6 results about "Cyclobutane" patented technology

The present application provides a kind of singlet oxygen activated photo-cage chemiluminescence molecule, which has the structure shown in formula (I), wherein X is hydrogen or halogen, PC represents photo-cage group, R 1 It is an electron-withdrawing group containing oxygen and / or nitrogen, R 2 It is selected from adamantane, cyclobutane, methyl cyclobutyl formate and tetrahydrothiopyran-1,1-dioxide. The chemiluminescence molecule is activated by singlet oxygen and triggered by light of a specific wavelength, and through the processes of oxidation, photolysis, electron transfer, etc., an excited state benzoate structure is generated, which emits blue-green light when returning to the ground state. 2 Group, photo-cage group and R 1 Electron-withdrawing group synergistic effect, oxidation, photolysis, electron transfer, etc. process, generate excited state benzoate structure, it emits blue-green light when returning to the ground state.

This invention provides a method for synthesizing milobalin benzylsulfonic acid, comprising the following steps: a chiral enone undergoes a condensation reaction with cyanoacetate in the presence of ammonium acetate to obtain an unsaturated cyano ester; next, the unsaturated cyano ester undergoes a condensation reaction with nitromethane to obtain a nitro ester; the nitro ester is then deesterified at high temperature to obtain a chiral nitro nitrile, which is then reduced to a chiral amino nitrile; subsequently, the chiral amino nitrile is hydrolyzed to obtain the free base of milobalin; finally, the free base of milobalin is salted with benzylsulfonic acid to obtain milobalin benzylsulfonic acid. This invention stereospecifically constructs a chiral cyclobutane quaternary carbon center to obtain a chiral nitro ester with a single stereoconfiguration, avoiding the chiral isomer waste generated by chiral isomer resolution, eliminating the need for chiral column separation or chiral resolution, significantly reducing production costs, and simultaneously avoiding the environmental pollution caused by residual heavy metal titanium in the product and solid waste heavy metal titanium.

The application relates to a continuous flow preparation process of cyclobutane tetracarboxylic dianhydride, maleic anhydride is added into a material storage bottle, a reaction solvent is added, the saturated solution of maleic anhydride is prepared by fully stirring, and temperature control is conducted on the saturated solution; the light source of a reactor is turned on in advance, the saturated solution of maleic anhydride is sent to the reactor, the reaction liquid output from the reactor is sent to a product separator, the separated solid is recycled, and the liquid is sent back to the material storage bottle; a circulating channel is formed among the material storage bottle, the reactor, the product separator and the material storage bottle, and the circulating channel is always maintained in a fluid flow state. The application constructs the continuous flow production equipment capable of always maintaining the fluid flow, the solid separated in the reactor by light excitation can be timely taken into the product separator for separation, the solid cannot adhere to the inner wall of the reactor to affect the light blocking, and the light can always be more uniformly and thoroughly penetrated through the reactor and utilized.