29 results about "Synbiotics" patented technology

The invention provides an application of synbiotics in preparation of a composition for improving glucagon-like peptide-1 (GLP-1). The composition comprises litchi polyphenol, probiotics and methionine. The probiotics comprise bifidobacterium animalis BCRC910645, bifidobacterium longum BCRC910812, or a combination of the bifidobacterium animalis BCRC910645 and the bifidobacterium longum BCRC910812, so that the content of the glucagon-like peptide-1 is increased.

The invention discloses a strain for preventing and treating Parkinson's disease as well as a composition, application and a product thereof, and relates to the technical field of microorganisms. The invention provides three strains from human milk, namely lactobacillus helveticus LV-20, plant lactobacillus LPP8 and lactobacillus fermentum PL-15, the invention further provides a composition capable of preventing and treating the Parkinson's disease, and the three strains can well prevent and treat the Parkinson's disease and can be used for preventing and treating the Parkinson's disease. The composition can significantly improve dyskinesia (such as static tremor, muscle stiffness, movement retardation, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive disorder, relieve sleep disorder, inhibit neuroinflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, and improve the curative effect. As probiotics or synbiotics, products for treating and preventing Parkinson's disease have a wide application prospect.

The invention discloses a synbiotics-like feed prepared from vegetable waste polymerized vegetable cakes and a method, and relates to the field of agricultural circular economy, cellulose in vegetable waste cell walls is effectively decomposed under mild conditions through a specific catalytic decomposition enzyme combination, and part of cellulose is converted into carbon dioxide and water, so that the utilization rate of the cellulose is improved. By combining physical heat energy conduction, liquid in cell vesicles is heated to generate micro air pressure to break through residual cell walls, so that recessive water in cells is successfully converted into surface dominant water, the energy consumption in the dehydration process is greatly reduced, and the loss of dry basis substances in the resource utilization process is effectively reduced; the vegetable cake product obtained through final polymerization is rich in various nutrient substances such as crude fibers and / or dietary fibers, proteins, vitamin C and carbohydrates, the recycling rate of the vegetable waste is larger than or equal to 95%, the recycling efficiency and the additional value are remarkably improved, meanwhile, the difficulty of subsequent harmless treatment is reduced from the source, and the economic input and the treatment cost are reduced.

The invention belongs to the technical field of animal feeds, and relates to a livestock feed with an immunoregulation function and a preparation method thereof. The feed comprises whey powder, fermented soybean meal, konjaku flour, beet pulp, tabletted corn, baked wheat, whey protein, palm oil, synbiotics powder, composite vitamins, composite minerals, calcium propionate, potassium sorbate and sodium selenite, and the synbiotics powder comprises freeze-dried probiotic powder and prebiotics powder. Probiotics in the probiotic freeze-dried powder are fermented saccharomyces cerevisiae and fermented bacillus subtilis, and the prebiotics powder comprises pachymaran, astragalus polysaccharide, inulin and fructo-oligosaccharide. The fermented saccharomyces cerevisiae and the fermented bacillus subtilis are embedded by adopting modified sodium alginate, the modified sodium alginate is modified by adopting glycine, and nano-montmorillonite and a soluble pore-foaming agent are added for optimization. The prepared feed has the function of regulating immunity.

The invention relates to screening and application of synergistic synbiotics beneficial to human health. The invention discloses a composition which comprises probiotic bifidobacterium lactis Bb-12, probiotic bifidobacterium longum BB536 and prebiotics 2 '-FL, and the composition can be used for enhancing immunity, promoting growth and development and / or promoting gastrointestinal tract health. The composition can be used for preparing food raw materials, food additives, feed additives, medicines, liquid drinks, foods or health-care products.

Synthetic oligosaccharides and mixtures thereof which resemble polysaccharides produced by plants, yeast and other fungi, bacteria, and algae are described. The oligosaccharides and compositions provided herein are useful as synbiotics, prebiotics, immune modulators, digestion aids, and food additives.

The invention discloses a preparation method of a nested sodium alginate / synbiotics edible fresh-keeping film, and belongs to the technical field of functional food packaging materials. Mixing probiotics with xylooligosaccharide, glycerol, sodium alginate and the like to prepare an inner-layer solution, and performing vacuum drying to obtain an inner-layer functional film; a natural thickening agent and sodium alginate are compounded to prepare an outer layer matrix solution, a semi-solid supporting bottom layer is prepared firstly, then an inner layer film is flatly laid, an outer layer solution is poured for the second time, and the nested film is obtained after drying. A hydrophobic physical barrier is constructed on the outer layer, the water contact angle is increased to 108.03 degrees, the ultraviolet light transmittance is reduced to 25.58%, and the permeability of oxygen is remarkably limited. And the viable count of the probiotics stored for 30 days reaches 7.36 Log CFU / g, which is obviously superior to that of a single-layer film. The quality of the strawberries in the storage period is remarkably improved when the strawberries are used as outer packages. Through collaborative innovation of structural design and a co-embedding system, the film is excellent in barrier property, probiotic activity maintenance and fresh-keeping effect, and is suitable for open type food long-acting fresh-keeping packaging.

The present invention discloses a feed containing a cereal and fruit fermentation composition and a preparation method thereof, and belongs to the field of livestock and poultry feeds, the feed comprises the following components in parts by weight: 50-100 parts of a cereal and fruit fermentation composition, 10-20 parts of synbiotics, 3-7 parts of organic trace elements, 1-5 parts of a mineral premix, and 0.5-3 parts of a vitamin premix, wherein the cereal and fruit fermented composition comprises feed syrup and cereal and fruit wet residues. By using the feed prepared by the invention, the problems that the feed in the prior art cannot provide efficient nutrition supply, protect intestinal health, degrade mycotoxin and efficiently utilize resources can be solved.

This invention consists of a process for producing bacteria and yeasts from agave sap and juice and honey, and using them as synbiotics in various functional beverages, including some tea-like liquid yogurt beverages. One process involves mixed culture to prepare a functional beverage with synbiotic action, comprising the combination of at least one yeast and one lactic acid bacterium with probiotic function, in a prebiotic solution of natural origin based on oligo- and polysaccharides from agave or honey, or both, for human consumption. The functional beverages described may contain alcohol in low concentrations or be completely alcohol-free. Another described process establishes the separate use of lactic acid bacteria and yeasts to generate fermented alcoholic, acidic, or both types of beverages, with or without live microorganisms, possessing high organoleptic quality.It also establishes the process by which a freeze-dried powder can be prepared, either individually or through a mixture of strains with probiotic activity, from honey or agave syrups.

The invention relates to a synbiotics for improving growth performance of weaned piglets and application thereof. The synbiotics comprise the following components: a) a probiotic component: bacterial powder of Bifidobacterium infantis B.infantis-zju (the preservation number is CCTCC NO: 20251039), the bacterial powder is prepared by culturing the bacterial strain in a TPY culture medium under anaerobic conditions, concentrating, freeze-drying and adding maltodextrin; and b) a prebiotic component: 3 '-sialylated milk oligosaccharide (3'-SL) with the purity of more than 95%, and the addition amount of the prebiotic component in the daily ration is 5g / kg. The synbiotics provided by the invention can significantly reduce the diarrhea rate of piglets after weaning, significantly improve the average daily gain of pigs in the nursing period, and reduce the feed-to-weight ratio. In addition, the synbiotics can also significantly reduce the level of proinflammatory factors in the serum of the weaned piglets and significantly improve the level of anti-inflammatory factors in the serum of the weaned piglets, which prompts that the synbiotics can reduce the level of intestinal inflammation and improve intestinal health, and has a great application prospect in healthy breeding of live pigs.

The present invention is directed to synbiotic compositions of probiotic strains and prebiotics, along with uses thereof for targeted human and animal applications, for example, in promoting health and well-being and / or treating therapeutic conditions. The present invention is also directed to methods of probiotic selection and detection of strains with the ability to produce neurochemicals in the gastrointestinal tract of a subject, providing a microbial endocrinology-based mechanism and approach for optimization of synbiotic delivery of a probiotic with a neurochemical precursor. Still further the present invention is directed to industrial applications for production of dopamine utilizing methods and media suitable for the same.

The application discloses strains for preventing and treating Parkinson's disease and compositions, applications and products thereof, and relates to the technical field of microorganisms.The application provides three strains of human milk origin, namely Lactobacillus helveticus LV-20, Lactobacillus plantarum LPP8 and Lactobacillus fermentum PL-15.The application also provides a composition capable of preventing and treating Parkinson's disease.The three strains can preferably prevent and treat Parkinson's disease.The composition can significantly improve motor dysfunction (such as static tremor, muscle rigidity, bradykinesia, posture balance and the like), reduce neuron damage, significantly reduce alpha-syn deposition, reverse sensory function degradation and cognitive impairment, relieve sleep disorders, inhibit neural inflammation and oxidative stress, reduce and repair intestinal barrier damage, relieve gastrointestinal dysfunction, improve constipation and regulate intestinal flora composition, and has a wide application prospect as a probiotic or synbiotic product for treating and preventing Parkinson's disease.

The present disclosure is directed to dopamine producing probiotics to increase immune responses to vaccination and to provide increased immune protection. The present disclosure is further directed to dopamine producing synbiotic compositions, formulations, plants, and synthetic compounds and their use for targeted clinical and veterinary applications, for example, in promoting health and well-being and enhancing vaccine efficacy. The present disclosure also provides an approach for optimization of synbiotic delivery of a probiotic or other dopamine producing product with a dopamine precursor to beneficially aid in the use of such products for a variety of conditions and diseases, and particularly in the field of vaccines, whether prophylactic or therapeutic.

The present invention provides a combination of vitamin mixtures and synbiotics for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or developmental delay.

The invention discloses a Pickering embedded space probiotic microbial agent with thermal stability and capable of improving intestinal inflammation as well as preparation and application of the Pickering embedded space probiotic microbial agent. The space probiotics are space strains which are carried by Tiangong No.2 and Shenzhou 11 spacecrafts, return to the ground and are subjected to space mutagenesis. The Pickering emulsion embedded space probiotics are prepared from the probiotics by taking long-chain inulin as a natural particle stabilizer without adding a chemical synthesis emulsifier and an oil phase embedding and interfacial film dual protection structure, so that the impact of severe environments such as gastric acid and cholate on the probiotics can be obviously buffered, the colonization effect is improved, and the survival rate of the probiotics is increased. The effect of improving intestinal inflammation and the synbiotics synergistic effect are obviously enhanced, and meanwhile, the thermal stability of the compound preparation in the processing, storage and eating processes is obviously improved. The composition is natural, the process is simple and convenient, the stability is excellent, an efficient and feasible embedding solution is provided for a probiotic preparation, and the composition becomes the most potential probiotic preparation which has strong heat resistance and can improve intestinal inflammation, and has a wide application prospect.

The application discloses a kind of flavonoids with the synergistic effect of reducing sugar and its preparation method and application, belong to functional food and microbial technology field.The synbiotic comprises plant lactobacillus N107 live bacteria and rhizoma polygonati polysaccharide ferment, and the ferment is prepared from the crude polysaccharide of raw rhizoma polygonati fermented by homologous bacteria under optimized conditions.After fermentation, the molecular weight of polysaccharide is reduced by more than 70%, the reducing sugar is significantly improved, and butyric acid is produced.In vitro hypoglycemic activity analysis shows that the synbiotic can significantly inhibit alpha-glucosidase activity;Cell experiment shows that it can significantly improve the glucose uptake rate of insulin-resistant HepG2 cells;Mechanically, it inhibits gluconeogenesis and promotes Glut4 translocation through PI3K / Akt / FoxO1 pathway.The present application directly uses raw rhizoma polygonati polysaccharide, avoids degradation by cooking, realizes green biotransformation of polysaccharide and synergistic hypoglycemic effect of synbiotic, has the advantages of probiotics and prebiotics, and the polysaccharide utilization rate is high.

The invention discloses a traditional Chinese medicine compound preparation for treating nephrotic syndrome and a preparation method of the traditional Chinese medicine compound preparation, and belongs to the technical field of nephrotic syndrome treatment.The synbiotic microcapsule is prepared by compatibility of traditional Chinese medicines such as safflower, scutellaria baicalensis and perilla frutescens, and the synbiotic microcapsule is prepared by embedding traditional Chinese medicine extracts such as astragalus membranaceus and lily with lactobacillus acidophilus and bifidobacterium; and the wall material is prepared from mannose grafted meadowfoam seed extract, sodium alginate and fucoidin sulfate. The synbiotics microcapsule utilizes a Maillard reaction modified wall material to enhance gastric acid erosion resistance, realizes intestinal targeted colonization through mannose residues, protects probiotics, directionally releases traditional Chinese medicine active components, adjusts intestinal flora balance and inhibits uremia toxin generation. The traditional Chinese medicine components such as the safflower and the scutellaria baicalensis improve kidney blood circulation, relieve inflammatory response and regulate lipid metabolism by inhibiting an NF-kappa B channel, activating an AMPK channel and the like; the components such as the Chinese yam and the Chinese wolfberry can repair the permeability of glomerular basement membrane and improve the hypoproteinemia.

The invention provides a method for preparing a synbiotics microcapsule based on a Maillard reaction of protein and oligosaccharide and application, and belongs to the technical field of microbial preparations. The preparation method of the synbiotics microcapsule comprises the following steps: mixing galactooligosaccharide and soybean protein isolate to prepare a protein solution, stirring, and hydrating at 4 DEG C overnight; adjusting the hydrated overnight solution to be alkaline, and carrying out wet-process Maillard reaction at 80-90 DEG C to form a protein glycosylation wall material; the method comprises the following steps: drying a protein glycosylation wall material, preparing a wall material solution by using a calcium chloride solution, and mixing a microbial bacterial liquid, D-(+)-gluconic acid delta-lactone and the wall material solution to obtain a mixed solution; mixing soybean oil and span 80 to obtain an oil phase, pouring the mixed solution into the oil phase, stirring to form microspheres, removing the oil phase, and drying to obtain the synbiotics microcapsule. The wall material for preparing the microcapsule is low in raw material cost, mild in reaction condition, suitable for industrial production, high in microorganism embedding rate and capable of adjusting intestinal microecology.

The invention provides a synbiotics preparation for feed as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: S1, carrying out anaerobic high-density culture on clostridium butyricum to the middle and later periods of logarithmic growth; s2, when the clostridium butyricum is cultured to the middle and later periods of logarithmic growth, bacillus subtilis is inoculated, aerobic high-density fermentation is performed, and fermentation liquor is obtained; and S3, carrying out spray drying on the fermentation broth to prepare the synbiotics preparation of clostridium butyricum and bacillus subtilis. The synbiotic preparation for the feed is prepared by adopting a double-bacterium staged culture mode, clostridium butyricum culture is performed in the previous stage, the bacillus subtilis is added in the later stage, and complex enzyme and antibacterial peptide substances secreted by the bacillus subtilis can degrade saccharomycetes cell walls and release butyric acid and other substances, so that the synbiotic preparation for the feed is prepared. And the bacillus subtilis is fermented and propagated by using nutrient substances released by the clostridium butyricum. The synbiotics preparation obtained by the invention not only has a broad-spectrum antibacterial effect, but also has an intestinal micro-ecological regulation effect.

Synthetic oligosaccharides and mixtures thereof which resemble polysaccharides produced by plants, yeast and other fungi, bacteria, and algae are described. The oligosaccharides and compositions provided herein are useful as synbiotics, prebiotics, immune modulators, digestion aids, and food additives.

The present invention provides a combination of a vitamin mixture and a synbiotic for use in enhancing bone growth and / or bone strength, for example, in children suffering from and / or being suffering from a growth retardation and / or growth retardation.

Synbiotic compositions comprising, consisting of, or consisting essentially of, one or more prebiotics and one or more probiotics are provided. Such compositions may be used to treat gut dysbiosis and / or to ameliorate one or more symptoms associated therewith.

In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, comprising combinations or formulations of microbes, such as non-pathogenic, live bacteria and / or bacterial spores, for example as probiotics, for the control, amelioration, prevention, and treatment of a disease or condition, for example, a dysbiosis, or for augmenting the health or ability to thrive in an individual. In alternative embodiments, provided are compositions or formulations, including products of manufacture and kits, and methods, comprising at least one non-pathogenic, live bacteria and / or bacterial spore and at least one probiotic, or synbiotic. In alternative embodiment, these non-pathogenic, live bacteria and / or bacterial spores (and optionally also a probiotic) are administered to an individual in need thereof, thereby resulting in a modification or modulation of the individual's gut microfloral population(s).

The present invention relates to a strong benefit prebiotic product based on polyphenols, said prebiotic product exhibiting a stimulating effect on the growth of Saccharomyces boulardii and an inhibitory effect on the growth of Candida albicans (C. albicans). Polyphenolic compounds have been identified and the optimum concentration of pure polyphenol compounds exhibiting the strongest stimulating effect on yeast growth has been determined. The saccharomyces boulardii strain has a positive effect on the growth of saccharomyces boulardii (S. boulardii) due to the fact that the saccharomyces boulardii strain contains the caffeic acid, the chlorogenic acid, the cinnamic acid, the apigenin and the luteolin. In addition, it has been demonstrated that a mixture of polyphenol compounds has a synergistic effect on Saccharomyces boulardii (S. boulardii). The same mixture almost completely inhibits the growth of Candida albicans (C. albicans). Selective stimulation of certain polyphenol compounds to some types of microorganisms and inhibition of other types of microorganisms are disclosed. The present invention provides a prebiotic formulation comprising a polyphenol compound, a synbiotic formulation comprising S. bourlardii and a polyphenol component, which provides a wide range of possibilities for applications in the food and pharmaceutical industries.

The invention provides a synbiotics composition capable of promoting proliferation of intestinal flora as well as a preparation method and application of the synbiotics composition, and relates to the technical field of microorganisms. The synbiotics composition is prepared from the following raw materials: probiotics and prebiotics, the probiotics are a mixture of lactobacillus crispatus, lactobacillus acidophilus and bifidobacterium animalis in a mass ratio of (0.1-2): (2-4): (5-7); the prebiotics are a mixture of xylooligosaccharide, oat beta-glucan, arabinoxylan and 2 '-fucosyllactose in the mass ratio of the xylooligosaccharide to the oat beta-glucan to the arabinoxylan to the 2'-fucosyllactose being (3-5) to (1-2) to (3-4) to (0.1-1). According to the invention, the specific probiotics and the specific prebiotics interact with each other, so that the proliferation of effective microbial communities in intestinal tracts is obviously promoted.

The invention discloses a pseudomonas koreensis PSE6, which is classified and named as pseudomonas koreensis, and the preservation number of the pseudomonas koreensis PSE6 is CGMCC (China General Microbiological Culture Collection Center) No.24810. The pseudomonas koreensis PSE6 is named as pseudomonas koreensis PSE6. The invention discloses an application of pseudomonas PSE6 in promoting plant growth or preparing a fertilizer or a preparation for promoting plant growth. The invention discloses a ginkgo leaf fermentation synbiotics which is prepared by taking pseudomonas koreensis PSE6 and trichoderma Guizhou NJAU4742 as functional microorganisms and ginkgo leaves as a substrate through solid fermentation, the ginkgo leaf fermentation synbiotics contain pseudomonas koreensis PSE6, trichoderma Guizhou NJAU4742 spores and indoleacetic acid. The pseudomonas PSE6 in the synbiotics is between 1 * 10 < 9 > CFU.g <-1 > dw and 1 * 10 < 10 > CFU.g <-1 > dw; and meanwhile, IAA in the synbiotics is remarkably enriched, so that the growth of plants can be remarkably promoted.

The invention concerns the specific combination of non-digestible saccharides and lactic acid producing bacteria that was found to be especially suitable for young children, facilitating the most favorable development of the microbiota from an infant-like to an adult-like type taking into account the composition as well as the metabolic activity, and on top of that, advantageously enabling a high level of intestinal butyrate formation.

The invention concerns the specific combination of non-digestible saccharides and lactic acid producing bacteria that was found to be especially suitable for young children, facilitating the most favorable development of the microbiota from an infant-like to an adult-like type taking into account the composition as well as the metabolic activity, and on top of that, advantageously enabling a high level of intestinal butyrate formation.

In alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, comprising combinations or formulations of microbes, such as non-pathogenic, live bacteria and / or bacterial spores, for example as probiotics, for the control, amelioration, prevention, and treatment of a disease or condition, for example, a dysbiosis, or for augmenting the health or ability to thrive in an individual. In alternative embodiments, provided are compositions or formulations, including products of manufacture and kits, and methods, comprising at least one non-pathogenic, live bacteria and / or bacterial spore and at least one probiotic, or synbiotic. In alternative embodiment, these non-pathogenic, live bacteria and / or bacterial spores (and optionally also a probiotic) are administered to an individual in need thereof, thereby resulting in a modification or modulation of the individual's gut microfloral population(s).