38 results about "Diethyl malonate" patented technology

The invention belongs to the technical field of separation of drug intermediates, and particularly relates to a control method for a process impurity 2-ethyl valeric acid (EP-B) in preparation of valproic acid or sodium valproate by a diethyl malonate method. According to the method disclosed by the invention, the content of 2-ethyl-2-propylmalonic acid process impurities in dipropylmalonic acid is controlled, so that the content of 2-ethylvaleric acid (EP-B) which is a process impurity in valproic acid or sodium valproate is accurately controlled; adding a polar solvent into the dipropylmalonic acid crude product, heating, pulping for a certain time, cooling, filtering and drying to obtain a high-purity dipropylmalonic acid refined product; high-purity valproic acid (RRT is equal to 1.00) is prepared through decarboxylation of the dipropyl malonic acid fine product, and the purity is 99.779%; 0.020% of 2-ethyl valeric acid (RRT is equal to 0.90); and valeric acid (RRT = 0.77), 0.039%. The valproic acid product quality meets the requirements of European Pharmacopoeia. According to the method, the problems of quality control and process evaluation of valproic acid or sodium valproate prepared by a diethyl malonate method are solved.

The present invention relates to a method of adding an isocitrate lyase specific inhibitor to a lactic acid fermentation process to block the production of succinic acid as a byproduct of fermentation. The specific inhibitor includes a combination of one or more of glycolic acid methyl ester, malonic acid dimethyl ester, hydroxymalonic acid diethyl ester, 3-nitropropionic acid ethyl ester, mercuric chloride, or 5,5'-dithiobis(2-nitrobenzoic acid) to effectively reduce the amount of succinic acid in the lactic acid.

The invention discloses a positive pole piece and a preparation method thereof, a diaphragm-free battery and a battery. The positive pole piece comprises a positive pole current collector and a positive pole active material layer arranged on at least one side of the positive pole current collector, the positive pole active material layer comprises a polymer, and the polymer is formed by polymerizing at least one of small molecules of the following raw material components: vinylethylene carbonate, vinylene carbonate, 2, 3, 4-trimethyl-1, 3-pentanedione, 2, 3, 4-trimethyl-1, 3-pentanedione and 2, 3, 4-trimethyl-1, 3-pentanedione. The adhesive is prepared from 2, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The adhesive is prepared from the following raw materials: 1, 4-hexadienoic acid, allyl trifluoroacetate, diethyl allylmalonate, allyl methacrylate, allyl chloroformate, allyl phenylacetate, allyl acetate, allyl 4-hydroxybenzoate and allyl phenoxyacetate. The positive pole piece provided by the invention comprises the polymer, so that the interface impedance can be reduced, and the rate capability of the battery can be improved.

The invention discloses a method for preparing a fluorinated ethylene-propylene emulsion, and relates to a polymer emulsion polymerization technology. Comprising the following steps: adding water into a reaction kettle, heating, and replacing with nitrogen to control oxygen; adding perfluoropolyether ammonium carboxylate, heating, adding an initial TFE / HFP mixed monomer, stirring, and adding a potassium persulfate solution to initiate polymerization; supplementing the mixed monomer in the reaction to maintain the pressure, and adding diethyl malonate and a copolymerization composition regulator at the same time; and stopping the reaction after the designed feeding amount is reached. According to the invention, the proportion of copolymerization units can be optimized, high monomer conversion is realized, and the emulsion with high solid content and uniform particle size is obtained.

The application relates to a preparation method of 4-chloropyrrolopyrimidine, in particular to a four-step high-yield synthesis of 4-chloropyrrolopyrimidine by taking diethyl malonate and bromoacetaldehyde diethyl acetal as raw materials, through substitution reaction, then ring closure reaction with formamidine acetate, ring closure reaction under acidic conditions, and then chlorination reaction with phosphorus oxychloride; the preparation method of 4-chloropyrrolopyrimidine provided by the synthesis route is a preparation method with high yield, low cost, easy operation and suitability for industrialization.

To provide a collagen-containing composition and a method for producing the same, a collagen-containing composition for addition to foods and drinks, and a collagen odor masking agent and a masking method that enable effective masking of collagen odor.SOLUTION: A collagen-containing composition contains collagen, a steviol glycoside, α-glucosyl rutin, and diethyl succinate and / or diethyl malonate.SELECTED DRAWING: None

The invention relates to the technical field of cables, and provides an extruded insulation low-voltage power cable which sequentially comprises a conductor, an insulation layer, an armor layer and a sheath layer from inside to outside. The sheath layer is prepared from the following raw material components in parts by weight: 80 to 100 parts of polyvinyl chloride, 10 to 20 parts of ethylene propylene diene monomer, 15 to 25 parts of ethylene vinyl acetate copolymer, 20 to 30 parts of filler, 25 to 35 parts of flame retardant, 3 to 5 parts of plasticizer, 1 to 3 parts of antioxidant and 3 to 5 parts of compatilizer; the filler is obtained by modifying potassium titanate whiskers with a titanate coupling agent and diethyl aminovinylmalonate, and the insulating layer is obtained by extruding an insulating layer material on the outer side of the conductor. According to the technical scheme, the problem of insufficient tensile strength of the sheath layer in the prior art is solved.

A biphenylthiourea carboxylic acid metal organic framework crystal material and a preparation method and application thereof.The material has the following chemical formula: {[Zn4O(L)3]·DMF·H2O} n , wherein L is a 6-thio-6,7-dihydro-5H-dibenzo[d,f][1,3]diazepine-3,9-dicarboxylate divalent anion, and n is a degree of polymerization.The metal organic framework crystal material of the present application is synthesized by a solvothermal method, is simple to operate, has low cost, high yield, and is easy to mass industrial production.The prepared metal organic framework crystal material has a high specific surface area (a BET specific surface area of 594 m 2 / g), and an adsorption amount of CO2 of 46.0 cm 3 / g at 1 atm and 273 K.The biphenylthiourea carboxylic acid metal organic framework crystal material of the present application can efficiently catalyze a Friedel-Crafts alkylation reaction of substituted indole and substituted trans-nitrostyrene to generate an indole 3-substituted derivative, and can also efficiently catalyze a Michael addition reaction of diethyl malonate and substituted trans-nitrostyrene, both of which have mild conditions, and the catalyst can be recycled with almost no activity loss, and are good heterogeneous catalysts.

The invention belongs to the technical field of medicine detection, and particularly relates to a high performance liquid chromatography detection method for dipropylmalonic acid and impurities thereof. The method comprises the following steps: preparing a to-be-detected sample into a test solution; the to-be-detected sample is dipropyl malonic acid prepared by adopting a diethyl malonate method and impurities of the dipropyl malonic acid; and detecting the test solution by adopting a high performance liquid chromatography method to obtain a detection result of dipropylmalonic acid and impurities thereof in the sample to be detected. According to the detection method provided by the invention, the detection of dipropylmalonic acid prepared by adopting a diethyl malonate method and impurities thereof is realized through high performance liquid chromatography (HPLC) for the first time, and the problems of quality control and process evaluation of the dipropylmalonic acid prepared by adopting the diethyl malonate method, which is an intermediate of a sodium valproate raw material medicine, are solved; therefore, detection and control of impurities (including 2-ethyl valeric acid) in the sodium valproate raw material medicine are realized.

The present application relates to phenylethyl malonic acid diethyl ester heating technical field, specifically, it is a kind of phenylethyl malonic acid diethyl ester reaction heating device capable of uniform heating.It includes heating tank, feeding opening, discharge port and heater, heating tank is fixedly provided with sleeve inside, the sleeve is used to separate the inner wall of heating tank and sleeve into liquid storage cavity and shunt cavity, liquid storage cavity is located above shunt cavity, auxiliary liquid mixing stirring mechanism is arranged in the inner ring of sleeve, reciprocating mechanism is arranged at the top end of sleeve inside and the end of stirring mechanism.Liquid inside the sleeve is guided into the liquid storage cavity, then steam in the heater flows outward through shunt ring and steam pipe, the flowing steam can continuously conduct heat to the shunt ring, the shunt ring conducts heat to the sprayed liquid, and the sprayed liquid is divided into two streams under the action of shunt ring, so that the contact area of liquid and shunt ring is increased, thereby improving the efficiency of heat transfer and enhancing the uniformity of heat conduction.

A preparation process of 2-[2-(2, 4-difluorophenyl)-2-propylene-1-yl]-1, 3-propylene glycol belongs to the field of medical intermediates, and comprises the following steps: step 1, adding 1-[1-(bromomethyl) vinyl]-2, 4-difluoro-benzene and diethyl malonate into N, N-dimethylformamide, and then adding potassium carbonate for reaction; 2, after the reaction in the step 1 is completed, filtering to remove potassium carbonate, and then carrying out acid pickling, toluene extraction, saturated saline solution washing, concentration and rectification to obtain an oily substance; and step 3, adding the oily substance obtained in the step 2 into methanol, mixing, then adding sodium borohydride for reaction, and after the reaction is completed, concentrating, crystallizing and filtering to obtain the 2-[2-(2, 4-difluorophenyl)-2-propylene-1-yl]-1, 3-propylene glycol. According to the method, the cost is effectively reduced, so that the reaction period can be shortened, meanwhile, the reaction yield can be increased, and industrial production is facilitated.

The invention provides a preparation method of diethyl malonate and a preparation method of valproic acid, and belongs to the technical field of organic synthesis. According to the method, diethyl carbonate and ethyl acetate are taken as initial raw materials, the ethyl acetate has three alpha-H and loses one alpha-H under the attack of strong base, so that ethyl acetate enol negative ions are formed, and ethyl acetate carbon negative ions are obtained through rearrangement; carrying out nucleophilic addition on carbonyl of diethyl carbonate by using the ethyl acetate carbon negative ions to obtain an addition intermediate, and then removing ethanol negative ions from the addition intermediate to obtain diethyl malonate; by controlling the reaction temperature, ethanol generated in the reaction process is continuously distilled out, so that the reaction is carried out in the forward direction, and side reactions are reduced to the greatest extent; as the condensation catalyst used in the invention has strong nucleophilicity and alkalinity, the use of the aprotic solvent can avoid the consumption of the condensation catalyst by the solvent.

This invention discloses a method for synthesizing 3-oxa[3.1.1]spiropropane, belonging to the fields of organic synthetic chemistry and medicinal chemistry. This method is the first to introduce oxygen atoms into the high-strength skeleton of [3.1.1]spiropropane, successfully synthesizing the 3-oxa[3.1.1]spiropropane molecule. The specific synthetic route is as follows: starting with 3,3-bis(bromomethyl)oxacyclobutane, the 3-oxabicyclo[3.1.1]heptane diol skeleton is constructed sequentially via nucleophilic substitution with diethyl malonate, reduction, and intramolecular cyclization. Then, oxidation and Barton decarboxylation iodination are performed to obtain the key intermediate 1,3-diiodo-3-oxabicyclo[3.1.1]heptane, which is finally reacted with an organolithium reagent to obtain the target product. This invention fills a technological gap in the synthesis of heteroatom-substituted spiroalkyl, providing a key precursor for the subsequent development of its free radical bifunctionalization reaction and the construction of structurally diverse 3-oxabicyclic [3.1.1]heptane dominant skeletons. It has important application prospects in drug design, especially as a bio-electroisoster of meta-substituted aromatics.

The invention relates to a cuprous salt antioxidant containing a phosphite structure and a preparation method and application thereof.The preparation method comprises the steps that firstly, diethyl malonate reacts in the presence of ammonia gas to obtain an intermediate A, then the intermediate A and 3-amino-2, 5-di-tert-butylphenol are subjected to condensation cyclization to obtain an intermediate B, finally, after the intermediate B and a phosphite derivative react, the cuprous salt antioxidant containing the phosphite structure is obtained, and the cuprous salt antioxidant containing the phosphite structure is obtained. And coordinating with cuprous salt to obtain a final product. The invention also provides a nylon composition containing the antioxidant. The antioxidant disclosed by the invention has the characteristics of high-efficiency oxidation resistance, hydrolysis resistance and good compatibility with nylon through the synergistic effect of a plurality of intramolecular stable mechanisms, and can be used for remarkably improving the thermal oxidation stability of a nylon material, inhibiting degradation in the processing and using processes and effectively keeping the mechanical properties, appearance and color of the material.

The invention relates to the technical field of organic synthesis, and discloses a preparation method of 2-oxoglutaric acid, which comprises the following steps: by taking diethyl 2-oxosuccinate and diethyl 2-bromomalonate as raw materials, carrying out condensation reaction in an absolute ethyl alcohol solvent under the catalytic action of sodium ethoxide; adjusting the pH value of the obtained condensation product, performing intermediate purification, transferring into a mixed system of sulfuric acid and ethanol, performing hydrolysis and decarboxylation reaction, and finally crystallizing and refining to obtain a target product. The invention provides a brand new synthesis route, the reaction conditions are mild, the use of raw materials with higher toxicity and the reaction conditions with great danger are avoided, and the safety of the production process is high. And by setting a key intermediate product purification step, the purity of the final product is effectively ensured, and the product quality is high. Meanwhile, raw materials used in the method are commercially available conventional chemicals, operation is easy and convenient, cost is controllable, and the method is suitable for industrial production.

The application relates to a high-flame-retardant electronic connecting wire and a preparation method thereof, and belongs to the technical field of high polymer materials. The electronic connecting wire is composed of a wire and a surface flame-retardant protective layer, wherein the components of the flame-retardant protective layer are as follows: modified phosphorus-silicon flame retardant 7.5-10 wt%, plasticizer 14-18 wt%, heat stabilizer 1.7-2.2 wt%, antioxidant 0.12-0.16 wt% and lubricant 0.9-1.3 wt%, and the rest is PVC resin; the modified phosphorus-silicon flame retardant is synthesized by synthesizing a phosphorus oxychloride intermediate 1 with a double spiro ring structure from pentaerythritol and phosphorus oxychloride, carrying out amine-ester exchange between terminal amino polydimethylsiloxane and ketone-based diethyl malonate to prepare an intermediate 2 containing terminal amino groups, and then reacting the intermediate 2 with active phosphorus oxychloride of the intermediate 1 to form a chain-shaped macromolecular phosphorus amide compound, so that in-situ toughening, migration inhibition and carbon net flame retardation are simultaneously realized in the PVC matrix.

The invention relates to the field of chemical synthesis, in particular to a synthesis method of 6-bromoindole-2-carboxylic acid. Comprising the following steps: preparing 4-bromo-2-aminotoluene; preparation of 6-bromoindole-2-carboxylic acid ethyl ester; and preparing the 6-bromoindole-2-carboxylic acid. According to the present invention, the reduction cyclization and hydrolysis process is improved, the diethyl malonate is adopted as the mild reducing agent, and the step-by-step temperature control technology is combined so as to significantly improve the yield and the purity; the invention discloses a three-step synthesis process of a bromo-indole carboxylic acid derivative. The method comprises the following steps: 1, in an improved mixed solvent system, carrying out a reduction reaction of reducing nitryl into amino; in the second step, a controllable reduction cyclization technology is adopted, and nitro amination is achieved; in the third step, the ester bond breaking efficiency is improved through the synergistic effect of alkaline hydrolysis and a solvent.

This invention relates to the field of pharmaceutical intermediate synthesis, specifically to a method for synthesizing 3,4-difluoro-2-methoxyphenylacetic acid. The method includes the following steps: Compound III reacts with diethyl malonate in the presence of a copper catalyst, a nitrogen-containing ligand, and base I; then, an inorganic strong base II is directly added for hydrolysis, followed by acidification to obtain compound IV; compound IV undergoes decarboxylation in an acidic solution to yield 3,4-difluoro-2-methoxyphenylacetic acid (compound I) with a purity of up to 99.3% and an overall yield of up to 74.04%. This invention features a simple route, mild reaction conditions, low cost, environmental friendliness, stable yields at each step, and simple post-processing, making it suitable for industrial production.

The invention relates to the technical field of synthesis of 4, 6-dihydroxypyrimidine, in particular to a synthesis method of 4, 6-dihydroxypyrimidine. The synthesis method of the 4, 6-dihydroxypyrimidine comprises the following steps: S1, adding formamide, a composite catalyst system, a phase transfer catalyst and a solvent into a container, and uniformly stirring and mixing to obtain a mixed solution; s2, adding the mixed solution obtained in the step S1 and diethyl malonate into a reactor, heating to 110-120 DEG C, carrying out condensation cyclization reaction for 0.5-5 hours, and filtering to remove the catalyst while hot after the reaction to obtain a reaction solution; s3, cooling the reaction liquid obtained in the step S2 to-5 to 0 DEG C, and filtering to obtain a solid; and S4, recrystallizing the solid obtained in the step S3 to obtain the product. The synthesis method is simple in preparation process, stable in reaction process, simple in purification method, high in product purity, easy for industrial production and capable of being quickly popularized and applied.

The present application relates to ethyl malonate mixing technical field, specifically, it relates to a kind of condensation device for reducing mixing time of diethyl phenylethyl malonate production.The condensation device includes mixing bin, condensation kettle, stirring device and storage bin fixedly arranged at the top of mixing bin, the bottom of mixing bin is communicated with condensation kettle with communicating pipe, storage bin is formed with liquid storage cavity and nitrogen cavity for storing raw materials and nitrogen respectively in the inside, and isolating mechanism for separating first mixed liquid and secondary mixed liquid is movably arranged in the inside of mixing bin.The gravity of secondary mixed liquid on the floating plate is used to pressurize first mixed liquid in discharge cavity, at the same time, the gravity of secondary mixed liquid is used to hit reciprocating plate, so that nitrogen in nitrogen cavity is transported into discharge cavity, the pressure in discharge cavity is increased, the speed of liquid discharge is improved, and in the process of first mixed liquid discharge, stirring device can also stir first mixed liquid and secondary mixed liquid simultaneously, so as to shorten mixing time.

The application belongs to the technical field of solar cells, and discloses a perovskite solar cell, a preparation method and application thereof. The perovskite solar cell comprises, from bottom to top, a flexible conductive substrate, a hole transport layer, a perovskite active layer, a passivation layer, an electron transport layer and a metal electrode layer. The perovskite active layer comprises APbX3. A comprises at least one of formamidinium ion, methylamine ion, cesium ion and potassium ion. X comprises at least one of chloride ion, bromide ion and iodide ion. The passivation layer comprises 2-ethyl-2-phenyl malonic acid diethyl ester. The solar cell has excellent photoelectric conversion efficiency and long-term stability, and can be used to prepare photovoltaic modules and electronic devices. In addition, the preparation method is simple and easy to implement, does not require complex equipment and processes, can effectively control the thickness of each layer, is used to prepare large-area high-performance perovskite solar cells, and meets the needs of industrial production.

This invention provides a method for preparing (E)-octyl-4-en-1,8-diic acid, comprising the steps of reacting diethyl malonate and allyl chloride as raw materials first in the presence of an organic base, then in the presence of a catalyst, and finally obtaining (E)-octyl-4-en-1,8-diic acid through hydrolysis and decarboxylation. The starting materials of this invention are inexpensive and readily available, the reaction operation is simple, the conditions are mild, the safety is good, and the product yield and purity are high, making it of great value for widespread application.

The invention discloses a dihydroxamic acid flotation collecting agent and a preparation method and application thereof. The molecular structural formula of the dihydroxamic acid flotation collecting agent is shown in the formula I in the specification. The preparation method comprises the steps that diethyl 2-hexylmalonate, hydroxylamine and a solvent are mixed under the alkaline condition to be subjected to a hydroximation reaction, acidification is conducted, and the dihydroxamic acid flotation collecting agent is obtained. Compared with an existing hydroxamic acid collecting agent, the dihydroxamic acid flotation collecting agent shows higher collecting capacity and higher selectivity, rare earth metal in rare earth minerals can be efficiently recycled when the dihydroxamic acid flotation collecting agent is used for conducting flotation on the rare earth minerals, and the dihydroxamic acid flotation collecting agent has the advantages of being easy to operate, high in flotation efficiency, wide in application range and the like, and is high in use value and good in application prospect. Meanwhile, the preparation method of the dihydroxamic acid flotation collecting agent has the advantages of being low in raw material cost, easy to operate, mild in reaction condition, high in reaction yield, few in by-product and the like, and is suitable for large-scale preparation and convenient for industrial application.

The application belongs to the technical field of biological medicine, and particularly relates to a preparation method of N-(3-bromo-5-fluoro-4-methylphenyl)acetamide. The application takes 3,4-difluoro-5-bromonitrobenzene as an initial raw material, first carries out a coupling reaction with malonic acid diethyl ester, then carries out a decarboxylation reaction in the presence of a chlorinated salt, then carries out a nitro reduction reaction in the presence of a reducing agent and a catalyst, and finally carries out amino protection by using acetic anhydride. The preparation method provided by the application obtains the target product N-(3-bromo-5-fluoro-4-methylphenyl)acetamide through four-step reactions, has high total yield of the target product, is simple to operate, has good repeatability, has few side reactions, is simple to purify, has low production cost, and is suitable for industrialized scale production. As shown in the test results of examples, the total yield of N-(3-bromo-5-fluoro-4-methylphenyl)acetamide prepared by the preparation method provided by the application is 78.4%.

The invention discloses apple essence for electronic atomized liquid and a preparation method of the apple essence, and relates to the technical field of essence for electronic atomized liquid. The apple essence for the electronic atomized liquid is prepared from the following components: n-hexanoic acid, strawberry acid, stellate, isoamyl alcohol, trans-2-hexenol, peach aldehyde, n-butyl alcohol, damascenone, allyl heptanoate, trans-2-hexene acetate, citronellyl acetate, trans-2-hexenal, isoamyl isovalerate, hexyl butyrate, hexanal, ethyl n-hexanoate, butyl acetate and isoamyl acetate. The cleaning agent is prepared from leaf acetate, ethyl butyrate, diethyl malonate, hexyl acetate, leaf alcohol, hexyl alcohol, leaf butyrate, acetic acid and methyl maltol. According to the apple essence for the electronic atomized liquid and the preparation method of the apple essence, the essence can accurately simulate the fresh, sour and crisp taste of green apples, provides taste experience close to that of real fruits, is specially designed for the electronic atomized liquid, and can still keep the flavor consistency after being heated, and burnt taste or pungent smell is avoided.

The application discloses a method for preparing a valproic acid intermediate, diethyl dipropylmalonate, and belongs to the technical field of medicines. The method comprises the following steps: adding a compound shown in formula III, a compound shown in formula A, a base and a phase transfer catalyst into an amide solvent to react, so as to obtain a compound shown in formula I. The method can significantly reduce the content of a propylmalonic acid diethyl ester impurity in the product, and the content of the propylmalonic acid diethyl ester impurity is controlled to be less than or equal to 0.17%. The diethyl dipropylmalonate prepared by the method has a purity of greater than or equal to 98.16% and a yield of greater than or equal to 85%. The method is economical and environment-friendly, simple and convenient to operate, low in cost, safe and controllable, and suitable for large-scale industrial production.

This invention belongs to the field of organic synthesis technology and relates to a method for synthesizing 3,4-difluoro-2-methoxyphenylacetic acid, comprising the following steps: S1 Using 3,4-difluoro-2-methoxyaniline and a diazotizing reagent as raw materials, a diazotization reaction is carried out under the action of a copper catalyst and an inorganic acid to obtain the 3,4-difluoro-2-methoxyaniline diazonium salt; subsequently, a Sandmeyer reaction is performed with bromine to obtain 6-bromo-2,3-difluoroanisole; S2 The 6-bromo-2,3-difluoroanisole obtained in step S1 is reacted with diethyl malonate under the action of a ferricyanide to obtain 2-(3,4-difluoro-2-methoxyphenyl)malonic acid; S3 The 2-(3,4-difluoro-2-methoxyphenyl)malonic acid obtained in step S2 is reacted with concentrated sulfuric acid to obtain 3,4-difluoro-2-methoxyphenylacetic acid. This invention features mild reaction conditions, high yield, and high purity, making it suitable for industrial production.

The application relates to the technical field of biodegradable polyesters, and provides a modified polybutylene terephthalate-co-adipate and a preparation method thereof. The repeating structural unit of the modified polybutylene terephthalate-co-adipate comprises a terephthalic acid structural unit, an adipic acid structural unit, a 1,4-butanediol structural unit and a fourth monomer structural unit; the fourth monomer comprises at least one of oxalic acid, dimethyl oxalate, furan dicarboxylic acid, dimethyl furan dicarboxylic acid, malonic acid, dimethyl malonic acid, methylmalonic acid and diethyl methylmalonic acid. The modified polybutylene terephthalate-co-adipate provided by the application has higher glass transition temperature and breaking strength, lower melt index and better product hue than conventional pure PBAT, can meet the use requirements of PBAT, and effectively solves various problems caused by poor heat resistance and strength of conventional PBAT products in the processing process and subsequent application.

The invention belongs to the field of organic synthesis, and discloses a synthesis method of isoamyl p-methoxycinnamate, which comprises the following steps: step 1, introducing an isoamyl alcohol solution containing p-methoxybenzaldehyde, diethyl malonate and an ionic liquid catalyst into a first tubular reactor to carry out Knoevenagel condensation reaction; a first mixture containing ethyl p-methoxycinnamate and water is obtained; 2, water in the first mixture is removed, and a second mixture is obtained; and 3, introducing the second mixture into a second tubular reactor, and carrying out transesterification to obtain isoamyl p-methoxycinnamate. The method disclosed by the invention has the advantages of high reaction efficiency, high conversion rate, convenience in product recovery, no need of considering an amplification effect and the like.