63 results about "Pyridoxine" patented technology

The invention belongs to the technical field of biological detection, and particularly relates to a method for synchronously and quantitatively detecting various folic acid metabolism related substances in trace plasma or serum, which comprises the following steps of: detecting a pretreated trace plasma or serum sample by adopting a liquid chromatography-tandem mass spectrometry method; the following nine folic acid metabolism related substances are synchronously and quantitatively detected: 5-formyl tetrahydrofolic acid, folic acid, 5-methyl tetrahydrofolic acid, S-adenosine-L-methionine, S-adenosine-L-homocysteine, vitamin B12, pyridoxamine, pyridoxine and pyridoxal. The invention further relates to application of the detection method in related detection of child neurodevelopment. According to the detection method, only trace plasma or serum is used, methotrexate is used for replacing an expensive isotope internal standard for more economical detection, and nine folate metabolism related substances can be accurately quantified at the same time. Therefore, the detection method disclosed by the invention has important clinical significance and wide market application prospect.

The invention discloses a hair-raising and protecting series composition for treating alopecia as well as a preparation method and application thereof, and relates to the technical field of medicines, and the composition is prepared from minoxidil, propylene glycol, menthol, betaine, an amino acid compound, glycyrrhizic acid, tocopheryl acetate, hinokiol, pyridoxine, ethanol and purified water. The preparation method comprises the following steps: mixing propylene glycol, minoxidil, menthol and ethanol, adding hinokiol, mixing, adding pyridoxine, an amino acid compound and betaine, mixing, adding tocopheryl acetate and glycyrrhizic acid, and mixing. According to the minoxidil composition, the absorption rate of minoxidil can be increased, the drug resistance of the minoxidil composition after being used for a long time is reduced, and the treatment effect of the minoxidil composition on various types of alopecia patients is effectively improved. The invention solves the problem that minoxidil and hinokiol are difficult to dissolve and easy to separate out, has the advantages of good absorption effect and lasting alopecia treatment effect, effectively improves newborn hair quality and scalp greasy state, and brings new dawn to alopecia patients.

The invention discloses a method for efficiently producing pyridoxal phosphate based on a three-enzyme cascade reaction and a recombinant strain, and belongs to the technical field of biological engineering. The recombinant escherichia coli for co-expressing the pyridoxine phosphate phosphatase mutant, the pyridoxine phosphate oxidase and the hydrogen peroxide decomposing enzyme is constructed, three-enzyme synergy is realized by optimizing the copy number of a carrier, and the catalytic efficiency of a recombinant strain as a cell catalyst is improved. The invention further provides a one-pot method for preparing pyridoxal phosphate, the production cost is reduced, an efficient, green and economical biosynthesis path is provided for industrial production of PLP, and the method can be widely applied to the fields of food, medicine and the like and has important industrial value and application prospects.

The present invention relates to a disintegrant free delayed release pharmaceutical tablet composition comprising doxylamine succinate and pyridoxine hydrochloride as active ingredients. It relates to a process for preparing said composition having a specific ratio of mannitol and dibasic calcium phosphate as diluent / filler providing excellent storage stability of the produced tablets.

The invention relates to a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, and belongs to the technical field of biosynthesis. In order to solve the existing problem of serious environmental pollution, the invention provides a biosynthesis method of pyridoxal phosphate or pyridoxine phosphate, which comprises the following steps: in the presence of polyphosphate, magnesium salt, ATP (adenosine triphosphate), pyridoxal kinase and polyphosphate kinase, performing phosphorylation reaction on pyridoxal or pyridoxine and acid salts thereof, thereby obtaining the pyridoxal phosphate or pyridoxine phosphate. The temperature of the phosphorylation reaction is controlled to be 30-38 DEG C, after the reaction is finished, protein separation is conducted on reaction liquid, mother liquor is separated, the compound pyridoxal phosphate or pyridoxine phosphate shown in the formula I is obtained, and the mother liquor is recycled and reused. According to the method, a large amount of ammonium acetophosphate does not need to be additionally added, operation is simpler, mother liquor can be recycled, a large amount of waste water is prevented from being discharged, environment friendliness is better achieved, and the yield is high.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for distinguishing hypertrophic cardiomyopathy and left ventricular hypertrophy and application. The application analyzes the metabolome of hypertrophic cardiomyopathy (HCM) patients, left ventricular hypertrophy (LVH) patients caused by non-hypertrophic cardiomyopathy and healthy people, finds that carnitine C16:2, carnitine C14:0, carnitine C16:0, carnitine C18:0 and carnitine C18:1 are differentially expressed in HCM patients and LVH patients, pyridoxine phosphate, ito acid, adenosine monophosphate, adenosine diphosphate and adenosine triphosphate are differentially expressed in HCM patients and healthy people, lysine base, methyl glutamic acid, acetyl proline, malate semialdehyde and citramalate are differentially expressed in LVH patients and healthy people, and ROC curve analysis shows excellent prediction effect, strong specificity and high sensitivity.

A sprayable polymeric scaffold composition for localized anti-inflammatory therapy is disclosed. The composition comprises lipid nanorods encapsulating inflammasome inhibitors, a thermogelling agent, and a thickening agent. The lipid nanorods, which can be formed using pyridoxine dipalmitate and DSPE-PEG (2000) carboxylic acid, inhibit NLRP3 and AIM2 inflammasomes, reducing inflammation. The thermogelling agent, such as poloxamer 407, enables the composition to transition from a fluid sol state at room temperature to a semi-solid gel state at body temperature, forming a localized gel film upon topical application. The thickening agent, such as mucin, enhances viscosity and provides additional anti-inflammatory effects. The composition delivers sustained release of encapsulated inhibitors, effectively reducing inflammatory markers and symptoms in conditions such as psoriasis. The sprayable scaffold offers a novel, localized treatment platform with improved skin penetration, ease of administration, and reduced systemic side effects.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The present invention relates to a nutritional vitamin complex for pets intended to improve the fur and skin quality of pets such as dogs and cats. The composition of the complex contains omega-3, curcumin, piperine, biotin (vitamin H or vitamin B7), vitamin B2 (riboflavin), vitamin B3 (nicotinic acid or niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cyanocobalamin), folic acid (vitamin B9), vitamin E (alpha-tocopherol), vitamin C, zinc (zinc glycine chelate), coenzyme Q10, hydrolysed type II collagen, astaxanthin, DL-methionine, selenium, L-glycine, L-proline, L-phenylalanine, L-leucine, L-isoleucine, L-histidine, L-arginine, L-lysine, L-tyrosine, resveratrol, and a flavouring agent.

The invention provides a pyridoxine phosphate oxidase mutant and application of the pyridoxine phosphate oxidase mutant in synthesis of pyridoxal phosphate. The mutant is obtained by performing one or more mutations on an amino acid sequence as shown in SEQ: ID: NO: 4, wherein the amino acid sequence contains the 24th site (D24N), the 141 site (Q141S), the 190 site (R190G) and the 195 site (H195A) as a mutant 1; the mutant 2 contains a 66th site (R66K), a 141 site (Q141S), a 180 site (Q180T) and a 193 site (R193H); and the mutant 3 contains the 141 site (Q141S) and the 190 site (R190G). Compared with wild type pyridoxine phosphate oxidase, the pyridoxine phosphate oxidase mutant disclosed by the invention has relatively high catalytic efficiency, and when the pyridoxine phosphate oxidase mutant is used for synthesizing pyridoxal phosphate, the conversion rate of 99.76% or above can be realized within 5 hours.

The present disclosure provides compositions and methods for providing a health benefit to a growing animal comprising administering a food composition to the animal, wherein the food composition includes a brain development blend. The brain development blend generally comprises DHA, EPA, taurine, choline, thiamine, riboflavin, pantothenic acid, niacin, pyridoxine, vitamin B12, and folic acid.

The invention provides a pyridoxine 5 '-phosphate oxidase mutant and an application of the pyridoxine 5'-phosphate oxidase mutant in synthesis of pyridoxine 5 '-phosphate. The mutant is obtained by mutating the amino acid sequence of pyridoxine 5 '-phosphate oxidase DrPNPO, and the mutation site comprises at least one of the 45th amino acid, the 68th amino acid, the 91th amino acid, the 114 amino acid, the 127th amino acid, the 141 amino acid, the 147th amino acid, the 158th amino acid, the 174th amino acid and the 205th amino acid. Compared with wild type pyridoxine phosphate oxidase, the pyridoxine 5 '-phosphate oxidase mutant disclosed by the invention has higher catalytic efficiency, the pyridoxine 5'-phosphate oxidase mutant can be used for efficiently synthesizing pyridoxine 5 '-phosphate through a whole-cell catalytic reaction only in 4 hours, and the conversion rate reaches 99% or above.

A composition contains Nicotinamide and pyridoxine. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be administered to an individual in need thereof orally or intravenously for preventing and / or treating sarcopenia, physical frailty, a loss of and / or improving skeletal muscle mass, lean muscle mass, skeletal muscle strength and / or skeletal muscle function.

The present invention aims to provide an oral composition that has an astringent sensation while effectively suppressing discoloration over time. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, (B) component: fluorine-containing compound, and (C) component: an anionic surfactant, wherein the content of component (B) is such that when converted to a fluoride ion concentration it is 1000 to 4000 ppm, and the content of component (C) is such that it is 0.05 to 5% by mass, preferably further comprising (D) component: at least one selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol, and more preferably further comprising (E) component: at least one selected from the group consisting of tocopherol acetate and tocopherol nicotinate.

The invention discloses a formula of an organic mixed health-care beverage and a preparation method of the organic mixed health-care beverage. The raw materials comprise, by weight, 1-3 g of ginseng, 1-3 g of deer-horn glue, 2-5 g of folium cortex eucommiae, 2-5 g of gynostemma pentaphylla, 2-5 g of hawthorn, 2-5 g of ligusticum wallichii, 1-3 g of schisandra chinensis, 3-5 g of rhizoma polygonati, 2-5 g of radix ophiopogonis, 100-200 mg of algal oil, 200-300 mg of taurine, 150-200 mg of grape seed extract, 3-5 ml of perilla seed oil, 50-80 ml of yoghourt, 30-50 ml of walnut juice and 30-50 ml of peanut liquid. The selenium-enriched beverage is prepared from 30 to 50 milliliters of sweet almond liquid, 30 to 50 milliliters of black sesame liquid, 30 to 50 milliliters of mango juice, 50 to 100 milliliters of apple juice, 30 to 50 milliliters of tomato juice, 50 to 80 micrograms of selenium-enriched yeast, 25 to 50 milligrams of vitamin C, 125 to 25 milligrams of vitamin E, 0 to 15 milligrams of vitamin B1 {thiamine}, 15 milligrams of vitamin B2 {riboflavin}, 0 to 15 milligrams of vitamin B2 {pyridoxine}, 15 milligrams of vitamin B6 {pyridoxine}, 25 milligrams of vitamin B9 {folic acid}, 40 micrograms of vitamin B9 {folic acid}, and 0 to 75 milligrams of vitamin B12 {cobalamin}. After being taken by various people for a period of time, the health-care food is smooth and delicious in taste and free of adverse reaction through evaluation in multiple aspects, and the health-care effect and feeling state of the health-care food are better than those of the prior art. And the health-care tea is suitable for a wide range of people, is beneficial to market promotion, and enables more people to achieve the health-care effect of preventing diseases before diseases.

The present invention aims to provide a cosmetic containing a pyridoxine and having excellent stability and usability. The cosmetic of the present invention is characterized by comprising: (A) pyridoxine, a salt or a derivative thereof; (B) ethyl ascorbic acid; and (C) a higher fatty acid or a higher alcohol which is liquid at 25°C.

The present disclosure relates to a non-therapeutic use of a human milk oligosaccharide (HMO) selected from 3'-sialyllacto-N-tetraose (LSTa), 6'-sialyllacto-N-neotetraose (LSTc) and 3'-sialyl- 3-fucosyllactose (FSL), or a combination thereof, in supporting or improving one or more of brain health, immune system health, gut health, and metabolic health, in a subject, optionally by increasing the production of one or more metabolites selected from the group consisting of of pyridoxine, pyridoxamine, nicotinic acid, N-acetyl-L-glycine, sarcosine, N-acetyl-L-glutamine, N- acetyl-L-aspartic acid, trigonelline, trans-4-hydroxyproline, 3-hydroxybutyric acid (BHB), 4- hydroxybenzoic acid, and N-acetyl-L-tryptophan, in the gastrointestinal tract of the subject.

The present invention aims to provide an oral composition in which discoloration over time caused by pyridoxine or its salts is suppressed, and bitterness is reduced. [Solution] The present invention provides an oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: a fluorine-containing compound, wherein the content of component (A) is 0.11 to 0.95% by mass, and the content of component (B) is such that when converted to a fluoride ion concentration, it is 1000 to 20000 ppm, and preferably further comprising (C) component: at least one sweetener selected from the group consisting of saccharin sodium, sucralose, xylitol, erythritol, maltitol, acesulfame potassium, trehalose, and mannitol.

The invention relates to a washing and caring composition with dandruff removing, itching relieving and repairing effects and a preparation method of the washing and caring composition, and belongs to the technical field of daily chemicals. Aiming at dandruff formation and itching factors of scalp, the piroctone olamine salt, palmitoyl tetrapeptide-10, tetrapeptide-1 and speranskia herb extract are correspondingly compounded to play a role in removing dandruff and relieving itching, and the limitation of a single component is made up by compounding chemical components and plant extracts, so that more efficient and milder scalp care is realized. In addition, the dihydrooat acyl o-aminobenzoic acid, pyridoxine tripalmitate and quaternary ammonium salt-73 are combined for use, so that the shampoo also has an excellent synergistic repairing capability on scalp with symptoms such as acne, red and swollen, slight folliculitis and the like.

The invention provides a pyridoxal kinase mutant and application thereof in synthesis of pyridoxine phosphate, and belongs to the field of enzyme engineering. The mutant disclosed by the invention is obtained by mutating an amino acid sequence of wild type pyridoxal kinase, and mutation sites comprise at least one of the 23rd amino acid, the 25th amino acid, the 30th amino acid, the 31st amino acid, the 52nd amino acid, the 54th amino acid, the 57th amino acid, the 57th amino acid, the 96th amino acid, the 125th amino acid, the 127th amino acid, the 130th amino acid, the 136th amino acid, the 157th amino acid, the 158th amino acid, the 159th amino acid, the 230th amino acid, the 233th amino acid, the 235th amino acid, the 236th amino acid, the 257th amino acid, the 260th amino acid and the 264th amino acid; wherein the amino acid sequence of the wild type pyridoxal kinase is shown as SEQ: ID: NO: 1. Compared with wild type pyridoxal kinase and other mutants, the pyridoxal kinase mutant provided by the invention has higher catalytic efficiency, has the advantages of simple process, high conversion rate and low production cost when being applied to a pyridoxine phosphate synthesis process, and has a good industrial application prospect.

The present invention discloses a hydrophobically modified vitamin B6, a preparation method thereof, and an application thereof, belonging to the field of cosmetic technology. Nervonic acid is selected as a hydrophobic modifier for water-soluble vitamin B6, and pyridoxine neuramide is synthesized. This allows the water-soluble vitamin B6 to carry natural nervonic acid through the stratum corneum of the skin, thereby increasing the transdermal absorption of vitamin B6. The present invention selects nervonic acid as a hydrophobic modifier for water-soluble vitamin B6, and synthesizes pyridoxine neuramide. This allows the water-soluble vitamin B6 to carry natural nervonic acid through the stratum corneum of the skin, thereby increasing the transdermal absorption of vitamin B6. The pyridoxine neuramide prepared by the present invention simultaneously exerts the physiological activities of vitamin B6 and nervonic acid on the skin, has a good skin barrier repair effect, reduces transepidermal water loss of the skin, improves moisturizing efficiency, and also has certain anti-inflammatory and antioxidant effects. It is a skin conditioning agent that is easy to use and has excellent effects.

The present invention relates to over the counter (OTC) film coated tablet compositions comprising one or more types of vitamins. Specifically, the invention focuses on formulations that include B vitamins, such as thiamine (B1), riboflavin (B2), nicotinamide (B3), pantothenic 5 acid (B5), pyridoxine (B6), biotin (B7), folic acid (B9), and cobalamin (B12). These vitamin- enriched tablets are intended for dietary supplementation to support various bodily functions, including energy metabolism, nervous system health, and the maintenance of healthy skin, hair, and eyes.

The present invention provides an oral composition that can effectively suppress the bitter taste after use, even when pyridoxine or a salt thereof is used. [Solution] An oral composition comprising (A) component: pyridoxine or a salt thereof, and (B) component: inorganic powder, wherein the content of component (A) is 0.01% to 3% by mass, and the content of component (B) is 0.01% or more and less than 15% by mass.

A composition for supporting nicotinamide adenine dinucleotide (NAD+) concentrations in humans is provided. The composition includes a synergistically effective amount of: nicotinamide riboside, nicotinamide and nicotinic acid; at least one of thiamin (vitamin B1), riboflavin (vitamin B2), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9) and cobalamin (vitamin B12); and at least one of magnesium, trans-resveratrol and caffeine. Related methods are also provided.

A composition contains Nicotinamide and Vitamin B6, for example pyridoxine. The composition may be an oral nutritional composition, for example an infant formula, a follow up formula, a nutritional supplement, an oral nutritional supplement, a food product. The composition can be administered to an individual in need thereof for promoting muscle growth and / or for maintaining and / or increasing muscle function and / or muscle mass in infants and children. For example, the composition can be useful for increasing muscle function and / or muscle mass by modulating muscle stem cells.

To provide a minoxidil-containing composition for external use, blended with pyridoxine, which suppresses the precipitation caused by minoxidil which may occur after application, and also suppresses deterioration of stability of the pyridoxine.SOLUTION: There is provided a composition for external use which comprises minoxidil, pyridoxine and / or a salt thereof, propylene glycol and at least one acid selected from the group consisting of phosphoric acid, citric acid, lactic acid, hydrochloric acid, acetic acid, sulfuric acid, nitric acid, tartaric acid and maleic acid and / or a salt thereof. It can be used as a composition for external use such as a lotion, an aerosol, a tonic agent, a cream agent, an ointment and a gelling agent and the most preferable formulation of it is a lotion.SELECTED DRAWING: None

The invention discloses compound B vitamin and inositol nutrition fortified flour and a preparation method of fine dried noodles, and relates to the field of food processing, nutrition fortifying and functional staple food. Every 100 g of the flour contains 50 to 100 mg of nicotinic acid (vitamin B3), 5 to 10 mg of pantothenic acid (vitamin B5), 5 to 10 mg of pyridoxine (vitamin B6), 250 to 500 [mu] g of cobalamin (vitamin B12), 100 to 200 [mu] g of biotin (vitamin B7), 500 to 1000 [mu] g of folic acid (vitamin B9), 5 to 10 mg of choline and 5 to 10 mg of inositol. The mass ratio of the riboflavin (vitamin B2) to the pyridoxine (vitamin B6) to the folic acid (vitamin B9) is 1: (0.1-0.2): (0.01-0.02). A sodium alginate-hydroxypropyl methylcellulose double-embedding microcapsule technology and a segmented adding technology are adopted for preparation, and the gastric juice passing rate of the microcapsule is larger than 95%. According to the invention, the vitamin B lost in traditional flour processing is supplemented, a synergistic nutrition system is formed, the bioavailability is improved, the nutrition supplement compliance is improved through the staple food carrier, and the food can be used for preparing food for preventing metabolic syndrome, anemia or neural tube defects.

The invention relates to the field of medicines, in particular to a construction method of an Alzheimer's disease non-human primate model. A small dose of thiamine antagonist pyrithiamine is given to the chronic abdominal cavity to induce chronic thiamine metabolic disorder, so that the non-human primate marmoset Alzheimer disease model capable of reflecting the Alzheimer disease course is established, and the method has the advantages of simplicity in operation, small animal injury and the like; therefore, the method is beneficial to further basic clinical transformation research and the like, and has more important scientific significance and economic value.

This invention belongs to the field of enzyme engineering technology, specifically relating to an EcCAT mutant of catalase and its applications. The mutant is obtained by mutating at least one amino acid from the following positions in SEQ ID NO:1: Ile (126th position), Ser (167th position), Val (199th position), Gly (200th position), Asn (201st position), Phe (206th position), Ala (211th position), Phe (214th position), Gly (273rd position), Ala (389th position), Phe (391st position), Leu (407th position), and Gly (410th position). Compared to wild-type catalase, the EcCAT mutant of this invention exhibits higher catalytic efficiency. When used in combination with pyridoxine 5'-phosphate oxidase, the whole-cell catalytic synthesis of pyridoxal 5'-phosphate can be completed in just 5 hours, with a conversion rate exceeding 99%.

The purpose of the present invention is to provide a cosmetic that has exceptional stability and usability while containing pyridoxine.　A cosmetic according to the present invention is characterized by containing: (A) pyridoxine, or a salt or a derivative thereof; (B) ethyl ascorbic acid; and (C) a higher fatty acid or a higher alcohol that is liquid at 25°C.