48 results about "Intestinal colonization" patented technology

The invention relates to the technical field of microorganisms, in particular to bifidobacterium bifidum BGLP1 capable of regulating sugar digestion and producing GLP-1 at high yield and application of the bifidobacterium bifidum BGLP1. The preservation number of the bifidobacterium bifidum BGLP1 is CGMCC (China General Microbiological Culture Collection Center) No.35718, and the bifidobacterium bifidum BGLP1 can be used for preparing the feed additive. The strain has the capability of inhibiting alpha-glucosidase and alpha-amylase; sTC-1 cells are stimulated to secrete GLP-1, and the blood glucose reducing pathway capacity of the intestinal tract is activated; the activity of pancreatic lipase is obviously inhibited, and the dietary fat absorption capability can be effectively reduced; redundant cane sugar is converted into exopolysaccharide, so that the probiotic function capability is improved; the capability of converting white fat into brown fat is promoted; macrophages are activated, and the body immune function is improved. In addition, the bifidobacterium bifidum BGLP1 also has relatively strong intestinal colonization ability, has good tolerance in artificial gastric juice and artificial intestinal juice, and can smoothly reach the intestinal tract of a human body.

The invention provides a bacillus subtilis strain and application thereof, the bacillus subtilis strain is named as bacillus subtilis Ya3.1, is preserved in China General Microbiological Culture Collection Center on July 7, 2025, and has a preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35019; the bacillus subtilis Ya3.1 is separated from intestinal tracts of healthy hybrid sturgeons, and can be used as a probiotic additive for aquaculture, especially for sturgeon culture. The bacillus subtilis Ya3.1 provided by the invention has high safety, strong stress resistance and efficient intestinal colonization ability, and can significantly improve the activity of sturgeon intestinal digestive enzymes, improve the growth performance of sturgeons, enhance the non-specific immunity of sturgeons, improve the intestinal flora structure and significantly improve the ability to resist aeromonas bacterial infection; and a special probiotic resource can be provided for sturgeon culture.

The present invention discloses a CBP lysine children growth milk powder and a preparation method thereof, and belongs to the technical field of milk powder, the CBP lysine children growth milk powder comprises the following components by mass: a wet process part: 575 parts of whole milk powder, 175 parts of dried skim milk, 175 parts of isomaltooligosacharide (type 50) powder, 30 parts of polydextrose, 28 parts of edible plant blend oil, 4 parts of milk mineral salt, and 13.7 parts of a compound children modified milk powder three-nutrition enhancer; cBP lysine is cooperated with bifidobacterium and seven traditional Chinese medicine extracts, DHA and ARA are accurately proportioned, the calcium absorption efficiency and the intestinal colonization capacity of probiotics are remarkably improved, a three-step mixing method is combined with a two-way shearing low-temperature technology, rapid and uniform mixing is achieved, the activity of the probiotics and the stability of DHA are reserved to the maximum extent, high uniformity of products is ensured, and the product quality is improved. The low-moisture wet-process base powder inhibits moisture absorption of traditional Chinese medicine components, nitrogen protection blocks oxidation in the whole process, the shelf life is prolonged, and the reconstituability is improved.

The invention discloses klebsiella pneumoniae and application thereof in production of indole-3-carboxylic acid (I3CA), and belongs to the fields of microbial technology, biological catalysis and fermentation engineering. The preservation number of the klebsiella pneumoniae is CCTCC NO: M 20252762, the classification name of the klebsiella pneumoniae is Klebsiella pneumoniae I3CA-02, the strain can efficiently convert tryptophan into I3CA in a time-dependent mode through a one-step method, high sensitivity to various clinically common antibiotics is kept, and the klebsiella pneumoniae has good intestinal colonization ability and safety, and can be used for preparing I3CA. The method has the potential of being directly applied to oral micro-ecological preparations and industrial production. The technical bottlenecks that the existing I3CA biosynthesis efficiency is low and the safety of recombinant bacteria is limited are broken through, the microorganism sources of indole derivatives are widened, and a foundation is laid for green manufacturing of high-purity I3CA and development of intestinal-brain-immune axis related functional products.

The invention relates to a microbial single-cell gelation encapsulation method based on aloe gel and application, the method realizes single-cell gelation encapsulation through electrostatic interaction of sterile aloe gel and intestinal anaerobic bacteria (such as Agathobacter rectasis), and the method comprises the specific steps of aloe gel preparation, bacterial suspension culture and oscillation mixing to form a stable structure. The preparation method has the advantages that the acid resistance and biocompatibility of the natural aloe gel are utilized to replace a traditional synthetic material, so that the gastrointestinal tolerance of thalli is improved; meanwhile, the synergistic effect of aloe active ingredients (such as aloe-emodin) and intestinal bacterial metabolites (butyric acid) is combined, so that the anti-inflammatory and intestinal steady-state regulation and control effects are enhanced. Experiments show that the survival rate of the encapsulated bacteria in simulated gastric juice within 4 hours is larger than or equal to 90%, the intestinal colonization rate is effectively increased compared with naked bacteria, the inflammatory factor level of a colitis model mouse can be remarkably reduced, and a safe and efficient new strategy is provided for micro-ecological treatment of inflammatory bowel diseases.

The invention discloses application of lactobacillus plantarum LP-Y01 and a fungicide thereof in preparation of a medicine for preventing and / or treating carbapenem-resistant drug-resistant bacterium infection. The invention verifies that the lactobacillus plantarum can generate a direct inhibition effect on carbapenem-resistant klebsiella pneumonia in vitro and has certain effective activity on colonization of the carbapenem-resistant klebsiella pneumonia in vivo through flora regulation and control. Probiotic pretreatment shows remarkable clinical potential by regulating and controlling a flora structure, provides a precise strategy for prevention and control of drug-resistant bacteria, and has a relatively good application prospect.

The present application relates to the technical field of microorganisms, and particularly relates to a bifidobacterium BGLP1 capable of regulating sugar digestion and high GLP-1 production and application thereof. Bifidobacterium bifidum The bifidobacterium BGLP1 (CGMCC No. 35718) has the abilities of inhibiting alpha-glucosidase and alpha-amylase, stimulating STC-1 cells to secrete GLP-1 and activating the intestinal glucose-lowering pathway, significantly inhibiting pancreatic lipase activity and effectively reducing dietary fat absorption, converting excess sucrose into extracellular polysaccharides to increase the probiotic function, promoting the conversion of white fat into brown fat, and activating macrophages and improving the immune function of the body. In addition, the bifidobacterium BGLP1 has strong intestinal colonization ability, has good tolerance in artificial gastric juice and artificial intestinal juice, and can successfully reach the human intestinal tract.

The invention discloses traditional Chinese medicine substitutional tea granules for aiding digestion and reducing fat and a preparation method thereof, probiotic microcapsules, traditional Chinese medicine lipid nanoparticles and Tibetan tea active ingredients are combined, and the effects of improving digestion and reducing fat are achieved through a triple synergistic mechanism. The probiotic microcapsules are embedded with citrus fibers through the poria cocos extract and then are mixed with the Chinese yam thick soup for freeze-drying, so that the survival rate of probiotics and the intestinal colonization effect are remarkably improved. The rhizoma alismatis and semen cassiae extracts are encapsulated in lecithin / lauric acid / palmitic acid lipid nanoparticles, so that unpleasant odor is covered, slow release is realized, and the metabolic regulation effects of palmitic acid and lauric acid are coordinated. In addition, Tibetan tea is used as a compound substrate, traditional Chinese medicines such as codonopsis pilosula, hawthorn and poria cocos are fused, honey, coix seeds and Chinese yam are used as auxiliary materials for granulation, and medicinal material natural polysaccharide is used for replacing a chemical adhesive. The product has probiotic activity protection, traditional Chinese medicine slow release and tea fragrance palatability, and has remarkable synergistic advantages in the aspects of improving the digestion function and regulating body fat.

The invention relates to the technical field of dairy products, in particular to a fermented dairy product based on compound ingredient flavor and nutrient enrichment and a preparation method of the fermented dairy product. The raw materials comprise 80-90 parts of raw milk, 3-8 parts of a composite flavor nutrition synergistic ingredient, 2-5 parts of a targeted release type nutrition enhancer, 0.3-1.0 part of a composite probiotic leavening agent, 0.1-0.8 part of a gamma-ray modified functional stabilizer, 0.05-0.2 part of a microencapsulated natural antioxidant, 0.03-0.1 part of an intestinal colonization accelerant and the balance of deionized water. The fermented dairy product disclosed by the invention has the advantages of synergistic flavor and nutrition, high nutrition absorption and utilization rate, strong probiotic colonization capability, good product stability and long shelf life, has both high-quality sensory experience and comprehensive probiotic efficacy, and is superior to the existing fermented dairy product.

The invention belongs to the technical field of prebiotics, and particularly relates to plant extract composite prebiotics as well as a preparation method and application thereof. The invention provides a plant extract composite prebiotics, which is prepared by compounding a purslane ethanol extract and a common turnip ethanol extract in equal mass ratio, and the purslane ethanol extract and the common turnip ethanol extract are prepared by soaking purslane and common turnip in an ethanol solution with the volume concentration of 94-96%, performing ultrasonic extraction, concentrating and freeze-drying. The plant extract composite prebiotics provided by the invention can remarkably promote the growth of probiotics such as lactobacillus plantarum, lactobacillus paracasei and pediococcus pentosaceus, have the effects of regulating intestinal flora balance and promoting intestinal colonization of the probiotics, and also have antioxidant activity, thereby providing a new choice for development of prebiotics with natural sources.

The invention relates to application of plant lactobacillus FBL002 in bird's nest fermentation, and belongs to the technical field of fermentation. The invention finds that the plant lactobacillus FBL002 has stable intestinal colonization ability and antioxidant activity, and can significantly improve the antioxidant ability of an aged mouse and relieve an inflammatory state in an aged mouse model. When the plant lactobacillus FBL002 is applied to bird's nest fermentation, bird's nest protein can be decomposed into small molecule active peptides (the total peptide content is larger than or equal to 12%), 90% of sialic acid can be reserved, and meanwhile, synergistic antioxidant components such as short-chain fatty acid, SOD (the SOD activity is larger than or equal to 150 U / g) and vitamin B can be generated; therefore, the cubilose fermentation liquor prepared by the fermentation method disclosed by the invention has high oxidation resistance (the ABTS free radical scavenging rate is greater than 90%) while retaining 90% of cubilose acid, and has a wide application prospect.

This invention relates to the technical field of food processing, specifically to a method for preparing and applying probiotics that can improve intestinal colonization efficiency. The method uses corydalis yanhusuo protein as one of the reaction substrates and employs a two-stage fermentation process to cultivate probiotics. In the first stage of fermentation, the probiotics rapidly proliferate and produce spores. In the second stage of fermentation, they form a biofilm. The resulting probiotic fermentation broth is then dried and pulverized to produce the probiotic powder that improves intestinal colonization efficiency. This invention's preparation method is the first to employ a high-density fermentation mode that enhances the formation of a probiotic biofilm. By adjusting the initial fermentation medium ratio and fermentation parameters, the probiotics rapidly proliferate and produce spores. In the second stage of fermentation, the medium is supplemented and parameters are changed to achieve biofilm formation. This method solves the technical difficulties of slow proliferation and low biomass in single-stage biofilm static culture of probiotics, as well as the problems of poor processing tolerance and intestinal membrane adhesion of planktonic probiotics.

The invention discloses bifidobacterium breve HX-5M3 and application thereof, and belongs to the technical field of biomedicine. The bifidobacterium breve HX-5M3 disclosed by the invention is preserved in the China Center for Type Culture Collection, and the preservation number of the bifidobacterium breve HX-5M3 is CCTCC (China Center for Type Culture Collection), and the preservation number of the bifidobacterium breve HX-5M3 is CCTCC NO: M 20242244. The invention also discloses an application of the bifidobacterium breve HX-5M3 in preparation of a product for metabolizing oligosaccharide in breast milk. The strain HX-5M3 disclosed by the invention not only can efficiently utilize LNT and LNnT, but also shows good metabolic capability on 2 '-FL and 3-FL; the strain can tolerate cholate, has good intestinal colonization potential, is sensitive to various antibiotics, and does not produce hemolysin. The strain HX-5M3 disclosed by the invention has a large number of GHs genes related to HMOs metabolism, which indicates that the strain HX-5M3 has a relatively strong utilization capability on decomposing carbohydrates, especially on HMOs.

The invention discloses bifidobacterium longum subsp. Infantis HX-4M1 and application thereof, and belongs to the technical field of biomedicine. The bifidobacterium longum subsp. Infantis HX-4M1 disclosed by the invention is preserved in the China Center for Type Culture Collection, and the preservation number of the bifidobacterium longum subsp. Infantis HX-4M1 is CCTCC (China Center for Type Culture Collection) NO: M 20242243. The invention also discloses an application of the bifidobacterium longum subsp. Infantis HX-4M1 in preparation of a product for metabolizing oligosaccharide in breast milk. The strain HX-4M1 not only can efficiently utilize LNT and LNnT, but also shows good metabolic capability to 2 '-FL and 3-FL, can tolerate cholate, has good intestinal colonization potential, is sensitive to various antibiotics and does not generate hemolysin, has a large number of GHs genes related to HMOs metabolism of the strain HX-4M1, and contains typical HMOs metabolism gene clusters of model strains.

The invention discloses a screening and fermentation preparation method of high-yield antibacterial peptide probiotics, and relates to the technical field of microbial fermentation and animal nutrition, the method comprises three core steps of intestinal colonization-oriented multi-phenotype collaborative screening, self-assembled antibacterial peptide engineering bacterium construction, and in-situ nanocrystallization fermentation preparation. The preparation method comprises the following steps: firstly, screening out a probiotic host with gastrointestinal tolerance, colonization capability and self-assembly precursor peptide secretion potential, then constructing a fusion gene engineering bacterium containing an intestinal environment induced promoter, and finally, performing staged fermentation to realize fusion peptide in-situ self-assembly and spray drying to obtain a finished product, and the finished product contains colonization type recombinant viable bacteria and antibacterial peptide nanoparticles. The method can realize targeted colonization and long-acting bacteriostasis of intestinal tracts, has application stability and efficacy persistence, and is suitable for production of feed antibacterial peptide preparations.

The application provides a cat-derived fermented lactobacillus muciadegus ZY001, application and product thereof, and relates to the technical field of biology. The fermented lactobacillus muciadegus ZY001 provided by the application is derived from a cat, and the inventor has found that the strain has good high-temperature resistance, acid resistance and bile salt resistance, can effectively inhibit the growth and proliferation of various diarrhea pathogenic bacteria, can be used for preventing or treating diarrhea, has antioxidant capacity, can relieve oxidative stress, is beneficial to animal anti-aging, and prolongs the life of a pet; has very strong self-aggregation and moderate hydrophobicity, and is beneficial to the strain in intestinal colonization and long-term exertion of the probiotic function.

This invention discloses a strain of *Bacillus belyceae* with broad-spectrum antibacterial activity and its application in the prevention and treatment of necrotic enteritis in poultry. The *Bacillus belyceae* strain provided by this invention (… Bacillus from Velez The genome of strain GDG25CB056 is approximately 3.91 Mb in size, contains no virulence factors, and is rich in gene clusters encoding non-ribosomal peptides and polyketide synthases. Studies have confirmed that this strain exhibits significant growth advantages, strong tolerance to high temperatures, gastric acid, and bile salts, which facilitates intestinal colonization. It can produce siderophores and various enzymes, and has overcome the technical bottleneck of a narrow antibacterial spectrum, possessing broad-spectrum antibacterial activity, especially strong specific antagonistic activity against Clostridium perfringens. In vivo experiments have shown that this strain can significantly reduce the Clostridium perfringens load in the cecum of chicks with necrotizing enterocolitis, alleviate intestinal congestion and swelling, repair damaged intestinal villi, and enhance mucosal barrier function, providing a safe and efficient strain resource for the prevention and treatment of bacterial enteric diseases.

The invention discloses a culture medium for promoting intestinal colonization of probiotics. Every 1000 parts by weight of water of the culture medium is prepared from the following components in parts by weight: 2 to 10 parts of casein, 4 to 12 parts of yeast extract powder, 10 to 12 parts of beef extract powder, 1.5 to 2.5 parts of trisodium citrate or triammonium citrate, 4.5 to 5.5 parts of sodium acetate, 0.1 to 0.3 part of magnesium sulfate heptahydrate, 0.05 to 0.1 part of manganese chloride and 1 to 3 parts of dipotassium phosphate. When the culture medium is used for culturing the probiotics, the secretion amount of exopolysaccharides, proteins and other substances can be remarkably increased, a protective layer is formed, the stress resistance of the strain is improved, the survival ability of the probiotics in a complex gastrointestinal tract environment is improved, and a new strategy is provided for development of the oral probiotics.

The invention discloses lactobacillus plantarum ZYT028 and application thereof, the strain is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 20251257, and the lactobacillus plantarum ZYT028 has good acid cholate tolerance and intestinal colonization ability, can still keep high survival rate under the condition of pH 2.0, and can grow in an environment containing 1.0 g / L cholate. The ZYT028 strain can promote the generation of short-chain fatty acid and improve the imbalance of intestinal flora caused by high fat diet; in animal experiments, the content of serum total cholesterol and triglyceride can be remarkably reduced, excessive weight increase is inhibited, and good lipid-lowering and weight-regulating effects are shown. The strain disclosed by the invention can be widely applied to development of functional foods, health-care products, fermented dairy products and probiotic preparations, and is used for assisting in controlling body weight and improving blood lipid metabolism.

A functionalized probiotic system comprising a complex consisting of the following (A) to (C): A) a polymer carrier, the polymer carrier comprising a polymer backbone (A1) and a phenylboronic acid end group (A2) bonded to the polymer backbone (A1), the polymer backbone (A1) being at least one of hyaluronic acid or a salt thereof; (B) a polyphenol P2X7 inhibitor; and, (C) a probiotic; wherein (A) and (B) form a compound 2, and the compound 2 forms a functional modification layer on the surface of all or at least part of the probiotics. The functional probiotic system disclosed by the invention has P2X7 inhibition performance and high intestinal colonization efficiency, can resist inflammation, regulate body immunity and regulate and control intestinal flora of a patient, and is suitable for treating inflammatory bowel diseases such as ulcerative colitis and the like.

The present application relates to the technical field of microbial separation, and particularly relates to a separation method and application of intestinal probiotic escherichia; the separation method of intestinal probiotic escherichia is to take bovine large intestine content as raw material, to realize pre-screening of potential colonization strains through mucus anaerobic targeted enrichment, then to obtain resistant colonies through bile salt-short chain fatty acid stress primary screening, to scrape the colonies with metallic luster and fluorescence quenching ring through FITC-labeled mucus fluorescence indication secondary screening, and finally to obtain target strains through multiple PCR screening of negative virulence gene-positive functional gene, to realize directional separation of intestinal probiotic escherichia after purification of nutrient agar; the present application realizes targeted enrichment of intestinal colonization bacteria, environmental tolerance pressure screening and mucus binding visualization identification, solves the problems of strong randomness of traditional probiotic screening and inability to predict colonization potential, and provides a new strategy of efficient and safe probiotic strain screening for development of functional food and microecological preparation.

The invention belongs to the technical field of targeted drugs, and discloses surface chemical modified intestinal probiotics as well as a preparation method and application thereof, and the method comprises the following steps: dissolving PBA-PEG2000-NHS-ester in a phosphate buffer solution to prepare a PPN solution; mixing the PPN solution with the LGG bacterial suspension, and carrying out incubation reaction under a constant temperature condition to obtain a B-L suspension; and carrying out centrifugal washing on the B-L suspension to obtain the surface modified composite thallus B-L. According to the invention, the LGG is subjected to surface chemical modification through PBA-PEG2000-NHS-ester to prepare the composite thallus B-L, the problem of rapid discharge caused by intestinal colonization resistance and gastrointestinal motility is effectively overcome by utilizing the specific adhesion effect of PBA groups and intestinal epithelium mucus, the LGG is smoothly delivered to the colon part in a targeted manner, long-acting retention is realized, the colonization efficiency of the LGG at the colon part is remarkably improved, and the colonization effect of the LGG at the colon part is improved. The anti-colitis effect is enhanced.

The invention belongs to the technical field of microbial engineering, discloses an application of bifidobacterium longum subsp. Infantis i18 in products helpful for improving and preventing infant colitis and a composition, and discloses a new application of the bifidobacterium longum subsp. Infantis i18 in the aspect of helpful for improving and preventing the infant colitis. The invention further provides a composition which contains the bifidobacterium longum subsp. Infantis i18 and is beneficial to improving and preventing the colitis of the infants, the composition can achieve synergistic interaction, the effects of improving and preventing the colitis of the infants and promoting ILA synthesis are achieved, the intestinal colonization survival ability of probiotics is higher, and the nutrition is more comprehensive. The invention is suitable for preparing the composition helpful for improving and preventing the infant colitis, and is used for preparing the formula milk powder or other products helpful for improving and preventing the infant colitis.

The present application belongs to the field of broiler feed additives, and provides a broiler Clostridium butyricum activation feeding method. The present application reasonably utilizes the mechanical stirring anaerobic fermentation system technology customized for anaerobic fermentation, can utilize inert gas to protect the bacteria, and can activate a large number of bacteria in vitro to adapt to production; after the bacteria are activated in vitro, the bacteria can quickly play a role in the body, can reduce the loss of most probiotics caused by insufficient in-vivo activation and intestinal colonization resistance, and can improve the use effect of metabolic products, so that the feed-to-weight ratio is reduced in the actual application of broiler breeding, and therefore the present application provides a new method for the reasonable use of probiotics.

The present application relates to the technical field of feed engineering and microbial application, and discloses a probiotic chicken feed and a preparation method thereof.The feed comprises corn flour, soybean meal, wheat bran, a synergistically modified probiotic carrier, natural plant enzyme and various probiotics, wherein the probiotics comprise Lactobacillus delbrueckii subsp.Bulgaricus, Bacillus subtilis, yeast and rice koji.The synergistically modified probiotic carrier is formed into a limited inclusion and ion crosslinking structure by β-cyclodextrin and chitosan in the presence of calcium lactate, and is used to coat and modify the probiotics and natural plant enzyme.Through the above structure design, the stability of the probiotics and enzyme during processing and storage can be effectively improved, and the survival ability in the gastrointestinal environment and the intestinal colonization effect can be enhanced, so as to improve the feed utilization rate and improve the growth performance of chickens.The present application has simple process, is suitable for large-scale production, and has good application prospect.

The invention discloses enterococcus faecium for promoting intestinal tissue repair of aquatic animals and application of the enterococcus faecium, and relates to the technical field of aquaculture, the strain is named as GCE-2, the Latin name is Enterococcus faecium, the strain is preserved in the China General Microbiological Culture Collection Center on January 7, 2026, and the preservation number is CGMCC NO.37319. The invention further discloses a preparation method of the enterococcus faecium capable of promoting intestinal tissue repair of the aquatic animals and application of the enterococcus faecium capable of promoting the intestinal tissue repair of the aquatic animals. The enterococcus faecium GCE-2 provided by the invention can efficiently promote the repair of intestinal tissues of aquatic animals, has relatively strong intestinal colonization ability and good environmental adaptability, and can directly promote the regeneration of intestinal villus and the repair of epithelial cell injury, quickly relieve the pathological symptoms of intestinal tracts and remarkably improve the repair efficiency of the intestinal tissues.

The present invention relates to a method for improving the survival rate, storage stability, acid tolerance, or bile tolerance and intestinal epithelial cell attachment ability of lactic acid bacteria by applying fibroin to the surface of the lactic acid bacteria, and a lactic acid bacteria composition prepared thereby. The prior art establishes a physical barrier only on the outside of the lactic acid bacteria cell by a multi-step application, and thus has the limitation that the effect of the lactic acid bacteria on the intestinal epithelial cell attachment ability upon ingestion cannot be confirmed, but the present invention is a method for applying lactic acid bacteria using fibroin extracted from a cocoon, thereby not only improving the stability under storage and circulation conditions, but also significantly increasing the stability and colonization ability in the intestinal environment.

This invention relates to the field of biomedical technology, disclosing a targeted probiotic nanocapsule, its preparation method, and its application. The method involves using a photosensitizing agent ICG and polysaccharides to covalently couple probiotics to prepare probiotic nanocapsules. The core material of the microcapsule is primarily probiotics, and the microcapsule wall material is carboxymethyl dextran and the photosensitizing agent ICG. These microcapsules are easy to prepare, exhibit good sustained-release and controlled-release properties, and the materials are non-toxic, biocompatible, and biodegradable. This invention improves the wall material of the probiotic microcapsules and designs the preparation method and overall process accordingly. By utilizing polysaccharides and photosensitizing agents to form the capsule wall, the resulting nano-probiotics are acid-resistant, bile salt-resistant, digestive enzyme-resistant, and heat-resistant, resulting in improved probiotic stability and enhanced intestinal colonization.

The invention discloses application of bifidobacterium adolescentis in preparation of a medicine for treating prostatic cancer, and belongs to the field of biological medicine. According to the application, it is found for the first time that an endogenous fibroblast growth factor 21 (FGF21) has the effect of inhibiting the growth of the prostatic cancer tumor, it is found that the abundance of bifidobacterium adolescentis in FGF21 transgenic mouse intestinal flora is remarkably improved, and the bifidobacterium adolescentis is selected as potential probiotics for inhibiting the growth of the prostatic cancer tumor. The intestinal colonization experiment result shows that the bifidobacterium adolescentis can efficiently inhibit the growth of the prostatic cancer tumor by inhibiting the proliferation of tumor cells, and can be prepared into the medicine for treating the prostatic cancer. The invention provides a new treatment strategy and medicine for the treatment of the prostatic cancer, and also provides a brand new medicine development path and a clinical application scheme for the micro-ecological treatment of the prostatic cancer.

The application discloses a Bacillus coagulans body weight management composition for adjusting a metabolic environment, relates to the technical field of probiotics and functional food, and comprises Bacillus coagulans, animal bifidobacterium, lactobacillus plantarum and cell-free supernatant metabolic filtrate produced by fermentation of the Bacillus coagulans, wherein the animal bifidobacterium and the lactobacillus plantarum are dispersed in the metabolic filtrate to form a mixture. The application is designed by pre-incubation of strain metabolic filtrate and multi-strain time sequence cooperation, so that the three strains form a progressive functional cooperation system in the intestinal tract, effectively improve the intestinal colonization efficiency and storage stability of the strains, can safely and efficiently adjust the intestinal metabolic environment of a host, realize the core function of body weight management, and can be widely applied to preparation and production of functional food, dietary supplements and body weight management related products.