104 results about "Heptene" patented technology

Provided herein are polymorphs and crystalline forms of 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline (Compound of Formula (I)), pharmaceutical compositions thereof, and methods of their use, for example, in the treatment of cancer. Also provided herein are synthetic processes for the manufacture of a compound of Formula (I) (i.e., 2-fluoro-5-((5S,5aS,6S,9R)-1-fluoro-12-(((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methoxy)-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]heptalen-2-yl)-3-methyl-4-(trifluoromethyl)aniline). Also provided are compounds useful in its synthesis (e.g., those of Formulae (A), (B), (By), and (H)) and synthetic processes directed thereto.

The present invention relates to the field of metal corrosion and protection, and specifically to a preparation method and application of a modified chitosan Schiff base corrosion inhibitor. The preparation method comprises six steps: (1) preparing a gel-like chitosan dispersion; (2) preparing an ethanol solution of 2,6-dimethyl-5-heptenal; (3) adding the gel-like chitosan dispersion; (4) adding the ethanol solution of 2,6-dimethyl-5-heptenal and conducting a Schiff base reaction; (5) rotary evaporation and dehydration of the reaction product; and (6) washing, filtering, and drying. The present invention utilizes 2,6-dimethyl-5-heptenal, a common food additive, as a modifier to condense with natural polymer chitosan to prepare an acid corrosion-resistant corrosion inhibitor, with a simple process and low production cost. The invention is applied to N80 steel sheets in a hydrochloric acid medium for corrosion protection, uses a low concentration, and effectively improves the corrosion inhibition rate of the corrosion inhibitor on metals. The invention is a green, environmentally friendly, economical, and efficient corrosion inhibitor with good promotion prospects.

The invention belongs to the technical field of stripping liquid, and particularly discloses water-based photoresist stripping liquid and a preparation method thereof. The water-based photoresist stripping liquid is prepared from the following raw materials in percentage by mass: 10 to 15 percent of quaternary ammonium salt compound, 15 to 25 percent of water-soluble organic solvent, 0.2 to 0.5 percent of alkanolamine substance, 0.03 to 0.05 percent of metal protective agent and the balance of deionized water, the quaternary ammonium salt compound is prepared by the following steps: reacting 6-heptene-1-alcohol with ethylene oxide to obtain a compound 1, carrying out amidation reaction on allyl glycidyl ether and dimethylamine to obtain a compound 2, and carrying out chlorination reaction on sodium 2-chloroethanesulfonate and the compound 2 to obtain a compound 3; and finally polymerizing the compound 1 and the compound 3 under the initiation action of azodiisobutyronitrile. All the components in the stripping liquid have a synergistic effect, so that the photoresist is effectively stripped, and the stripping liquid is free of residues, more efficient and good in corrosion-resistant effect.

The invention discloses an enzyme catalysis preparation method of a milobalin intermediate. According to the method, racemization 3-ethyl bicyclo [3.2. 0] hept-3-ene-6-ketone is used as a substrate, specific ketoreductase is used as a catalyst, (1S, 5R)-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-ketone is selectively reduced into (1S, 5R)-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-alcohol, and a target compound milobalin intermediate (1R, 5S)-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-ketone is reserved. According to the method disclosed by the invention, only one enzyme is used, the concentration of a conversion substrate can reach 200g / L, the yield can reach 47.4%, the ee value can reach 99.8%, the operation is simple, the resolution efficiency is high, the selectivity is good, and the method can be used for industrial production.

The present application relates to bicyclo[2.2.1]hept-5-en-2-ol and related compounds, methods of making them, and methods of using them as flavor and fragrance ingredients in food, cosmetic, pharmaceutical, consumer, and other compositions and products.

The invention discloses a composition for repelling aphids and preventing potato Y virus infection and a virus and insect inhibitor, and belongs to the technical field of plant disease prevention and control. The pharmaceutical composition provided by the invention is prepared from at least two of 1-pentene-3-ketone, 2-ethyl furan and cis-4-heptenal, and the pharmaceutical composition is prepared from at least two of 1-pentene-3-ketone, 2-ethyl furan and cis-4-heptenal. The pharmaceutical composition not only can avoid aphids and reduce the probability that crops are infected by potato Y viruses, but also can realize the synergistic interaction among the drugs and avoid or reduce the drug resistance of the aphids to the drugs, so that the pharmaceutical composition has important practical value and application prospect in the technical field of plant disease control.

The invention relates to a preparation method of a catalyst for preparing 1-hexyl methyl acetate by addition of n-heptene and acetic acid, which comprises the following steps: impregnating a carrier sulfonic acid group strong acid resin into a heteropoly acid solution, stirring at 20-50 DEG C for 8-24 hours, and controlling the mass ratio of the sulfonic acid group strong acid resin to the heteropoly acid solution to be (10: 1)-(1: 3); and after stirring, filtering, and drying a solid obtained after filtering at 80-140 DEG C to obtain a finished product. The invention also provides a synthetic method for synthesizing 1-hexyl methyl acetate by using the catalyst. The supported solid acid catalyst can be recycled from reaction slurry through simple liquid-solid separation means such as filtration and centrifugation, and good product selectivity can be obtained.

The application discloses a fruit essence preparation method, comprising the following steps: S1. mixing and stirring 2-acetyl-5-methyl furan 0.8-1.9 parts by mass, 2-ethyl furan 1.5-3 parts by mass, hop tincture 1.7-3.2 parts by mass, angelica root oil 1.1-2.5 parts by mass, linalool 1-3 parts by mass and 2,6-dimethyl-5-heptenal 1.3-2.8 parts by mass to obtain a fragrance base; and S2. mixing and stirring the fragrance base and solvent 70-80 parts by mass, adding a surfactant 7-12 parts by mass, and continuously stirring to obtain the fruit essence. The fruit essence prepared by the fruit essence preparation method has pure fruit aroma.

This invention discloses a lemongrass fermentation broth, its preparation method, and its application. The lemongrass fermentation broth simultaneously meets the following conditions: it contains live Lactiplantibacillus microorganisms, and the total number of live bacteria is ≥1×10⁻⁶. 9 The fermented lemongrass broth contains cfu / mL and contains volatile active ingredients, including at least linalool and methyl heptenone. Compared with unfermented lemongrass raw materials, the content of methyl heptenone in the lemongrass fermentation broth has increased from undetectable to over 10%, and the relative content of linalool has increased to over 20%. This invention's lemongrass fermentation broth possesses both a high viable bacterial count and a specific spectrum of volatile active ingredients. Through microbial fermentation, it achieves the targeted transformation of volatile components in lemongrass raw materials, particularly significantly increasing the content of linalool, methyl heptenone, and various ester aroma components, thus possessing broad prospects for industrial application.

The application discloses a polyolefin resin composition and a preparation method and application thereof, and the polyolefin resin composition comprises the following components in parts by weight: linear PE resin 60-92 parts; HDPE 2-10 parts; and cyclic polyolefin resin 6-30 parts; the content of bicycloheptene in the cyclic polyolefin resin is greater than or equal to 75%, and the heat distortion temperature is greater than or equal to 127 DEG C. The polyolefin resin composition has good extinction effect and is suitable for packaging materials with high extinction effect requirements.

This invention discloses a thermal insulation and soundproof building decorative panel, characterized in that it is made from the following raw materials in parts by weight: 30-40 parts of N-(4-cyano-3-trifluoromethylphenyl)methacrylamide / N-tris(hydroxymethyl)methacrylamide / 5-vinylbicyclo[2.2.1]hept-2-ene copolymer, 8-12 parts of hollow SiO2 nanofibers, 3-5 parts of foamed alumina, 5-8 parts of terminal thiol hyperbranched polysulfide, 20-25 parts of inorganic filler, 1-3 parts of coupling agent, 0.8-1.2 parts of peroxide initiator, and 0.3-0.5 parts of foaming agent. This invention also discloses a method for preparing the aforementioned thermal insulation and soundproof building decorative panel. The thermal insulation and soundproof building decorative panel disclosed in this invention has significant thermal insulation effect, excellent comprehensive performance and performance stability, good fire resistance, and low preparation cost.

The invention discloses a 2-azabicyclo [3.1. 1] heptene derivative as well as a synthesis method and application of the 2-azabicyclo [3.1. 1] heptene derivative. The 2-azabicyclo [3.1. 1] heptene derivative provided by the invention is obtained by exciting a rhodium complex by visible light to catalyze bicyclo [1.1. 0] butane to perform cycloaddition reaction. The 2-azabicyclo [3.1. 1] heptene derivative constructed by the method can be applied to the aspects of simulating bioisosteres and the like, is expected to obtain more innovative achievements in the field of organic synthesis methodology, and also can provide a brand new thought and a structural basis for developing novel drug molecules; and the medicine with better curative effect and less side effect can be designed.

The present invention relates to a method for detecting related substances in an oseltamivir phosphate starting material. The oseltamivir phosphate starting material is ethyl 5-(pentan-3-yloxy)-7-oxo-bicyclo[4.1.0]hept-3-ene-3-carboxylate. The detection method comprises the following steps: using reverse-phase high performance liquid chromatography (RP-HPLC) and acetonitrile-water as a mobile phase to detect ethyl 5-(pentan-3-yloxy)-7-oxo-bicyclo[4.1.0]hept-3-ene-3-carboxylate and seven related substance impurities thereof; wherein C10-SM1-ZZ9 is the process source of impurity C10-ZZF (impurity F in EP9.0) in an oseltamivir phosphate finished product; the detection method can quantitatively detect a content of C10-SM1-ZZ9 equivalent to 0.0084% of a test sample concentration, and can effectively control the content of impurity F in the finished product; the method is highly practical, and the detection process is simple and quick.

The present application relates to the field of separating and purifying hydrocarbon-containing streams, and discloses a method and system for separating and purifying 1-hexene, 1-heptene and 1-octene from a hydrocarbon-containing stream, comprising: cutting the hydrocarbon-containing stream into fractions to obtain a C5 ‑ fraction stream, a C6-C8 fraction stream, a C9 + fraction stream; contacting the C6-C8 fraction stream, a composite extractant and an aqueous phase to perform extraction separation to obtain an extract phase and a raffinate phase; performing rectification separation treatment, fine separation and heavy removal treatment and extractive rectification treatment on the raffinate phase in sequence to obtain 1-hexene, 1-heptene and 1-octene; wherein the extract phase, after solvent recovery, is recycled into the composite extractant to obtain a recovered extractant; the composite extractant comprises an extractant a and an extractant b, the extractant a is selected from N-methyl pyrrolidone and / or N,N dimethylacetamide, and the extractant b is selected from gamma-butyrolactone and / or N-formyl morpholine; and the composite extractant is used for extractive rectification treatment. The extractant is single, and the content of oxygen-containing compounds in the final Fischer-Tropsch synthesis oil is less than or equal to 10 ppm (mass).

The invention relates to the technical field of attractants and pest control, in particular to a volatile matter luring ball for luring hoverflies, which comprises a PVC (polyvinyl chloride) shell, a non-woven fabric liner and a slow-release attractant, the slow-release attractant is composed of a composite attractant, a paraffin oil solvent and a macroporous resin slow-release part in proportion. The compound attractant is prepared by mixing trans-beta-farnesene, nerolidol, 6-methyl-5-heptene-2-ketone and cis-3-hexene acetate according to a specific volume ratio, and the compound attractant can be used for attractant attractants. The preparation method comprises the following steps: oscillating and mixing the components with a solvent under a low-temperature condition, adsorbing on macroporous resin, and packaging. Through the synergistic effect of the multi-component volatile matters and the multi-stage slow-release structure, the luring ball realizes efficient, specific and lasting behavior luring on hoverflies, effectively prolongs the field lasting period, and improves the stability and practicability of natural enemy insect regulation and control.

The invention relates to the technical field of polymer preparation, in particular to poly (6, 6-dimethyl-2-vinyl bicyclo [3.1. 1] heptyl-2-ene) and a preparation method thereof, 6, 6-dimethyl-2-vinyl bicyclo [3.1. 1] heptyl-2-ene is taken as a monomer, and a homopolymerization reaction is carried out by adopting a cyclopentadienyl rare earth complex, organic boron salt and alkyl aluminum compound three-way catalytic system in an inert atmosphere. The number-average molecular weight Mn of the obtained polymer can reach 3.0 * 10 < 4 >, the molecular weight distribution Mw / Mn is 1.54-1.86, the highest yield is 99%, efficient rare earth catalytic polymerization of the monomer is achieved, the process is simple and convenient, the activity is high, and the product can be applied to the fields of surface coatings, biological medicine, tissue engineering and the like.

The invention discloses an enzymatic synthesis method of a melogabalin intermediate and related alcohol dehydrogenase, racemic 3-ethyl bicyclo [3.2. 0] hept-3-ene-6-ketone is used as a substrate, a genetically engineered bacterium for producing alcohol dehydrogenase is used as an enzyme catalyst, a genetically engineered bacterium for producing formate dehydrogenase, ammonium formate and coenzyme are matched, an enzymatic reaction is carried out under a stirring condition, and the melogabalin intermediate is obtained. And carrying out purification and separation on a reaction product to obtain the melogabalin intermediate (1R, 5S)-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-ketone. The method has the advantages of simple reaction, few steps, mild reaction, less pollution and the like, and has great industrial application potential and commercial value.

The present application relates to bicyclo[2.2.1]heptane and bicyclo[2.2.1]heptene derivatives, methods of making them, and methods of using them as flavor and fragrance ingredients in food, cosmetic, pharmaceutical, consumer, and other compositions and products.

The invention discloses an insulating varnish for a new energy vehicle battery pack and a preparation method thereof, relating to the technical field of insulating coatings. The insulating varnish is prepared from the following raw materials, measured by weight: 30-40 parts of a vinyl-containing hyperbranched polysiloxane, 15-20 parts of a functional film-forming copolymer, 20-30 parts of a filler, 1-3 parts of 5-vinylbicyclo[2.2.1]hept-2-ene, 2-4 parts of 2,4-diamino-6-diallylamino-1,3,5-triazine, 1-3 parts of 2,4,6-trivinylboroxine, 1-3 parts of bicyclo[2.2.1]heptanedimethylamine, 0.4-0.8 parts of a photoinitiator, 1-3 parts of an auxiliary agent, and 30-40 parts of a solvent. The insulating varnish has good insulation, strong adhesion to substrates, excellent resistance to high and low temperature cycling, and sufficient toughness.

This invention provides a method for preparing squalene. The method involves reacting 1,4-dihalobutane and magnesium powder via a Grignard reaction to obtain the corresponding Grignard reagent, which is then reacted with 5-chloro-2-pentanone via an addition reaction and acidification to prepare 1,12-dichloro-4,9-dimethyldodecyl-4,8-diene. The obtained 1,12-dichloro-4,9-dimethyldodecyl-4,8-diene and magnesium powder are then reacted with the Grignard reagent to obtain the corresponding Grignard reagent, which is then reacted with 6-methyl-5-hepten-2-one via an addition reaction and acidification to prepare squalene. The raw materials used in this invention are inexpensive and readily available. Only two Grignard and addition reactions are required to obtain the target product, making the steps simple. The reaction conditions are mild, the equipment is simple, the cost is low, and it is easy to industrialize. Wastewater generation is low, making it green, safe, and environmentally friendly. The reaction has high selectivity, few byproducts, and high yield and purity of the target product, making it suitable for green industrial production.

The invention belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of a milobalin intermediate. The preparation method comprises the following steps: carrying out hydrogenation reaction on [(1RS, 5SR, 6RS)-6-cyano-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-yl] diethyl malonate serving as a raw material under the action of palladium on carbon or raney nickel to obtain a compound III, and carrying out acid hydrolysis on the compound III to obtain [6-aminomethyl-3-ethyl bicyclo [3.2. 0] hept-3-ene-6-yl] acetic acid (racemization), namely a compound I. The preparation method comprises the following steps: carrying out a reaction on the raw material and the compound I, the method is novel in route, raw materials are easy to obtain, and compared with the prior art, the method has higher yield and is suitable for industrial production.

An object of the present invention is to provide a technique capable of reducing naringin-derived bitterness in a naringin-containing beverage and improving its good aftertaste.SOLUTION: The present invention provides a beverage comprising naringin and nerol and / or 6-methyl-5-hepten-2-one, wherein the content of nerol is 10 to 1000ppb, and the content of 6-methyl-5-hepten-2-one is 10 to 1000ppb.SELECTED DRAWING: None

The utility model relates to the technical field of separation and purification devices, and discloses a separation and purification device for methyl heptenone, which comprises a preheating tank, a water inlet pipe and a water outlet pipe, and the motor is arranged at the bottom of the preheating tank, a rotor of the motor is coaxially provided with a rotating rod, the rotating rod is located in the preheating tank, cleaning frames are evenly distributed on the surface of the rotating rod, and cleaning plates are installed on the surfaces of the cleaning frames. Clean water can be injected into the preheating tank through a water inlet pipe, and a motor is started to drive a rotating rod to rotate, so that a cleaning frame can be driven to rotate to scatter the clean water, and a water body is driven to flow along the interior of the preheating tank, so that residual raw materials in the preheating tank can be scoured; and raw materials adsorbed on the inner wall of the preheating tank can be scraped off through the cleaning plate, the situation that residues are coked or crystallized on the pipe wall to reduce the heat transfer area is avoided, and therefore the preheating efficiency of the preheating tank can be improved.

The application discloses a Pediococcus pentosaceus strain derived from high-temperature Daqu and application thereof, the strain is named Pediococcus pentosaceus zqw75, and the preservation number is CGMCC NO.25146.The strain can produce aroma substances such as lauryl acetate, n-heptanol, butyl dodecalactone, benzene acetaldehyde, methyl heptenone and pyrazine, and when the strain is used in combination with commercial sweet wine starter, the relative content of phenylethanol is increased from 8.562% to 10.455%, the relative content of ethyl butyrate is increased from 0.460% to 1.473%, the relative content of ethyl octanoate is increased from 0.754% to 1.672%, the relative content of ethyl n-hexanoate is increased from 0.832% to 3.446%, and the relative content of isoamyl acetate is increased from 0.832% to 2.155%; and the strain can produce aroma substances that are not produced by the commercial sweet wine starter, such as hexanoic acid, butyric acid, octanoic acid, ethyl hexanoate and lauryl acetate.The strain can be applied in the field of liquor making, including pit mud making and liquor flavor substance improvement, and has great industrial application value.

Methods of preparing trans-silacycloheptenes and their use in preparing polymers thereof under ring-opening metathesis polymerization (ROMP) conditions are disclosed. Also disclosed are methods for preparing oligosilane diene monomers and their use in preparing unsaturated poly(carbooligosilane)s via acyclic diene metathesis polycondensation. The alkene moieties of the unsaturated poly(carbooligosilane)s can be converted to epoxides via post-polymerization epoxidation.

The invention belongs to the field of chemical synthesis, and particularly relates to an industrial production and synthesis method of spice 5-methyl-2-heptene-4-ketone, which comprises the following steps: reacting butanone serving as a raw material with 2-methylbutyryl chloride under alkaline conditions, creating an alkaline environment by using a solid base catalyst, filtering and separating the catalyst after the reaction is finished, and purifying filtrate by using a molecular sieve to obtain the spice 5-methyl-2-heptene-4-ketone. The preparation method comprises the following steps: taking 3-methyl-2-pentanone as a raw material to obtain an intermediate 3-methyl-2-pentanone, then reacting the intermediate 3-methyl-2-pentanone with acetaldehyde under an acidic condition, creating an acidic environment by using a solid acid catalyst, and carrying out a continuous flow reaction in a microchannel reactor to obtain the spice 5-methyl-2-heptene-4-ketone. By adjusting the process and raw materials, the yield and purity of the product are improved, the catalyst can be recycled, the emission of three wastes is less, the reaction is efficient, and the energy consumption is low.

The present invention provides a composition containing a hexafluoropropylene trimer represented by C9F18 for replacing a heat transfer fluid containing at least one selected from the group consisting of perfluorotripropylamine, perfluoropolyether, and methoxytridecafluoroheptene isomer mixtures.