21 results about "Cyclopropane" patented technology

The present invention provides a salt of a dioxane quinoline compound, a crystal form thereof, preparation methods therefor and uses thereof. Specifically, the present invention relates to N-(3-fluoro-4-((5-(3-morpholinopropoxy)-2,3-dihydro-[1,4]dioxano[2,3-f]quinolin-10-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, a crystal form thereof and preparation methods therefor, and uses in the preparation of a drug as an inhibitor of tyrosine kinases (e.g. VEGFR-2 and c-MET, etc.).

A working medium for a heat cycle includes trifluoroethylene, a low boiling point compound having a lower boiling point than the boiling point of the trifluoroethylene, and high boiling point compounds having higher boiling points than the boiling point of the trifluoroethylene. In the working medium, the low boiling point compound is at least one selected from the group consisting of carbon dioxide, R116, and R41, and the high boiling point compounds are at least two selected from the group consisting of HFC-32, HFO-1234yf, HFO-1234ze (E), HFO-1243zf, PFC-14, HFC-134, HFC-143a, HFC-227ea, cyclopropane, isobutene, isobutane, dimethyl ether, and ammonia. An application of the working medium is provided.

The invention provides a method for chiral resolution of (trans)-2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid. The method comprises the steps of: (a) treating (trans)-2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid with a chiral base selected from the list consisting of: quinine, R )-1-cyclohexylethan-1-amine, S )-1-cyclohexylethan-1-amine and L )-leucinamide, in an organic solvent to form a suspension, (b) separating the desired enantiomer and diastereomeric salt of the chiral base from the suspension, and (c) optionally, treating the separated diastereomeric salt with an acid to obtain the desired enantiomer of 2,2-dichloro-3-(3-chloro-4-fluorophenyl)cyclopropane-1-carboxylic acid.

High temperature lubricants for magnetic media include a plurality of segments according to general formula (I):where Rd is any linker chemistry and each Re may be a reactive end-group and anchoring group containing at least one constituent configured for at least one of tribochemical, thermochemical, or optochemical bonding. The at least one constituent can be cyclopropane or cyclobutane.

The disclosure is in part directed to crystalline free base forms of N-(4-((2-methoxy-3-(1-(methyl-d / 3)-1H,2,4-triazol-3-yl)phenyl) amino)-5-(propanoyl-3,3,3-d / 3)pyridin-2-yl) cyclopropane carboxamide, pharmaceutical compositions thereof, and methods of use.

This invention relates to the field of coating technology, specifically to a printing coating for colored paper and its preparation method. In the preparation process, this invention incorporates dithiol dihydroxyacetic acid to increase the crosslinking points of the system, and trimethylolpropane tris(2-methyl-1-azacyclopropane propionate) containing an unstable aziridine three-membered ring to improve the degree of crosslinking. It also introduces isoborneol methacrylate to reduce internal stress, effectively balancing the crosslinking density and volume shrinkage of the system, resulting in a coating with excellent adhesion. Furthermore, this invention adds the bifunctional monomer 1,6-hexanediol diacrylate to make the network structure more uniform and provide anti-photooxidation properties, making the system less prone to oxidative discoloration. The addition of tripropylene glycol diacrylate reduces the risk of yellowing caused by small molecule migration. Therefore, the coating obtained in this way has significant anti-yellowing effects, preventing color distortion of colored paper and maintaining the appearance stability of the colored paper.

Provided are formulations comprising (5R,6S)-10,11-difhioro-12-((2-fhioro-4-iodophenyl)amino)-5,6-dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][l,5,4]oxathiazecine-3,1'-cyclopropane] 2,2-dioxide or a pharmaceutically acceptable salt or solid form thereof, methods for treating, preventing and managing diseases or disorders, such as cancer, using the same.

The present invention relates to a crystalline form of the heterocyclic compound N-(4-(1-(2-cyanoacetyl)-3-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-6-yl)cyclopropanecarboxamide as a protein kinase inhibitor.

The present invention relates to substituted 1,2,3-triyl tris(cyanomethylidene)cyclopropanes for use in VTE, electronic devices and semiconductor materials using the same. In particular, the present invention relates to a method of preparing an electrically doped semiconductor material comprising a [3]-fused p-dopant or of preparing an electronic device containing a layer comprising a [3]-fused p-dopant, the corresponding [3]-fused compounds as well as semiconductor materials and layers and electronic devices comprising said compounds; said method comprising the steps of (i) loading an evaporation source with a [3]-fused p-dopant, and (ii) evaporating said [3]-fused p-dopant at elevated temperature and reduced pressure, wherein said [3]-fused p-dopant is selected from the group consisting of compounds having a structure according to formula (I), wherein A 1 and A 2 is independently aryl or heteroaryl substituted cyanomethylidene.

Described herein are solid forms of (5R,6S)-10,11-difluoro-12-((2-fluoro-4- iodophenyl)amino)-5,6-dihydroxy -4,5,6, 7 -tetrahydro- 1H-spiro[benzo[b] [1,5, 4]oxathiazecine- 3,1'-cyclopropane] 2,2-dioxide in amorphous and crystalline forms, and processes of preparation, and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating a disease or disorder in which the RAS pathway is upregulated such as cancer, RASopathies and laminopathies. Formula (I).

The present invention relates to substituted 1,2,3-triyl tris(cyanomethylidene)cyclopropanes for use in VTE, electronic devices and semiconductor materials using the same. In particular, the present invention relates to a method of preparing an electrically doped semiconductor material comprising a [3]-fused p-dopant or of preparing an electronic device containing a layer comprising a [3]-fused p-dopant, the corresponding [3]-fused compounds as well as semiconductor materials and layers and electronic devices comprising said compounds; said method comprising the steps of (i) loading an evaporation source with a [3]-fused p-dopant, and (ii) evaporating said [3]-fused p-dopant at elevated temperature and reduced pressure, wherein said [3]-fused p-dopant is selected from the group consisting of compounds having a structure according to formula (I), wherein A 1 and A 2 is independently aryl or heteroaryl substituted cyanomethylidene.

A high temperature lubricant for magnetic media includes a plurality of segments according to the general formula (I): Rc-Rd-Rc (I) wherein Rd is any of the linker chemical structures, and each Rc can be a reactive end group and an anchor group comprising at least one component configured to effect at least one of frictional chemical bonding, thermal chemical bonding, or photo-chemical bonding. The at least one component can be cyclopropane or cyclobutane.

The application discloses a method for preparing a five-membered azo compound mediated by laughing gas, and comprises the following steps: S1, reacting gem-boronate compounds shown in formula I with laughing gas in the presence of a solvent and a base reagent to obtain a diazo compound; S2, adding olefin compounds shown in formula II to the reaction system containing the diazo compound to continue the reaction to obtain five-membered azo compounds shown in formula III. The preparation method uses laughing gas as a nitrogen source, and cheap and easily obtained gem-boronate and olefin as reaction raw materials, so that known and novel five-membered azo compounds can be prepared by one-pot method. The preparation method is simple, the reaction condition is mild, and the reaction yield is high, and the method is suitable for industrialized production of the five-membered azo compounds. In addition, the five-membered azo compounds prepared by the application can be used for further conversion to prepare cyclopropane compounds and 1,3-diamine compounds, and have important application value in the fields of biological medicines, pesticides and the like.

The application belongs to the technical field of medicines, and provides a pyrimidine derivative containing a cyclopropane sulfonamide group, a pharmaceutically acceptable salt thereof, a preparation method and application thereof. The pyrimidine derivative containing a cyclopropane sulfonamide group has a structure shown in formula I. The pyrimidine derivative containing a cyclopropane sulfonamide group has a cyclopropane sulfonamide group substituted in the A ring and no alkoxy group substituted in the C ring. The active molecules can not only effectively inhibit the drug resistance of the third generation targeted drug Osimertinib after EGFR C797S mutation, but also can significantly inhibit EGFR single mutation or double mutation (L858R, del 19, T790M). The preparation method of the pyrimidine derivative containing a cyclopropane sulfonamide group and the pharmaceutically acceptable salt thereof has the advantages of simple synthesis process and low cost.

[00463] Pharmaceutical compositions comprising g3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5- yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid (Compound 1) in Form I and a solid dispersion comprising substantially amorphous N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4- oxo-1H-quinoline-3-carboxamide (Compound 2), methods of treating, lessening the severity of, or symptomatically treating CFTR mediated diseases, such as cystic fibrosis, methods of manufacturing, methods of administering, and kits thereof are disclosed. 145 20 24 20 02 73 16 J an 2 02 4 1 6 J a n 2 0 2 4 2 0 2 4 2 0 0 2 7 3 1 4 5

This invention relates to a method for preparing chiral spirocyclopentane-oxidized indole compounds in the field of organic synthesis. The general reaction formula is as follows: A class of spirocyclopentane-oxidized indole compounds are synthesized from spirolylcyclopropane-oxidized indole and methyl acrylate derivatives as substrates under the combined action of a palladium catalyst and ligands. This method features mild reaction conditions and simple operation, providing a simple preparation method for chiral spirocyclopentane-oxidized indole compounds. Furthermore, the chiral spirocyclopentane-oxidized indole provided by this invention is an important synthetic intermediate that can be applied to the preparation of complex propylene oxide and tertiary amine compounds.

The present disclosure provides salts, crystalline forms, and formulations of KRAS inhibitors and methods of their preparation and use.

Described herein are 10,11-difluoro-12-((2-fluoro-4-iodophenyl)amino)-5,6- dihydroxy-4,5,6,7-tetrahydro-1H-spiro[benzo[b][1,5,4]oxathiazecine-3,1'-cyclopropane] 2,2- dioxide stereoisomer compounds and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating a disease or disorder in which the RAS pathway is upregulated such as cancer, RASopathies and laminopathies.

A mixture for killing pests, comprising, as the active compound, A) an ethyl sulfone compound having formula (I) and B) At least one additional compound B, selected from fipronil, λ-cyhalothrin, bifenthrin, heptafluthrin, α-cyhalothrin, thiamethoxam, thiamethoxam, acetamiprid, imidacloprid, dinotefuran, trifluralin, dithiamethoxam, spinosad, ethyl spinosad, abamectin, bispyribac-methyl, indoxacarb; cyfluthrin, methoxypiperazine ethyl ester, dispirenil, chlorantraniliprole, brofenoxuronamide, tetrazolium acetonitrile, cyclobromhizobium acetonitrile, brofenoxuron dimethoate; pyrimethanil, M.UN.1: 1-[6-(2,2-difluoro-7-methyl-[1,3]m-dioxacyclopenten[4,5-f]benzimidazol-6-yl)-5-ethylsulfonyl-3-pyridyl]cyclopropaneformonium, M.UN.2: 6-(5-cyclopropyl-3-ethylsulfonyl- 2-pyridyl)-2,2-difluoro-7-methyl-[1,3]m-dioxacyclopenten[4,5-f]benzimidazole; and difenoconazole, prothioconazole, fenbendazole, tebuconazole, chlorfluazuron, cymoxanil, fluopyram, tetrazoxystrobin, azoxystrobin, oxadiazon, azoxystrobin, fluopyram, fluopyram, fluopyram, fluopyram, fluopyram, isopropoxystrobin, trifluoropyridamole, fluthiazolinone, flusaprolin, metalaxyl, tetrazoxystrobin, fludioxonil, thiophanate-methyl; these mixtures are used to combat invertebrate pests such as insects, arachnoides or nematodes inside and on the surface of plants, and for the protection of such plants, especially for the protection of plant propagation material such as seeds from pest infestation.

This invention discloses a method for preparing 1-alkoxy-1-arylacetone compounds, belonging to the field of organic synthesis technology. The method uses geminitrofluorocyclopropane and alcohols as raw materials, and reacts them in a nitrogen atmosphere at 80-100°C for 12-24 hours under a catalytic system consisting of a rhodium catalyst, a phosphine ligand, and a silver additive, to efficiently synthesize the target product. This method has advantages such as readily available raw materials, simple operation, good selectivity, and few byproducts. It is compatible with various substituents such as phenyl, naphthyl, alkyl, and halogen, and is suitable for the synthesis of structurally diverse 1-alkoxy-1-arylacetone compounds, showing promising application prospects in the preparation of drug molecules and functional materials.