41 results about "Synbiotics" patented technology

The invention discloses application of cobalamin and beneficial bacteria in prevention and control of tomato soil-borne bacterial wilt. The beneficial bacterium is Chryseobacterium CHR6, and the preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) The invention discloses a synbiotics for preventing and controlling tomato soil-borne bacterial wilt. The synbiotics consist of beneficial bacteria and cobalamin, and the beneficial bacterium is Chryseobacterium CHR6. The invention discloses a method for preventing and controlling tomato soil-borne bacterial wilt by matching cobalamin and beneficial bacteria, which comprises the following steps: 7-10 days after transplanting tomato seedlings, adding synbiotics into soil by a root irrigation method, adding 10-20 mL of cobalamin solution with the concentration of 5-10 nM into each tomato seedling, and inoculating 10-20 mL of beneficial bacteria suspension with the concentration of 1 * 10 < 7 >-1 * 10 < 9 > CFU / mL. By adding cobalamin, inhibition of growth of ralstonia solanacearum through siderophore mediation of Chryseobacterium CHR6 can be remarkably enhanced, and occurrence of tomato soil-borne bacterial wilt is reduced.

The invention provides an application of synbiotics in preparation of a composition for improving glucagon-like peptide-1 (GLP-1). The composition comprises litchi polyphenol, probiotics and methionine. The probiotics comprise bifidobacterium animalis BCRC910645, bifidobacterium longum BCRC910812, or a combination of the bifidobacterium animalis BCRC910645 and the bifidobacterium longum BCRC910812, so that the content of the glucagon-like peptide-1 is increased.

The invention discloses a strain for preventing and treating Parkinson's disease as well as a composition, application and a product thereof, and relates to the technical field of microorganisms. The invention provides three strains from human milk, namely lactobacillus helveticus LV-20, plant lactobacillus LPP8 and lactobacillus fermentum PL-15, the invention further provides a composition capable of preventing and treating the Parkinson's disease, and the three strains can well prevent and treat the Parkinson's disease and can be used for preventing and treating the Parkinson's disease. The composition can significantly improve dyskinesia (such as static tremor, muscle stiffness, movement retardation, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive disorder, relieve sleep disorder, inhibit neuroinflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, and improve the curative effect. As probiotics or synbiotics, products for treating and preventing Parkinson's disease have a wide application prospect.

The invention discloses a synbiotics-like feed prepared from vegetable waste polymerized vegetable cakes and a method, and relates to the field of agricultural circular economy, cellulose in vegetable waste cell walls is effectively decomposed under mild conditions through a specific catalytic decomposition enzyme combination, and part of cellulose is converted into carbon dioxide and water, so that the utilization rate of the cellulose is improved. By combining physical heat energy conduction, liquid in cell vesicles is heated to generate micro air pressure to break through residual cell walls, so that recessive water in cells is successfully converted into surface dominant water, the energy consumption in the dehydration process is greatly reduced, and the loss of dry basis substances in the resource utilization process is effectively reduced; the vegetable cake product obtained through final polymerization is rich in various nutrient substances such as crude fibers and / or dietary fibers, proteins, vitamin C and carbohydrates, the recycling rate of the vegetable waste is larger than or equal to 95%, the recycling efficiency and the additional value are remarkably improved, meanwhile, the difficulty of subsequent harmless treatment is reduced from the source, and the economic input and the treatment cost are reduced.

The invention belongs to the technical field of animal feeds, and relates to a livestock feed with an immunoregulation function and a preparation method thereof. The feed comprises whey powder, fermented soybean meal, konjaku flour, beet pulp, tabletted corn, baked wheat, whey protein, palm oil, synbiotics powder, composite vitamins, composite minerals, calcium propionate, potassium sorbate and sodium selenite, and the synbiotics powder comprises freeze-dried probiotic powder and prebiotics powder. Probiotics in the probiotic freeze-dried powder are fermented saccharomyces cerevisiae and fermented bacillus subtilis, and the prebiotics powder comprises pachymaran, astragalus polysaccharide, inulin and fructo-oligosaccharide. The fermented saccharomyces cerevisiae and the fermented bacillus subtilis are embedded by adopting modified sodium alginate, the modified sodium alginate is modified by adopting glycine, and nano-montmorillonite and a soluble pore-foaming agent are added for optimization. The prepared feed has the function of regulating immunity.

The invention provides a high-activity synbiotics nourishment as well as a preparation method and application thereof, and relates to the technical field of activity excitation and protection of probiotics, prebiotics and metabiotics. The preparation method provided by the invention comprises the following steps: freeze-drying and crushing pomelo peel white capsules to obtain pomelo peel powder; stirring and dispersing the shaddock peel powder in ethanol, separating and drying to obtain modified powder; mixing the modified powder with a ferroferric oxide nano suspension, and separating to obtain a magnetic carrier; mixing and loading the magnetic carrier and the probiotic liquid in an alternating magnetic field, and separating to obtain a probiotic carrier; mixing and adsorbing the probiotic carrier in a sodium alginate solution, and separating to obtain a gel precursor; performing ultrasonic dispersion on the gel precursor in a calcium ion solution, and performing gel shaping to obtain the high-activity synbiotic nourishment. According to the invention, not only can the shaddock peel be subjected to resource utilization, but also the damage of gastrointestinal tracts to the probiotics can be reduced, the release time of the probiotics can be delayed, and the viable bacteria quantity of the probiotics reaching the colon can be increased, so that the physiological activity of the probiotics and the bioavailability of a human body can be improved.

The invention relates to screening and application of synergistic synbiotics beneficial to human health. The invention discloses a composition which comprises probiotic bifidobacterium lactis Bb-12, probiotic bifidobacterium longum BB536 and prebiotics 2 '-FL, and the composition can be used for enhancing immunity, promoting growth and development and / or promoting gastrointestinal tract health. The composition can be used for preparing food raw materials, food additives, feed additives, medicines, liquid drinks, foods or health-care products.

Synthetic oligosaccharides and mixtures thereof which resemble polysaccharides produced by plants, yeast and other fungi, bacteria, and algae are described. The oligosaccharides and compositions provided herein are useful as synbiotics, prebiotics, immune modulators, digestion aids, and food additives.

The invention discloses a preparation method of a nested sodium alginate / synbiotics edible fresh-keeping film, and belongs to the technical field of functional food packaging materials. Mixing probiotics with xylooligosaccharide, glycerol, sodium alginate and the like to prepare an inner-layer solution, and performing vacuum drying to obtain an inner-layer functional film; a natural thickening agent and sodium alginate are compounded to prepare an outer layer matrix solution, a semi-solid supporting bottom layer is prepared firstly, then an inner layer film is flatly laid, an outer layer solution is poured for the second time, and the nested film is obtained after drying. A hydrophobic physical barrier is constructed on the outer layer, the water contact angle is increased to 108.03 degrees, the ultraviolet light transmittance is reduced to 25.58%, and the permeability of oxygen is remarkably limited. And the viable count of the probiotics stored for 30 days reaches 7.36 Log CFU / g, which is obviously superior to that of a single-layer film. The quality of the strawberries in the storage period is remarkably improved when the strawberries are used as outer packages. Through collaborative innovation of structural design and a co-embedding system, the film is excellent in barrier property, probiotic activity maintenance and fresh-keeping effect, and is suitable for open type food long-acting fresh-keeping packaging.

The invention provides arabinoxylan-bifidobacterium longum synbiotics and application of the arabinoxylan-bifidobacterium longum synbiotics in regulation of arachidic acid metabolism, and belongs to the technical field of microbial preparations. The preparation method of the arabinoxylan-bifidobacterium longum synbiotics comprises the following steps: mixing prefermented bifidobacterium longum and arabinoxylan, adding a mixed solution of sodium alginate and chitosan for embedding, and freeze-drying to obtain the arabinoxylan-bifidobacterium longum synbiotics. According to the invention, bifidobacterium longum is taken as probiotics, araboxylan is taken as prebiotics, sodium alginate-chitosan nanoparticles are taken as an embedding carrier, and a nano embedding technology is adopted, so that the gastrointestinal tract tolerance of the synbiotics is remarkably improved, and the bioavailability of the synbiotics is enhanced; compared with the single use of prebiotics or probiotics, the synbiotics have a better effect of regulating SCFAs and arachidonic acid metabolism, can influence inflammatory factors through intestinal flora-SCFAs-arachidonic acid metabolic axis, and have a wide application prospect on chronic inflammation related diseases.

The present invention discloses a feed containing a cereal and fruit fermentation composition and a preparation method thereof, and belongs to the field of livestock and poultry feeds, the feed comprises the following components in parts by weight: 50-100 parts of a cereal and fruit fermentation composition, 10-20 parts of synbiotics, 3-7 parts of organic trace elements, 1-5 parts of a mineral premix, and 0.5-3 parts of a vitamin premix, wherein the cereal and fruit fermented composition comprises feed syrup and cereal and fruit wet residues. By using the feed prepared by the invention, the problems that the feed in the prior art cannot provide efficient nutrition supply, protect intestinal health, degrade mycotoxin and efficiently utilize resources can be solved.

This invention consists of a process for producing bacteria and yeasts from agave sap and juice and honey, and using them as synbiotics in various functional beverages, including some tea-like liquid yogurt beverages. One process involves mixed culture to prepare a functional beverage with synbiotic action, comprising the combination of at least one yeast and one lactic acid bacterium with probiotic function, in a prebiotic solution of natural origin based on oligo- and polysaccharides from agave or honey, or both, for human consumption. The functional beverages described may contain alcohol in low concentrations or be completely alcohol-free. Another described process establishes the separate use of lactic acid bacteria and yeasts to generate fermented alcoholic, acidic, or both types of beverages, with or without live microorganisms, possessing high organoleptic quality.It also establishes the process by which a freeze-dried powder can be prepared, either individually or through a mixture of strains with probiotic activity, from honey or agave syrups.

The invention relates to the technical field of feed additives, and particularly discloses a synbiotic feed additive as well as a preparation method and application thereof. The synbiotics feed additive provided by the invention is prepared from the following components in parts by weight: 2 to 3 parts of probiotics, 0.8 to 1.5 parts of lycopodium powder, 0.3 to 1 part of herba lysimachiae extract, 0.3 to 1 part of herba arundinae macrophyllae extract, 0.1 to 0.4 part of fir fruit extract and 30 to 40 parts of a carrier, furthermore, the probiotics comprise saccharomyces cerevisiae boulardii, lactobacillus gasseri and lactobacillus rhamnosus, and the probiotics comprise saccharomyces cerevisiae boulardii, lactobacillus gasseri and lactobacillus rhamnosus. Further, the weight ratio of the saccharomyces cerevisiae boulardii to the lactobacillus gasseri to the lactobacillus rhamnosus is 1 to (2-3) to (0.5-1); the invention further provides a preparation method and application of the synbiotics feed additive. The synbiotics feed additive provided by the invention can improve animal immunity while improving animal production performance, reduce disease incidence and greatly improve breeding benefits.

The invention relates to a synbiotics for improving growth performance of weaned piglets and application thereof. The synbiotics comprise the following components: a) a probiotic component: bacterial powder of Bifidobacterium infantis B.infantis-zju (the preservation number is CCTCC NO: 20251039), the bacterial powder is prepared by culturing the bacterial strain in a TPY culture medium under anaerobic conditions, concentrating, freeze-drying and adding maltodextrin; and b) a prebiotic component: 3 '-sialylated milk oligosaccharide (3'-SL) with the purity of more than 95%, and the addition amount of the prebiotic component in the daily ration is 5g / kg. The synbiotics provided by the invention can significantly reduce the diarrhea rate of piglets after weaning, significantly improve the average daily gain of pigs in the nursing period, and reduce the feed-to-weight ratio. In addition, the synbiotics can also significantly reduce the level of proinflammatory factors in the serum of the weaned piglets and significantly improve the level of anti-inflammatory factors in the serum of the weaned piglets, which prompts that the synbiotics can reduce the level of intestinal inflammation and improve intestinal health, and has a great application prospect in healthy breeding of live pigs.

The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and / or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in the gastrointestinal tract of a subject, providing a microbial endocrinology-based mechanism and approach for optimization of synbiotic delivery of a probiotic with a neurochemical precursor. Still further the present invention is directed to industrial applications for production of dopamine utilizing methods and media suitable for the same.

The application discloses strains for preventing and treating Parkinson's disease and compositions, applications and products thereof, and relates to the technical field of microorganisms.The application provides three strains of human milk origin, namely Lactobacillus helveticus LV-20, Lactobacillus plantarum LPP8 and Lactobacillus fermentum PL-15.The application also provides a composition capable of preventing and treating Parkinson's disease.The three strains can preferably prevent and treat Parkinson's disease.The composition can significantly improve motor dysfunction (such as static tremor, muscle rigidity, bradykinesia, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive impairment, relieve sleep disorders, inhibit neural inflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, improve constipation and regulate intestinal flora composition, and has a wide application prospect as a probiotic or synbiotic product for treating and preventing Parkinson's disease.

The present disclosure is directed to dopamine producing probiotics to increase immune responses to vaccination and to provide increased immune protection. The present disclosure is further directed to dopamine producing synbiotic compositions, formulations, plants, and synthetic compounds and their use for targeted clinical and veterinary applications, for example, in promoting health and well-being and enhancing vaccine efficacy. The present disclosure also provides an approach for optimization of synbiotic delivery of a probiotic or other dopamine producing product with a dopamine precursor to beneficially aid in the use of such products for a variety of conditions and diseases, and particularly in the field of vaccines, whether prophylactic or therapeutic.

The invention belongs to the technical field of food processing, and particularly relates to a foxtail millet leavening and a preparation method thereof, and the preparation method comprises the following steps: carrying out enzymolysis on foxtail millet, and sterilizing to obtain foxtail millet enzymatic hydrolysate; inoculating a mixed seed solution of non-saccharomyces cerevisiae and lactic acid bacteria into the millet enzymatic hydrolysate, and fermenting to obtain a millet fermented product; according to the preparation method provided by the invention, the content of nutritional ingredients such as total phenols, flavones and the like of the foxtail millet is increased, the foxtail millet has various flavor substances, can be used as a raw material of prebiotics or synbiotics, is further processed into synbiotic products, and has a wide application prospect in the fields of food industry and health care products.

The present invention provides a combination of vitamin mixtures and synbiotics for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or developmental delay.

The invention provides sialylated IgG (immunoglobulin G) synbiotics oleogel emulsion for promoting intestinal colonization of bifidobacterium bifidum and a preparation method of the sialylated IgG synbiotics oleogel emulsion, and relates to the technical field of food processing. The emulsion consists of an oil phase, a water phase and polyglycerol ricinoleate, wherein the oil phase consists of beta-sitosterol, glyceryl monostearate and cocoa butter; the water phase consists of a phosphate buffer solution, bifidobacterium bifidum and sialylated IgG. The preparation method overcomes the defects in the prior art, and the obtained synbiotics oil gel emulsion is in a solid state at the temperature lower than 36 DEG C and is in a flowable liquid state after being orally taken into a human body at the temperature of 36 DEG C. In addition, the synbiotics oil gel emulsion stably exists in the stomach and is effectively released in the intestinal tract. And the released sialylated IgG can promote colonization of the bifidobacterium bifidum in the intestinal tract by simultaneously adhering surface sialidase SiaBb2 of the bifidobacterium bifidum and FcRn of an intestinal epithelial cell receptor. And the method has important significance for further realizing the in-vivo biological efficacy of colonizing the bifidobacterium bifidum.

The invention belongs to the technical field of microorganisms, and discloses a preparation method of synbiotics-loaded pH-responsive emulsion beads and application of the synbiotics-loaded pH-responsive emulsion beads in targeted improvement of colitis. Taking a mixed solution of activated and cultured probiotic bacterial sludge and fructo-oligosaccharide as a W1 phase; mixing the W1 phase with the oil phase, shearing and homogenizing to obtain a W1 / O emulsion; dispersing into a W2-phase aqueous solution dissolved with polysaccharide-protein mixed nanoparticles, and shearing and homogenizing to obtain a W1 / O / W2 dual emulsion; and cross-linking the double emulsion with polylysine, adding a sodium alginate solution, and then dropwise adding into a calcium chloride solution for curing to obtain the emulsion condensate beads. The synbiotics are loaded in the emulsion gel beads, so that the emulsion gel beads have excellent biocompatibility, enzyme triggering property and pH responsiveness. Experiments show that the emulsion gel beads improve the UC model rat colon shortening, repair the intestinal mucosa barrier, reduce the content of inflammatory factors IL-1beta, IL-6 and TNF-alpha, increase the content of an anti-inflammatory factor IL-10, increase the expression of tight junction proteins ZO-1, Claudin-1 and Occludin and regulate the intestinal flora balance of rats through synergistic interaction.

The invention discloses a Pickering embedded space probiotic microbial agent with thermal stability and capable of improving intestinal inflammation as well as preparation and application of the Pickering embedded space probiotic microbial agent. The space probiotics are space strains which are carried by Tiangong No.2 and Shenzhou 11 spacecrafts, return to the ground and are subjected to space mutagenesis. The Pickering emulsion embedded space probiotics are prepared from the probiotics by taking long-chain inulin as a natural particle stabilizer without adding a chemical synthesis emulsifier and an oil phase embedding and interfacial film dual protection structure, so that the impact of severe environments such as gastric acid and cholate on the probiotics can be obviously buffered, the colonization effect is improved, and the survival rate of the probiotics is increased. The effect of improving intestinal inflammation and the synbiotics synergistic effect are obviously enhanced, and meanwhile, the thermal stability of the compound preparation in the processing, storage and eating processes is obviously improved. The composition is natural, the process is simple and convenient, the stability is excellent, an efficient and feasible embedding solution is provided for a probiotic preparation, and the composition becomes the most potential probiotic preparation which has strong heat resistance and can improve intestinal inflammation, and has a wide application prospect.

The application discloses a kind of flavonoids with the synergistic effect of reducing sugar and its preparation method and application, belong to functional food and microbial technology field.The synbiotic comprises plant lactobacillus N107 live bacteria and rhizoma polygonati polysaccharide ferment, and the ferment is prepared from the crude polysaccharide of raw rhizoma polygonati fermented by homologous bacteria under optimized conditions.After fermentation, the molecular weight of polysaccharide is reduced by more than 70%, the reducing sugar is significantly improved, and butyric acid is produced.In vitro hypoglycemic activity analysis shows that the synbiotic can significantly inhibit alpha-glucosidase activity;Cell experiment shows that it can significantly improve the glucose uptake rate of insulin-resistant HepG2 cells;Mechanically, it inhibits gluconeogenesis and promotes Glut4 translocation through PI3K / Akt / FoxO1 pathway.The present application directly uses raw rhizoma polygonati polysaccharide, avoids degradation by cooking, realizes green biotransformation of polysaccharide and synergistic hypoglycemic effect of synbiotic, has the advantages of probiotics and prebiotics, and the polysaccharide utilization rate is high.

The invention discloses a traditional Chinese medicine compound preparation for treating nephrotic syndrome and a preparation method of the traditional Chinese medicine compound preparation, and belongs to the technical field of nephrotic syndrome treatment.The synbiotic microcapsule is prepared by compatibility of traditional Chinese medicines such as safflower, scutellaria baicalensis and perilla frutescens, and the synbiotic microcapsule is prepared by embedding traditional Chinese medicine extracts such as astragalus membranaceus and lily with lactobacillus acidophilus and bifidobacterium; and the wall material is prepared from mannose grafted meadowfoam seed extract, sodium alginate and fucoidin sulfate. The synbiotics microcapsule utilizes a Maillard reaction modified wall material to enhance gastric acid erosion resistance, realizes intestinal targeted colonization through mannose residues, protects probiotics, directionally releases traditional Chinese medicine active components, adjusts intestinal flora balance and inhibits uremia toxin generation. The traditional Chinese medicine components such as the safflower and the scutellaria baicalensis improve kidney blood circulation, relieve inflammatory response and regulate lipid metabolism by inhibiting an NF-kappa B channel, activating an AMPK channel and the like; the components such as the Chinese yam and the Chinese wolfberry can repair the permeability of glomerular basement membrane and improve the hypoproteinemia.

The invention provides a method for preparing a synbiotics microcapsule based on a Maillard reaction of protein and oligosaccharide and application, and belongs to the technical field of microbial preparations. The preparation method of the synbiotics microcapsule comprises the following steps: mixing galactooligosaccharide and soybean protein isolate to prepare a protein solution, stirring, and hydrating at 4 DEG C overnight; adjusting the hydrated overnight solution to be alkaline, and carrying out wet-process Maillard reaction at 80-90 DEG C to form a protein glycosylation wall material; the method comprises the following steps: drying a protein glycosylation wall material, preparing a wall material solution by using a calcium chloride solution, and mixing a microbial bacterial liquid, D-(+)-gluconic acid delta-lactone and the wall material solution to obtain a mixed solution; mixing soybean oil and span 80 to obtain an oil phase, pouring the mixed solution into the oil phase, stirring to form microspheres, removing the oil phase, and drying to obtain the synbiotics microcapsule. The wall material for preparing the microcapsule is low in raw material cost, mild in reaction condition, suitable for industrial production, high in microorganism embedding rate and capable of adjusting intestinal microecology.

The invention relates to a synbiotic composition, which comprises probiotics and dietary fibers, the probiotics are selected from one or more of Bifidobacterium pseudocatenuum HYL95, Faecalibacterium prausnitzii F20 and Eubacterium rectum BPB22, the dietary fibers are selected from dietary fibers, the dietary fibers are selected from dietary fibers, the dietary fibers are selected from dietary fibers, and the probiotics are selected from one or more of Bifidobacterium pseudocatenuum HYL95, Faecalibacterium prausnitzii F20 and Eubacterium rectum BPB22. The dietary fibers are selected from one or more of white hyacinth beans, Chinese wolfberry fruits, red dates, bitter gourds, lotus seeds, buckwheat, Chinese yams, oats, corn stigma and coix seeds. The synbiotics composition disclosed by the invention can be used for remarkably improving the symptoms, such as excessive calorie intake, weight gain, fat accumulation, muscle loss, impaired insulin sensitivity, impaired sugar tolerance, insulin resistance, reduction of the content of short-chain fatty acid in excrement and the like, which are caused by high-fat diet.

The invention provides a synbiotics preparation for feed as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: S1, carrying out anaerobic high-density culture on clostridium butyricum to the middle and later periods of logarithmic growth; s2, when the clostridium butyricum is cultured to the middle and later periods of logarithmic growth, bacillus subtilis is inoculated, aerobic high-density fermentation is performed, and fermentation liquor is obtained; and S3, carrying out spray drying on the fermentation broth to prepare the synbiotics preparation of clostridium butyricum and bacillus subtilis. The synbiotic preparation for the feed is prepared by adopting a double-bacterium staged culture mode, clostridium butyricum culture is performed in the previous stage, the bacillus subtilis is added in the later stage, and complex enzyme and antibacterial peptide substances secreted by the bacillus subtilis can degrade saccharomycetes cell walls and release butyric acid and other substances, so that the synbiotic preparation for the feed is prepared. And the bacillus subtilis is fermented and propagated by using nutrient substances released by the clostridium butyricum. The synbiotics preparation obtained by the invention not only has a broad-spectrum antibacterial effect, but also has an intestinal micro-ecological regulation effect.

Synthetic oligosaccharides and mixtures thereof which resemble polysaccharides produced by plants, yeast and other fungi, bacteria, and algae are described. The oligosaccharides and compositions provided herein are useful as synbiotics, prebiotics, immune modulators, digestion aids, and food additives.

The present invention provides a combination of a vitamin mixture and a synbiotic for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or being suffering from a growth retardation and / or growth retardation.

The invention belongs to the technical field of fermented feed, and relates to a cottonseed processing waste liquid synbiotic feed additive and application thereof. The invention provides free gossypol degrading bacteria in cottonseed processing waste liquid. A screening culture medium of the free gossypol degrading bacteria comprises the cottonseed processing waste liquid, yeast extract powder, ammonium sulfate, sodium chloride, magnesium sulfate, monopotassium phosphate and water. The free gossypol degrading bacteria consist of aspergillus niger, lactobacillus gasseri and saccharomyces cerevisiae. By optimizing the culture medium formula and the combination of the free gossypol degrading bacteria, the free gossypol degrading rate of the cottonseed processing waste liquid and the retention rate of oligosaccharide are improved, so that the quality and the safety of the cottonseed processing waste liquid synbiotics feed additive are ensured.