47 results about "Cobalamin" patented technology

The invention discloses a fermentation medium for regulating and controlling a clostridium aerovorans target product and a fermentation method of the clostridium aerovorans target product. The medium comprises a basic component and a regulating component, the basic components comprise ammonium chloride, potassium chloride, magnesium sulfate heptahydrate, sodium chloride, monopotassium phosphate, yeast powder, calcium chloride dihydrate, sodium selenite, nickel chloride hexahydrate, biotin, folic acid, pyridoxine hydrochloride, thiamine, riboflavin, nicotinic acid, D-calcium pantothenate, cobalamin, para aminobenzoic acid and lipoic acid; the adjusting component comprises sodium tungstate, ferrous sulfate and sodium molybdate, sodium tungstate and ferrous sulfate have a forward adjusting effect on increasing the yield of acetic acid, ethanol and butanol in the target product, and sodium molybdate has a reverse adjusting effect on the target product. By optimizing the proportion of trace elements in the culture medium, the clostridium metabolism efficiency is improved, synthesis of a target product is regulated and controlled, and the method is particularly suitable for industrial production of acetic acid, ethanol, butanol and the like.

The invention relates to the field of environmental microbial remediation, in particular to a strain of trichlorobacterium and application thereof in bioremediation of pollutants. According to the present invention, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, the bacillus subtilis is bacillus subtilis, and the bacillus subtilis is bacillus subtilis. The strain NB-12 obtained by the invention is a strain of self-synthesized cobalamin screened from river bottom sediments, is suitable for extensive industrial production and degrades a plurality of halogenated alkanes in the environment.

The application provides a method for detecting the titer of vitamin B12 in a fermentation liquor. The method comprises the following steps: preparing a potassium dichromate solution, a hydrochloric acid solution and a potassium dihydrogen phosphate solution, mixing the three solutions with the vitamin B12 fermentation liquor under certain conditions to generate cyanocobalamin, and then testing the titer of the cyanocobalamin by using a high performance liquid chromatography. The titer of the vitamin B12 detected by using the method is consistent with the titer detected by using a sodium cyanide method. The operation method greatly reduces the safety risk of an analyst caused by using the sodium cyanide, and the operation method is simple, easy to manage in a laboratory and can save the testing cost.

This application provides a barrier-repairing composition and its use. The composition comprises panthenol, niacinamide, folic acid, and cobalamin in a mass ratio of 3-7:1-5:0.0005-0.1:0.00005-0.01. This application also provides uses of the composition and products containing the same. The composition utilizes panthenol, niacinamide, folic acid, and cobalamin in combination, where the components complement and enhance each other, achieving a synergistic effect in upregulating BMAL2 gene expression. This enhances the DNA damage repair capacity of skin fibroblasts and potentially promotes barrier repair. Furthermore, the composition provided herein can significantly reduce the expression of capsaicin receptor 1 (TRPV1) and increase the expression of involucrin, PIEZO1, and TNXB, reducing skin discomfort and enhancing skin barrier function. Furthermore, the composition provided herein can reduce the expression of inflammatory factors, demonstrating its anti-inflammatory effect.

The main purpose set by the present inventors is to provide a technology for suppressing inflammation particularly in aged tissue in the oral cavity.　The present inventors have discovered that it is possible to suppress inflammation particularly in aged tissue in the oral cavity by an oral cavity composition that contains β-glycyrrhetinic acid and at least one selected from the group consisting of retinol acetate, retinol, all-trans-retinoic acid, ascorbic acid, cobalamin, calciferol, anthraquinone, L-histidine, methylhesperidin, and chemically possible salts thereof.

The invention belongs to the field of animal nutrition and feed science, and relates to a feeding technology capable of improving production performance, body health (immunity and oxidation resistance) and economic benefit of mutton sheep and improving rumen pH value, blood buffer capability and blood acid-base balance maintaining capability, namely preventing chronic rumen acidosis, and a daily ration preparation method thereof. According to the feeding technology and the daily ration preparation method, vitamin B12 (cyanocobalamine) is added into the mutton sheep high-concentrate daily ration (the concentrate-to-coarse ratio is 6: 4), the adding level is 0.5 mg / kg in terms of dry matter per kg of the daily ration, it is at least guaranteed that the pre-feeding period is 7 days and the positive test period is 30 days or above in the feeding time of the mutton sheep, the production performance, the organism immunity, the oxidation resistance and the economic benefits of the mutton sheep can be improved, and the mutton sheep feed is suitable for large-scale production. The pH value of the rumen, the blood buffering power and the blood acid-base balance maintaining capacity are improved, namely the effect of preventing chronic acidosis of the rumen is achieved, and the mutton sheep feed additive is suitable for mutton sheep with the weight being 34 kg or above. The method is easy to operate and safe in production, and a new thought and method are provided for preventing chronic rumen acidosis under the condition that mutton sheep are fed with high-concentrate daily ration.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

This invention belongs to the field of detection technology and relates to a highly sensitive method for quantitative analysis and structural identification of cobalamin, as well as its application. Using three common natural cobalamins with different structures found in the environment as standards, a full-scan, automatically triggered secondary mass spectrometry acquisition method is employed to obtain the cobalamin precursor ion and a series of high-abundance characteristic ion fragments. Based on the principle that fragments of the same cobalamin have the same fragment ion m / z and the fragment ion search function of the software, the structure of unknown cobalamin is identified. Then, a parallel reaction monitoring mass spectrometry quantitative method is used. A large number of interfering ions are filtered out by a quadrupole, and the cobalamin low-position ligand fragment ions with the highest abundance and high identifiability are used as quantitative ions to analyze the type and content of cobalamin in the sample. This invention, by combining two data acquisition methods of high-resolution mass spectrometry, can effectively eliminate interference from the endogenous matrix, improve the sensitivity of sample analysis, and enhance the specificity of quantification, thereby achieving highly sensitive detection of different types of cobalamin.

This invention discloses a strain of *Lactobacillus paracasei* capable of converting cyanocobalamin and promoting its absorption, thereby enhancing brain nerve repair and improving cognition, and its postbiotic, belonging to the fields of microbial technology and pharmaceutical technology. The *Lactobacillus paracasei* CCFM1527 and its prepared postbiotic provided by this invention promote the growth of vitamin B1 in the host. 12 The neuroprotective effects of upregulating the expression of absorption receptors and converting CN-CbI to methylcobalamin include: (1) promoting the upregulation of Amnionless expression in intestinal cells (Caco-2); (2) converting CN-CbI to methylcobalamin; and (3) promoting the upregulation of Amnionless expression in mouse ileum. AMN Upregulation of gene expression (4) significantly increased the levels of vitamin B in mice. 12 (5) Significantly promotes the expression of MBP and PSD-95 proteins in mice; (6) Improves the decline in cognitive ability in mice, and has great application prospects.

This invention belongs to the field of biotechnology and discloses a strain that produces vitamin B. 12 This invention relates to *Propionibacterium ferruginea* with anti-anemia function, its post-biotics, preparations, methods, and applications. The strain is named S2A35, classified as *Propionibacterium ferruginea*, with accession number CGMCC No. 37757, accession date February 9, 2026, and deposited at the China General Microbiological Culture Collection Center (CGMCC), No. 3, Courtyard 1, Beichen West Road, Chaoyang District, Beijing. This *Propionibacterium ferruginea* strain is capable of producing active vitamin B. 12 This strain has the function of cobalamin, and both the live bacteria and its post-biotics have the function of treating anemia. It is expected to be used for vitamin B12. 12 Its production, as well as its use in preparing foods, health products, foods for special medical purposes, and medicines for the prevention, improvement, and treatment of anemia, have very broad application prospects.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

To provide cosmetics that are aesthetically superior by suppressing discoloration over time and the precipitation of ingredients contained in the cosmetics. [Solution] By including (A) hydrolyzed gardenia extract, (B) cyanocobalamin, and (C) cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol, the cosmetic composition can suppress discoloration over time and precipitation of components contained in the cosmetic composition, resulting in superior aesthetics. The cosmetic composition may also contain (A) hydrolyzed gardenia extract in an amount of 0.0005 to 0.05% by mass, (B) cyanocobalamin in an amount of 0.0005 to 0.005% by mass, and (C) cyclohexane-1,4-dicarboxylic acid bisethoxydiglycol in an amount of 0.05 to 0.5% by mass.

This invention provides a pharmaceutical composition combining azelastine and methylcobalamin. [Solution] An orally administered pharmaceutical composition is provided, comprising azelastine or a pharmaceutically acceptable salt of azelastine, methylcobalamin, and one or more pharmaceutically acceptable excipients, wherein the pharmaceutical composition is formulated as a capsule, caplet, tablet, or pill configured for oral administration and absorption in the gastrointestinal tract, and the azelastine or a pharmaceutically acceptable salt of azelastine and methylcobalamin are present together in the pharmaceutical composition in a therapeutically effective daily dose for treating Alzheimer's disease or Parkinson's disease in human patients.

The present invention provides a novel food and drink containing at least one cobalamin selected from the group consisting of cyanocobalamin, hydroxocobalamin, adenosylcobalamin, methylcobalamin, and sulfitocobalamin. According to an embodiment of the present invention, there is provided a bottled beverage containing carnosine and at least one cobalamin selected from the group consisting of cyanocobalamin, hydroxocobalamin, adenosylcobalamin, methylcobalamin, and sulfitocobalamin, wherein the content of carnosine is 0.70-15 mg / mL and the content of the at least one cobalamin is 0.005-1 µm / mL.

The present invention relates to a combination of a vitamin B selected from cobalamin and or vitamin B6, and a medium chain fatty acid or a salt thereof, and compositions comprising the combination.

The disclosed invention relates to a chemical composition that can be taken orally and supplements an unhealthy diet and lifestyle. In one aspect of the invention the chemical composition includes Retinol Palmitate, Thiamine, Riboflavin, Niacin, Nicotinamide mononucleotide (NMN), Pyridoxal, Folic Acid, Cyanocobalamin, Cholecalciferol, Zinc, Manganese, Copper, Calcium, Magnesium, Iron, L-Selenomethionine, Lysine, Phenylalanine, L-Threonine, L-Methionine, L-Histidine, L-Tryptophan, L-Leucine, L-Isoleucine, L-Valine, Cinnamon Bark Powder, and Curcumin.

The invention provides an anti-inflammatory repair composition containing various B vitamins and cornflower extract and application. The anti-inflammatory repair composition comprises panthenol, nicotinamide, folic acid, cobalamin and cornflower extract. According to the composition, the panthenol, the nicotinamide, the folic acid, the cobalamin and the cornflower extract are compounded for use, the components are mutually matched and promoted, and a synergistic effect is achieved in the aspect of up-regulation of expression of two key factors, namely FGF2 and CAT, so that the effect of promoting skin repair is achieved. In addition, the composition provided by the invention can also significantly reduce expression of inflammatory factors, such as IL-8, and has a stronger effect of inhibiting inflammation.

The invention provides a barrier repairing composition and application. The composition is prepared from panthenol, nicotinamide, folic acid and cobalamin according to the mass ratio of (3 to 7) to (1 to 5) to (0.0005 to 0.1) to (0.00005 to 0.01). The invention also provides application of the composition and a product comprising the composition. According to the application, the panthenol, the nicotinamide, the folic acid and the cobalamin are compounded for use, all the components are mutually matched and promoted, and a synergistic effect is obtained in the aspect of up-regulating BMAL2 gene expression, so that the DNA damage repair capability of skin fibroblasts can be enhanced, and a potential barrier repair promoting function is played. Meanwhile, the composition provided by the invention can significantly reduce the expression of capsaicin receptor 1 (TRPV1), improve the expression of endoprotein, PIEZO1 and TNXB, reduce the skin discomfort reaction and make the skin barrier function more stable. In addition, the composition provided by the invention can reduce expression of inflammatory factors and has an effect of inhibiting inflammation.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.

A composition for supporting nicotinamide adenine dinucleotide (NAD+) concentrations in humans is provided. The composition includes a synergistically effective amount of: nicotinamide riboside, nicotinamide and nicotinic acid; at least one of thiamin (vitamin B1), riboflavin (vitamin B2), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9) and cobalamin (vitamin B12); and at least one of magnesium, trans-resveratrol and caffeine. Related methods are also provided.

The invention pertains to an oral anti-ageing formulation comprising the active ingredients Niacinamide mononucleotide (NMN), Hydroxycobalamin or Adenosylcobalamin, 5-MTHF, Methionine, and Vitamin B6. Further, a method of promoting overall health and mitigating aging effects in a subject, where the subject may have MTHFR, MTR, MTRR, AHCY, and / or COMT gene mutations, is disclosed. Also, a food product or dietary supplement comprising the composition.

The application provides an anti-inflammatory repair composition containing multiple B vitamins and cornflower extract and an application thereof, and comprises panthenol, nicotinamide, folic acid, cobalamin and cornflower extract. The application uses panthenol, nicotinamide, folic acid, cobalamin and cornflower extract in combination, and each component is mutually matched and promoted, and a synergistic effect is obtained in up-regulating the expression of two key factors FGF2 and CAT, so that the skin repair effect is promoted. In addition, the composition provided by the application can also significantly reduce the expression of inflammatory factors such as IL-8, and has a stronger effect of inhibiting inflammation.

A composition for improving female health, sexual performance, and benefiting the gut-brain axis is disclosed. The composition includes sufficient amounts of Black Cohosh Extract 20:1, Black Pepper Pepper Extract (95% piperine), Korean Red Ginseng 8:1, Ginkgo Biloba Leaf 8:1, Horny Goat Weed Extract 8:1, Tribulis Terrestris vine 8:1, Avena Sativa Extract Seed 8:1, Pine Bark Extract 8:1, Muira Pauma Extract 8:1, Lemon Balm P.E. 4:1 (Melissa officinalis folium), Red Raspberry Leaf Extract 4:1, Damiana Leaf Extract 4:1, Butea Superba Root 8:1, Ashwagandha Extract 4:1, L-Arginine HCL Powder, L-Citrulline, a Probiotic Blend, TKA 200, Fermented Green Tea Extract with L-Theanine and Caffeine, Folic Acid, Zinc Aspartate, Vitamin E (D-alpha Tocopheryl Acetate), Vitamin D3, Vitamin C (Ascorbic Acid), Vitamin B12 (Methyl cobalamin), Vitamin B6 (Pyridoxine HCL), Pantothenic Acid (D-Calcium Pantothenate), Vitamin B3 Crystalline Powder (Niacinamide), Vitamin B2 Powder (Riboflavin), Biotin (D-biotin), Vitamin B1 HCl (Thiamine HCL).

This application belongs to the field of daily chemical technology and provides an anti-inflammatory and repairing composition containing multiple B vitamins and its application. The composition includes panthenol, nicotinamide, folic acid, cobalamin, cornflower extract, and asiaticoside. This application uses panthenol, nicotinamide, folic acid, cobalamin, cornflower extract, and asiaticoside in combination. The components work synergistically and promote each other, achieving a synergistic effect in upregulating the expression of PIEZO1 and / or TNXB genes, thereby enhancing skin protective functions such as barrier repair, anti-inflammatory regulation, and influencing inflammation resolution. In addition, the composition provided in this application can significantly upregulate the expression of inner lining protein genes, improving skin barrier function; the composition also significantly reduces the expression of inflammatory factors, exhibiting a stronger anti-inflammatory effect.

The invention discloses compound B vitamin and inositol nutrition fortified flour and a preparation method of fine dried noodles, and relates to the field of food processing, nutrition fortifying and functional staple food. Every 100 g of the flour contains 50 to 100 mg of nicotinic acid (vitamin B3), 5 to 10 mg of pantothenic acid (vitamin B5), 5 to 10 mg of pyridoxine (vitamin B6), 250 to 500 [mu] g of cobalamin (vitamin B12), 100 to 200 [mu] g of biotin (vitamin B7), 500 to 1000 [mu] g of folic acid (vitamin B9), 5 to 10 mg of choline and 5 to 10 mg of inositol. The mass ratio of the riboflavin (vitamin B2) to the pyridoxine (vitamin B6) to the folic acid (vitamin B9) is 1: (0.1-0.2): (0.01-0.02). A sodium alginate-hydroxypropyl methylcellulose double-embedding microcapsule technology and a segmented adding technology are adopted for preparation, and the gastric juice passing rate of the microcapsule is larger than 95%. According to the invention, the vitamin B lost in traditional flour processing is supplemented, a synergistic nutrition system is formed, the bioavailability is improved, the nutrition supplement compliance is improved through the staple food carrier, and the food can be used for preparing food for preventing metabolic syndrome, anemia or neural tube defects.

Compositions and methods for treating oxidative stress, and conditions where oxidative stress contributes to conditions such as diabetes, in a subject by administering an effective amount of cobinamide. Oxidative stress can be caused by, for example, increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the patient. Compositions and methods for treating oxidative stress that contributes to diabetes-associated conditions such as cardiac fibrosis, and to aortic aneurysm, lipid or protein oxidation, or DNA damage, in a subject by administering an effective amount of cobinamide.

The present application belongs to the technical field of tea tree breeding, and particularly relates to a pollination method for improving cross efficiency of tea trees, a nutrient agent and use thereof. The pollination method comprises the following steps: collecting pollen of a male parent; removing the male parent to obtain a female parent, smearing the pollen on the stigma of the female parent to complete the pollination operation and form a cross flower; wrapping the cross flower with an isolation bag; taking the day of pollination as the 0th day, taking off the isolation bag on the 3rd day to the 5th day after the pollination, applying the nutrient agent, and then continuing to wrap the cross flower with the isolation bag; the formula of the nutrient agent is as follows: 3g-8g of potassium dihydrogen phosphate, 0.05g-0.1g of cobalamin, and 1L of sterile water; the application amount is to wet the stigma of the female parent; and the isolation bag is completely removed on the 7th day to the 9th day after the pollination, and the cross flower is developed by relying on the natural environment. The present application improves the fruit setting rate, reduces the young fruit drop rate of artificial cross, and further improves the cross efficiency.

The present invention concerns cobalamin derivatives of formula (I)wherein X is a ligand having a formula selected from among:—(CH2)1-5—S—(CH2)0-3—CH3, —S—(CH2)1-5—NH2 andfurther wherein R1 is H, methyl or ethyl, R2 isand R3 is —H orand its use in diseases caused by lack of vitamin B12 support.

A composition of the present invention is used for oral administration. The composition incudes thiamine at least 5% by weight, pyridoxine at least 5 wt. %; cyanocobalamin at least 0.1 wt. %, polysorbate 40 at least 1.8 wt. %, and water for the rest, up to 100 wt. %. The composition provides high concentrations of pyridoxine, thiamine, cyanocobalamin, stability for a long period of storage under standard conditions.