Probiotic pellet preparation and preparing method thereof

A technology of probiotics and pellets, which is applied to medical raw materials derived from bacteria, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Probiotic colonization and other problems, to achieve the effect of regulating the micro-ecological balance

Inactive Publication Date: 2010-06-30
BEIJING TRADE STAR MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also some probiotic drugs marketed in the form of solid or liquid preparations, but there are problems with the storage stability of the product and the destruction by pepsin after oral administration, which affects the colonization of Bacillus probiotics in the intestinal tract and reduces the original The number of flora in the preparation does not meet the expected curative effect

Method used

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  • Probiotic pellet preparation and preparing method thereof
  • Probiotic pellet preparation and preparing method thereof
  • Probiotic pellet preparation and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] prescription:

[0015]

[0016] The preparation steps of the probiotic preparation of the present embodiment are as follows:

[0017] ①Put 800g of bifidobacterium powder and 80g of hydroxypropyl methylcellulose into the wet granulator, stir and mix evenly. Add the ethanol solution of 480ml6.5wt% then, stir and make wet material;

[0018] ② Put the wet material obtained in step ① into an extrusion cutting granulator (the aperture of the screen is 0.3-2.5 mm, usually 0.9 mm), and extrude it into cylindrical wet granules (the length does not exceed 4.0 mm, usually 0.9 mm) 2.0mm). Then put it into a spheronizer to make spherical wet granules. Put the spherical wet particles into a hot air drying oven and dry until the volatile solvent and moisture residue meet the requirements (wherein the solvent content shall not exceed 5000ppm, and the moisture shall not exceed 8%, the same below), the temperature of the hot air shall be 40°C, and the relative humidity shall be 45%...

Embodiment 2

[0021] prescription:

[0022]

Embodiment 3

[0024] prescription:

[0025]

[0026] The preparation part of Examples 2-3 is the same as that of Example 1, except that the feeding of auxiliary materials is slightly different.

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Abstract

The invention discloses a probiotic pellet preparation and a preparing method thereof. The preparation is a pellet which consists of a probiotic pellet core and an enteric coating layer wrapping the probiotic pillet core. The preparing method comprises the following steps: (1) evenly mixing probiotics and excipients, adding solvents and stirring the mixture to prepare wet material; (2) extruding, cutting and rounding the wet material prepared in step (1) to prepare a spherical wet granule and drying and selecting the probiotic pellet core; and (3) spraying an enteric coating material solution to the probiotic pellet core and drying to obtain an enteric coated pellet core. The probiotic pellet preparation prepared in the method has high intestinal colonization rate and reliable curative effect after being taken orally.

Description

technical field [0001] The invention relates to a pellet preparation of probiotics, which is a pellet preparation coated with an enteric coating. Background technique [0002] Probiotics, prebiotics, and synbiotics are substances opposite to antibiotics. Preparations that use them and their metabolites as active drugs are called probiotics. Guided by the theory of microecology, adjust the balance of microecology, improve the health level of the host or improve the health status. At present, probiotics are becoming an important biological agent for people to prevent diseases and maintain health. It has quick and short-term effects, such as: preventing and treating acute and chronic diarrhea, constipation, and improving gastric function. There are also significant long-term effects, such as: by reducing the level of toxins in the human body, improving nutritional status, helping the growth of liver cells, improving human immunity, etc., it can protect the liver and help impro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/74A61K9/16A61K47/32A61K47/36A61K47/38A61K47/40A61K47/46A61P1/00A61K35/741
Inventor 张耀春
Owner BEIJING TRADE STAR MEDICAL TECH
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