1641 results about "Formamides" patented technology

Embodiments of the present invention provide methods and intermediates for the large scale preparation of 2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide hemisuccinate, as well as formulations and product forms prepared by these methods. Embodiments of the present invention further provide for the preparation of lamidetan acetate (2, 4, 6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl] benzamide acetate) and / or a pharmaceutical composition thereof, and / or the use of lamidetan acetate and formulations thereof in subcutaneous drug delivery.

The present disclosure relates with the development of a process for producing gels from polymeric materials crosslinked with organic agents and their use controlling water in porous media under high salinity and temperature conditions. The characteristics of these gels enable them to have a good performance withstanding extreme conditions in mature Mexican oil wells and in others located in other parts of the world. The gels featured in the present disclosure include novel ionic terpolymers based on acrylamide (AM), N-vinylpyrrolidone (VP), N,N′-methylenebisacrylamide (BAA), 1-vinyl-3-butylimidazolium bromide (VIM4C[Br]) and organic crosslinking agents.

The invention discloses a low-temperature zinc ion battery high-entropy eutectic electrolyte and a preparation method and application thereof, and relates to the field of batteries, the electrolyte comprises a hydrogen bond donor, a hydrogen bond acceptor and a solvent; the hydrogen bond donor is at least one of methyl sulfonamide, thioformamide, butyramide, asparagine, tert-butylamine, dimethyl propane diamine, oxalyl diamine, benzamide, sulfamide and ethyl sulfonamide; the hydrogen bond receptor is at least one of aspartic acid, glutamic acid, methionine, zinc chloride, zinc perchlorate, zinc fluoborate and zinc acetate; the preparation method comprises the following steps: mixing a hydrogen bond donor and a hydrogen bond acceptor, and heating to convert a solid into a liquid phase; and adding a solvent, and uniformly mixing to obtain the product. The invention also provides a zinc ion battery containing the electrolyte. The high-entropy eutectic electrolyte has the beneficial effects that-NH2 and halogen or carboxyl form hydrogen bonds to perform eutectic reaction, the freezing point of the eutectic solution is lower than that of a reactant, and the solvent is added to improve the confusion degree of the electrolyte, so that the high-entropy eutectic electrolyte is prepared.

The present invention provides a preparation method of 4,6-dihydroxypyrimidine, and the preparation method comprises the following steps: adding a mixed solution of malonate and formamide to an alkali metal alcoholate / solvent containing a catalyst, and then keeping the mixture warm for reaction after the addition is completed. After the reaction is completed, the solvent is evaporated to dryness, and after being dissolved in water, the mixture is acidified to a pH of 2-3, filtered, washed with water, and dried to obtain 4,6-dihydroxypyrimidine. The present invention utilizes a catalyst to catalyze the reaction, thereby improving the reaction yield, having a high atomic economy, and reducing the amount of raw materials used, reducing the generation of saline wastewater, and alleviating environmental pressure.

The present disclosure relates to a fungicidal composition. More particularly, the present disclosure relates to a granular fungicidal composition comprising a copper compound and a benzamide fungicide. The present disclosure also relates to a process for preparing the fungicidal composition and a method for controlling growth of fungal phytopathogens using the same.

The invention relates to an Ag quantum dot-SnS2 composite nano gas-sensitive material, a preparation method thereof and application of the Ag quantum dot-SnS2 composite nano gas-sensitive material in a formamide sensor, and belongs to the technical field of semiconductor gas sensors. The micro-morphology of the Ag quantum dot-SnS2 composite nano gas sensitive material is that Ag quantum dots are loaded on the surface of SnS2, the SnS2 is of a flower-shaped structure assembled by SnS2 nanosheets with the thickness of 10-20 nm, and the crystal structure is a hexagonal phase crystal structure; the Ag quantum dots are nano-particles which are composed of Ag atoms and have the diameter of 5-15 nm. The sensor based on the Ag quantum dot-SnS2 nano composite material shows good gas-sensitive performance to formamide at the room temperature of 25 DEG C, has high sensitivity, good reproducibility, selectivity and long-term stability, solves the problem of high working temperature of a traditional metal oxide semiconductor gas sensor, and has good application prospects. The method has important significance in the aspects of industrial production, environment detection and the like.

The invention relates to a preparation method of 2-(2-amino-5-bromo-benzoyl) pyridine, which comprises the following steps: by taking 1, 2-diphenyl-1H-benzimidazole (I) as a starting material, oxidizing under the action of chromium trioxide and acetic acid to obtain N-[2-(2-pyridinecarbonyl) phenyl] benzamide (II), hydrolyzing the N-[2-(2-pyridinecarbonyl) phenyl] benzamide (II) under the action of sulfuric acid to obtain 2-(2-aminobenzoyl) pyridine (III), and reacting the 2-(2-amino-5-bromo-benzoyl) pyridine (III) with the 2-(2-amino-5-bromo-benzoyl) pyridine (III) to obtain the 2-(2-amino-5-bromo-benzoyl) pyridine. And (III) performing substitution reaction with NBS in DCM to obtain the target product 2-(2-amino-5-bromo-benzoyl) pyridine. The method has the advantages of mild reaction conditions, higher product purity, high yield, simplicity and convenience in operation, low cost and easiness in industrialization.

The invention relates to the technical field of cable materials, in particular to a flame-retardant efficient cross-linked polyolefin cable body and a preparation method thereof. The cable body comprises a polyolefin matrix, 2, 4-dihydroxy-6-methyl benzamide, an intumescent flame retardant, dicumyl peroxide, an antioxidant, a light stabilizer and a lubricant, wherein the polyolefin matrix is subjected to synergistic modification by phosphorus-nitrogen heterocyclic silane-plasma. The preparation method of the polyolefin matrix synergistically modified by phosphorus-nitrogen heterocyclic silane-plasma comprises the following steps: performing grafting reaction on polyolefin resin and phosphorus-nitrogen heterocyclic silane under the action of an initiator, and performing plasma surface treatment to endow the material with dual active sites. The preparation method comprises the following steps: melting and granulating a polyolefin matrix subjected to phosphorus-nitrogen heterocyclic silane-plasma synergistic modification, small organic molecules and auxiliaries, and performing extrusion molding under a crosslinking condition to obtain a cable body. The material disclosed by the invention has comprehensive advantages in flame-retardant efficiency, crosslinking degree and mechanical property, and is suitable for manufacturing high-safety power cables.

A preparation system and method for an isocyanate. The preparation system comprises a cold phosgenation reactor and a hot phosgenation reactor, which are connected in series, wherein the hot phosgenation reactor is used for receiving a material flow output from the cold phosgenation reactor and allows the material flow to undergo a hot phosgenation reaction so as to obtain an isocyanate; the hot phosgenation reactor comprises a rectifying section, a reaction section and a stripping section; a material flow inlet is provided between the rectifying section and the reaction section; and the reaction section comprises a plurality of layers of trays (100), and an outer weir (102) of an overflow weir of the reaction-section tray (100) at each layer has a different angle of inclination, so as to make the residence duration of the material flow on each reaction-section tray (100) greater than a set duration. By means of the solution, the residence duration of the material flow in the reaction section can reach the set duration, and the duration of a reaction of chloroformamide can be adjusted, which can thus reduce the number of solid particles generated, thereby solving the problem of same silting up a reactor.

Disclosed is a pharmaceutical composition for the treatment of tumors, the pharmaceutical composition comprising (6S, 9aS)-N-benzyl-8-({6-[3-(4-ethylpiperazin-1-yl) azetidin-1-yl] pyridin-2-yl} methyl)-6-(2-fluoro-4-hydroxybenzyl)-4, 7-dioxo-2-(propyl-2-en-1-yl) hexahydro-2H-pyrazino [2, 1-c] [1, 2, 3] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [1, 2, 4] triazolo [ The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof and administered in combination with a MEK inhibitor.

The invention relates to a flow battery carbon-based electrode and a preparation method and application thereof, and the preparation method comprises the following steps: respectively dissolving cobalt salt and alkali in a polar organic solvent, and uniformly mixing to form a precursor solution; placing a carbon-based material in the precursor solution, and carrying out a hydrothermal reaction to obtain a carbon-based electrode precursor; and performing high-temperature carbonization on the carbon-based electrode precursor in an inert atmosphere, cooling to room temperature after the reaction is completed, and then cleaning and removing impurities from a product to obtain the carbon-based electrode, the polar organic solvent is at least one of formamide, acetonitrile and N, N-dimethylformamide; after cobalt cyanide is deposited on the surface of the carbon-based material, surface etching and nitrogen doping are carried out on the carbon-based material under the high-temperature condition, surface modification of the carbon-based material is achieved, the contact area of the surface of the carbon-based electrode and electrolyte is increased, and the electrochemical performance of the carbon-based electrode is improved.

To provide a method for producing 4-ketobenzamide derivatives and 4-ketobenzoic acid derivatives.SOLUTION: The present invention provides a method for producing a 4-ketobenzamide compound represented by formula (2), by amidating a compound represented by formula (1), which is obtained through cyanation of a compound represented by formula (3), as well as a method for producing a 4-ketobenzoic acid derivative represented by formula (6), by hydrolyzing the compound represented by formula (1) or the compound represented by formula (2), and a method for producing a 4-ketobenzoic acid ester derivative represented by formula (5), by esterifying the compound represented by formula (2), wherein R1 represents a C1-C6 alkyl group or the like, R2 represents a C1-C6 alkyl group or the like, R3 represents a C1-C6 alkyl group or the like, X represents a halogen atom or the like, Y represents a C1-C6 alkyl group or the like, and n represents an integer of 0-3.SELECTED DRAWING: None

The invention relates to the technical field of environmental protection, and discloses a method for degrading formamide organic wastewater and recycling key metals of a retired lithium ion battery. The method comprises the following steps: S1, obtaining the positive electrode material of the retired lithium ion battery, mixing the positive electrode material with formamide organic wastewater, and carrying out hydrothermal reaction to obtain a leachate; s2, adjusting the pH value of the leachate to 6-14, and carrying out a transition metal precipitation reaction to obtain a transition metal hydroxide precursor and a lithium-rich filtrate; and S3, adding a sodium carbonate solution into the lithium-rich filtrate, carrying out a precipitation reaction, and collecting lithium carbonate. The formamide organic wastewater serves as an endogenous reducing agent, deep degradation of the formamide organic wastewater is achieved under the hydrothermal condition, efficient leaching of key metal in the retired lithium ion battery is achieved, and waste is treated with waste; the formamide degradation efficiency can reach 90% or above, and the defects that an existing formamide wastewater treatment method is high in energy consumption, large in reagent consumption, high in cost, low in degradation efficiency and large in environmental treatment pressure are overcome.

The invention provides a method for constructing planar chiral [2, 2] paracyclophane by cobalt-catalyzed asymmetric carbon-hydrogen bond activation-kinetic resolution, which comprises the following steps: by using a cobalt catalyst, a chiral ligand and an additive, taking a graphite felt electrode as an anode and taking a platinum sheet electrode as a cathode, carrying out racemization on [2, 2] paracyclophane under the condition of direct-current electrolysis, so as to obtain the planar chiral paracyclophane. The preparation method comprises the following steps: carrying out asymmetric carbon-hydrogen bond dehydrogenation coupling / kinetic resolution on 2, 2] paracyclophane formamide and aryl acid, and after the reaction is finished, carrying out corresponding post-treatment to obtain planar chiral [2, 2] paracyclophane formamide and planar chiral oxopara-[2, 2] paracyclophane; according to the method, electrochemical synthesis of planar chiral oxara-[2, 2] paracyclophane is realized through a method for catalyzing asymmetric carbon-hydrogen bond activation by virtue of a crustal high-yield transition metal, a reaction substrate is wide in universality and excellent in stereoselectivity, and a product and a split and recycled raw material can have an excellent ee value (up to gt; 99% ee) and a splitting factor (up to 1057).

The invention discloses an azodicarbonamide ratio fluorescence detection method based on a CoOOH nanosheet loaded Au nano-cluster material, and belongs to the technical field of fluorescence sensing. The CoOOH nanosheet loaded Au nano-cluster material provided by the invention is prepared by carrying out a one-step electrostatic assembly method on AuNCs and a CoOOH nanosheet. The CoOOH nanosheet loaded Au nano-cluster material has the fluorescence property of the AuNCs and the biomimetic catalytic performance of the CoOOH nanosheet at the same time. The invention further provides an azodicarbonamide ratio fluorescence detection method based on the CoOOH nanosheet loaded Au nano-cluster material, and compared with an existing detection method, the azodicarbonamide ratio fluorescence detection method has the remarkable advantages that the method is high in selectivity; by utilizing a ratio fluorescence mechanism, interference caused by environment and instrument fluctuation can be effectively reduced, reliable quantitative analysis of azodicarbonamide is realized, and the method has the advantages of high sensitivity and high credibility and has a wide prospect in the field of fluorescence sensing detection.

The present invention relates to a process for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of formula (I) and to the preparation and use of crystalline modification I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of formula (I).

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a 3-sulfamoyl benzamide compound as well as a preparation method and application thereof. The 3-sulfamoyl benzamide compound has a structure as shown in a formula I. In the formula I, X is chlorine or trifluoromethyl; r1 and R2 are independently C1-4 alkyl or R1, R2 and N atoms connected with R1 and R2 jointly form a heterocyclic group, and the heterocyclic group is a substituted or unsubstituted five-membered or six-membered heterocyclic group; and when the heterocyclic group is a substituted heterocyclic group, the substituent group in the substituted heterocyclic group is one or more of C1-4 alkyl, phenyl and acetyl. The 3-sulfamoyl benzamide compound disclosed by the invention has a remarkable proliferation inhibition effect on HCT116 colon cancer cells, HeLa human cervical cancer cells, MDA-MB-231 human breast cancer cells and A375 human malignant melanoma cells.

The present disclosure relates to a fungicide composition. More specifically, the present disclosure relates to a liquid fungicide composition comprising a combination of a benzamide based fungicide and a surfactant. The present disclosure also relates to a method for preparing the fungicide composition and a method for controlling the growth of a fungal plant pathogen using the fungicide composition.

The invention discloses a pesticide composition containing a pyrazolecarboxamide pesticide and application of the pesticide composition. The pesticide composition comprises an active component A which is the pyrazolecarboxamide pesticide and a component B which is at least one other pesticide defined in the specification, specifically, the invention relates to a pesticide composition for preventing and treating common lepidoptera, coleoptera, diptera, thysanoptera and homoptera pests of plants.

The present disclosure provides, in part, five-membered heteroarylcarboxamide compounds useful for disrupting HBV core protein assembly, and pharmaceutical compositions thereof, and methods for treating hepatitis B (HBV) infection. In another aspect, the present disclosure provides a method of treating HBV infection in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable excipient.

The invention relates to preparation of a crystalline allyl covalent organic framework material and application research of the crystalline allyl covalent organic framework material in benzamide cyclization green photocatalytic conversion. The SF-COF material is prepared by adopting a step-by-step synthesis method. The preparation method comprises the following steps: synthesizing a COF precursor by taking 1, 3-benzenetricarboxaldehyde and p-aminophenylacetonitrile as raw materials, and preparing the allylation covalent organic framework material with the electronic push-pull effect from the COF precursor and 5, 5 ', 5'-(benzene-1, 3, 5-triyl) tri (thiophene-2-formaldehyde) through a solvothermal method. The material is applied to the field of photocatalytic organic conversion, and benzamide cyclization and conversion of derivatives of benzamide are achieved under irradiation of a blue light LED. The prepared SF-COF has the advantages of efficient charge separation and electron conduction performance, good structural stability and chemical stability and the like. And a catalyzed organic reaction substrate has the advantages of wide universality range, good cycle stability and the like, and shows excellent photocatalytic conversion capability.

The invention relates to a lithium ion battery electrolyte additive 2, 4-dicarboxamido sulfonyl cyclobutanone and a corresponding high-temperature lithium ion battery electrolyte. The electrolyte comprises the following components: lithium salt, an anhydrous organic solvent and an electrolyte additive; wherein the electrolyte additive comprises 2, 4-dicarboxamido sulfonyl cyclobutanone, and the electrolyte additive comprises 2, 4-dicarboxamide sulfonyl cyclobutanone; the use amount of the 2, 4-dicarboxamido sulfonyl cyclobutanone in the electrolyte is 0.1%-10% of the total mass of the electrolyte. The high-temperature lithium ion battery electrolyte added with 2, 4-dicarboxamidosulfonyl cyclobutanone can improve the high-temperature discharge performance, the high-temperature charge performance, the high-temperature cycle performance and the safety performance of a lithium ion battery when the lithium ion battery works at 4.2 V, does not influence the first efficiency and the rate capability, and has a relatively good application prospect in a high-temperature system.

The invention belongs to the technical field of drug development, and particularly relates to application of (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide in preparation of drugs for treating nervous system diseases. The invention aims to provide a medicine which has small toxic and side effects and can target SLC11A2 to treat or improve nerve cell injury. According to the technical scheme, the invention relates to application of (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide in preparation of a medicine for treating nervous system diseases, in particular to application of (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide. It is proved that the compound (E)-N-benzyl-2-((5-(thiophenyl) furan-2-yl) methylene) hydrazine-1-thioformamide is small in toxic and side effect, and nerve cell damage can be protected or improved by targeting SLC11A2; and a new choice is provided for treating or improving nerve cell injury.

The invention discloses a continuous flow production method of high-purity chlorantraniliprole, and belongs to the technical field of chemical synthesis. The method comprises the following steps: simultaneously pumping a mixed solution containing 3-bromo-1-(3-chloro-2-pyridyl)-1H-pyrazole-5-formic acid, a solvent, an acid-binding agent and 2-amino-5-chloro-N, 3-dimethylbenzamide and a catalyst solution into a mixing unit of a continuous flow reactor I to form a reaction mixture flow; the material flow enters a continuous flow reactor I for condensation reaction to obtain a chlorantraniliprole solution; simultaneously pumping the mixed solution and a quenching agent solution into a continuous flow reactor II, and quenching to separate out crystals; and continuously centrifugally separating the quenching liquid containing the crystals, washing and drying to obtain a chlorantraniliprole refined product. According to the present invention, the full continuous flow process is adopted, the reaction unit and the post-treatment unit are included, the material continuously flows, and when the process is stable, the material composition, the temperature and other parameters in the reactor are only related to the reaction position and do not change with time, such that the production process and the product quality stability are ensured.

The invention discloses a molybdenum-manganese composite metal oxide catalyst for efficiently purifying NO2 as well as a preparation method and application of the molybdenum-manganese composite metal oxide catalyst, and relates to the technical field of catalysts. According to the technical scheme, ammonium metavanadate, oxalic acid, ammonium metatungstate and titanium dioxide are mixed to prepare turbid liquid, the turbid liquid is heated in a water bath, stirred and evaporated until the turbid liquid is solidified, and a vanadium-tungsten-titanium composite oxide precursor is prepared after drying and calcination; the preparation method comprises the following steps: dissolving manganese salt and ammonium molybdate in formamide, carrying out ultrasonic treatment to form a uniform solution, mixing the solution with the vanadium-tungsten-titanium composite oxide precursor powder, carrying out heat preservation and stirring, and finally drying and calcining to prepare the molybdenum-manganese metal diatom vanadium-tungsten-titanium composite oxide catalyst. The molybdenum-manganese composite metal oxide catalyst provided by the invention can realize efficient catalytic reduction of NO2 to form N2 and H2O at a low temperature of 200 DEG C, and the conversion rate of NO2 in a temperature interval of 200-400 DEG C is higher than 85%; and meanwhile, the N2 selectivity is kept close to that of a V2O5-WO3 / TiO2 catalyst.

There is provided a process for preparing 5,7-dimethyl-N-((1R,4R)-4- (pentyloxy)cyclohexyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, said process comprising at least a step of amide coupling a 5,7-Dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid with trans-4-(pentyloxy)cyclohexanamine using carbonyldiimidazole (CDI).

The present invention relates to a process for preparing acyloxymethyl esters of (4S)-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid of the formula (IIa) by optical resolution of the compound of the formula (II) using a hydrolase. The invention also relates to a process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (Ia), wherein the process comprises the optical resolution of the compound of the formula (II) using a hydrolase. The invention additionally also relates to the use of a hydrolase in a process for preparing a compound of formula (IIa). The invention further relates to the use of a hydrolase in a process for preparing a compound of formula (Ia).

The invention relates to the technical field of liquid crystal polymers, and discloses a high-temperature-resistant, electricity-conducting and heat-conducting graphene-LCP material and a preparation method thereof.The preparation method comprises the steps that a diacid monomer, p-hydroxybenzoic acid and 4, 4 '-bis (4-hydroxyphthalimide)-benzamido benzene are subjected to a carboxyl reaction, liquid crystal polyarylester is obtained and mixed with graphene oxide, and the high-temperature-resistant, electricity-conducting and heat-conducting graphene-LCP material is obtained. The liquid crystal polyarylester molecular chain contains an imide ring, so that the thermal decomposition mass loss temperature of the liquid crystal polyarylester LCP material can be improved. The liquid crystal polyarylester contains amido bonds and forms strong interaction with hydroxyl and carboxyl on the surface of the graphene oxide, the interfacial compatibility between the graphene oxide and the liquid crystal polyarylester can be improved, the graphene oxide does not need surface modification and has good dispersity in the LCP material, a conductive path is formed, and the conductivity and the antistatic performance are improved.

The invention relates to the technical field of wastewater treatment, and discloses a preparation method of a heavy metal capturing agent for wastewater treatment, which comprises the following steps: reacting 2-chloroethanol with trimellitic anhydride acyl chloride, and reacting with N, N-dimethyl ethyl trimesoamide to obtain a novel quaternary ammonium salt anhydride intermediate. The three-dimensional hyperbranched molecular chain heavy metal capturing agent contains three anhydride groups which are subjected to amidation polymerization reaction with two amino groups of diaminooxane to obtain the three-dimensional hyperbranched molecular chain heavy metal capturing agent. The heavy metal capturing agent has good adsorption sites, hydrophilicity and dispersibility in water, is not easy to gather, and is beneficial to improving the adsorption performance of the heavy metal capturing agent. Meanwhile, the heavy metal trapping agent contains a large number of carboxyl groups which can be coordinated with Pb < 2 + > and other metal ions, and meanwhile, quaternary ammonium salt cations can be subjected to electrostatic interaction with Cr2O7 < 2-> ions, so that the adsorption capacity of the heavy metal trapping agent on the Pb < 2 + >, Cr2O7 < 2-> and other metal ions is remarkably improved.

The invention provides a preparation method of an insecticide synergistic responsive release delivery system, and belongs to the technical field of insecticides. Chlorantraniliprole insecticide is dissolved in an acetone solvent containing Tween 80 to form a drug-carrier complex; then polymerizing the N-isopropylacrylamide temperature-sensitive monomer under the action of an ammonium persulfate and tetramethylethylenediamine initiation system to form a temperature-responsive hydrogel matrix; four key parameters including the optimal molar ratio, the optimal embedding temperature, the optimal embedding time and the optimal phase change temperature control precision of an amido hydrophilic group and an isopropyl hydrophobic group are calculated by applying a double-layer game model, and a drug-carrier complex is embedded into a hydrogel matrix through a physical embedding effect to construct a three-layer nested delivery structure; the technical problem that the pesticide effect utilization rate is low due to the fact that the pesticide lacks an accurate temperature-responsive release control mechanism in environmental application is solved.