48 results about "Pyridoxine" patented technology

The invention belongs to the technical field of biological detection, and particularly relates to a method for synchronously and quantitatively detecting various folic acid metabolism related substances in trace plasma or serum, which comprises the following steps of: detecting a pretreated trace plasma or serum sample by adopting a liquid chromatography-tandem mass spectrometry method; the following nine folic acid metabolism related substances are synchronously and quantitatively detected: 5-formyl tetrahydrofolic acid, folic acid, 5-methyl tetrahydrofolic acid, S-adenosine-L-methionine, S-adenosine-L-homocysteine, vitamin B12, pyridoxamine, pyridoxine and pyridoxal. The invention further relates to application of the detection method in related detection of child neurodevelopment. According to the detection method, only trace plasma or serum is used, methotrexate is used for replacing an expensive isotope internal standard for more economical detection, and nine folate metabolism related substances can be accurately quantified at the same time. Therefore, the detection method disclosed by the invention has important clinical significance and wide market application prospect.

The invention discloses a method for efficiently producing pyridoxal phosphate based on a three-enzyme cascade reaction and a recombinant strain, and belongs to the technical field of biological engineering. The recombinant escherichia coli for co-expressing the pyridoxine phosphate phosphatase mutant, the pyridoxine phosphate oxidase and the hydrogen peroxide decomposing enzyme is constructed, three-enzyme synergy is realized by optimizing the copy number of a carrier, and the catalytic efficiency of a recombinant strain as a cell catalyst is improved. The invention further provides a one-pot method for preparing pyridoxal phosphate, the production cost is reduced, an efficient, green and economical biosynthesis path is provided for industrial production of PLP, and the method can be widely applied to the fields of food, medicine and the like and has important industrial value and application prospects.

The present invention relates to a disintegrant free delayed release pharmaceutical tablet composition comprising doxylamine succinate and pyridoxine hydrochloride as active ingredients. It relates to a process for preparing said composition having a specific ratio of mannitol and dibasic calcium phosphate as diluent / filler providing excellent storage stability of the produced tablets.

The invention relates to a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, and belongs to the technical field of biosynthesis. In order to solve the existing problem of serious environmental pollution, the invention provides a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, which comprises the following steps: in the presence of polyphosphate, magnesium salt, ATP (adenosine triphosphate), pyridoxal kinase and polyphosphate kinase, performing phosphorylation reaction on pyridoxal or pyridoxine and acid salts thereof, thereby obtaining the pyridoxal phosphate or pyridoxine phosphate. The temperature of the phosphorylation reaction is controlled to be 30-38 DEG C, after the reaction is finished, protein separation is conducted on reaction liquid, mother liquor is separated, the compound pyridoxal phosphate or pyridoxine phosphate shown in the formula I is obtained, and the mother liquor is recycled and reused. According to the method, a large amount of ammonium acetophosphate does not need to be additionally added, operation is simpler, mother liquor can be recycled, a large amount of waste water is prevented from being discharged, environment friendliness is better achieved, and the yield is high.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for distinguishing hypertrophic cardiomyopathy and left ventricular hypertrophy and application. The application analyzes the metabolome of hypertrophic cardiomyopathy (HCM) patients, left ventricular hypertrophy (LVH) patients caused by non-hypertrophic cardiomyopathy and healthy people, finds that carnitine C16:2, carnitine C14:0, carnitine C16:0, carnitine C18:0 and carnitine C18:1 are differentially expressed in HCM patients and LVH patients, pyridoxine phosphate, ito acid, adenosine monophosphate, adenosine diphosphate and adenosine triphosphate are differentially expressed in HCM patients and healthy people, lysine base, methyl glutamic acid, acetyl proline, malate semialdehyde and citramalate are differentially expressed in LVH patients and healthy people, and ROC curve analysis shows excellent prediction effect, strong specificity and high sensitivity.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

A composition contains Nicotinamide and pyridoxine. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be administered to an individual in need thereof orally or intravenously for preventing and / or treating sarcopenia, physical frailty, a loss of and / or improving skeletal muscle mass, lean muscle mass, skeletal muscle strength and / or skeletal muscle function.

The present invention aims to provide an oral composition that has an astringent sensation while effectively suppressing discoloration over time. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, (B) component: fluorine-containing compound, and (C) component: an anionic surfactant, wherein the content of component (B) is such that when converted to a fluoride ion concentration it is 1000 to 4000 ppm, and the content of component (C) is such that it is 0.05 to 5% by mass, preferably further comprising (D) component: at least one selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol, and more preferably further comprising (E) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

The present invention aims to provide a cosmetic containing a pyridoxine and having excellent stability and usability. The cosmetic of the present invention is characterized by comprising: (A) pyridoxine, a salt or a derivative thereof; (B) ethyl ascorbic acid; and (C) a higher fatty acid or a higher alcohol which is liquid at 25°C.

The present disclosure relates to a non-therapeutic use of a human milk oligosaccharide (HMO) selected from 3'-sialyllacto-N-tetraose (LSTa), 6'-sialyllacto-N-neotetraose (LSTc) and 3'-sialyl- 3-fucosyllactose (FSL), or a combination thereof, in supporting or improving one or more of brain health, immune system health, gut health, and metabolic health, in a subject, optionally by increasing the production of one or more metabolites selected from the group consisting of of pyridoxine, pyridoxamine, nicotinic acid, N-acetyl-L-glycine, sarcosine, N-acetyl-L-glutamine, N- acetyl-L-aspartic acid, trigonelline, trans-4-hydroxyproline, 3-hydroxybutyric acid (BHB), 4- hydroxybenzoic acid, and N-acetyl-L-tryptophan, in the gastrointestinal tract of the subject.

The present invention aims to provide an oral composition in which discoloration over time caused by pyridoxine or its salts is suppressed, and bitterness is reduced. [Solution] The present invention provides an oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: a fluorine-containing compound, wherein the content of component (A) is 0.11 to 0.95% by mass, and the content of component (B) is such that when converted to a fluoride ion concentration, it is 1000 to 20000 ppm, and preferably further comprising (C) component: at least one sweetener selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

The invention relates to a washing and caring composition with dandruff removing, itching relieving and repairing effects and a preparation method of the washing and caring composition, and belongs to the technical field of daily chemicals. Aiming at dandruff formation and itching factors of scalp, the piroctone olamine salt, palmitoyl tetrapeptide-10, tetrapeptide-1 and speranskia herb extract are correspondingly compounded to play a role in removing dandruff and relieving itching, and the limitation of a single component is made up by compounding chemical components and plant extracts, so that more efficient and milder scalp care is realized. In addition, the dihydrooat acyl o-aminobenzoic acid, pyridoxine tripalmitate and quaternary ammonium salt-73 are combined for use, so that the shampoo also has an excellent synergistic repairing capability on scalp with symptoms such as acne, red and swollen, slight folliculitis and the like.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.

The present invention provides an oral composition that can effectively suppress the bitter taste after use, even when pyridoxine or a salt thereof is used. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: inorganic powder, wherein the content of component (A) is 0.01% to 3% by mass, and the content of component (B) is 0.01% or more and less than 15% by mass.

A composition for supporting nicotinamide adenine dinucleotide (NAD+) concentrations in humans is provided. The composition includes a synergistically effective amount of: nicotinamide riboside, nicotinamide and nicotinic acid; at least one of thiamin (vitamin B1), riboflavin (vitamin B2), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9) and cobalamin (vitamin B12); and at least one of magnesium, trans-resveratrol and caffeine. Related methods are also provided.

A composition contains Nicotinamide and Vitamin B6, for example pyridoxine. The composition may be an oral nutritional composition, for example an infant formula, a follow up formula, a nutritional supplement, an oral nutritional supplement, a food product. The composition can be administered to an individual in need thereof for promoting muscle growth and / or for maintaining and / or increasing muscle function and / or muscle mass in infants and children. For example, the composition can be useful for increasing muscle function and / or muscle mass by modulating muscle stem cells.

The invention relates to the field of medicines, in particular to a construction method of an Alzheimer's disease non-human primate model. A small dose of thiamine antagonist pyrithiamine is given to the chronic abdominal cavity to induce chronic thiamine metabolic disorder, so that the non-human primate marmoset Alzheimer disease model capable of reflecting the Alzheimer disease course is established, and the method has the advantages of simplicity in operation, small animal injury and the like; therefore, the method is beneficial to further basic clinical transformation research and the like, and has more important scientific significance and economic value.

This invention belongs to the field of enzyme engineering technology, specifically relating to an EcCAT mutant of catalase and its applications. The mutant is obtained by mutating at least one amino acid from the following positions in SEQ ID NO:1: Ile (126th position), Ser (167th position), Val (199th position), Gly (200th position), Asn (201st position), Phe (206th position), Ala (211th position), Phe (214th position), Gly (273rd position), Ala (389th position), Phe (391st position), Leu (407th position), and Gly (410th position). Compared to wild-type catalase, the EcCAT mutant of this invention exhibits higher catalytic efficiency. When used in combination with pyridoxine 5'-phosphate oxidase, the whole-cell catalytic synthesis of pyridoxal 5'-phosphate can be completed in just 5 hours, with a conversion rate exceeding 99%.

The present invention relates to a cocrystal of 1,1-dioxo-3,3-dibutyl-5-phenyl-7-methylthio-8-(N-{(R)-α-[N-((S)-1-carboxypropyl) carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)-2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine (odevixibat) and pyridoxine. The invention also relates to a pharmaceutical composition comprising said cocrystal, and to its use in the treatment of various conditions as described herein.

FIELD: biotechnology.SUBSTANCE: modified composition of a nutrient medium for inducing the formation of soybean regenerated plants in vitro, including ammonium nitrate (NH4NO3) – 1650 mg / l; potassium nitrate (KNO3) – 1900 mg / l; calcium chloride dihydrate (CaCl2×2H2O) – 440 mg / l; magnesium sulfate (MgSO4×7H2O) – 370 mg / l; potassium phosphate (KH2PO4) – 170 mg / l; disodium salt of ethylenediaminetetraacetic acid (Na2 EDTA) – 37.3 mg / l; ferrous sulfate (FeSO4×7H2O) – 27.95 mg / l; boric acid (H3VO3) – 6.2 mg / l; manganese sulfate (MnSO4×4H2O) – 22.3 mg / l; zinc sulfate (ZnSO4×H2O) – 8.6 mg / l; sodium molybdate (Na2MoO4×2H2O) – 0.25 mg / l; copper sulfate (CuSO4×5H2O) – 0.025 mg / l; thionyl chloride (CoCl2×H2O) – 0.025 mg / l; agar-agar – 7000 mg / l, according to the invention the following components are additionally introduced: glycine – 1.0 mg / l; mesoinositol – 120 mg / l; ascorbic acid – 3.0 mg / l; nicotinic acid – 1.0 mg / l; pyridoxine-HCl – 1.5 mg / l; thiamine-HCl – 1.0 mg / l; biotin – 0.03 mg / l; sucrose – 25000 mg / l; 6-BAP – 1.0 mg / l; indole-butyric acid (IBA) – 1.5 mg / l; starch – 9000 mg / l; activated carbon – 3.0 mg / l; water is the rest.EFFECT: expanding the range of nutrient medium compositions for inducing the formation of soybean regenerated plants in vitro.1 cl, 3 tbl

This invention relates to a composition containing protoplasts of ginseng as an active ingredient, which improves aging caused by the deepening of wrinkles or loss of firmness in the skin. Specifically, the present invention contains protoplasts of ginseng as an active ingredient and can improve aging caused by deep wrinkles or loss of firmness of the skin. Furthermore, by including one or more components selected from the group consisting of phloretin, oryzanol, tranexamic acid, and pyridoxine, the stability of the composition can be enhanced and the effect of improving skin wrinkles and firmness can be strengthened by suppressing the clumping or cell membrane defects of the ginseng protoplasts in the composition.

To provide an oral composition that can suppress discoloration over time. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: a nonionic surfactant, wherein the content of component (A) is 0.01% by mass or more and less than 0.5% by mass, the content of component (B) is 0.01% or more and less than 1%, and the ratio of the content of component (B) to the content of component (A) ((B) / (A)) is 0.5 or more and less than 20.

The application discloses a method for lossless reduction of toxic components in ginkgo nuts and products and applications prepared by the method. The method comprises the following steps: removing the middle seed coat and inner seed coat of raw ginkgo nuts to obtain raw ginkgo whole kernel; boiling the raw ginkgo whole kernel with water to obtain boiled ginkgo whole kernel; cooling the boiled ginkgo whole kernel and water boiling liquid to room temperature; adding alpha-amylase to the boiled ginkgo whole kernel and water boiling liquid; performing constant temperature water bath after adding the alpha-amylase, filtering out the boiled ginkgo whole kernel to obtain water bath extraction liquid and attenuated boiled ginkgo whole kernel; and recovering 4'-O-methyl pyridoxine and 4'-O-methyl pyridoxine-5'-glucoside in the water bath extraction liquid. The method effectively removes MPN and MPNG in ginkgo nuts, is simple in process operation, is high in safety, and uses only water and heat treatment. The low-toxicity boiled ginkgo whole kernel obtained by the method can be used as raw material of various ginkgo foods, and is particularly suitable for ginkgo foods that need to be cooked with whole kernel.

Disclosed herein is a composition containing nicotinamide and pyridoxine. The composition can be an oral nutritional composition, such as a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purposes (FSMP). The composition can be administered orally or intravenously to an individual in need thereof for preventing and / or treating sarcopenia, physical frailty, loss of skeletal muscle mass, loss of lean muscle mass, loss of skeletal muscle strength, and / or loss of skeletal muscle function, and / or improving skeletal muscle mass, lean muscle mass, skeletal muscle strength, and / or skeletal muscle function.

The invention discloses a method for high-selectivity synthesis of pyridoxine phosphate based on a phase transfer catalysis system. According to the method, pyridoxine phosphate is used as an initial raw material, and in a water-organic solvent two-phase system, under the synergistic catalysis of a phase transfer catalyst and TEMPO, chlorite and pypocholoride are used for oxidation. The quaternary ammonium salt phase transfer catalyst is introduced, so that the reaction activation energy is remarkably reduced, and the reaction can be quickly carried out at the low temperature of 0-10 DEG C; meanwhile, a specific narrow window of which the reaction pH value is 5.8-6.2 is accurately locked. The method effectively solves the technical problems that the reaction rate is slow, phosphate bonds are easy to hydrolyze and pyridine rings are easy to generate chlorination side reaction when a traditional TEMPO oxidation system is used for preparing compounds containing phosphate groups. The yield of the obtained product can reach 90% or above, the content of specific dephosphorized impurities is lower than 0.05%, and the method is suitable for preparing high-purity medical standard substances.

The invention belongs to the technical field of flame-retardant materials, and discloses a bio-based flame-retardant anti-ultraviolet polyvinyl alcohol composite material and a preparation method thereof. The method comprises the following steps: taking pyridoxal phosphate, p-phenylenediamine and 9, 10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide as raw materials, carrying out Schiff base condensation and P-H nucleophilic addition reaction to prepare a bio-based flame-retardant anti-ultraviolet agent N, N '-bis (DOPO-pyridoxol group methyl) p-phenylenediamine (denoted as DPP), and adding the bio-based flame-retardant anti-ultraviolet agent N, N'-bis (DOPO-pyridoxol group methyl) p-phenylenediamine (denoted as DPP) into a polyvinyl alcohol system to prepare the high-performance composite material. In the composite material disclosed by the invention, phosphorus-nitrogen active components released by thermal decomposition of DPP can quench gas-phase combustion free radicals and catalyze dehydration crosslinking of a polyvinyl alcohol matrix at the same time, so that a continuous, compact and highly graphitized carbon layer is formed, and gas-condensation double-phase synergistic flame retardance is realized; the aromatic conjugated structure endows the composite material with an intrinsic excellent anti-ultraviolet function; strong hydrogen bonds between DPP and polyvinyl alcohol molecular chains construct a physical cross-linked network, so that the crystallinity and thermal stability of the composite material are improved, and the mechanical property is remarkably enhanced.