568results about "Amino preparation by functional substitution" patented technology

An improved continuous process for converting methane, natural gas, and other hydrocarbon feedstocks into one or more higher hydrocarbons, methanol, amines, or other products comprises continuously cycling through hydrocarbon halogenation, product formation, product separation, and electrolytic regeneration of halogen, optionally using an improved electrolytic cell equipped with an oxygen depolarized cathode.

The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.

The present invention generally relates to processes for the chemocatalytic conversion of a carbohydrate source to an adipic acid product. The present invention includes processes for the conversion of a carbohydrate source to an adipic acid product via a furanic substrate, such as 2,5-furandicarboxylic acid or derivatives thereof. The present invention also includes processes for producing an adipic acid product comprising the catalytic hydrogenation of a furanic substrate to produce a tetrahydrofuranic substrate and the catalytic hydrodeoxygenation of at least a portion of the tetrahydrofuranic substrate to an adipic acid product. The present invention also includes products produced from adipic acid product and processes for the production thereof from such adipic acid product.

Processes for preparing cinacalcet are provided.

Applicant has discovered an in situ method of preparing quaternary ammonium methocarbonate salts and quaternary ammonium alkylcarbonate salts in high yield from tertiary amines, methanol, and at least one of a cyclic carbonate, an aliphatic polyester (such as a polycarbonate), or an ester (such as a carbonate ester), and their subsequent conversion to quaternary ammonium bicarbonates, quaternary ammonium carbonates or both in a one-pot reaction. According to one embodiment of the invention, the method includes reacting an amine and methanol with at least one of a cyclic carbonate and an aliphatic polyester to yield a quaternary ammonium methocarbonate. This method does not produce or require the handling of corrosive quaternary ammonium hydroxides. Another embodiment is a method of preparing quaternary ammonium alkylcarbonate salts by reacting tertiary amines, methanol, and an ester. The quaternary ammonium methocarbonate or alkylcarbonate can be converted to the corresponding bicarbonate, carbonate, or mixture thereof by methods known in the art.

A method for sequentially performing a synthesis, separation and screening of chemical entities, especially a combinatorial library, is described. The method utilises a bulk of a stationary phase (e.g. silica gel, aluminium oxide, cellulose, etc. for example arranged on a backing) for the performance of the synthesis, separation and screening. The technique described enables a rapid route from synthesis to the testing of chemical compounds. Screening can be performed without need for reaction work-up. Preferred screening methods are those used to determine the biological activity of the compounds.

Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin with a depolymerization agent to depolymerize the lignin and form a mixture of aldehyde containing compounds; contacting the mixture of aldehyde containing compounds with an amine under conditions suitable to convert the mixture of aldehyde containing compounds to a mixture of amine containing compounds; and contacting the mixture of amine containing compounds with an acid under conditions suitable to form an ammonium salt, thereby preparing the ionic liquid.

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

The invention discloses a preparation method of N,N-diisopropylethylamine, which comprises the following steps of: reacting diisopropylamine and ethyl chloride as raw materials in a high-pressure autoclave by adopting an MIX type catalyst, wherein the mol ratio of the diisopropylamine to the ethyl chloride is 2-4:1, the mass ratio of the MIX type catalyst to the ethyl chloride is 1:20-10, the reaction temperature is 130-230 DEG C, the reaction pressure is 0.8-2.5MPa, and the reaction time is 4-10 hours; and adding a strongly alkaline solution into the obtained reaction liquid until the pH is 12.5-13.5, and then carrying out liquid separation and rectification to obtain the N,N-diisopropylethylamine. The preparation method of the N,N-diisopropylethylamine has the characteristics of simple process, high yield, low cost and little discharge of the three wastes.

Polyamines having the formula:or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen;N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's;a and b may be the same or different and are integers from 1 to 4;A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines:(i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and(ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell;the polyamines, upon binding to the biological counter-anion in the cell, function in a manner biologically different than the intracellular polyamines, the polyamines not occurring in nature; as well as pharmaceutical compositions embodying the polyamines and methods of treating patients requiring anti-neoplastic therapy.

The invention discloses a method for synthesizing 3-amino-1, 2-propanediol via a tubular reactor, which comprises (1) ammoniation such as premixing liquid chlorine glycerol and ammonia water via a mixer, and reacting in a tubular reactor while the reaction temperature is 60-100DEG C, the pressure is 3-6MPa and the time is 6-12min, and obtain the mixture solution of 3-amino-1, 2-propanediol and ammonia water, (2) purification such as treating the mixture solution by depressurizing, flash evaporation and deamination, and treating the liquid after the deamination by adding alkali to neutralize, dehydrating, depressurizing and distilling, to obtain 3-amino-1, 2-propanediol. The synthesized 3-amino-1, 2-propanediol has the advantages of high yield.

The invention discloses a synthetic method for a quaternary ammonium salt, especially to a synthetic method for a high-purity quaternary ammonium salt. The synthetic method comprises the following steps: adding a certain amount of a solvent, tertiary amine and an alkylation reagent into a reaction vessel with reaction temperature being 20 to 105 DEG C and reaction time being 2 to 24 h; and after a reaction is ended, carrying out direct cooling, centrifugation and drying so as to obtain the high-purity quaternary ammonium salt. The solvent used in the method can be used indiscriminately and repeatedly, so production cost is reduced, and the method has a high industrial practical value.

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.

The present invention provides a synthesis system that can synthesize aniline and / or styrene efficiently, a synthesis system that can synthesize butadiene (1,3-butadiene) efficiently, a rubber chemical for a tire which is synthesized from the aniline obtained by the synthesis system, a synthetic rubber for a tire which is synthesized from the styrene and / or butadiene obtained by the synthesis systems, and a pneumatic tire produced using the rubber chemical for a tire and / or the synthetic rubber for a tire. The present invention relates to a synthesis system for synthesizing aniline and / or styrene from an alcohol having two or more carbon atoms via an aromatic compound.

The invention discloses an improved preparing method of anti-parkinson medicine detonate sand java blue important intermediate 2, 3- di-hydrogen- 1H-indenes-1-amine, which is characterized by the following: reacting 2, 3- di-hydrogen- 1H-indenes-1-ketoximes and alumino-nickel in queous alkali getting the product. This invention also discloses a 'one pot boiling' preparing method of 2, 3- di-hydrogen- 1H-indenes-1-amine with 2, 3- di-hydrogen- 1H-indenes-1- ketone. This invention also discloses a 'two steps one pot boiling' preparing method and 'three steps one pot boiling' preparing method of detonate sand java blue with 2, 3- di-hydrogen- 1H-indenes-1-ketoxime and 2, 3- di-hydrogen- 1H-indenes-1- ketone. This invention possesses simple operation, low cost and high productive efficiency, which is fit for industrial production.

The invention discloses a preparation method of 2-chloro-5-tirfluoromethylpyridine. The invention provides a preparation method of 2-chloro-5-tirfluoromethylpyridine, and the preparation method comprises the following steps of: reacting 2-chloro-5-trichloromethylpyridine with hydrogen fluoride in a closed system in the presence of a catalyst to obtain the 2-chloro-5-tirfluoromethylpyridine, wherein the catalyst is antimony trioxide and / or antimony pentoxide. The invention further provides a preparation method of a compound 2, and the preparation method comprises the following steps of: reacting a compound 3 with ammonia in the presence of alkali to obtain the compound 2. The preparation method provided by the invention is cheap and liable to obtain raw materials, low in cost, few in reaction by-products, simple in post treatment, safe to operate, environment-friendly and suitable for large-scale industrial production.

A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

Embodiments of the present invention include methods for producing a cyclohexanedimethanamine by a reductive amination process.

The invention provides a method for preparing aromatic primary amine by taking ammonia water as an ammonia source in a water phase system. In the method, aromatic halogenate and the ammonia water are used as raw materials, water is used as a solvent, at room temperature or under the heating condition of common oil bath, carbonates, fluorides, phosphates and hydroxides of alkali metals or alkaline-earth metals are taken as alkalis, and a catalytic reaction is preformed through adding a surfactant and using a temary catalysis system composed of copper catalyst, hydrazide and ketone. The method has the characteristics that the operation is simple, wide substrate application range is wide, the product is simple and easy to separate, the yield is high, the process is economic and is environment-friendly and the like; and reaction conditions are flexible, thus corresponding room temperature or heating mode can be selected according to practical requirements. In addition, the environment friendliness of the reaction is effectively improved by using water as a reaction solvent, thereby better conforming to the development requirements of green chemistry. Especially, the substrate is wide in application range and has wide application prospects in the aspects of preparing natural products, medicines and pesticides.

The invention relates to preparation method for efficient tetramethylammonium hydroxide, which comprises the following steps: methyl-carbonate and trimethylamine are taken as reactive substances to be prepared into tetramethyl ammonium bicarbonate, wherein the molar ratio of methyl-carbonate: trimethylamine is 1 to 1:5; and then a three-room two-membrane electrobath method is used for preparing the tetramethylammonium hydroxide; the reaction is carried out in gap phase and liquid phase; a kettle-type single reactor is used for production; the specific operation conditions thereof are that the pressure is the normal pressure, the temperature is 30 to 100 DEG C, and gas airspeed of the trimethylamine is 50 to 100kg / h. The preparation method has the advantages that an ion-exchange membrane electrodialysis is quite an ideal method for preparing tetramethylammonium hydroxide, firstly, the process flow of the ion-exchange membrane electrodialysis is simpler, secondly, both of the quality and purity of the tetramethylammonium hydroxide products prepared by the ion-exchange membrane electrodialysis can reach very high degree and meet the manufacturing requirements of cutting-edge high-tech industries, in addition, the ion-exchange membrane electrodialysis can effectively reduce the generation of three industrial wastes and has no pollution and the production is relatively safe.

The invention relates to a preparation method capable of improving the composition obtained by recycling hydrocarbon, and belongs to the field of preparation of a quaternary ammonium compound. The preparation method comprises the following steps of mixing alpha-alkyl halide and N, N, N', N'-tetramethylethylenediamine at the mole ratio of (2-3):1, and stirring at 50-90 DEG C for 8-16 hours, thereby obtaining the quaternary ammonium salt type dimeric surfactant. A purification method comprises the following steps of recrystallizing a crude product of the quaternary ammonium salt type dimeric surfactant obtained by the preparation method by using a solvent, then drying so as to obtain a white powdery solid which is the purified quaternary ammonium salt type dimeric surfactant. According to the preparation and purification methods of the quaternary ammonium salt type dimeric surfactant, a method of cooking in one pot is adopted, so that the inconvenience caused by charging step by step is prevented. Other reaction solvents are not added in the synthesis process, so that the production cost is reduced greatly, and the technological process is shortened; the synthesized surfactant is very high in productivity, is good in performance, and can be used for producing detergents, foam drilling fluids and displacement agent for tertiary oil recovery and the like.

The present invention relates to an asymmetric cationic Gemini surfactant and a preparation method thereof. The surfactant has a structural formula shown as below. Synthesis of the surfactant comprises a unilateral reaction of a short chain and a reaction of a long chain connecting with the other end. In the molecular structure of the surfactant, a sum of the total length of both carbon chains is 24, but the carbon chains at two sides of a head group have different lengths, so as to form an asymmetric quaternary ammonium salt cationic Gemini surfactant. The structure is helpful to enrich knowledge of the Gemini surfactant self-organization.

The invention relates to bi(diallylalkylamine) and a preparation method thereof. The preparation method uses a technical scheme comprising the steps of using water or alcohol as a reaction medium, using diallylamine and terminal dihalohydrocarbon as raw materials, performing a nucleophilic substitution reaction on the raw materials under an alkaline condition, separating the obtained liquid phase, performing reduced pressure distillation on the oil phase obtained through separation to obtain the bi(diallylalkylamine), returning water phase obtained through the separation and low-boiling-point fractions obtained through the reduced pressure distillation to a reactor for the next round of reaction, so as to prepare the bi(diallylalkylamine) which contains two groups of diallylamine radicals distributed at the two ends of an alkyl chain and is similar to the binary star. The invention overcomes the defects that the existing diallyl quaternary ammonium salt monomer molecule only has a group of diallylamine radicals and relatively less active radicals, and the application range thereof is relatively narrow; and the product of the invention is used as an inorganic synthetic intermediate, the intermediate of a bi(diallyl) quaternary ammonium salt monomer and cross-linking agent for macromolecular synthesis.

The invention discloses a new method for synthesizing alverine citrate. The method comprises the following steps of: performing bromination on phenylpropanol to prepare 3-phenyl bromopropane by taking phenylpropanol as an initiative raw material; reacting the 3-phenyl bromopropane with ethylamine solution to prepare ethylamphetamine; reacting ethylamphetamine with 3-phenyl bromopropane under the alkaline condition to prepare diphenyl propyl ethylamine; and finally reacting the diphenyl propyl ethylamine with citric acid to prepare the alverine citrate serving as the final product. The process flow has the advantage of readily available raw material, simple operation, safe reaction and economy and practicability.

Embodiments in accordance with the present invention provide for a palladium complex characterized by the general Formula (I): where A is a bidentate monoanionic ligand, NHC is a nucleophilic heterocyclic carbene, and Z is an anionic ligand. Such palladium complexes are useful in initiating cross-coupling reactions.

The invention discloses an environment-friendly synthesis method for cinacalcet. The cinacalcet is prepared by reacting R(+)-1-naphthyl ethamine and [3-(3'-trifluoromethyl)phenyl]-1-halopropane or [3-(3'-trifluoromethyl)phenyl]-1-propylsulfonate serving as raw materials with water serving as medium under the action of a phase-transfer catalyst. The process has the advantages of reducing the cost, along with high yield, no any organic solvent during the reaction, and low environmental pollution, and thus is a synthesis method suitable for industrialization.