27 results about "Cobalamin" patented technology

The application provides a method for detecting the titer of vitamin B12 in a fermentation liquor. The method comprises the following steps: preparing a potassium dichromate solution, a hydrochloric acid solution and a potassium dihydrogen phosphate solution, mixing the three solutions with the vitamin B12 fermentation liquor under certain conditions to generate cyanocobalamin, and then testing the titer of the cyanocobalamin by using a high performance liquid chromatography. The titer of the vitamin B12 detected by using the method is consistent with the titer detected by using a sodium cyanide method. The operation method greatly reduces the safety risk of an analyst caused by using the sodium cyanide, and the operation method is simple, easy to manage in a laboratory and can save the testing cost.

The main purpose set by the present inventors is to provide a technology for suppressing inflammation particularly in aged tissue in the oral cavity.　The present inventors have discovered that it is possible to suppress inflammation particularly in aged tissue in the oral cavity by an oral cavity composition that contains β-glycyrrhetinic acid and at least one selected from the group consisting of retinol acetate, retinol, all-trans-retinoic acid, ascorbic acid, cobalamin, calciferol, anthraquinone, L-histidine, methylhesperidin, and chemically possible salts thereof.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

This invention discloses a strain of *Lactobacillus paracasei* capable of converting cyanocobalamin and promoting its absorption, thereby enhancing brain nerve repair and improving cognition, and its postbiotic, belonging to the fields of microbial technology and pharmaceutical technology. The *Lactobacillus paracasei* CCFM1527 and its prepared postbiotic provided by this invention promote the growth of vitamin B1 in the host. 12 The neuroprotective effects of upregulating the expression of absorption receptors and converting CN-CbI to methylcobalamin include: (1) promoting the upregulation of Amnionless expression in intestinal cells (Caco-2); (2) converting CN-CbI to methylcobalamin; and (3) promoting the upregulation of Amnionless expression in mouse ileum. AMN Upregulation of gene expression (4) significantly increased the levels of vitamin B in mice. 12 (5) Significantly promotes the expression of MBP and PSD-95 proteins in mice; (6) Improves the decline in cognitive ability in mice, and has great application prospects.

This invention belongs to the field of biotechnology and discloses a strain that produces vitamin B. 12 This invention relates to *Propionibacterium ferruginea* with anti-anemia function, its post-biotics, preparations, methods, and applications. The strain is named S2A35, classified as *Propionibacterium ferruginea*, with accession number CGMCC No. 37757, accession date February 9, 2026, and deposited at the China General Microbiological Culture Collection Center (CGMCC), No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing. This *Propionibacterium ferruginea* strain is capable of producing active vitamin B. 12 This strain has the function of cobalamin, and both the live bacteria and its post-biotics have the function of treating anemia. It is expected to be used for vitamin B12. 12 Its production, as well as its use in preparing foods, health products, foods for special medical purposes, and medicines for the prevention, improvement, and treatment of anemia, have very broad application prospects.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

To provide cosmetics that are aesthetically superior by suppressing discoloration over time and the precipitation of ingredients contained in the cosmetics. [Solution] By including (A) hydrolyzed gardenia extract, (B) cyanocobalamin, and (C) cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, the cosmetic composition can suppress discoloration over time and precipitation of components contained in the cosmetic composition, resulting in superior aesthetics. The cosmetic composition may also contain (A) hydrolyzed gardenia extract in an amount of 0.0005 to 0.05% by mass, (B) cyanocobalamin in an amount of 0.0005 to 0.005% by mass, and (C) cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol in an amount of 0.05 to 0.5% by mass.

This invention provides a pharmaceutical composition combining azelastine and methylcobalamin. [Solution] An orally administered pharmaceutical composition is provided, comprising azelastine or a pharmaceutically acceptable salt of azelastine, methylcobalamin, and one or more pharmaceutically acceptable excipients, wherein the pharmaceutical composition is formulated as a capsule, caplet, tablet, or pill configured for oral administration and absorption in the gastrointestinal tract, and the azelastine or a pharmaceutically acceptable salt of azelastine and methylcobalamin are present together in the pharmaceutical composition in a therapeutically effective daily dose for treating Alzheimer's disease or Parkinson's disease in human patients.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.

A composition for supporting nicotinamide adenine dinucleotide (NAD+) concentrations in humans is provided. The composition includes a synergistically effective amount of: nicotinamide riboside, nicotinamide and nicotinic acid; at least one of thiamin (vitamin B1), riboflavin (vitamin B2), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9) and cobalamin (vitamin B12); and at least one of magnesium, trans-resveratrol and caffeine. Related methods are also provided.

The invention pertains to an oral anti-ageing formulation comprising the active ingredients Niacinamide mononucleotide (NMN), Hydroxycobalamin or Adenosylcobalamin, 5-MTHF, Methionine, and Vitamin B6. Further, a method of promoting overall health and mitigating aging effects in a subject, where the subject may have MTHFR, MTR, MTRR, AHCY, and / or COMT gene mutations, is disclosed. Also, a food product or dietary supplement comprising the composition.

A composition for improving female health, sexual performance, and benefiting the gut-brain axis is disclosed. The composition includes sufficient amounts of Black Cohosh Extract 20:1, Black Pepper Pepper Extract (95% piperine), Korean Red Ginseng 8:1, Ginkgo Biloba Leaf 8:1, Horny Goat Weed Extract 8:1, Tribulis Terrestris vine 8:1, Avena Sativa Extract Seed 8:1, Pine Bark Extract 8:1, Muira Pauma Extract 8:1, Lemon Balm P.E. 4:1 (Melissa officinalis folium), Red Raspberry Leaf Extract 4:1, Damiana Leaf Extract 4:1, Butea Superba Root 8:1, Ashwagandha Extract 4:1, L-Arginine HCL Powder, L-Citrulline, a Probiotic Blend, TKA 200, Fermented Green Tea Extract with L-Theanine and Caffeine, Folic Acid, Zinc Aspartate, Vitamin E (D-alpha Tocopheryl Acetate), Vitamin D3, Vitamin C (Ascorbic Acid), Vitamin B12 (Methyl cobalamin), Vitamin B6 (Pyridoxine HCL), Pantothenic Acid (D-Calcium Pantothenate), Vitamin B3 Crystalline Powder (Niacinamide), Vitamin B2 Powder (Riboflavin), Biotin (D-biotin), Vitamin B1 HCl (Thiamine HCL).

Compositions and methods for treating oxidative stress, and conditions where oxidative stress contributes to conditions such as diabetes, in a subject by administering an effective amount of cobinamide. Oxidative stress can be caused by, for example, increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the patient. Compositions and methods for treating oxidative stress that contributes to diabetes-associated conditions such as cardiac fibrosis, and to aortic aneurysm, lipid or protein oxidation, or DNA damage, in a subject by administering an effective amount of cobinamide.

The present application belongs to the technical field of tea tree breeding, and particularly relates to a pollination method for improving cross efficiency of tea trees, a nutrient agent and use thereof. The pollination method comprises the following steps: collecting pollen of a male parent; removing the male parent to obtain a female parent, smearing the pollen on the stigma of the female parent to complete the pollination operation and form a cross flower; wrapping the cross flower with an isolation bag; taking the day of pollination as the 0th day, taking off the isolation bag on the 3rd day to the 5th day after the pollination, applying the nutrient agent, and then continuing to wrap the cross flower with the isolation bag; the formula of the nutrient agent is as follows: 3g-8g of potassium dihydrogen phosphate, 0.05g-0.1g of cobalamin, and 1L of sterile water; the application amount is to wet the stigma of the female parent; and the isolation bag is completely removed on the 7th day to the 9th day after the pollination, and the cross flower is developed by relying on the natural environment. The present application improves the fruit setting rate, reduces the young fruit drop rate of artificial cross, and further improves the cross efficiency.

The invention discloses an anti-aging compound nutritional composition as well as a preparation method and application thereof, and belongs to the technical field of foods. The composition is prepared from the following components in unit dose: 150 to 250 mg of nicotinamide ribose, 10 to 30 mg of pyrroloquinoline quinone disodium salt, 100 to 200 mg of quercetin phospholipid complex, 300 to 500 [mu] g of (6S)-5-calcium methyltetrahydrofolate, 30 to 80 [mu] g of methyl cobalamin, 5 to 15 mg of pyridoxine hydrochloride, 50 to 100 mg of radix astragali seu hedysari extract, 50 to 100 mg of fructus lycii extract, 50 to 100 mg of rhizoma polygonati extract and auxiliary materials. Through the synergistic effect of the nutrients and the traditional Chinese medicine extracts, NAD < + > improvement, mitochondrial protection, oxidation resistance and energy metabolism regulation are achieved, and the nutrient composition has novelty, safety and industrial practicability and can be used for preparing anti-aging nutritional supplements or health-care foods.

This invention provides a cobalamin derivative, its preparation method, and its application in the synthesis of arsenopyrine, relating to the field of heterocyclic compounds, and more specifically to the field of arsenopyrine synthesis technology. This cobalamin derivative is prepared by linking a 3-amino-3-carboxypropyl (ACP) group to the cobalt atom of cobalamin (CbI), and protecting the 3-amino-3-carboxypropyl group with a 9-fluorenemethoxycarbonyl (Fmoc) and a tert-butyl (tBu) group.

The main purpose of the present inventors is to provide a technique for suppressing inflammation, in particular, in aging tissues within the oral cavity.　The present inventors have found that an oral composition containing at least one selected from the group consisting of β-glycyrrhetinic acid, glycyrrhizic acid, ascorbic acid, tocopherol nicotinate, tocopherol acetate, pyridoxine, cobalamin, retinol, retinol acetate, riboflavin, phylloquinone, calciferol, anthraquinone, menaquinone-4, and L-aspartic acid, and chemically acceptable salts thereof, quercetin, genistein, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof, and methyl hesperidin can suppress inflammation, in particular, in aging tissues within the oral cavity.

The purpose of the present invention is to provide a pharmaceutical composition for preventing or treating dementia, and a method for preventing or treating dementia.　The present invention pertains to: a pharmaceutical composition for preventing or treating dementia, the pharmaceutical composition comprising methylcobalamin as an active ingredient and being administered parenterally; a prevention or treatment method for preventing or treating dementia; and use.

This invention provides a continuous flow preparation method for cobalt sulfite or its salts, and its applications. The preparation method includes: S1 loading a compound of formula III onto an adsorbent as a stationary phase; S2 using an aqueous solution of sulfite as a mobile phase, conveying the mobile phase liquid through the stationary phase, and obtaining cobalt sulfite on the adsorbent through a continuous flow ion exchange reaction. This invention, by loading cyanocobalamin onto the adsorbent as a stationary phase and using a sulfite solution as the mobile phase, allows the flowing solution to carry away cyano ions, disrupting the original ion exchange equilibrium and causing the reaction to irreversibly proceed towards cobalt sulfite. This allows cyanocobalamin to be almost completely converted to cobalt sulfite, greatly reducing the residual cyanocobalamin. The preparation method of this invention can provide high-purity cobalt sulfite, providing high-quality raw materials for the preparation of drugs such as hydroxycobalamin, and reducing the risk of excessive impurities.

The invention relates to a preparation method and application of a gastric cancer organoid culture medium. The culture medium for the gastric cancer organoid comprises a basic culture medium, a complete culture medium, a cell factor supply system, swine-derived hydrogel, beneficial bacterium metabolites and plant extracts, the basic culture medium is a DMEM / F12 basic culture medium; the complete culture medium is a DMEM / F12 complete culture medium; the cell factor supply system consists of fibroblasts, vascular endothelial cells and mesenchymal stem cells; the pig source hydrogel is prepared from pig small intestine tissues or pig stomach tissues; the beneficial bacterium metabolite is prepared from butyrate, indole-3-propionic acid, reuterin and cobalamin; the plant extract is prepared from tea polyphenol, baicalin, ginsenoside Rg3, curcumin and resveratrol. The culture medium for the gastric cancer organoid breaks through the bottlenecks of high cost, low stability and weak function of traditional organoid culture, and provides a model system capable of being popularized on a large scale for precise medical treatment of gastric cancer.

The application provides a cobalamin derivative, a preparation method thereof and application thereof in arsenicotin synthesis, relates to the field of heterocyclic compounds, and more particularly to the technical field of arsenicotin synthesis. The cobalamin derivative is obtained by linking 3-amino-3-carboxypropyl (3-amino-3-carboxypropyl, abbreviated as ACP) to a cobalt atom of cobalamin (abbreviated as CbI), and protecting the 3-amino-3-carboxypropyl by 9-fluorenylmethyloxycarbonyl (Fmoc) and tert-butyl (tBu).

The present invention provides a skin cosmetic containing cyanocobalamin that provides a moisturizing effect while also improving skin elasticity, caring for pores, and enhancing skin texture and radiance. [Solution] The skin cosmetic comprises (A) cyanocobalamin, (B) sugar alcohol, and (C) nonionic surfactant. Furthermore, the skin cosmetic may have at least one component (B) selected from inositol, maltitol, and sorbitol, and component (C) may have at least one component selected from polyoxyethylene sorbitan fatty acid ester and polyoxyethylene hydrogenated castor oil.

The present invention relates to methods and compositions comprising a combination of oleuropein and / or metabolite thereof and adenosylcobalamin in an effective amount for use in achieving at least one result selected from the group consisting of i) preventing and / or treating a mitochondria-related disease or condition associated with altered mitochondrial function and / or ii) at least one physical state selected from the group consisting of oxidative stress or a condition associated with oxidative stress in an individual; (iii) increasing mitochondrial energy, cellular energy, mitochondrial function and mitochondrial calcium uptake in one or more cells, (iv) increasing resistance to age-related pathologies; (v) improving a physiological state or disorder related to cell ageing or metabolic fatigue in one or more cells; (vi) improving mobility and / or (vii) improving healthspan and / or lifespan in an individual.

The invention relates to the field of microbial production of Vitamin B12.

The present application relates to the field of environmental microbial remediation, and in particular to a strain of trichlorobacter and its application in bioremediation of pollutants. The trichlorobacter is strain NB-12, which is trichlorobacter (Trichlorobacter NB-12) Tricholorbacter lovelyi ), and the strain has been preserved in the China General Microbiological Culture Collection Center on October 14, 2025, with the strain preservation number of CGMCC No. 46613. The strain NB-12 obtained by the present application is a strain of trichlorobacter that can self-synthesize cobalamin and is suitable for extensive industrial production and degradation of various halogenated alkanes in the environment.

The application discloses a method for accelerating straw degradation in a composting process, and belongs to the technical field of composting degradation. In order to solve the problem that straw degradation is slow in the composting process, the method comprises technical problems such as difficulty in degrading cellulose and semi-cellulose and complexity of a process. The method for accelerating straw degradation in the composting process comprises the following steps: adding methylcobalamin in a fermentation reaction in the composting process. The method realizes efficient and green utilization of straw, improves an ecological environment, and promotes environmental pollution treatment.