46 results about "Cyclobutane" patented technology

The invention provides a preparation method of (S)-oxetane-2-methylamine. The preparation method of (S)-oxetane-2-methylamine comprises the following steps: (1) carrying out ring closing reaction on a compound A under an alkaline condition to obtain a compound B; (2) reacting the compound B with dibenzylamine to obtain a compound C; (3) reacting the compound C with a reducing agent to obtain a compound D; (4) reacting the compound D with paratoluensulfonyl chloride to obtain a compound E; (5) reacting the compound E with alkali to obtain a compound F; and (6) carrying out a reaction on the compound F and palladium on carbon to obtain the (S)-oxetane-2-methylamine. According to the preparation method provided by the invention, ring expansion reaction using trimethylsulfoxide iodide in the prior art is avoided, the problem that residual sulfur elements cause poisoning of a palladium-carbon catalyst is solved, meanwhile, sodium azide is also avoided, and the preparation method is safe and reliable in process, high in chiral purity and yield and suitable for industrial large-scale production.

Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.

The present invention relates to compounds of formula (I) or formula (II) or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula (I) and said compound of formula II each comprises at least one ONO2 or ONO moiety; R1 is C1-C3alkyl; R2 is H, C1-C6alkyl, C3-C6cycloalkyl, C1-C2alkoxy, C2-C4alkenyl; R3 is C1-C4alkyl optionally substituted with C1-C2alkoxy, C3-C4cycloalkyl, C2-C4alkenyl; R4 and R5 are each independently H or C1-C6alkyl optionally substituted with F, OH, ONO, ONO2, COOH, C1-C3alkoxy, C3-C6cycloalkyl; or together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein preferably said heterocyclic ring is selected from aziridine, azetidine, pyrollidine, piperidine, morpholine, piperazine, homo-piperazine, 2,5-diazabicyclo[2,2,1]heptane and 3,7-diazabicyclo[3,3,0]octane, wherein said heterocyclic ring is optionally substituted with independently one or more R6; R6 is C1-C6alkyl optionally substituted with independently one or more halogen, OH, ONO, ONO2, C1-C3alkoxy, C1-C3haloalkoxy, COOR7, NR8R9, C═NR10; R7 is H, or C1-C4alkyl optionally substituted with F, OH, ONO, ONO2, NR8R9; R8 and R9 are independently H, or C1-C4alkyl optionally substituted with ONO, ONO2; R10 is C1-C4alkyl optionally substituted with F, ONO, ONO2; C3-C6cycloalkyl; pharmaceutical compositions thereof, and their use in methods of treating or preventing a disease alleviated by inhibition of PDE5 in a human or in a non-human mammal.

The invention relates to a method for synthesizing a 3, 3-dimethoxy cyclobutane-1, 1-isopropyl diformate compound IV, and the reaction is as follows: M is selected from potassium, sodium, lithium, calcium and magnesium; comprising the following steps: (1) carrying out salt forming reaction on a compound shown as a formula I in an organic solvent in the presence of alkali, and filtering after the reaction is completed to obtain a solid compound shown as a formula II; and (2) carrying out ring closing reaction on the solid compound as shown in the formula II and a compound as shown in a formula III in an aprotic solvent in the presence of a catalyst to obtain a compound as shown in a formula IV. The method is simple in synthesis route, mild in process condition, simple and convenient to operate, high in yield and good in product purity, solves the technical problems of tar impurities and alcohol ester exchange byproducts in the prior art, and is suitable for industrial large-scale production.

The invention relates to a synthesis method of chiral N-Fmoc-2-methyl azetidine-2-carboxylic acid, and relates to the technical field of organic synthesis.The synthesis method comprises the following steps that Fmoc-alpha-methyl-L-glutamic acid-5-tert-butyl ester is subjected to deprotection, and a compound I is obtained; carrying out esterification reaction on the compound I and aryl halide in an alkaline solution to obtain a compound II; removing an Fmoc protecting group from the compound II in an alkaline solution to obtain a compound III; the compound III is subjected to lactamization under the action of trimethylchlorosilane and tert-butyl magnesium bromide, and a compound IV is obtained; selectively reducing amide of the compound IV under the action of a borane reducing reagent to obtain a compound V; hydrolyzing the compound V in an alkaline solution, and removing benzyl to obtain a compound VI; and protecting the amino group of the compound VI through Fmoc to obtain a compound VII, namely the chiral N-Fmoc-2-methyl azetidine-2-carboxylic acid. The method has the effect of improving the synthesis efficiency of the chiral N-Fmoc-2-methyl azetidine-2-carboxylic acid, and the product has high yield and purity.

The invention discloses a 2-azabicyclo [3.1. 1] heptene derivative as well as a synthesis method and application of the 2-azabicyclo [3.1. 1] heptene derivative. The 2-azabicyclo [3.1. 1] heptene derivative provided by the invention is obtained by exciting a rhodium complex by visible light to catalyze bicyclo [1.1. 0] butane to perform cycloaddition reaction. The 2-azabicyclo [3.1. 1] heptene derivative constructed by the method can be applied to the aspects of simulating bioisosteres and the like, is expected to obtain more innovative achievements in the field of organic synthesis methodology, and also can provide a brand new thought and a structural basis for developing novel drug molecules; and the medicine with better curative effect and less side effect can be designed.

The present invention relates to a novel salt of an imidazo[1,2-a] pyridine compound, and more specifically, to azetidin-1-yl\{8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl\}methanone diphosphate and a method for preparing same. The azetidin-1-yl\{8-[(2,6-dimethylbenzyl)amino]-2,3-dimethylimidazo[1,2-a]pyridin-6-yl\}methanone diphosphate according to the present invention has excellent solubility, volume density, light / temperature stability, acid / base stability, and the like, and thus can be usefully used in the formulation of pharmaceuticals.

The invention discloses a copper-catalyzed aryl aldehyde ortho-position direct C-H etherification method, which comprises the following steps: by taking aryl aldehyde as a raw material, adding alcohol or phenol as shown in a formula (II), a copper catalyst, a guiding group, alkali and a solvent into a reactor, and reacting in an argon gas atmosphere to prepare an aryl ether compound as shown in a formula (III), a substituent group R1 is hydrogen, methyl, trifluoromethyl, methoxyl, phenyl, iodo, isopropyl, trimethylsilyl, dimethylamino, fluoro, chlorine, ester, tourmaline, naphthyl, isoquinolyl, benzothienyl or phenanthryl; a substituent group R2 is hydrogen, methyl, trifluoromethyl, methoxyl, phenyl, iodo, isopropyl, trimethylsilyl, dimethylamino, fluoro, chlorine, ester, tourmaline, naphthyl, isoquinolyl, benzothienyl or phenanthryl; and a substituent group R2 is methyl, 4-fluorophenyl, cyclobutane methyl, 4-tert-butyl phenyl, pentafluorophenyl, 4-cyanophenyl, 4-methyl ester phenyl, 3-nitrophenyl, adamantane methyl, cyclohexyl or an oestrone analogue. The copper catalyst and amino acid which are low in cost and easy to obtain are used as guiding groups, the operation process is simple and efficient, and the corresponding aryl ether compound can be obtained with the good yield.

The invention belongs to the technical field of biological medicines, and particularly relates to a synthetic method and application of a cyclobutane and chroman skeleton molecular compound, which is a method for synthesizing a cyclobutane and chroman skeleton molecular compound through a triplet-triplet energy transfer mechanism by using a blue light excitation photocatalyst under a mild condition. The invention discloses a method for constructing a cyclobutane and chroman skeleton molecular compound by efficiently, highly regionally and stereoselectively catalyzing intramolecular [2 + 2] cycloaddition of a 2H-chromene compound, and further explores the application potential of the cyclobutane and chroman skeleton molecular compound in research and development of anti-glioma drugs. The obtained compound can specifically and effectively kill glioma stem cells, and a new lead compound and thought are provided for research and development of anti-glioma drugs.

To provide a composition containing a compound having at least one of a thiirane group or a thietane group, the composition imparting a cured product excellent in storage stability, curability and thermostability.SOLUTION: A composition includes: a compound (A) having one or more of a thiirane group or a thietane group; a compound (B) selected from a compound group having a skeleton of expression (I) or (II).SELECTED DRAWING: None

To provide a new compound, polymer and composition which can be derived from a biomass-derived compound.SOLUTION: A polymer includes a plurality of constitutional units represented by the following formula (1) or (2), wherein R1 represents a methylene group or an ethane-1,2-diyl group.SELECTED DRAWING: None

The present application provides a kind of singlet oxygen activated photo-cage chemiluminescence molecule, which has the structure shown in formula (I), wherein X is hydrogen or halogen, PC represents photo-cage group, R 1 It is an electron-withdrawing group containing oxygen and / or nitrogen, R 2 It is selected from adamantane, cyclobutane, methyl cyclobutyl formate and tetrahydrothiopyran-1,1-dioxide. The chemiluminescence molecule is activated by singlet oxygen and triggered by light of a specific wavelength, and through the processes of oxidation, photolysis, electron transfer, etc., an excited state benzoate structure is generated, which emits blue-green light when returning to the ground state. 2 Group, photo-cage group and R 1 Electron-withdrawing group synergistic effect, oxidation, photolysis, electron transfer, etc. process, generate excited state benzoate structure, it emits blue-green light when returning to the ground state.

The present application relates to a kind of flame-retardant polyester solid electrolyte membrane and its preparation method, belong to solid battery technical field, the preparation raw material of flame-retardant polyester solid electrolyte membrane includes neopentyl glycol diacrylate, 1-methyl-1-propyl piperidine-1-ol double ((trifluoromethyl) sulfonyl) imidazole, fluorinated ethylene carbonate, cyclobutane sulfone, sodium bis (trifluoromethylsulfonyl) imide, triethylene glycol dimethyl acrylate, azobisdimethylvaleronitrile, dust cloth, and the flame-retardant performance of this flame-retardant polyester solid electrolyte membrane is excellent, while the performance of flame-retardant polyester solid electrolyte membrane in electrochemical window and ionic conductivity etc. Excellent, the assembled solid battery has excellent electrochemical performance and stability at room temperature, and can be adapted to a variety of positive electrode materials, it is beneficial to the commercialization development of solid battery.

This disclosure provides a method for treating sulfolane waste liquid, wherein the sulfolane waste liquid is mixed with a photocatalyst and then subjected to a dark reaction and a photocatalytic reaction sequentially; wherein the photocatalyst is a BiPO4 / C3N4 composite photocatalyst. This method is green, energy-saving, simple, and efficient, and can convert sulfolane in the sulfolane waste liquid into sulfolane and sulfuric acid under normal temperature and pressure conditions without the addition of external organic reagents. In this method, sulfolane is directly released in gaseous form, reducing the time and energy costs associated with waste liquid separation; small molecule organic pollutants in the sulfolane waste liquid are degraded under photocatalysis, leaving only the sulfuric acid generated in the reaction and a small amount of the original inorganic salts after degradation.

The present invention relates to compounds of formula (I) or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein R1 is C1-C3alkyl optionally substituted with F, C3-C6cycloalkyl, C1-C3alkoxy; X represents a bond or C1-C3alkylene optionally substituted with OH, ONO, ONO2; R2 is H, OH, ONO, ONO2, C(O)OH, C(O)OC1-C3alkyl, CHO, CN, C1-C3alkoxy, OC(O)H, OC(O)—C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3alkyl, OC1-C3alkylene-C(O)N(R6)OR7, S(O0-2)C1-C3alkyl, CR8═N—OR9, CR8═N—NR10R11, CR8═NR12 or CR8═N—ONO2; R3 is C1-C6alkyl optionally substituted with F, OH, ONO, ONO2, C1-C3alkoxy, C3-C6cycloalkyl; C3-C6cycloalkyl, C2-C6alkenyl, C2-C6alkynyl; R4 is C1-C6alkyl optionally substituted with C3-C6cycloalkyl, C1-C6alkoxy, F, ONO, ONO2; C2-C6alkenyl, C2-C6alkynyl, C3-C6cycloalkyl; R5 is H, SO2N—R13R14, NHSO2NR13R14; R6 is H or C1-C3alkyl; R7 is H, C1-C3alkyl, C1-C3alkoxy, C1-C3alkyl substituted with phenyl, benzyl or a heterocyclic ring, wherein said phenyl, benzyl or said heterocyclic ring are independently optionally substituted by C1-C3alkyl, F; R8 is H, CH3 or C2H5; R9: H, C1-C3alkyl optionally substituted with OH, ONO, ONO2, CN, COOH, COOC1-C3alkyl, C1-C3alkoxy, OC(O)H, OC(O)—C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3alkyl, OC1-C3alkylene-C(O)N(R6)OR7, S(O0-2)C1-C3alkyl; R10 and R11 are each independently H, C1-C3alkyl optionally substituted with OH, ONO, ONO2, CN, COOH, COOC1-C3, C1-C3alkoxy, OC(O)H, OC(O)—C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3alkyl, OC1-C3alkylene-C(O)N(R6)OR7, S(O0-2)C1-C3alkyl; i or together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein preferably said heterocyclic ring is selected from aziridine, azetidine, pyrolidine, piperidine, morpholine, piperazine and homopiperazine, wherein said heterocyclic ring is optionally substituted with C1-C3 alkyl; R12 is C1-C3 alkyl optionally substituted with OH, ONO, ONO2, CN, COOH, COOC1-C3alkyl, C1-C3alkoxy, OC(O)H, OC(O)—C1-C3alkyl, C(O)N(R6)OR7, OC1-C3alkylene-C(O)OH, OC1-C3alkylene-C(O)OC1-C3alkyl, OC1-C3alkylene-C(O)N(R6)OR7, S(O0-2)C1-C3alkyl; R13 and R14 are each independently H or C1-C6alkyl optionally substituted with F, OH, ONO, ONO2, COOH, C1-C3alkoxy, C3-C6Cycloalkyl; or together with the nitrogen atom to which they are attached form a heterocyclic ring, wherein preferably said heterocyclic ring is selected from aziridine, azetidine, pyrolidine, piperidine, morpholine, piperazine, homopiperazine, 2,5-diazabicyclo[2,2,1]heptane and 3,7-diazabicyclo[3,3,0]octane, wherein said heterocyclic ring is optionally substituted with R15; R15 is C1-C6alkyl optionally substituted with halogen, OH, ONO, ONO2, C1-C3alkoxy, C1-C3haloalkoxy, COOR16, NR17R18, C═NR19, or with a tetrazole group which is optionally substituted with C1-C3alkyl; or a heteroaryl ring which is optionally substituted with F, wherein the at least one heteroatom of said heteroaryl ring is nitrogen; R16 is H, or C1-C4alkyl optionally substituted with F, OH, ONO, ONO2, NR17R18, or with a heteroaryl ring, wherein the at least one heteroatom of said heteroaryl ring is nitrogen, and wherein preferably said heteroaryl ring is selected from pyrrolidine, piperidine, piperazine, morpholine, pyrrole, and imidazole, wherein nitrogen atom is directly bound to C1-C4 alkyl; R17 and R18 are each independently H or C1-C4alkyl optionally substituted with ONO, ONO2; R19 is C1-C4alkyl optionally substituted with F, ONO, ONO2; C3-C6Cycloalkyl; and their use in methods of treating or preventing a disease alleviated by inhibition of PDE-5 in a human or in a non-human mammal.

The invention relates to stoichiometric salts of tetracarboxylic acids and diamines of the general formula (I) wherein R1 is selected from the group consisting of tetravalent residues of butane, cyclobutane, cyclopentane, cyclohexane, tetrahydrofuran and benzophenone and R2 is selected from the group consisting of divalent residues of unbranched, branched or cyclic aliphatic hydrocarbons having 3 to 15 carbon atoms, with the proviso that the salts of the formula (I) are water-soluble and are selected from the group consisting of compounds (1) to (28); and to polyimides prepared from these salts by polycondensation.

The application discloses a method for synthesizing polyether sulfone resin, and specifically comprises the following steps: adding solvent cyclobutane sulfone into a reactor provided with a nitrogen gas pipe, a gas distributor, mechanical stirring and a water separation condensing device, starting stirring, and adding monomer 4,4'-dichlorodiphenyl sulfone, bisphenol S and a salifying agent; after nitrogen replacement, the nitrogen flow is adjusted, and the temperature is raised to 210-240 DEG C; the gas distributor is used for distributing nitrogen, the system is continuously bubbled by nitrogen flow for dehydration, and the reaction is carried out for 3-5 hours; the nitrogen is turned off, the polymerized mucus is poured into water for precipitation, and the polyether sulfone resin is obtained through the steps of crushing, washing and drying. The application uses high-purity nitrogen flow for dehydration, thus avoiding the addition of flammable and toxic organic water-carrying agents, improving operation safety, not polluting products, and being simple in operation and short in reaction period.

The invention relates to a compound, a composition, a cured product thereof, a molded product, a display device, and a solid-state imaging device. The present invention addresses the problem of providing a composition capable of providing a cured product exhibiting a high refractive index and excellent solvent resistance. The solution of the present invention is a composition containing: a compound having at least one thiirane group or thietanyl group; an alicyclic epoxy compound having a structure in which an alicyclic unsaturated hydrocarbon is epoxidized; a photoacid generator; and a compound having a group represented by formula (Z). In formula (Z), A represents a hydrogen atom or a cation. And * represents a bonding position. # imgabs0 #

This invention provides a method for synthesizing milobalin benzylsulfonic acid, comprising the following steps: a chiral enone undergoes a condensation reaction with cyanoacetate in the presence of ammonium acetate to obtain an unsaturated cyano ester; next, the unsaturated cyano ester undergoes a condensation reaction with nitromethane to obtain a nitro ester; the nitro ester is then deesterified at high temperature to obtain a chiral nitro nitrile, which is then reduced to a chiral amino nitrile; subsequently, the chiral amino nitrile is hydrolyzed to obtain the free base of milobalin; finally, the free base of milobalin is salted with benzylsulfonic acid to obtain milobalin benzylsulfonic acid. This invention stereospecifically constructs a chiral cyclobutane quaternary carbon center to obtain a chiral nitro ester with a single stereoconfiguration, avoiding the chiral isomer waste generated by chiral isomer resolution, eliminating the need for chiral column separation or chiral resolution, significantly reducing production costs, and simultaneously avoiding the environmental pollution caused by residual heavy metal titanium in the product and solid waste heavy metal titanium.

The application relates to the technical field of materials, and discloses a production method of MPP functional material for communication pipelines, the MPP functional material is prepared by mixing polypropylene as a base material with multiple additives and then performing a melt extrusion process, modified additive one and modified additive two in the additives can react with a maleic anhydride grafted polypropylene compatibilizer in the melt extrusion process, can not only introduce rigid cyclobutane and carbazole alternate chain links into the polypropylene structure, effectively improve the impact toughness of the polypropylene, but also form a micro three-dimensional connection network between the aluminum silicate fiber and the polypropylene base material, enable the aluminum silicate fiber to undertake a chemical crosslinking core, realize efficient stress load transmission and transfer, enable the advantages of the aluminum silicate fiber to be efficiently utilized, thereby effectively enhancing the mechanical strength of the polypropylene, in addition, the natural rubber can play a toughening effect, and further improve the toughness of the material.

To provide a composition capable of giving a cured product exhibiting a high refractive index and having good film-forming properties.SOLUTION: The composition contains a compound (A) having a thiirane group or a thietane group, and a compound (B) having a group represented by formula (b) and a urethane bond in the molecule. [In Formula (b), * represents a bonding position. ] SELECTED DRAWING: None

The invention discloses a polythiazolidine compound as well as a preparation method and application thereof. The structural formulas of the polythiazolidine compounds are shown as a formula I, a formula II and a formula III. The preparation method comprises the following steps: carrying out a first-step reaction on a polyisocyanide compound and elemental sulfur under the catalytic action of elemental selenium or alkali, and then adding a polyamino oxetane compound to carry out a second-step reaction to obtain the polythiazolidine compound. The preparation method is mild in condition, efficient in reaction, high in yield and novel in product structure, use of dangerous reagents can be avoided, and in-situ construction of the polythiazolidine compound can be achieved; the polythiazolidine compound provided by the invention has high molecular weight, good thermal stability, high refractive property and unique luminescence property.

To provide a method for producing compounds having a perfluoro five-membered ring sulfonylamide and compounds having perfluoro azacyclobutane (azetidine).SOLUTION: There is provided a method for producing compounds represented by formulas (2) and (3) by subjecting a benzene-based aromatic hydrocarbon-substituted perfluoro cyclic sulfonylimide compound represented by formula (1) (where R represents a benzene-based aromatic hydrocarbon group) to the action of a photosensitizer under light irradiation.SELECTED DRAWING: None

The invention discloses high-toughness thermosetting polyimide resin as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out a reaction on a dianhydride monomer containing a benzobisnorbornene cyclobutane structure, an aromatic diamine monomer and a phenylacetylene phthalic anhydride end-capping reagent by adopting a one-pot method to obtain a reactant, and carrying out post-treatment to obtain the soluble thermosetting polyimide resin. The structural formula of the soluble thermosetting polyimide resin is # imgabs0 #; according to the invention, the polyimide resin is directly prepared by adopting a one-pot method, not only can the release of small molecule volatile matters in the molding process of the composite material be avoided, but also the dianhydride monomer containing the benzobisnorbornene cyclobutane structure is adopted, so that the prepared thermosetting polyimide resin has high solubility, heat resistance and mechanical toughness after being imidized; advanced composite materials prepared from the resin can be widely applied to the field of aerospace.

Described is a process for preparing a recycle content polyester, the process comprising obtaining a recycled propylene composition derived from cracking a recycle content pyrolysis oil composition made from a waste plastic-containing stream, using the recycled propylene as a feedstock in a reaction scheme to produce a polyester reactant, and reacting the polyester reactant to prepare at least one polyester.

This invention discloses a high-throughput synthesis method for 1-phenylazine heterocyclic butane compounds, comprising the following steps: in a solvent, the compound shown in Formula I and the compound shown in Formula II undergo a C-N coupling reaction in the presence of a catalyst and a base to obtain the 1-phenylazine heterocyclic butane compound shown in Formula III; wherein, R1 and R2 are any one of alkyl, halogen, aryl, substituted aryl, alkoxy, hydroxy, and nitrile groups; R3 is any one of F, Cl, Br, and I; and R4 is any one of hydroxyl, alkyloxy, H, halogen, and alkyl groups. This invention constructs a series of nitrogen heterocyclic compounds through high-throughput synthesis, obtaining a series of nitrogen heterocyclic compounds, and, through appropriate high-throughput screening, obtains the optimal reaction conditions in a very short time, thus solving the problems of the complexity of constructing carbon-nitrogen heterocycles and the difficulty in selecting conditions, as well as the high labor and time costs associated with existing synthetic methods.

The invention relates to the technical field of analytical chemistry mass spectrum imaging, in particular to a P-B reaction online detection system and method, and the system comprises a sample fixing unit, a multi-dimensional control platform, a fluid transmission unit, an auxiliary catalysis unit and a mass spectrum acquisition unit. According to the present invention, the P-B reaction and the mass spectrometry imaging technology are combined, the P-B reaction is adopted to generate the oxetane structure at the double bond through the ultraviolet light induced [2 + 2] cycloaddition reaction, and the characteristic fragment is generated after the collision induced dissociation so as to achieve the accurate positioning of the double bond position, and solve the problem of the lipid isomer spatial distribution analysis; meanwhile, accurate positioning and analysis of lipid carbon-carbon double bond positions in a complex biological sample are realized by utilizing high sensitivity and spatial resolution capability of a mass spectrum imaging technology; the method can be applied to the fields of biomedical research, metabonomics and drug development, and an innovative analysis method is provided for lipid molecular structure analysis and function research.