67 results about "Diethyl malonate" patented technology

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a control method for a process impurity 2-ethyl valeric acid (EP-B) in preparation of valproic acid or sodium valproate by a diethyl malonate method. According to the method disclosed by the invention, the content of 2-ethyl-2-propylmalonic acid process impurities in dipropylmalonic acid is controlled, so that the content of 2-ethylvaleric acid (EP-B) which is a process impurity in valproic acid or sodium valproate is accurately controlled; adding a polar solvent into the dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying to obtain a high-purity dipropylmalonic acid refined product; high-purity valproic acid (RRT is equal to 1.00) is prepared through decarboxylation of the dipropyl malonic acid fine product, and the purity is 99.779%; 0.020% of 2-ethyl valeric acid (RRT is equal to 0.90); and valeric acid (RRT = 0.77), 0.039%. The valproic acid product quality meets the requirements of European Pharmacopoeia. According to the method, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a diethyl malonate method are solved.

The invention discloses a low-temperature cured polyurethane varnish resin for automobiles and a preparation method thereof, and belongs to the technical field of chemical product processing, the low-temperature cured polyurethane varnish resin comprises a resin matrix and a curing agent, the resin matrix comprises a component A and a component B. The component A comprises a crosslinking system A1, a crosslinking system A2 and an auxiliary agent, the component B is a curing activity regulator of a double-crosslinking system of the crosslinking system A1 and the crosslinking system A2; the curing agent is diethyl malonate blocked isocyanate; the cross-linking system A1 is mainly composed of hydroxy acrylic resin containing beta-diketone metal ligand and a bismuth neodecanoate catalyst; the bismuth neodecanoate catalyst and a beta-diketone metal ligand form a bismuth complex; the cross-linking system A2 is mainly composed of hydroxyl acrylic resin containing alkoxy silane groups; the component B is prepared from poly (decane-4, 6-diyne diacid) modified nano porous fibers and a silane coupling agent. The service life of the varnish is prolonged on the basis of ensuring low-temperature rapid curing.

The present invention relates to a method of adding an isocitrate lyase specific inhibitor to a lactic acid fermentation process to block the production of succinic acid as a byproduct of fermentation. The specific inhibitor includes a combination of one or more of glycolic acid methyl ester, malonic acid dimethyl ester, hydroxymalonic acid diethyl ester, 3-nitropropionic acid ethyl ester, mercuric chloride, or 5,5'-dithiobis(2-nitrobenzoic acid) to effectively reduce the amount of succinic acid in the lactic acid.

The invention discloses a positive pole piece and a preparation method thereof, a diaphragm-free battery and a battery. The positive pole piece comprises a positive pole current collector and a positive pole active material layer arranged on at least one side of the positive pole current collector, the positive pole active material layer comprises a polymer, and the polymer is formed by polymerizing at least one of small molecules of the following raw material components: vinylethylene carbonate, vinylene carbonate, 2, 3, 4-trimethyl-1, 3-pentanedione, 2, 3, 4-trimethyl-1, 3-pentanedione and 2, 3, 4-trimethyl-1, 3-pentanedione. The adhesive is prepared from 2, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The adhesive is prepared from the following raw materials: 1, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The positive pole piece provided by the invention comprises the polymer, so that the interface impedance can be reduced, and the rate capability of the battery can be improved.

The invention discloses a method for preparing a fluorinated ethylene-propylene emulsion, and relates to a polymer emulsion polymerization technology. Comprising the following steps: adding water into a reaction kettle, heating, and replacing with nitrogen to control oxygen; adding perfluoropolyether ammonium carboxylate, heating, adding an initial TFE / HFP mixed monomer, stirring, and adding a potassium persulfate solution to initiate polymerization; supplementing the mixed monomer in the reaction to maintain the pressure, and adding diethyl malonate and a copolymerization composition regulator at the same time; and stopping the reaction after the designed feeding amount is reached. According to the invention, the proportion of copolymerization units can be optimized, high monomer conversion is realized, and the emulsion with high solid content and uniform particle size is obtained.

The application discloses a preparation method of ammonium glufosinate, which comprises the following steps: adding diethyl malonate and liquid bromine into a first solvent to react to obtain intermediate I; adding the intermediate I, potassium phthalimide and a quaternary ammonium salt catalyst into toluene to react to obtain intermediate II; adding the intermediate II, potassium carbonate, 1,2-dibromoethane and a phase transfer catalyst into a second solvent to react to obtain intermediate III; adding the intermediate III and diethyl methyl phosphonite into toluene to react under argon to obtain intermediate IV; adding the intermediate IV into hydrochloric acid to react under reflux; cooling, precipitation, drying to obtain intermediate V; mixing the intermediate V with water, passing in ammonia and adjusting pH value; adding methanol and stirring to react; cooling, filtering and drying to obtain ammonium glufosinate. The method can avoid using sodium cyanide or hydrocyanic acid, and no large amount of difficult-to-separate ammonium chloride is generated, the content of the obtained ammonium glufosinate is 90% to 98%, and the total yield is greater than 68%.

The application relates to a preparation method of 4-chloropyrrolopyrimidine, in particular to a four-step high-yield synthesis of 4-chloropyrrolopyrimidine by taking diethyl malonate and bromoacetaldehyde diethyl acetal as raw materials, through substitution reaction, then ring closure reaction with formamidine acetate, ring closure reaction under acidic conditions, and then chlorination reaction with phosphorus oxychloride; the preparation method of 4-chloropyrrolopyrimidine provided by the synthesis route is a preparation method with high yield, low cost, easy operation and suitability for industrialization.

To provide a collagen-containing composition and a method for producing the same, a collagen-containing composition for addition to foods and drinks, and a collagen odor masking agent and a masking method that enable effective masking of collagen odor.SOLUTION: A collagen-containing composition contains collagen, a steviol glycoside, α-glucosyl rutin, and diethyl succinate and / or diethyl malonate.SELECTED DRAWING: None

The invention relates to the technical field of cables, and provides an extruded insulation low-voltage power cable which sequentially comprises a conductor, an insulation layer, an armor layer and a sheath layer from inside to outside. The sheath layer is prepared from the following raw material components in parts by weight: 80 to 100 parts of polyvinyl chloride, 10 to 20 parts of ethylene propylene diene monomer, 15 to 25 parts of ethylene vinyl acetate copolymer, 20 to 30 parts of filler, 25 to 35 parts of flame retardant, 3 to 5 parts of plasticizer, 1 to 3 parts of antioxidant and 3 to 5 parts of compatilizer; the filler is obtained by modifying potassium titanate whiskers with a titanate coupling agent and diethyl aminovinylmalonate, and the insulating layer is obtained by extruding an insulating layer material on the outer side of the conductor. According to the technical scheme, the problem of insufficient tensile strength of the sheath layer in the prior art is solved.

A biphenylthiourea carboxylic acid metal organic framework crystal material and a preparation method and application thereof.The material has the following chemical formula: {[Zn4O(L)3]·DMF·H2O} n , wherein L is a 6-thio-6,7-dihydro-5H-dibenzo[d,f][1,3]diazepine-3,9-dicarboxylate divalent anion, and n is a degree of polymerization.The metal organic framework crystal material of the present application is synthesized by a solvothermal method, is simple to operate, has low cost, high yield, and is easy to mass industrial production.The prepared metal organic framework crystal material has a high specific surface area (a BET specific surface area of 594 m 2 / g), and an adsorption amount of CO2 of 46.0 cm 3 / g at 1 atm and 273 K.The biphenylthiourea carboxylic acid metal organic framework crystal material of the present application can efficiently catalyze a Friedel-Crafts alkylation reaction of substituted indole and substituted trans-nitrostyrene to generate an indole 3-substituted derivative, and can also efficiently catalyze a Michael addition reaction of diethyl malonate and substituted trans-nitrostyrene, both of which have mild conditions, and the catalyst can be recycled with almost no activity loss, and are good heterogeneous catalysts.

The application discloses a synthesis method of pimobendan, which comprises the following steps: a Friedel-Crafts acylation reaction: compound I and compound A are subjected to a Friedel-Crafts acylation reaction in aprotic solvent under the action of a Lewis acid to generate compound II; a substitution and hydrolysis reaction: under alkaline conditions, compound II and dimethyl malonate or diethyl malonate are subjected to a substitution reaction in an ether solvent, and the generated compound is subjected to a hydrolysis reaction in an alkaline aqueous solution to generate compound III; a decarboxylation and ring-closing reaction: compound III is heated under the condition of hydrazine hydrate and acid to generate compound IV; a substitution reaction: compound IV and an amine are subjected to a substitution reaction in a polar solvent to generate compound V; a reduction reaction: compound V is subjected to a reaction in an acidic aqueous solution of a protic solvent under the condition of palladium-carbon and hydrogen to generate compound VI; and a ring-closing reaction, so that the pimobendan is obtained. The method has high safety, short line steps and simple operation.

The invention belongs to the technical field of medicine detection, and particularly relates to a high performance liquid chromatography detection method for dipropylmalonic acid and impurities thereof. The method comprises the following steps: preparing a to-be-detected sample into a test solution; the to-be-detected sample is dipropyl malonic acid prepared by adopting a diethyl malonate method and impurities of the dipropyl malonic acid; and detecting the test solution by adopting a high performance liquid chromatography method to obtain a detection result of dipropylmalonic acid and impurities thereof in the sample to be detected. According to the detection method provided by the invention, the detection of dipropylmalonic acid prepared by adopting a diethyl malonate method and impurities thereof is realized through high performance liquid chromatography (HPLC) for the first time, and the problems of quality control and process evaluation of the dipropylmalonic acid prepared by adopting the diethyl malonate method, which is an intermediate of a sodium valproate raw material medicine, are solved; therefore, detection and control of impurities (including 2-ethyl valeric acid) in the sodium valproate raw material medicine are realized.

The present application relates to phenylethyl malonic acid diethyl ester heating technical field, specifically, it is a kind of phenylethyl malonic acid diethyl ester reaction heating device capable of uniform heating.It includes heating tank, feeding opening, discharge port and heater, heating tank is fixedly provided with sleeve inside, the sleeve is used to separate the inner wall of heating tank and sleeve into liquid storage cavity and shunt cavity, liquid storage cavity is located above shunt cavity, auxiliary liquid mixing stirring mechanism is arranged in the inner ring of sleeve, reciprocating mechanism is arranged at the top end of sleeve inside and the end of stirring mechanism.Liquid inside the sleeve is guided into the liquid storage cavity, then steam in the heater flows outward through shunt ring and steam pipe, the flowing steam can continuously conduct heat to the shunt ring, the shunt ring conducts heat to the sprayed liquid, and the sprayed liquid is divided into two streams under the action of shunt ring, so that the contact area of liquid and shunt ring is increased, thereby improving the efficiency of heat transfer and enhancing the uniformity of heat conduction.

The invention discloses a closed type polyisocyanate composition with stable storage and a preparation method and application thereof, the closed type polyisocyanate composition comprises a structure I, a structure II, a structure III and a structure IV, A represents a gel chromatography (GPC) integral area percentage of the structure I; b represents the gel chromatography test GPC integral area percentage of the structure II, C represents the gel chromatography test GPC integral area percentage of the structure III, and D represents the gel chromatography test GPC integral area percentage of the structure IV; wherein A / (A + B + C + D) = 0.15-0.25, and B / (A + B + C + D) = 0.30-0.45. The water-based polyurethane adhesive contains terminated polyisocyanate which is obtained by carrying out a reaction on a hexamethylene diisocyanate polymer, diethyl malonate and diisopropylamine. The composition is clear and transparent after being stored for 12 months at normal temperature.

A preparation process of 2-[2-(2, 4-difluorophenyl)-2-propylene-1-yl]-1, 3-propylene glycol belongs to the field of medical intermediates, and comprises the following steps: step 1, adding 1-[1-(bromomethyl) vinyl]-2, 4-difluoro-benzene and diethyl malonate into N, N-dimethylformamide, and then adding potassium carbonate for reaction; 2, after the reaction in the step 1 is completed, filtering to remove potassium carbonate, and then carrying out acid pickling, toluene extraction, saturated saline solution washing, concentration and rectification to obtain an oily substance; and step 3, adding the oily substance obtained in the step 2 into methanol, mixing, then adding sodium borohydride for reaction, and after the reaction is completed, concentrating, crystallizing and filtering to obtain the 2-[2-(2, 4-difluorophenyl)-2-propylene-1-yl]-1, 3-propylene glycol. According to the method, the cost is effectively reduced, so that the reaction period can be shortened, meanwhile, the reaction yield can be increased, and industrial production is facilitated.

The invention provides a preparation method of diethyl malonate and a preparation method of valproic acid, and belongs to the technical field of organic synthesis. According to the method, diethyl carbonate and ethyl acetate are taken as initial raw materials, the ethyl acetate has three alpha-H and loses one alpha-H under the attack of strong base, so that ethyl acetate enol negative ions are formed, and ethyl acetate carbon negative ions are obtained through rearrangement; carrying out nucleophilic addition on carbonyl of diethyl carbonate by using the ethyl acetate carbon negative ions to obtain an addition intermediate, and then removing ethanol negative ions from the addition intermediate to obtain diethyl malonate; by controlling the reaction temperature, ethanol generated in the reaction process is continuously distilled out, so that the reaction is carried out in the forward direction, and side reactions are reduced to the greatest extent; as the condensation catalyst used in the invention has strong nucleophilicity and alkalinity, the use of the aprotic solvent can avoid the consumption of the condensation catalyst by the solvent.

To provide an oral composition that contains an azulene compound while effectively inhibiting color change of the composition itself.SOLUTION: An oral composition comprising the following components (A) and (B): (A) one or two or more azulene compounds selected from azulene, azulene sulfonic acid and a salt thereof, and guaiazulene; and (B) one or two or more fragrance components selected from thymol, terpinolene, β-ionone, nerol, carvone, anisaldehyde, vanillin, cis-3-hexenone, menthyl lactate, benzyl alcohol, diethyl malonate, isopulegol, triethyl citrate, and citronellol.SELECTED DRAWING: None

This invention discloses a method for synthesizing 3-oxa[3.1.1]spiropropane, belonging to the fields of organic synthetic chemistry and medicinal chemistry. This method is the first to introduce oxygen atoms into the high-strength skeleton of [3.1.1]spiropropane, successfully synthesizing the 3-oxa[3.1.1]spiropropane molecule. The specific synthetic route is as follows: starting with 3,3-bis(bromomethyl)oxacyclobutane, the 3-oxabicyclo[3.1.1]heptane diol skeleton is constructed sequentially via nucleophilic substitution with diethyl malonate, reduction, and intramolecular cyclization. Then, oxidation and Barton decarboxylation iodination are performed to obtain the key intermediate 1,3-diiodo-3-oxabicyclo[3.1.1]heptane, which is finally reacted with an organolithium reagent to obtain the target product. This invention fills a technological gap in the synthesis of heteroatom-substituted spiroalkyl, providing a key precursor for the subsequent development of its free radical bifunctionalization reaction and the construction of structurally diverse 3-oxabicyclic [3.1.1]heptane dominant skeletons. It has important application prospects in drug design, especially as a bio-electroisoster of meta-substituted aromatics.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a milobalin intermediate. The preparation method comprises the following steps: carrying out hydrogenation reaction on [(1RS, 5SR, 6RS)-6-cyano-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-yl] diethyl malonate serving as a raw material under the action of palladium on carbon or raney nickel to obtain a compound III, and carrying out acid hydrolysis on the compound III to obtain [6-aminomethyl-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-yl] acetic acid (racemization), namely a compound I. The preparation method comprises the following steps: carrying out a reaction on the raw material and the compound I, the method is novel in route, raw materials are easy to obtain, and compared with the prior art, the method has higher yield and is suitable for industrial production.

The invention discloses a triazine desulfurizer as well as a preparation method and application thereof, and relates to the technical field of petrochemical engineering. The triazine desulfurizing agent prepared by the invention comprises the composite triazine methoxazole, the oxazolidine tetraformate and the additive, the composite triazine methoxazole is prepared by reacting sulfamethoxazole with paraformaldehyde and then mixing with fatty alcohol-polyoxyethylene ether, the desulfurization rate is improved, the reaction temperature of the triazine desulfurizing agent can also be improved, and the desulfurization efficiency is improved. The oxazolidine tetraformate is prepared by reacting diethyl malonate with 1, 3-bromopropane and then reacting with hydroxyethyl oxazolidine, and the hydroxyethyl oxazolidine is prepared by reacting diethanol amine with acetone, so that the compatibility with crude oil is further enhanced, and the desulfurization rate is increased.

The invention relates to a cuprous salt antioxidant containing a phosphite structure and a preparation method and application thereof.The preparation method comprises the steps that firstly, diethyl malonate reacts in the presence of ammonia gas to obtain an intermediate A, then the intermediate A and 3-amino-2, 5-di-tert-butylphenol are subjected to condensation cyclization to obtain an intermediate B, finally, after the intermediate B and a phosphite derivative react, the cuprous salt antioxidant containing the phosphite structure is obtained, and the cuprous salt antioxidant containing the phosphite structure is obtained. And coordinating with cuprous salt to obtain a final product. The invention also provides a nylon composition containing the antioxidant. The antioxidant disclosed by the invention has the characteristics of high-efficiency oxidation resistance, hydrolysis resistance and good compatibility with nylon through the synergistic effect of a plurality of intramolecular stable mechanisms, and can be used for remarkably improving the thermal oxidation stability of a nylon material, inhibiting degradation in the processing and using processes and effectively keeping the mechanical properties, appearance and color of the material.

The application discloses a cis-trans cyclopropane diacid diethyl ester nondestructive detection method based on feature screening, relates to the technical field of testing or analyzing materials by means of determining the chemical or physical properties of the materials, and comprises the following steps: taking a plurality of mixtures formed by cis isomers and trans isomers of cyclopropane diacid diethyl ester respectively at a plurality of mass ratios, and taking Raman characteristic peak parameters of the plurality of mixtures; based on the Raman characteristic peak parameters of the plurality of mixtures, a plurality of Raman characteristic peak proportional type variables between cis-trans isomers are constructed; a prediction model is constructed; and based on the prediction model, the mass ratio of the cis-trans isomers of cyclopropane diacid diethyl ester is predicted; the method has the advantages of rapidness, nondestructiveness, non-separation, high recognition precision and the like, and is suitable for the fields of isomer component analysis, structure identification and precise quantitative detection.

The invention discloses a preparation method of ketoprofen d3, which comprises the following steps: S1, adding 3-bromobenzophenone, diethyl malonate, a palladium catalyst, a phosphine ligand and a weakly alkaline compound into an organic solvent, and heating and refluxing under the protection of nitrogen until the 3-bromobenzophenone is completely reacted; s2, after the arylation reaction is completed, adding CD3I, and directly carrying out deuterium methylation reaction; s3, after the deuterium methylation reaction is completed, potassium hydroxide is added for a hydrolysis decarboxylation reaction, after the reaction is completed, purification is conducted, and ketoprofen d3 is obtained. The method is simple to operate, low in cost, high in yield and less in pollution.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of 2-oxoglutaric acid, which comprises the following steps: by taking diethyl 2-oxosuccinate and diethyl 2-bromomalonate as raw materials, carrying out condensation reaction in an absolute ethyl alcohol solvent under the catalytic action of sodium ethoxide; adjusting the pH value of the obtained condensation product, performing intermediate purification, transferring into a mixed system of sulfuric acid and ethanol, performing hydrolysis and decarboxylation reaction, and finally crystallizing and refining to obtain a target product. The invention provides a brand new synthesis route, the reaction conditions are mild, the use of raw materials with higher toxicity and the reaction conditions with great danger are avoided, and the safety of the production process is high. And by setting a key intermediate product purification step, the purity of the final product is effectively ensured, and the product quality is high. Meanwhile, raw materials used in the method are commercially available conventional chemicals, operation is easy and convenient, cost is controllable, and the method is suitable for industrial production.

The invention discloses a preparation method of 2-ethyl butyric acid. The preparation method comprises the following steps: S1, preparing diethyl diethyl malonate; s2, preparing preparation materials which comprise 32% sodium hydroxide solution, 95% ethanol and 31% hydrochloric acid, and S3, putting the diethyl diethyl malonate prepared in the S1 and the 32% sodium hydroxide solution and the 95% ethanol in the S2 into a reaction kettle; s4, dropwise adding the 31% hydrochloric acid in the S2 into the reaction kettle in the S3, adjusting to be strongly acidic, discharging the reaction kettle after a first index is reached, and performing centrifugal operation to obtain a diethyl malonic acid crude product. According to the preparation method, diethyl diethyl malonate is used as a main preparation material, is obtained by adopting a preparation mode, and reacts with 32% sodium hydroxide solution, 95% ethanol and 31% hydrochloric acid, so that the acquisition cost of the main raw material for preparing 2-ethyl butyric acid is reduced, and the yield of 2-ethyl butyric acid is increased. Meanwhile, the main content and the yield of the 2-ethyl butyric acid can be conveniently improved.

The utility model discloses a rectifying still for producing diethyl phenylethyl malonate, which is characterized in that a plurality of layers of pore plates are arranged in a still body through an annular support plate, a main shaft penetrates through guide sleeves of the pore plates, and after entering the still body, a diethyl phenylethyl malonate crude product reacts with rising steam, so that gas phase and liquid phase separation is realized; a gas phase is discharged from a gas phase outlet in the top, a liquid phase flows to the bottom of the kettle body, and in the process, when liquid phase stirring and heating in the kettle body are carried out through a stirring paddle at the bottom, the heat exchange effect is improved, so that the gas phase separation effect during boiling is improved, contact between steam and liquid is realized through a pore plate, and the gas-liquid separation effect is improved; a stirring rod is mounted above each layer of pore plate through a main shaft, so that the contact area of steam and the crude product of the diethyl phenylethylmalonate is greatly increased through stirring of the stirring rods, the gas-phase separation effect of the diethyl phenylethylmalonate is further improved, the rectification frequency is reduced, and the efficiency is improved.

A method for synthesizing a trifluoromethyl-containing nitrogen-containing heterocycle by metal catalysis is implemented by using a reinforced heating jacket to prepare 2-trifluoromethyl-4-hydroxy-5-nitropyridine from 2-trifluoromethyl-4-chloro-5-nitropyridine; then prepare 2-(5-nitro-2-(trifluoromethyl)pyridin-4-yl) diethyl malonate; further obtain 2-trifluoromethyl-4-methyl-5-nitropyridine; and finally obtain 2-trifluoromethyl-4-methyl-5-aminopyridine.

The present invention relates to a method for recovering monopropyl malonate of the chemical structural formula Ⅰ: Select 1-chloropropane and diethyl malonate in DMF, and under the action of potassium carbonate or sodium carbonate and quaternary ammonium salt, carry out dipropylation to obtain dipropyl malonate; in the process of preparing dipropyl malonate, add an alcohol solvent to the filter cake inorganic salt [residual dipropyl malonate monoester (Ⅲ)], and obtain the monopropyl malonate of the formula Ⅰ through pulping, acidification, crystallization, filtration and low-temperature vacuum drying: where M is selected from K or Na; R 1 is selected from: a C1-C5 straight-chain alkyl group or a C3-C5 branched-chain alkyl group; the alcohol solvent is selected from methanol, ethanol, a C3-C6 straight-chain or C3-C6 branched-chain monohydric alcohol, ethylene glycol, a C3-C5 straight-chain dihydric alcohol or a C4-C5 branched-chain dihydric alcohol; H + is selected from hydrochloric acid, phosphoric acid or sulfuric acid.

The application relates to a high-flame-retardant electronic connecting wire and a preparation method thereof, and belongs to the technical field of high polymer materials. The electronic connecting wire is composed of a wire and a surface flame-retardant protective layer, wherein the components of the flame-retardant protective layer are as follows: modified phosphorus-silicon flame retardant 7.5-10 wt%, plasticizer 14-18 wt%, heat stabilizer 1.7-2.2 wt%, antioxidant 0.12-0.16 wt% and lubricant 0.9-1.3 wt%, and the rest is PVC resin; the modified phosphorus-silicon flame retardant is synthesized by synthesizing a phosphorus oxychloride intermediate 1 with a double spiro ring structure from pentaerythritol and phosphorus oxychloride, carrying out amine-ester exchange between terminal amino polydimethylsiloxane and ketone-based diethyl malonate to prepare an intermediate 2 containing terminal amino groups, and then reacting the intermediate 2 with active phosphorus oxychloride of the intermediate 1 to form a chain-shaped macromolecular phosphorus amide compound, so that in-situ toughening, migration inhibition and carbon net flame retardation are simultaneously realized in the PVC matrix.