The invention relates to a plugging agent suitable for a malignant leakage formation and a preparation method and application thereof, and belongs to the technical field of
petroleum and
natural gas drilling engineering. According to the invention, through compounding of the skeleton particles, the intelligent response
adhesive and the
impact-resistant reinforcing component and cooperation of the skeleton particles and the intelligent response
adhesive, a mechanical barrier can be rapidly formed at a crack inlet and a crack is dynamically filled, so that the plugging efficiency and the anti-scouring capability are improved, the
compressive strength of a plugging layer is greater than or equal to 20MPa, and the anti-scouring time is prolonged to more than 48 hours; the intelligent response
adhesive enables the plugging agent to have good intelligent
response characteristics and reservoir protectiveness, self-adaptive adjustment in the plugging process is ensured through a temperature and pH
dual mechanism, the
biodegradation rate is larger than or equal to 70%, the reservoir
pollution risk is remarkably reduced, the
compressive strength of a plugging layer formed at high temperature and
high pressure is larger than or equal to 20 MPa and is improved by 100% or above compared with that of a traditional plugging agent, and the plugging agent has good application prospects. The
biodegradation rate is greater than or equal to 70%, and the plugging problem of the ultra-deep malignant leakage stratum is effectively solved.