63 results about "Intestinal motility" patented technology

The invention belongs to the technical field of probiotics, and particularly relates to probiotics for improving intestinal health and application thereof. Wherein the probiotics for improving the intestinal health are a Lactobacillus plantarum LV1000 strain with the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.30865, and the strain is preserved in the China General Microbiological Culture Collection Center (CGMCC) on June 5, 2024; through unique activation culture, streak separation and bacterial colony identification steps, high activity and high purity of the strain are ensured; based on the application of the strain, two product forms of probiotic microcapsules and probiotic compositions are developed, the probiotic microcapsules adopt sodium alginate, calcium lactate and other raw materials, the intestinal colonization ability of the strain is effectively improved, and the synergistic interaction of oxidation resistance and immunoregulation is achieved by combining rosa roxburghii tratt freeze-dried powder; and the probiotic composition can comprehensively regulate the balance of intestinal flora and improve the digestive function and intestinal motility.

The invention provides a preparation method of a Witzia ciliaris IOB502 microbial inoculum and an application of the Witzia ciliaris IOB502 microbial inoculum in the aspect of recovering intestinal motility, the Witzia ciliaris IOB502 microbial inoculum is prepared by adopting a method of carrying out low-oxygen stress staged fermentation on chickpeas by adopting the Witzia ciliaris IOB502, and the generation of vitamins B1 and B2 can be promoted. The microbial inoculum does not affect physiological development of important organs such as liver, spleen and small intestine of mice, can improve defecation symptoms of the mice with constipation, increase defecation times and water content of excrement, improve intestinal movement of the mice with constipation, promote smooth passage of intestinal contents, effectively improve colon injury of the mice with constipation, and improve the constipation rate of the mice with constipation. Comprising mucous membrane layer thinning and mucus secretion reduction.

A gastrointestinal motility detection capsule utilizes bidirectional ultrasound probe pairs to simultaneously obtain the distances from the capsule to the opposite sides of the gastrointestinal tract section. By adding the distances with the distance between the probe pair, a directional cavity diameter is obtained, which can eliminate data fusion errors caused by capsule movement. Based on multiple directional cavity diameters, gastrointestinal morphological features such as curvature, average diameter, volume, anatomical position, and 3D dynamics are acquired. Based on the time series of the features, gastrointestinal motility parameters such as peristaltic frequency and intensity, capsule movement trajectory, and emptying time are obtained. The capsule is to be used in routine gastrointestinal motility checks and disease diagnosis. The examinee does not need to clean the gastrointestinal tract and can pair it with different diets, making it convenient for self-examination at home or hospital check-ups.

The invention discloses a magnetic control soft robot with electrical stimulation and drug release functions, and relates to the technical field of medical instruments. In the magnetic control soft robot provided by the invention, the magnetic layer is used for driving the body to move and position in the gastrointestinal tract under the driving of an external magnetic field; the electric control layer is used for supplying power and is responsible for controlling the opportunity and parameters of electric stimulation and controlling a drug release instruction; after a microneedle of the conductive hydrogel microneedle layer penetrates into tissue, nerve endings or muscle cells can be stimulated by applying a weak electric signal so as to regulate gastrointestinal motility, relieve pain and the like, a drug can be loaded in the microneedle, and when the electric signal is applied, the drug can be loaded in the microneedle by means of electromigration, electroosmosis and the like. Triggering the drug to be controllably released into the target tissue as required; the adhesive layer is used for temporarily anchoring the robot at a specific working position of the gastrointestinal tract; according to the magnetic control soft robot and the preparation method thereof, the comprehensive requirements of gastrointestinal tract disease treatment can be met.

The invention discloses bifidobacterium longum subsp. Infantis for regulating intestinal motility and aquaporin and application of the bifidobacterium longum subsp. Infantis, and belongs to the technical field of microorganisms. According to the invention, the bifidobacterium longum subsp. Infantis CCFM1269 is screened, and the bifidobacterium longum subsp. Infantis CCFM1269 has the effects of intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The application discloses a postoperative gastrointestinal motility closed-loop management system and belongs to the technical field of postoperative gastrointestinal motility nursing, which comprises the following: a wireless distributed sensing node attached to key acupoints on the abdomen for collecting borborygmus, gastrointestinal slow wave, abdominal tension and IMU motion posture; an edge computing control terminal running an adaptive multi-modal fusion algorithm, calculating a gastrointestinal motility index MI(t) by dynamically updating weights through Kalman filtering or variational Bayesian inference; a two-stage safety execution module containing software logic fusing (stopping when the algorithm judges an abnormality) and hardware physical fusing (MOSFET relay forced power-off); and a cloud monitoring platform supporting remote visual monitoring, data tracing, OTA upgrading and adopting AES-256 hardware encryption; the system realizes a four-layer closed-loop architecture from sensing, decision-making, execution and monitoring. The application significantly shortens the postoperative gastrointestinal function recovery time and reduces the incidence of complications through non-invasive multi-modal monitoring and closed-loop feedback.

This invention provides the application of Liu Mo Tang freeze-dried powder in the preparation of products regulating intestinal flora imbalance, belonging to the field of biomedical technology. The Liu Mo Tang freeze-dried powder provided by this invention effectively improves intestinal flora imbalance, particularly in constipation-predominant irritable bowel syndrome (IBS). Constipation-predominant IBS leads to a decrease in butyrate-producing bacteria, reduced butyrate production capacity, impaired intestinal barrier function, increased permeability, and weakened intestinal motility, accompanied by pathogenic bacterial proliferation. After administration of Liu Mo Tang, the abundance of butyrate-producing bacteria is upregulated, and the increase of abnormal bacteria is inhibited, which helps restore intestinal butyrate supply, improves intestinal barrier function, and promotes the recovery of intestinal motility. By reshaping the balance between butyrate-producing bacteria and pro-inflammatory bacteria, it effectively improves intestinal flora imbalance in IBS.

The application provides application of Lactobacillus paracasei K56 in preparation of products for improving intestinal peristalsis and promoting defecation, and relates to the technical field of biotechnology. The application comprises application of Lactobacillus paracasei K56 in preparation of products containing at least one efficacy of improving small intestinal propulsion rate of a subject, promoting intestinal peristalsis of the subject and promoting defecation of the subject, wherein the products comprise a fermentation product fermented by using a fermenting agent containing Lactobacillus paracasei K56, and the fermentation substrate contains milk; and the application comprises increasing the proportion of the number of dead Lactobacillus paracasei K56 cells in the fermented product relative to the total number of Lactobacillus paracasei K56 cells. The application alleviates the technical problem that inactivation of bacteria in a fermented product causes the probiotic function to be affected.

The application provides a probiotic preparation and application thereof. The probiotic preparation comprises active ingredients and adjuvants, wherein the active ingredients comprise oxygen scavenging bacteria, organic acid producing bacteria and space-occupying bacteria; the oxygen scavenging bacteria are Weizmannia bacteria, the organic acid producing bacteria are lactobacillus or lactobacillus plantarum, and the space-occupying bacteria are bifidobacterium; the water activity of the probiotic preparation is less than or equal to 0.3, preferably 0.04-0.3, further preferably 0.04-0.2, and more preferably 0.04-0.15. The probiotic preparation has high live bacteria stability when stored at room temperature. Moreover, the probiotic preparation can effectively improve functional gastrointestinal diseases and has bidirectional regulation function, and is suitable for different intestinal motility disorders, such as diarrhea and constipation.

The invention provides a traditional Chinese medicine external application composition for treating gastroparesis after brain injury and a preparation method thereof. The traditional Chinese medicine external application composition is prepared from the following components: rhizoma acori graminei, paederia scandens, radix polygoni multiflori preparata, aloe, gastrodia elata, semen aesculi, phyllanthus emblica, stephania tetrandra, turmeric, radix fici simplicissimae, fructus piperis longi, swertia pseudochinensis, rhizoma nardostachyos, lily, ginkgo leaves and cynanchum paniculatum. Dual mechanisms of neuroprotection and gastrointestinal motility regulation are creatively fused, central nervous injury can be improved through components such as rhizoma acori graminei and radix polygoni multiflori preparata, gastrointestinal hormone secretion and slow-wave pace-making functions can be synchronously regulated through components such as paederia scandens and turmeric, and compared with a conventional single-target treatment means, the traditional Chinese medicine composition is more suitable for a complex pathological mechanism of gastric paralysis after brain injury. Meanwhile, the preparation process is simple, the cost is low, external application avoids aggravation of gastrointestinal burdens, common western medicine side effects such as arrhythmia are avoided, clinical operation is convenient, patient tolerance is good, the gastric emptying recovery time is remarkably shortened, and the risk of complications such as aspiration pneumonia is reduced.

The present application discloses a kind of 4-acetylamino butyric acid and 3,4-dihydroxyphenylacetic acid in Guizhou Kaili Hong acid soup, which can enhance intestinal microecological balance, promote intestinal motility, and improve constipation or inflammatory bowel disease. The principle is that 4-acetylamino butyric acid or 3,4-dihydroxyphenylacetic acid can significantly increase the expression of C-Kit in the intestine, and significantly inhibit the expression of macrophage inflammatory factors.

This application discloses a nutritional meal recommendation system, method, equipment, and medium for post-gynecological surgery, relating to the field of digital health management technology and applied to a computer device. It includes: an association matrix acquisition module, used to construct dynamic physiological signs by combining the patient's hormone levels and blood loss after gynecological surgery, and splicing them according to time sequence and the nutritional ratio of candidate ingredients to generate a nutritional metabolism association matrix; an evolution matrix acquisition module, used to perform first-order differentiation and normalization of the matrix in the time dimension to construct a metabolic nutritional evolution feature matrix; a node sequence construction module, used to split feature vectors, construct a heterogeneous graph using gastrointestinal dynamic impedance, and use a graph attention network to screen ingredient nodes to form a sequence of nodes with absorption potential; and a meal plan generation module, used to calculate the nutritional difference in the sequence, extract decreasing topological fragments, and generate an individualized nutritional meal plan adapted to the patient's dynamic physiology and gastrointestinal capacity.

The present application belongs to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating children's functional dyspepsia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: Fructus Aurantii Immaturus 5-20 parts, Magnolia officinalis 5-20 parts, Forsythia suspensa 5-30 parts, Dendrobium 5-30 parts, Atractylodes macrocephala 5-20 parts, and Glycyrrhiza 5-30 parts. The pharmacological experiment results show that the traditional Chinese medicine composition has the effects of improving gastrointestinal motility and regulating gastrointestinal hormone secretion, has a significant therapeutic effect on children's functional dyspepsia, has stable curative effect, and has a small dosage. Meanwhile, the present application has the advantages of simple process operation, low cost, good controllability and stability, and is suitable for industrialized mass production.

The application discloses a lactobacillus rhamnosus capable of significantly increasing the number of enteric neurons and neuroglial cells and an application thereof, and belongs to the field of microorganisms.The lactobacillus rhamnosus CCFM1360 has good activity, certain acid and alkali resistance and adhesion, can significantly increase the number of enteric neurons and neuroglial cells, repair intestinal barrier function, increase the content of SCFAs in colon contents, increase the number of Treg cells in mesenteric lymph nodes, reduce the expression level of inflammatory factors in colon tissues, reduce the intestinal inflammation level, and relieve the weakened intestinal motility disorder.

The invention discloses a degradation-controllable cellulose-based gastrointestinal motility marker and a preparation method thereof. The cellulose-based gastrointestinal motility marker is of a core-shell structure formed by the following components in percentage by weight through a double-crosslinking network: 15-20% of hydroxyethyl cellulose, 10-15% of a crosslinking agent, 10-15% of sodium alginate, 50-60% of type II barium sulfate, 5-8% of an emulsifier, 5-10% of a filler and 2-8% of calcium chloride, the inner core is a covalent cross-linked porous network formed by free radical polymerization of a cross-linking agent and hydroxyethyl cellulose, and is cross-linked with type II barium sulfate, an emulsifier and a filler; the shell is a gel layer formed by ionic crosslinking of sodium alginate and calcium chloride. The marker disclosed by the invention can realize controllable degradation, accurate counting and dynamic tracking in a human body, so that the purpose of medical diagnosis of observing the gastrointestinal motility function is achieved.

The invention provides a lactobacillus kunkeeei H09 and an application of the lactobacillus kunkeeei H09. The lactobacillus kunkeeei H09 is prepared from lactobacillus kunkeeei H09 and lactobacillus kunkeeei H09, the preservation number of the lactobacillus kkaike H09 provided by the invention in the China General Microbiological Culture Collection Center is CGMCC (China General Microbiological Culture Collection Center) NO.31250. According to the application, the lactobacillus kkaike H09 is applied to food intake regulation, intestinal development regulation, intestinal motility regulation and immunity regulation, and experimental results show that the lactobacillus kkaike H09 can remarkably improve the food intake of bees, increase the intestinal development length of the bees, promote the intestinal motility of the bees and improve the immunity of the bees, and has probiotic potential.

The present invention is directed to a balloon-based system and method for measuring gastrointestinal motility. The balloon can be a stand-alone balloon with pressure sensing capabilities or the balloon can be deployed as a component of a catheter-based system. The balloon can be deployed in an uninflated state and can be inflated with fluid such as air, water, or other biocompatible fluid while disposed within the gastrointestinal tract. The pressure sensor can take the form of a pressure sensor disposed within the balloon or disposed on a surface of the balloon. Additional, sensors can also be applied to monitor other conditions, function, or disease state.

The present invention relates to a system and method for the automatic and early detection of acute abdomen syndrome in horses by analysing audio recordings. The system comprises a capturing device, which is attached to the abdomen of a horse by means of a fastening means, to obtain an audio recording. The analysis is carried out by means of a processing device, with an artificial intelligence system, which identifies and assesses the peristaltic sounds of the horse to classify the condition of its intestinal motility and provide a diagnosis.

This invention discloses the application of Rehmannia glutinosa exosomes in the preparation of drugs for the prevention of colitis, belonging to the field of plant exosome technology. The Rehmannia glutinosa exosomes extracted using the specific process of this invention not only significantly reduced the DAI score of a colitis model to below 2.0 and restored TNF-α to normal levels, but also unexpectedly improved intestinal motility disorders associated with colitis by bidirectionally regulating gastrointestinal hormones (inhibiting VIP / ET-1 and promoting MTL / SP). This effect is significantly superior to that of traditional water and alcohol extracts of Rehmannia glutinosa.

This invention discloses a liposomal curcumin composition for regulating the gastrointestinal tract and its applications, belonging to the technical fields of food and health food. The composition consists of 60-80nm liposomal curcumin, prebiotics, and cardamom extract. The liposomal curcumin uses food-grade phospholipids to construct a biomimetic bilayer structure with an encapsulation rate ≥80%, ethanol residue ≤0.5‰, a 2-hour release rate <33% in simulated gastric juice, and a 2-hour release rate >80% in simulated intestinal juice at pH 7.4. The cardamom extract is a water or alcohol extract of cardamom, with a content of 10-60mg per serving. This invention achieves targeted sustained release of curcumin into the intestine through precise particle size control, synergistically regulating gut microbiota with prebiotics and enhancing gastrointestinal motility with cardamom extract. It regulates gastrointestinal function from multiple dimensions, including mucosal repair, microbiota balance, and motility improvement. The bioavailability is more than 18 times higher than ordinary curcumin. The product has high safety and good stability and can be prepared in various dosage forms such as oral liquid, solid beverage, soft capsules, or tablets, suitable for daily conditioning in people with gastrointestinal dysfunction.

1. Name of the product in this design: Gastrointestinal motility therapy device. 2. Purpose of this design: For the treatment of gastrointestinal motility disorders and functional diseases. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention discloses bifidobacterium breve for regulating intestinal motility and aquaporin and application of the bifidobacterium breve, and belongs to the technical field of microorganisms. According to the invention, a strain of bifidobacterium breve CCFM1078 is screened out, and the bifidobacterium breve CCFM1078 has the effect of regulating intestinal motility and aquaporin, specifically, the defecation frequency is reduced, and the water content of excrement and the small intestine propulsion rate are reduced. The intestinal motility abnormality is relieved by reducing the levels of neurotransmitters 5-HT, SP and VIP, and the intestinal moisture absorption and secretion are regulated by improving the mRNA expression of aquaporin AQP3, AQP4 and AQP8. Meanwhile, the intestinal flora is adjusted by improving the diversity of the intestinal flora, and the content of propionic acid and butyric acid in excrement is increased.

The invention discloses a pet feed additive for enhancing gastrointestinal peristalsis. A double-layer embedding structure is adopted, wherein the outer layer is a pH response type compound formed by chitosan and sodium alginate, and the effects of stomach protection and intestinal tract targeted slow release are achieved; the core of the inner layer is a compound of resveratrol and inulin and selenium-enriched yeast prepared through biotransformation. The composition has the synergistic effect through multiple target points: the resveratrol is used for regulating intestinal nerves and resisting inflammation, the inulin is used as prebiotics for promoting proliferation of beneficial bacteria, and the organic selenium is used for enhancing the oxidation resistance of intestinal mucosa, so that the gastrointestinal tract peristalsis is comprehensively and safely promoted. Experiments show that the additive can significantly improve the defecation condition, shorten the gastrointestinal transmission time, optimize the intestinal flora and reduce inflammation, and is suitable for being added to pet food needing to improve gastrointestinal motility.

The invention belongs to the technical field of medical application, and particularly relates to a traditional Chinese medicine application for improving gastrointestinal discomfort and a preparation method thereof. The traditional Chinese medicine patch for improving gastrointestinal discomfort comprises the following raw materials in parts by weight: 20-25 parts of clove, 18-22 parts of codonopsis pilosula, 13-18 parts of semen raphani, 10-15 parts of linaria lingua, 5-10 parts of pinellia ternate, 9-13 parts of fingered citron, 6-11 parts of maple and 3-8 parts of liquorice. The traditional Chinese medicine prescription provided by the invention is safe, non-toxic and mild in medicine property, and can tonify without stagnation and warm without dryness. The traditional Chinese medicine patch disclosed by the invention can regulate the gastrointestinal hormone level and promote motilin secretion, so that the gastric emptying rate and the small intestine propulsion rate are improved, the gastrointestinal motility is enhanced, the digestive function is improved, and the traditional Chinese medicine patch shows good potential in the aspect of improving gastrointestinal discomfort.

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for improving anorexia and a medicinal preparation. The traditional Chinese medicine composition comprises radix pseudostellariae, rhizoma atractylodis, fried hawthorn, raw malt, Chinese yam, endothelium corneum gigeriae galli, pericarpium citri reticulatae, fried rice sprout, fried semen raphani, liquorice and rhizoma atractylodis macrocephalae. The traditional Chinese medicine composition provided by the invention has the effects of strengthening the spleen and the stomach, improves gastrointestinal motility by regulating gastrointestinal hormone secretion, and can improve spleen functions and relieve spleen and stomach injuries, so that the food intake and the body weight of anorexia patients are effectively improved, and anorexia symptoms are remarkably improved.

The present application discloses a polysaccharide for preventing, treating or improving chronic constipation, and a preparation method and application thereof. The polysaccharide can improve or restore intestinal barrier integrity, increase the expression amount of colon tight junction proteins, regulate the proportion of intestinal microbe beneficial flora, increase the content of short-chain fatty acids, improve gastrointestinal motility, regulate intestinal oxidative stress, increase the fecal water content and intestinal transport rate of constipation subjects, reduce intestinal tissue damage, and the like, thereby being capable of being used for preventing, treating or improving chronic constipation. In addition, the polysaccharide has the advantages of high safety and good curative effect.

The application discloses a gastric electrical monitoring and evaluation method, comprising the following steps: determining a monitoring original signal and a lead signal corresponding to maximum power according to a power spectrum of a gastric electrical original signal; performing filtering processing to obtain a pretreated first signal and a pretreated second signal; determining amplitude phase information and artifact information according to the pretreated first signal and the pretreated second signal; determining a target analytical phase and a target gastric electrical signal according to the amplitude phase information, the pretreated second signal and the artifact information; determining a signal time-frequency domain index, a slow wave propagation direction and a gastric electrical slow wave phase coupling degree according to the target analytical phase and the target gastric electrical signal; and determining a gastrointestinal motility evaluation result according to the signal time-frequency domain index, the slow wave propagation direction and the gastric electrical slow wave phase coupling degree. The application further provides a gastric electrical monitoring and evaluation system. The application monitors from a time-frequency domain feature of a signal and a time-space feature of a stomach, obtains monitoring data for gastric evaluation, and improves the accuracy of gastric state evaluation.

This invention relates to the field of intelligent medical monitoring and health data analysis technology, specifically disclosing a method and system for analyzing digestive tract health data. It involves real-time acquisition of differential frequency and sound intensity data generated by intestinal peristalsis using a multi-source sensor array deployed on the abdominal surface. Empirical mode decomposition and Hilbert transform are combined to extract intestinal motility rhythm stability features. Normalization and Haar wavelet decomposition methods are used to calculate the variation features of bowel sound intensity, constructing an intestinal functional state feature vector. This feature vector is input into a health assessment model trained based on a random forest algorithm, outputting individualized digestive tract health scores and health level indicators, and triggering multiple types of abnormal warning signals. This constructs a closed-loop management system from data acquisition and intelligent analysis to risk warning, improving the intelligent level of early identification and health management of digestive tract diseases.

The invention discloses herbal glycerine enema and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine liquid of the glycerine enema is prepared from 20 parts of raw bighead atractylodes rhizome, 10 parts of immature bitter orange, 10 parts of fructus cannabis, 10 parts of wine-processed desert cistanche and 10 parts of polygonum cuspidatum, and two glycerine enema bodies are prepared according to the dosage of one day. During preparation, the medicinal materials are decocted and then injected into a mold. And the use mode is anal plugging retention. Through the synergistic effect of various traditional Chinese medicines, the bowel relaxing composition can relax bowel from multiple aspects of regulating intestinal motility, moistening dryness, lubricating intestines and the like, and the effect is remarkable and lasting. The composition is suitable for patients with diet difficulty and poor digestion and swallowing, and avoids the problem of oral administration. The traditional Chinese medicine components are safe, dependence is not prone to being generated, the preparation process is simple, and good clinical application value is achieved.

The present disclosure provides systems and methods relating to the neuromodulation of gastrointestinal dysmotility. In particular, the present disclosure provides systems and methods for delivering temporal patterns of electrical stimulation comprising burst-patterned stimulation according to various stimulation parameters to treat gastrointestinal dysmotility disorders in a subject. The system may be implantable.