly relates to probiotics for improving intestinal health and application thereof. Wherein the probiotics for improving the intestinal health are a Lactobacillus plantarum LV1000 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.30865, and the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on June 5, 2024; through unique activation culture, streak separation and bacterial colony identification steps, high activity and high purity of the strain are ensured; based on the application of the strain, two product forms of probiotic microcapsules and probiotic compositions are developed, the probiotic microcapsules adopt sodium alginate, calcium lactate and other raw materials, the intestinal colonization ability of the strain is effectively improved, and the synergistic interaction of oxidation resistance and immunoregulation is achieved by combining rosa roxburghii tratt freeze-dried powder; and the probiotic composition can comprehensively regulate the balance of intestinal flora and improve the digestive function and intestinal motility.

The invention provides a preparation method of a Witzia ciliaris IOB502 microbial inoculum and an application of the Witzia ciliaris IOB502 microbial inoculum in the aspect of recovering intestinal motility, the Witzia ciliaris IOB502 microbial inoculum is prepared by adopting a method of carrying out low-oxygen stress staged fermentation on chickpeas by adopting the Witzia ciliaris IOB502, and the generation of vitamins B1 and B2 can be promoted. The microbial inoculum does not affect physiological development of important organs such as liver, spleen and small intestine of mice, can improve defecation symptoms of the mice with constipation, increase defecation times and water content of excrement, improve intestinal movement of the mice with constipation, promote smooth passage of intestinal contents, effectively improve colon injury of the mice with constipation, and improve the constipation rate of the mice with constipation. Comprising mucous membrane layer thinning and mucus secretion reduction.

A gastrointestinal motility detection capsule utilizes bidirectional ultrasound probe pairs to simultaneously obtain the distances from the capsule to the opposite sides of the gastrointestinal tract section. By adding the distances with the distance between the probe pair, a directional cavity diameter is obtained, which can eliminate data fusion errors caused by capsule movement. Based on multiple directional cavity diameters, gastrointestinal morphological features such as curvature, average diameter, volume, anatomical position, and 3D dynamics are acquired. Based on the time series of the features, gastrointestinal motility parameters such as peristaltic frequency and intensity, capsule movement trajectory, and emptying time are obtained. The capsule is to be used in routine gastrointestinal motility checks and disease diagnosis. The examinee does not need to clean the gastrointestinal tract and can pair it with different diets, making it convenient for self-examination at home or hospital check-ups.

The present invention provides a fermented Lactobacillus fermentum IG50, which has a CGMCC accession number of 32111. The fermented Lactobacillus fermentum provided by the present invention can ferment Magnolia officinalis to produce a motilin receptor agonist. The present invention also provides a probiotic preparation that helps improve intestinal motility. The present invention also provides a method for preparing the probiotic preparation. The preparation method of the probiotic preparation is simple and can be produced on a large scale.

The invention discloses a magnetic control soft robot with electrical stimulation and drug release functions, and relates to the technical field of medical instruments. In the magnetic control soft robot provided by the invention, the magnetic layer is used for driving the body to move and position in the gastrointestinal tract under the driving of an external magnetic field; the electric control layer is used for supplying power and is responsible for controlling the opportunity and parameters of electric stimulation and controlling a drug release instruction; after a microneedle of the conductive hydrogel microneedle layer penetrates into tissue, nerve endings or muscle cells can be stimulated by applying a weak electric signal so as to regulate gastrointestinal motility, relieve pain and the like, a drug can be loaded in the microneedle, and when the electric signal is applied, the drug can be loaded in the microneedle by means of electromigration, electroosmosis and the like. Triggering the drug to be controllably released into the target tissue as required; the adhesive layer is used for temporarily anchoring the robot at a specific working position of the gastrointestinal tract; according to the magnetic control soft robot and the preparation method thereof, the comprehensive requirements of gastrointestinal tract disease treatment can be met.

The invention belongs to the technical field of application of natural products, and particularly relates to an anti-helicobacter pylori natural product composition and application, the anti-helicobacter pylori natural product composition comprises raspberry extract and cinnamon extract, and the composition contains anti-helicobacter pylori active substances. Besides, the natural product composition is combined with a clinical standard treatment method for treating helicobacter pylori, so that the curative effect can be further improved, and the gastrointestinal motility can be enhanced by adjusting intestinal flora disorder caused by pylorus infection, reducing toxic and side effects of antibiotic treatment, protecting gastric mucosa and enhancing gastrointestinal motility. The composition consists of two natural medicinal and edible plant extracts, is suitable for long-term use and has few adverse reactions. The Lycojaponicumin C can be used for preparing anti-helicobacter pylori medicines and preventive health-care foods, has obvious significance in prevention and treatment of helicobacter pylori infection, and has a good development prospect.

The invention belongs to the technical field of medicines, and provides a traditional Chinese medicine composition which comprises the following raw materials in parts by weight: 18-22 parts of clove, 10-35 parts of radix ophiopogonis and one of the following raw materials. I: 10-20 parts of hawthorn; iI: 20-30 parts of immature bitter orange, 20-30 parts of dried orange peel, 20-35 parts of endothelium corneum gigeriae galli and 20-30 parts of cinnamon. The traditional Chinese medicine composition capable of improving gastrointestinal motility is obtained on the basis of traditional Chinese medicine ancient prescriptions, modern pharmacological research and clinical medication experience through a large number of composition efficacy tests. The components and dosage ratio of the traditional Chinese medicine composition supplement each other, so that the traditional Chinese medicine composition has the functional effects of warming the stomach, strengthening the spleen, promoting the circulation of qi, relieving dyspepsia and the like, is specially used for people with gastrointestinal motility dysfunction, helps the people to relieve gastrointestinal motility dysfunction diseases caused by gastrointestinal motility dysfunction, and is wide in application prospect. In addition, the components of the traditional Chinese medicine composition are all medicinal and edible traditional Chinese medicinal materials, so that the traditional Chinese medicine composition has few side effects and remarkable curative effects.

The invention discloses bifidobacterium longum subsp. Infantis for regulating intestinal motility and aquaporin and application of the bifidobacterium longum subsp. Infantis, and belongs to the technical field of microorganisms. According to the invention, the bifidobacterium longum subsp. Infantis CCFM1269 is screened, and the bifidobacterium longum subsp. Infantis CCFM1269 has the effects of intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The application discloses a postoperative gastrointestinal motility closed-loop management system and belongs to the technical field of postoperative gastrointestinal motility nursing, which comprises the following: a wireless distributed sensing node attached to key acupoints on the abdomen for collecting borborygmus, gastrointestinal slow wave, abdominal tension and IMU motion posture; an edge computing control terminal running an adaptive multi-modal fusion algorithm, calculating a gastrointestinal motility index MI(t) by dynamically updating weights through Kalman filtering or variational Bayesian inference; a two-stage safety execution module containing software logic fusing (stopping when the algorithm judges an abnormality) and hardware physical fusing (MOSFET relay forced power-off); and a cloud monitoring platform supporting remote visual monitoring, data tracing, OTA upgrading and adopting AES-256 hardware encryption; the system realizes a four-layer closed-loop architecture from sensing, decision-making, execution and monitoring. The application significantly shortens the postoperative gastrointestinal function recovery time and reduces the incidence of complications through non-invasive multi-modal monitoring and closed-loop feedback.

This invention provides the application of Liu Mo Tang freeze-dried powder in the preparation of products regulating intestinal flora imbalance, belonging to the field of biomedical technology. The Liu Mo Tang freeze-dried powder provided by this invention effectively improves intestinal flora imbalance, particularly in constipation-predominant irritable bowel syndrome (IBS). Constipation-predominant IBS leads to a decrease in butyrate-producing bacteria, reduced butyrate production capacity, impaired intestinal barrier function, increased permeability, and weakened intestinal motility, accompanied by pathogenic bacterial proliferation. After administration of Liu Mo Tang, the abundance of butyrate-producing bacteria is upregulated, and the increase of abnormal bacteria is inhibited, which helps restore intestinal butyrate supply, improves intestinal barrier function, and promotes the recovery of intestinal motility. By reshaping the balance between butyrate-producing bacteria and pro-inflammatory bacteria, it effectively improves intestinal flora imbalance in IBS.

The application provides application of Lactobacillus paracasei K56 in preparation of products for improving intestinal peristalsis and promoting defecation, and relates to the technical field of biotechnology. The application comprises application of Lactobacillus paracasei K56 in preparation of products containing at least one efficacy of improving small intestinal propulsion rate of a subject, promoting intestinal peristalsis of the subject and promoting defecation of the subject, wherein the products comprise a fermentation product fermented by using a fermenting agent containing Lactobacillus paracasei K56, and the fermentation substrate contains milk; and the application comprises increasing the proportion of the number of dead Lactobacillus paracasei K56 cells in the fermented product relative to the total number of Lactobacillus paracasei K56 cells. The application alleviates the technical problem that inactivation of bacteria in a fermented product causes the probiotic function to be affected.

The invention discloses kynurenic acid with an effect of relieving vomitoxin toxicity, and belongs to the technical field of agricultural animals. The application proves that the kynurenic acid can effectively relieve the toxic effect induced by vomitoxin, and the kynurenic acid mainly has the effects of effectively promoting the weight gain of animals, improving the intestinal motility function, inhibiting the release of inflammatory factors, regulating intestinal flora and the like. The invention determines the effect of kynurenic acid in relieving vomitoxin toxicity, and the kynurenic acid has a wide application prospect in preparation of products for preventing and treating vomitoxin toxicity.

The application provides a probiotic preparation and application thereof. The probiotic preparation comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavenging bacteria, organic acid producing bacteria and space-occupying bacteria; the oxygen scavenging bacteria are Weizmannia bacteria, the organic acid producing bacteria are lactobacillus or lactobacillus plantarum, and the space-occupying bacteria are bifidobacterium; the water activity of the probiotic preparation is less than or equal to 0.3, preferably 0.04-0.3, further preferably 0.04-0.2, and more preferably 0.04-0.15. The probiotic preparation has high live bacteria stability when stored at room temperature. Moreover, the probiotic preparation can effectively improve functional gastrointestinal diseases and has bidirectional regulation function, and is suitable for different intestinal motility disorders, such as diarrhea and constipation.

The invention provides a traditional Chinese medicine external application composition for treating gastroparesis after brain injury and a preparation method thereof. The traditional Chinese medicine external application composition is prepared from the following components: rhizoma acori graminei, paederia scandens, radix polygoni multiflori preparata, aloe, gastrodia elata, semen aesculi, phyllanthus emblica, stephania tetrandra, turmeric, radix fici simplicissimae, fructus piperis longi, swertia pseudochinensis, rhizoma nardostachyos, lily, ginkgo leaves and cynanchum paniculatum. Dual mechanisms of neuroprotection and gastrointestinal motility regulation are creatively fused, central nervous injury can be improved through components such as rhizoma acori graminei and radix polygoni multiflori preparata, gastrointestinal hormone secretion and slow-wave pace-making functions can be synchronously regulated through components such as paederia scandens and turmeric, and compared with a conventional single-target treatment means, the traditional Chinese medicine composition is more suitable for a complex pathological mechanism of gastric paralysis after brain injury. Meanwhile, the preparation process is simple, the cost is low, external application avoids aggravation of gastrointestinal burdens, common western medicine side effects such as arrhythmia are avoided, clinical operation is convenient, patient tolerance is good, the gastric emptying recovery time is remarkably shortened, and the risk of complications such as aspiration pneumonia is reduced.

The present application discloses a kind of 4-acetylamino butyric acid and 3,4-dihydroxyphenylacetic acid in Guizhou Kaili Hong acid soup, which can enhance intestinal microecological balance, promote intestinal motility, and improve constipation or inflammatory bowel disease. The principle is that 4-acetylamino butyric acid or 3,4-dihydroxyphenylacetic acid can significantly increase the expression of C-Kit in the intestine, and significantly inhibit the expression of macrophage inflammatory factors.

The invention discloses mulberry solid health-preserving paste and a preparation method thereof, and belongs to the technical field of paste preparation. Comprising the following raw materials in parts by weight: 30-45 parts of fresh mulberry residues, 5-10 parts of dendrobium officinale, 20 parts of red dates, 10-20 parts of longan, 5 parts of radix puerariae dry powder, 10-20 parts of black beans and 40-60 parts of brown sugar. According to the preparation method of the mulberry solid health-preserving paste convenient to carry, the intestinal peristalsis function is improved through a mulberry-dendrobium officinale-radix puerariae powder compound system, and meanwhile, the radix puerariae powder has the effect of improving intestinal peristalsis as a natural active ingredient and can also improve the caking phenomenon of a base material. By adjusting the addition proportion of the brown sugar, the formability of the paste is guaranteed, the sugar content is reduced, and a natural solution with safety and efficacy is provided for people with difficulty in defecation.

The invention relates to a bifidobacterium composition for relieving mood disorder caused by constipation and application of the bifidobacterium composition, and belongs to the technical field of probiotics. According to the bifidobacterium composition containing the animal bifidobacterium subsp. Lactis Bb-12 and the bifidobacterium longum subsp. Longum BB536, through the synergistic effect of the Bb-12 and the BB536, the effect of relieving constipation can be achieved by improving the water content of excrement, improving the intestinal tract movement capacity and increasing the content of short-chain fatty acid in the intestinal tract. On the basis that constipation is relieved, emotional disorders caused by constipation can be further relieved, and particularly, the content of anxiety and depression related cranial nerve factors BDNF in hippocampus is increased, and the relative expression quantity of inflammatory factors TNF-alpha is reduced. A new thought is provided for the development of nutritional supplement food for relieving anxiety and depression caused by constipation.

The invention discloses a probiotic composition capable of enhancing intestinal motility, and relates to the technical field of probiotics, and the probiotic composition is technically characterized by comprising a core strain and a synergistic component, the core strain comprises bifidobacterium longum, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus plantarum and bacillus coagulans, and the synergistic component comprises lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus plantarum and bacillus coagulans. The synergistic components comprise a prebiotic mixture and auxiliary components, and the prebiotic mixture comprises fructo-oligosaccharide, inulin and resistant dextrin. According to the probiotic composition capable of enhancing intestinal motility, through reasonable proportioning of the core strain and the synergistic components, the capability of the probiotic composition in the aspect of enhancing intestinal motility can be effectively improved, proliferation of bifidobacterium can be promoted and colonization of flora can be enhanced by adding the prebiotic mixture and fructo-oligosaccharide, and the inulin can provide a long-acting fermentation substrate, so that the intestinal motility can be enhanced. And the resistant dextrin can increase the volume of excrement and relieve constipation.

This application discloses a nutritional meal recommendation system, method, equipment, and medium for post-gynecological surgery, relating to the field of digital health management technology and applied to a computer device. It includes: an association matrix acquisition module, used to construct dynamic physiological signs by combining the patient's hormone levels and blood loss after gynecological surgery, and splicing them according to time sequence and the nutritional ratio of candidate ingredients to generate a nutritional metabolism association matrix; an evolution matrix acquisition module, used to perform first-order differentiation and normalization of the matrix in the time dimension to construct a metabolic nutritional evolution feature matrix; a node sequence construction module, used to split feature vectors, construct a heterogeneous graph using gastrointestinal dynamic impedance, and use a graph attention network to screen ingredient nodes to form a sequence of nodes with absorption potential; and a meal plan generation module, used to calculate the nutritional difference in the sequence, extract decreasing topological fragments, and generate an individualized nutritional meal plan adapted to the patient's dynamic physiology and gastrointestinal capacity.

The present application belongs to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating children's functional dyspepsia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: Fructus Aurantii Immaturus 5-20 parts, Magnolia officinalis 5-20 parts, Forsythia suspensa 5-30 parts, Dendrobium 5-30 parts, Atractylodes macrocephala 5-20 parts, and Glycyrrhiza 5-30 parts. The pharmacological experiment results show that the traditional Chinese medicine composition has the effects of improving gastrointestinal motility and regulating gastrointestinal hormone secretion, has a significant therapeutic effect on children's functional dyspepsia, has stable curative effect, and has a small dosage. Meanwhile, the present application has the advantages of simple process operation, low cost, good controllability and stability, and is suitable for industrialized mass production.

The application discloses a lactobacillus rhamnosus capable of significantly increasing the number of enteric neurons and neuroglial cells and an application thereof, and belongs to the field of microorganisms.The lactobacillus rhamnosus CCFM1360 has good activity, certain acid and alkali resistance and adhesion, can significantly increase the number of enteric neurons and neuroglial cells, repair intestinal barrier function, increase the content of SCFAs in colon contents, increase the number of Treg cells in mesenteric lymph nodes, reduce the expression level of inflammatory factors in colon tissues, reduce the intestinal inflammation level, and relieve the weakened intestinal motility disorder.

The invention discloses a degradation-controllable cellulose-based gastrointestinal motility marker and a preparation method thereof. The cellulose-based gastrointestinal motility marker is of a core-shell structure formed by the following components in percentage by weight through a double-crosslinking network: 15-20% of hydroxyethyl cellulose, 10-15% of a crosslinking agent, 10-15% of sodium alginate, 50-60% of type II barium sulfate, 5-8% of an emulsifier, 5-10% of a filler and 2-8% of calcium chloride, the inner core is a covalent cross-linked porous network formed by free radical polymerization of a cross-linking agent and hydroxyethyl cellulose, and is cross-linked with type II barium sulfate, an emulsifier and a filler; the shell is a gel layer formed by ionic crosslinking of sodium alginate and calcium chloride. The marker disclosed by the invention can realize controllable degradation, accurate counting and dynamic tracking in a human body, so that the purpose of medical diagnosis of observing the gastrointestinal motility function is achieved.

The invention provides a lactobacillus kunkeeei H09 and an application of the lactobacillus kunkeeei H09. The lactobacillus kunkeeei H09 is prepared from lactobacillus kunkeeei H09 and lactobacillus kunkeeei H09, the preservation number of the lactobacillus kkaike H09 provided by the invention in the China General Microbiological Culture Collection Center is CGMCC (China General Microbiological Culture Collection Center) NO.31250. According to the application, the lactobacillus kkaike H09 is applied to food intake regulation, intestinal development regulation, intestinal motility regulation and immunity regulation, and experimental results show that the lactobacillus kkaike H09 can remarkably improve the food intake of bees, increase the intestinal development length of the bees, promote the intestinal motility of the bees and improve the immunity of the bees, and has probiotic potential.

The present invention is directed to a balloon-based system and method for measuring gastrointestinal motility. The balloon can be a stand-alone balloon with pressure sensing capabilities or the balloon can be deployed as a component of a catheter-based system. The balloon can be deployed in an uninflated state and can be inflated with fluid such as air, water, or other biocompatible fluid while disposed within the gastrointestinal tract. The pressure sensor can take the form of a pressure sensor disposed within the balloon or disposed on a surface of the balloon. Additional, sensors can also be applied to monitor other conditions, function, or disease state.

The present invention relates to a system and method for the automatic and early detection of acute abdomen syndrome in horses by analysing audio recordings. The system comprises a capturing device, which is attached to the abdomen of a horse by means of a fastening means, to obtain an audio recording. The analysis is carried out by means of a processing device, with an artificial intelligence system, which identifies and assesses the peristaltic sounds of the horse to classify the condition of its intestinal motility and provide a diagnosis.

This invention discloses the application of Rehmannia glutinosa exosomes in the preparation of drugs for the prevention of colitis, belonging to the field of plant exosome technology. The Rehmannia glutinosa exosomes extracted using the specific process of this invention not only significantly reduced the DAI score of a colitis model to below 2.0 and restored TNF-α to normal levels, but also unexpectedly improved intestinal motility disorders associated with colitis by bidirectionally regulating gastrointestinal hormones (inhibiting VIP / ET-1 and promoting MTL / SP). This effect is significantly superior to that of traditional water and alcohol extracts of Rehmannia glutinosa.

This invention discloses a liposomal curcumin composition for regulating the gastrointestinal tract and its applications, belonging to the technical fields of food and health food. The composition consists of 60-80nm liposomal curcumin, prebiotics, and cardamom extract. The liposomal curcumin uses food-grade phospholipids to construct a biomimetic bilayer structure with an encapsulation rate ≥80%, ethanol residue ≤0.5‰, a 2-hour release rate <33% in simulated gastric juice, and a 2-hour release rate >80% in simulated intestinal juice at pH 7.4. The cardamom extract is a water or alcohol extract of cardamom, with a content of 10-60mg per serving. This invention achieves targeted sustained release of curcumin into the intestine through precise particle size control, synergistically regulating gut microbiota with prebiotics and enhancing gastrointestinal motility with cardamom extract. It regulates gastrointestinal function from multiple dimensions, including mucosal repair, microbiota balance, and motility improvement. The bioavailability is more than 18 times higher than ordinary curcumin. The product has high safety and good stability and can be prepared in various dosage forms such as oral liquid, solid beverage, soft capsules, or tablets, suitable for daily conditioning in people with gastrointestinal dysfunction.

1. Name of the product in this design: Gastrointestinal motility therapy device. 2. Purpose of this design: For the treatment of gastrointestinal motility disorders and functional diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

According to the gastrointestinal motility capsule, a bidirectional ultrasonic probe pair is adopted to synchronously obtain the distance from the capsule to the opposite side of a digestive tract part, and a directional cavity diameter is obtained by adding the distance between the probe pair, so that a data fusion error caused by capsule movement can be eliminated; cavity diameters in multiple directions are synchronously obtained, the largest direction is the main shaft direction of the part, and the average value of the cavity diameters in all the directions orthogonal to the largest direction is taken as the average inner diameter; extracting morphological characteristics such as curvature, inner diameter, volume and anatomical position; on the basis of the feature sequence, alimentary canal power parameters such as peristalsis frequency and strength and the movement track and emptying time of the capsule are obtained; the device can be used for digestive tract motility routine examination and disease diagnosis, and examinees do not need to clean the stomach and intestine, can be matched with different diets, and can conveniently perform self-examination at home or go to hospitals for examination.

The invention discloses bifidobacterium breve for regulating intestinal motility and aquaporin and application of the bifidobacterium breve, and belongs to the technical field of microorganisms. According to the invention, a strain of bifidobacterium breve CCFM1078 is screened out, and the bifidobacterium breve CCFM1078 has the effect of regulating intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP3, AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.