45 results about "Methylmalonic acid" patented technology

The invention relates to the technical field of agricultural microbiology, and specifically relates to an application of methylmalonic acid in preparation of a nematode pesticide. Through determination of the fatality rate of meloidogyne incognita and caenorhabditis elegans, it finds that the methylmalonic acid has a good insecticidal effect on nematodes; LC50 of the methylmalonic acid to the meloidogyne incognita and the caenorhabditis elegans is separately 13.11 and 1.20; and after the methylmalonic acid and betaine are compounded, the LC50 of the methylmalonic acid to the meloidogyne incognita and the caenorhabditis elegans is separately 2.85 and 0.27; and at the same time, the methylmalonic acid has an inhibition effect on ralstonia solanacearum and erwinia carotovora. The preparationprovides new selectivity for the preparation of biocontrol preparations of meloidogyne.

The present invention relates to the determination of the presence of methylmalonic acid in biologic samples including the steps of methylmalonic extraction from the sample; derivatization of methylmalonic acid and use of mass spectrometry with negative mode atmospheric pressure chemical ionization to determine the presence of methymalonic acid through the formation of an ion of mass to charge ratio (m / z) 477. An additional objective of the present invention concerns diagnosis kits for determination of presence and quantification of methylmalonic acid based on the method mentioned before.

The invention discloses a bisabolane sesquiterpene analogue, and a preparation method and application thereof. The bisabolane sesquiterpene analogue provided by the invention has a structural formula as shown in a formula I. The preparation method for the bisabolane sesquiterpene analogue as shown in the formula I comprises the following steps: 1) subjecting 4-bromo-2-thiophenecarboxaldehyde and p-cyanophenylboric acid to the Suzuki coupling reaction so as to obtain a compound as shown in a formula II; (2) subjecting the compound as shown in the formula II and methylmalonic acid to the Knoevenagel condensation reaction so as to obtain a compound as shown in a formula III; and (3) subjecting ammonia water and a reaction product of the compound as shown in the formula III with thionyl chloride to a reaction an ice bath so as to obtain the compound as shown in the formula I. The compound as shown in the formula I or a pharmaceutically acceptable salt thereof provided by the invention is applicable to preparation of anti-tumor drugs. The anti-tumor drugs can inhibit propagation of tumor cells like breast cancer cells, cervical cancer cells and / or ovarian carcinoma cells; and specifically, the breast cancer cells may be MCF-7 cells, the cervical cancer cells may be HeLa cells, and the ovarian carcinoma cells may be HO8910 cells.

The invention relates to the detection of methylmalonic acid (MMA). In a particular aspect, the invention relates to methods for detecting derivatized methylmalonic acid (MMA) by mass spectrometry.

The invention discloses high-strength impact-resistant melamine resin tableware and a preparation method thereof. The high-strength impact-resistant melamine resin tableware is prepared from the following raw materials in parts by weight: 60 to 75 parts of melamine-formaldehyde resin, 16 to 22 parts of ethylene-methyl methacrylate copolymer powder, 25 to 33 parts of an elastomer, 5 to 8 parts of cellulose, 1.5 to 2.5 parts of zinc peroxide, 3 to 5 parts of aluminum borate whiskers, 3 to 5 parts of nano silicon dioxide, 2.5 to 3.5 parts of zinc stearate, 1 to 2 parts of triethanolamine and 1.5 to 2 parts of methylmalonic acid. The high-strength impact-resistant melamine resin tableware is high in impact strength, high in tensile strength, excellent in mechanical property, resistant to impact (impact), not prone to damage and cracking and the like; the migration volume of free formaldehyde is low, and the maximum migration volume of lead and cadmium is also low and is lower than the migration volume of free formaldehyde and the maximum migration volume of lead and cadmium in a comparison file 1, so that the tableware is healthy, environment-friendly and non-toxic; and in addition, the thermal decomposition initial temperature reaches 145 DEG C or above, the thermal decomposition initial temperature is high, and the heat resistance is good.

The invention discloses an improved synthesis process of fluopyram, which belongs to the technical field of fine chemicals. The process is based on 2-(3-chloro-5-trifluoromethyl-2-pyridyl)-2-[(2-trifluoromethylbenzoyl)aminomethyl]-1,3-malonic acid The diester is used as a raw material, and in the same solvent, undergoes two steps of hydrolysis and decarboxylation in alkaline and acidic steps respectively, and undergoes conventional post-treatment methods to obtain the target product. The technical route selection of the present invention is reasonable and convenient, realizes the process connection of two-step decarboxylation, has mild reaction conditions, simplifies post-treatment, is easy for industrialized production, and has a total separation yield of over 96%.

By determining the lethality rate to Meloidogyne incognita and Caenorhabditis elegans, it was found that the methylmalonic acid has a better nematicidal effect on the Caenorhabditis elegans, with the LC50 being 13.11 and 1.20 for the Meloidogyne incognita and the Caenorhabditis elegans, respectively. After compounding the methylmalonic acid with betaine, the LC50 was 2.85 and 0.27 for the Meloidogyne incognita and the Caenorhabditis elegans, respectively. Meanwhile, the methylmalonic acid also has an inhibiting effect on Pseudomonas solanacearum and Erwinia carotovora. The preparation of the methylmalonic acid provides a new choice for preparing novel biocontrol agents against the root-knot nematodes.

The invention relates to a preparation method of 4,7-dichloroquinoline in the technical field of medicine, which uses 2-amino-6-chlorobenzoic acid (I) as a starting material, and ethoxymethine in an organic solvent Diethyl malonate (II) undergoes condensation reaction to obtain (Ⅲ), III undergoes cyclization, hydrolysis, and acidification to obtain hydroxyquinoline dicarboxylic acid (V), V undergoes high-temperature decarboxylation to obtain hydroxyquinoline (VI), and VI undergoes Chlorination of phosphorus oxychloride gives 4,7-dichloroquinoline. The 4,7-dichloroquinoline prepared by the method of the present invention does not have the isomer 4,5-dichloroquinoline, and the temperature of the condensation reaction under the catalysis of the catalyst is low, which improves the yield of the reaction and avoids the generation of impurities , and reduce energy consumption, improve the economic benefits of the product.

The invention discloses a preparation method of an alminoprofen intermediate, belongs to the field of organic chemical synthesis, and provides a new technical route for improving the defects of synthetic reaction of ethyl 2-(4-amino-phenyl)propionate: 1) taking p-fluoronitrobenzene and diethyl methylmalonate as raw materials, adding alkali, conducting heating, finishing the reaction, conducting cooling, conducting hydrolyzing with alkali, after the reaction is finished, conducting layering, conducting washing with water, extracting impurities, adjusting the pH value, extracting a product, and conducting concentrating to obtain AMLF02; 2) heating AMLF02 in a solvent to 55-75 DEG C, and dropwise adding thionyl chloride for esterification reaction, conducting cooling, adjusting the pH, directly adding a catalyst for reduction at the temperature of 70-80 DEG C, after the reaction is finished, conducting filtering with the aid of diatomite, neutralizing the filtrate to 7-8, conducting concentrating to remove ethanol, extracting a water phase with methylbenzene, and conducting concentrating to obtain AMLF04. The method has the beneficial effects that the problem of slow filtration is solved, extraction is omitted, time is saved, and cost is saved; direct layering is performed after reaction, the amount of hydrochloric acid is reduced, and the treatment difficulty of three wastes is reduced; and safe hydrazine hydrate replaces active nickel.

The invention relates to a flame retardant for computer display, and belongs to the technical field of flame retardant articles. The flame retardant is prepared the following raw materials: water, N,N-dimethylaminoethyl acrylate, dimethyl methylmalonate, 2,3-dimethyl-2,3-butanediol, 2,2-dimethyl-1,3-propilidene dimethacrylate, phenylacrylic acid, and 1-(5-bicyclo [2.2.1] heptyl-2-vinyl)-1-phenyl-3-(1-piperidyl) propyl-1-alcohol hydrochloride. The flame retardant for computer display uses the interaction and mutual influence of correlative chemical components to effectively realize flame retardant effect. The flame retardant has stable chemical properties, does not decompose under high temperature, is attached to the surface of the plastic display, has no effect on the computer display, and can effectively prevent the spreading of flame, prevent the formation of computer fire, thus the flame retardant has excellent flame retardant effect.

The invention discloses a preparation method of topramezone. The particularly comprises the steps of carrying out cyclization, methylation, hydrolysis, amidation, Grignard reaction, oxidation and demethylation on 2-(alkoxymethylene)malonate as a raw material, so as to obtain a target product, wherein the yield of the target product reaches 61.8%-63.2%. According to the preparation method, the raw materials such as a palladium / platinum catalyst which is high in cost and difficult to recycle, a virulent rearrangement catalyst and high-cost methylhydrazine are not adopted, and the preparation method which is low in cost, easy in operation, low in pollution and accordant with large-scale industrial production requirements is provided.