73 results about "Pyridoxine" patented technology

The doxylamine succinate pyridoxine enteric-coated tablet comprises a tablet core and a coating layer, the coating layer comprises a first isolation layer, an enteric-coated layer and a second isolation layer, the materials of the enteric-coated layer comprise a plasticizer, an anti-sticking agent, a defoaming agent and a flexible coating material, and the flexible coating material accounts for 24-28% of the mass of the tablet core. By adding the flexible coating material, the stability of the pharmaceutical preparation is improved, the difference between batches is reduced, the drug dissolution rate reaches 90% or above, and the pharmaceutical preparation can be quickly released.

The invention belongs to the technical field of biological detection, and particularly relates to a method for synchronously and quantitatively detecting various folic acid metabolism related substances in trace plasma or serum, which comprises the following steps of: detecting a pretreated trace plasma or serum sample by adopting a liquid chromatography-tandem mass spectrometry method; the following nine folic acid metabolism related substances are synchronously and quantitatively detected: 5-formyl tetrahydrofolic acid, folic acid, 5-methyl tetrahydrofolic acid, S-adenosine-L-methionine, S-adenosine-L-homocysteine, vitamin B12, pyridoxamine, pyridoxine and pyridoxal. The invention further relates to application of the detection method in related detection of child neurodevelopment. According to the detection method, only trace plasma or serum is used, methotrexate is used for replacing an expensive isotope internal standard for more economical detection, and nine folate metabolism related substances can be accurately quantified at the same time. Therefore, the detection method disclosed by the invention has important clinical significance and wide market application prospect.

The invention discloses a hair-raising and protecting series composition for treating alopecia as well as a preparation method and application thereof, and relates to the technical field of medicines, and the composition is prepared from minoxidil, propylene glycol, menthol, betaine, an amino acid compound, glycyrrhizic acid, tocopheryl acetate, hinokiol, pyridoxine, ethanol and purified water. The preparation method comprises the following steps: mixing propylene glycol, minoxidil, menthol and ethanol, adding hinokiol, mixing, adding pyridoxine, an amino acid compound and betaine, mixing, adding tocopheryl acetate and glycyrrhizic acid, and mixing. According to the minoxidil composition, the absorption rate of minoxidil can be increased, the drug resistance of the minoxidil composition after being used for a long time is reduced, and the treatment effect of the minoxidil composition on various types of alopecia patients is effectively improved. The invention solves the problem that minoxidil and hinokiol are difficult to dissolve and easy to separate out, has the advantages of good absorption effect and lasting alopecia treatment effect, effectively improves newborn hair quality and scalp greasy state, and brings new dawn to alopecia patients.

The invention discloses a method for efficiently producing pyridoxal phosphate based on a three-enzyme cascade reaction and a recombinant strain, and belongs to the technical field of biological engineering. The recombinant escherichia coli for co-expressing the pyridoxine phosphate phosphatase mutant, the pyridoxine phosphate oxidase and the hydrogen peroxide decomposing enzyme is constructed, three-enzyme synergy is realized by optimizing the copy number of a carrier, and the catalytic efficiency of a recombinant strain as a cell catalyst is improved. The invention further provides a one-pot method for preparing pyridoxal phosphate, the production cost is reduced, an efficient, green and economical biosynthesis path is provided for industrial production of PLP, and the method can be widely applied to the fields of food, medicine and the like and has important industrial value and application prospects.

The present invention relates to a disintegrant free delayed release pharmaceutical tablet composition comprising doxylamine succinate and pyridoxine hydrochloride as active ingredients. It relates to a process for preparing said composition having a specific ratio of mannitol and dibasic calcium phosphate as diluent / filler providing excellent storage stability of the produced tablets.

The invention relates to a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, and belongs to the technical field of biosynthesis. In order to solve the existing problem of serious environmental pollution, the invention provides a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, which comprises the following steps: in the presence of polyphosphate, magnesium salt, ATP (adenosine triphosphate), pyridoxal kinase and polyphosphate kinase, performing phosphorylation reaction on pyridoxal or pyridoxine and acid salts thereof, thereby obtaining the pyridoxal phosphate or pyridoxine phosphate. The temperature of the phosphorylation reaction is controlled to be 30-38 DEG C, after the reaction is finished, protein separation is conducted on reaction liquid, mother liquor is separated, the compound pyridoxal phosphate or pyridoxine phosphate shown in the formula I is obtained, and the mother liquor is recycled and reused. According to the method, a large amount of ammonium acetophosphate does not need to be additionally added, operation is simpler, mother liquor can be recycled, a large amount of waste water is prevented from being discharged, environment friendliness is better achieved, and the yield is high.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for distinguishing hypertrophic cardiomyopathy and left ventricular hypertrophy and application. The application analyzes the metabolome of hypertrophic cardiomyopathy (HCM) patients, left ventricular hypertrophy (LVH) patients caused by non-hypertrophic cardiomyopathy and healthy people, finds that carnitine C16:2, carnitine C14:0, carnitine C16:0, carnitine C18:0 and carnitine C18:1 are differentially expressed in HCM patients and LVH patients, pyridoxine phosphate, ito acid, adenosine monophosphate, adenosine diphosphate and adenosine triphosphate are differentially expressed in HCM patients and healthy people, lysine base, methyl glutamic acid, acetyl proline, malate semialdehyde and citramalate are differentially expressed in LVH patients and healthy people, and ROC curve analysis shows excellent prediction effect, strong specificity and high sensitivity.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The invention provides a pyridoxine phosphate oxidase mutant and application of the pyridoxine phosphate oxidase mutant in synthesis of pyridoxal phosphate. The mutant is obtained by performing one or more mutations on an amino acid sequence as shown in SEQ: ID: NO: 4, wherein the amino acid sequence contains the 24th site (D24N), the 141 site (Q141S), the 190 site (R190G) and the 195 site (H195A) as a mutant 1; the mutant 2 contains a 66th site (R66K), a 141 site (Q141S), a 180 site (Q180T) and a 193 site (R193H); and the mutant 3 contains the 141 site (Q141S) and the 190 site (R190G). Compared with wild type pyridoxine phosphate oxidase, the pyridoxine phosphate oxidase mutant disclosed by the invention has relatively high catalytic efficiency, and when the pyridoxine phosphate oxidase mutant is used for synthesizing pyridoxal phosphate, the conversion rate of 99.76% or above can be realized within 5 hours.

The invention discloses a formula and a preparation method of a disease-preventing health-care oral liquid. The health-care food is prepared from the following raw materials in parts by weight: 4 to 6 milliliters of purple perilla seed oil, 5 to 7 milliliters of walnut oil, 100 to 150 milligrams of algal oil, 200 to 250 milligrams of grape seed extract, 50 to 80 milligrams of selenium-enriched yeast, 80 to 120 milligrams of vitamin C, 80 to 120 milligrams of vitamin E, 0.6 to 1.0 milligram of vitamin B1 (thiamine) and 0.6 to 1.0 milligram of vitamin B2 (riboflavin). After being taken by multiple persons for a period of time, the traditional Chinese medicine composition is proved to be safe to take, free of adverse reaction and obvious in health care effect, old people feel weak in action, heavy in whole body, dry in mouth and throat and insomnia and constipation before taking the traditional Chinese medicine composition, symptoms are relieved after taking the traditional Chinese medicine composition, and the traditional Chinese medicine composition is safe to take, free of adverse reaction and obvious in health care effect. Young people are good in working state and honor in spirit, and children are fast in learning progress, good in taste, high in adaptability and beneficial to popularization, and can play a positive role in prevention before illness.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The present disclosure describe a simple optimized method that allows the combined manufacture of five active substances: cyanocobalamin, pyridoxine, thiamine, pregabalin and celecoxib in a single solid, stable, immediate release pharmaceutical form for pain. The combined use of drugs that act at distinct levels is associated with greater pain relief and, as they can be used at lower doses, with a reduced risk of adverse effects. In this context, the combined use of B vitamins plus pregabalin and celecoxib would be associated with greater analgesic activity through complementary action mechanisms.

The invention relates to metabonomic characterization of microorganisms, in particular to a method for identifying cell types of cells in a sample, comprising: culturing the sample in a growth medium comprising nicotinamide to obtain a cultured growth medium; analyzing the cultured growth medium by chemical analysis; and identifying the cell type as at least one of the genus Escherichia, the genus Klebsiella, the genus Pseudomonas, the genus Enterococcus, the genus Staphylococcus or the genus Streptococcus when the cultured growth medium contains a higher concentration of nicotinate than the growth medium; wherein the growth culture medium comprises the following components in a buffer culture medium: 0.02 to 2 g / l of D-glucose, 0.0001 to 0.1 g / l of nicotinamide, 0.0001 to 0.1 g / l of pyridoxin.HCl, 0.02 to 1 g / l of hypoxanthine, 0.2 to 5 g / l of L-arginine, 0.2 to 5 g / l of L-threonine, 0.1 to 5 g / l of L-histidine, 0.02 to 2 g / l of spermine and catalase. According to the method, identification and toxin sensitivity detection can be completed within about half of time compared with that of an existing method.

The invention provides a pyridoxine 5 '-phosphate oxidase mutant and an application of the pyridoxine 5'-phosphate oxidase mutant in synthesis of pyridoxine 5 '-phosphate. The mutant is obtained by mutating the amino acid sequence of pyridoxine 5 '-phosphate oxidase DrPNPO, and the mutation site comprises at least one of the 45th amino acid, the 68th amino acid, the 91th amino acid, the 114 amino acid, the 127th amino acid, the 141 amino acid, the 147th amino acid, the 158th amino acid, the 174th amino acid and the 205th amino acid. Compared with wild type pyridoxine phosphate oxidase, the pyridoxine 5 '-phosphate oxidase mutant disclosed by the invention has higher catalytic efficiency, the pyridoxine 5'-phosphate oxidase mutant can be used for efficiently synthesizing pyridoxine 5 '-phosphate through a whole-cell catalytic reaction only in 4 hours, and the conversion rate reaches 99% or above.

A composition contains Nicotinamide and pyridoxine. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be administered to an individual in need thereof orally or intravenously for preventing and / or treating sarcopenia, physical frailty, a loss of and / or improving skeletal muscle mass, lean muscle mass, skeletal muscle strength and / or skeletal muscle function.

The present invention aims to provide an oral composition that has an astringent sensation while effectively suppressing discoloration over time. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, (B) component: fluorine-containing compound, and (C) component: an anionic surfactant, wherein the content of component (B) is such that when converted to a fluoride ion concentration it is 1000 to 4000 ppm, and the content of component (C) is such that it is 0.05 to 5% by mass, preferably further comprising (D) component: at least one selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol, and more preferably further comprising (E) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

The erythromycin fermentation culture medium is optimized by comparing transcriptomics analysis. Specifically, the invention relates to a method for optimizing the fermentation yield of erythromycin by adding six vitamins into a culture medium in a combined manner. More specifically, the six vitamins comprise thiamine pyrophosphate, riboflavin, pyridoxine, folic acid, cobalamin and hemin. The vitamin is added into the fermentation culture medium, so that the growth of erythromycin producing bacteria in the fermentation culture medium is promoted, and the yield of erythromycin is effectively increased.

The present invention aims to provide a cosmetic containing a pyridoxine and having excellent stability and usability. The cosmetic of the present invention is characterized by comprising: (A) pyridoxine, a salt or a derivative thereof; (B) ethyl ascorbic acid; and (C) a higher fatty acid or a higher alcohol which is liquid at 25°C.

The present disclosure relates to a non-therapeutic use of a human milk oligosaccharide (HMO) selected from 3'-sialyllacto-N-tetraose (LSTa), 6'-sialyllacto-N-neotetraose (LSTc) and 3'-sialyl- 3-fucosyllactose (FSL), or a combination thereof, in supporting or improving one or more of brain health, immune system health, gut health, and metabolic health, in a subject, optionally by increasing the production of one or more metabolites selected from the group consisting of of pyridoxine, pyridoxamine, nicotinic acid, N-acetyl-L-glycine, sarcosine, N-acetyl-L-glutamine, N- acetyl-L-aspartic acid, trigonelline, trans-4-hydroxyproline, 3-hydroxybutyric acid (BHB), 4- hydroxybenzoic acid, and N-acetyl-L-tryptophan, in the gastrointestinal tract of the subject.

The present invention aims to provide an oral composition in which discoloration over time caused by pyridoxine or its salts is suppressed, and bitterness is reduced. [Solution] The present invention provides an oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: a fluorine-containing compound, wherein the content of component (A) is 0.11 to 0.95% by mass, and the content of component (B) is such that when converted to a fluoride ion concentration, it is 1000 to 20000 ppm, and preferably further comprising (C) component: at least one sweetener selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

The invention relates to a washing and caring composition with dandruff removing, itching relieving and repairing effects and a preparation method of the washing and caring composition, and belongs to the technical field of daily chemicals. Aiming at dandruff formation and itching factors of scalp, the piroctone olamine salt, palmitoyl tetrapeptide-10, tetrapeptide-1 and speranskia herb extract are correspondingly compounded to play a role in removing dandruff and relieving itching, and the limitation of a single component is made up by compounding chemical components and plant extracts, so that more efficient and milder scalp care is realized. In addition, the dihydrooat acyl o-aminobenzoic acid, pyridoxine tripalmitate and quaternary ammonium salt-73 are combined for use, so that the shampoo also has an excellent synergistic repairing capability on scalp with symptoms such as acne, red and swollen, slight folliculitis and the like.

The invention provides a pyridoxal kinase mutant and application thereof in synthesis of pyridoxine phosphate, and belongs to the field of enzyme engineering. The mutant disclosed by the invention is obtained by mutating an amino acid sequence of wild type pyridoxal kinase, and mutation sites comprise at least one of the 23rd amino acid, the 25th amino acid, the 30th amino acid, the 31st amino acid, the 52nd amino acid, the 54th amino acid, the 57th amino acid, the 57th amino acid, the 96th amino acid, the 125th amino acid, the 127th amino acid, the 130th amino acid, the 136th amino acid, the 157th amino acid, the 158th amino acid, the 159th amino acid, the 230th amino acid, the 233th amino acid, the 235th amino acid, the 236th amino acid, the 257th amino acid, the 260th amino acid and the 264th amino acid; wherein the amino acid sequence of the wild type pyridoxal kinase is shown as SEQ: ID: NO: 1. Compared with wild type pyridoxal kinase and other mutants, the pyridoxal kinase mutant provided by the invention has higher catalytic efficiency, has the advantages of simple process, high conversion rate and low production cost when being applied to a pyridoxine phosphate synthesis process, and has a good industrial application prospect.

The present invention discloses a hydrophobically modified vitamin B6, a preparation method thereof, and an application thereof, belonging to the field of cosmetic technology. Nervonic acid is selected as a hydrophobic modifier for water-soluble vitamin B6, and pyridoxine neuramide is synthesized. This allows the water-soluble vitamin B6 to carry natural nervonic acid through the stratum corneum of the skin, thereby increasing the transdermal absorption of vitamin B6. The present invention selects nervonic acid as a hydrophobic modifier for water-soluble vitamin B6, and synthesizes pyridoxine neuramide. This allows the water-soluble vitamin B6 to carry natural nervonic acid through the stratum corneum of the skin, thereby increasing the transdermal absorption of vitamin B6. The pyridoxine neuramide prepared by the present invention simultaneously exerts the physiological activities of vitamin B6 and nervonic acid on the skin, has a good skin barrier repair effect, reduces transepidermal water loss of the skin, improves moisturizing efficiency, and also has certain anti-inflammatory and antioxidant effects. It is a skin conditioning agent that is easy to use and has excellent effects.

A beverage composition for hydration and for supporting head hair health is described. The beverage composition includes (i) amla and (ii) one or more head hair benefit ingredient(s). Head hair benefit ingredient(s) in the beverage composition may include trace elements such as zinc, calcium, and selenium, among others; and vitamins such as: vitamin A; vitamin B, e.g., riboflavin, biotin, folate, thiamine, niacin, pantothenic acid, pyridoxine, and cobalamins, etc.; vitamin C; vitamin D; vitamin E; and vitamin K. The beverage compositions of the present disclosure in addition to supporting head hair health and promoting growth of head hair have also been found to be beneficial to support health of skin and nails.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.

The present invention provides an oral composition that can effectively suppress the bitter taste after use, even when pyridoxine or a salt thereof is used. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: inorganic powder, wherein the content of component (A) is 0.01% to 3% by mass, and the content of component (B) is 0.01% or more and less than 15% by mass.

A composition for supporting nicotinamide adenine dinucleotide (NAD+) concentrations in humans is provided. The composition includes a synergistically effective amount of: nicotinamide riboside, nicotinamide and nicotinic acid; at least one of thiamin (vitamin B1), riboflavin (vitamin B2), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9) and cobalamin (vitamin B12); and at least one of magnesium, trans-resveratrol and caffeine. Related methods are also provided.