311 results about "Amine derivatives" patented technology

The invention relates to a pyrrolo [2, 3-d] pyrimidine-4-amine derivative and application thereof in medicine, in particular to a compound shown in a formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, pharmaceutically acceptable salt or eutectic of the compound, and application of the compound in preparation of medicines for treating sGC-related diseases.

The invention discloses a ketoazine-based polymer, an anion exchange membrane and a preparation method and application of the ketoazine-based polymer and the anion exchange membrane. A first linking group and a second linking group are mixed and then mixed with an aryl monomer A in an aprotic solvent of halogen atoms; slowly adding a super acid mixture; performing polymerization reaction in an environment of-5 to 3 DEG C to obtain a reaction solution; pouring the reaction liquid into a first mixed solvent to obtain PAAz; carrying out primary quaternization reaction on PAAz through carbonate, bicarbonate or hydroxide salt of alkali metal, and adding an organic base catalyst to assist the primary quaternization reaction; in the first quaternization reaction, a quaternization reagent is added; and pouring into a second mixed solvent, and precipitating to obtain purified PAAz. Under the condition of super acid catalysis, two or more alicyclic amine derivatives containing ketone groups react with one or more aromatic fused rings to generate a polymer containing secondary or tertiary amine. And carrying out quaternization treatment to finally form the cationic polymer.

The present disclosure relates to an OLED that includes a first electrode; a second electrode facing the first electrode; a first emitting material layer including a first host being an anthracene derivative and a first dopant being a pyrene derivative and positioned between the first and second electrodes; and a first electron blocking layer including an electron blocking material of a heteroaryl-substituted amine derivative and positioned between the first electrode and the first emitting material layer, wherein at least one of hydrogen atoms in the anthracene derivative and the pyrene derivative is deuterated.

The use of certain alkanolamines in hair treatment compositions as an alternative to some or all ammonium hydroxide is disclosed. These compositions are useful in curling and straightening applications. Benefits include similar or reduced hair damage; relatively mild alkalinity; the curling or straightening efficiency and the shape retentivity are very good; heating is not needed; and useful results have been obtained using different hair races.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a synthesis method of a thiophene naphthenic amine derivative. The method comprises the following steps: reacting with benzylamine to generate a halogenated thiophene imine derivative, carrying out cyclization reaction in the presence of alkali to generate a thiophene naphthenic imine derivative, and reacting with organic acid to generate the product thiophene naphthenic amine derivative, so that the reaction conditions are mild, the yield is high, and the method is more suitable for industrial production.

The present invention is directed to (phthalazin-3-yl)amine derivatives of formula (I) as BFL-1 inhibitors for use in methods of treatment of leukemias, lymphomas and other cancers.

The invention provides an aldehyde insect pheromone derivative, which takes a compound containing at least one primary amine group as a carrier, and aldehyde insect pheromone forms an imine derivative with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the aldehyde insect pheromone derivative. According to the aldehyde insect pheromone derivative provided by the invention, aldehyde insect pheromones are treated in a chemical reaction manner, the stability of the aldehyde insect pheromones can be remarkably improved, slow release and controlled release of the pheromones can also be realized, the carrier material is wide in source, more in selectivity, convenient and economical, and in addition, the aldehyde insect pheromone derivative has good application prospects. The aldehyde insect pheromone derivative provided by the invention can also realize combined fixation and release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The invention belongs to the technical field of organic dyes, and particularly relates to an anti-ultraviolet dye taking tannic acid as a coupling component as well as a preparation method and application of the anti-ultraviolet dye. Under a stirring condition, adding a diazonium salt solution of an arylamine derivative into the mixed solution for reaction, and continuously stirring for reaction after the diazonium salt solution is added, so as to obtain a reaction solution; adjusting the pH value of the reaction liquid, evaporating, filtering and drying to obtain the anti-ultraviolet dye taking tannic acid as the coupling component. The uvioresistant dye taking tannic acid as a coupling component can endow real silk with color and uvioresistant function during dyeing; the dyeing process is simple and short in time, damage to real silk is small, dye liquor composition is simple, follow-up wastewater is easy to treat, and the whole dyeing process is low-carbon and environment-friendly.

The present invention provides novel drug-linker conjugates and antibody-drug conjugates of imidazo quinoline amine derivatives, which have agonistic activity against Toll-like receptors (TLRs), in particular TLR7 and / or TLR8, also provided are pharmaceutical compositions and methods of treatment against certain diseases or conditions mediated by or associated with TLR7 and / or TLR8 (e.g., graft rejection, autoimmunity, inflammation, allergy, asthma, infection, sepsis, cancer, and immunodeficiency).

The invention discloses water-based paint for a magnesium alloy robot shell and a preparation method and a coating method of the water-based paint, and relates to the technical field of paints.The water-based paint for the magnesium alloy robot shell comprises 55-80 parts of modified epoxy dispersoid and 1-10 parts of adhesion promoter; wherein the modified epoxy dispersoid is used as a main film forming substance, and the compatibility and reaction activity of the modified epoxy dispersoid and the surface of the magnesium alloy can be improved through chemical modification, so that the adhesion performance of the coating is enhanced; the adhesion promoter comprises modified molybdate, a rare earth compound, an amine derivative and a heterocyclic compound; the modified molybdate can form a stable complex or deposition layer; the rare earth compound can form a uniform and compact oxide layer on the surface of the magnesium alloy; the amine derivative can generate a three-dimensional network structure; the heterocyclic compound can increase the affinity between the coating and the base material; therefore, the technical problem of poor binding force between the water-based paint and the magnesium alloy is solved.

The invention provides compounds of formula (IA) and compounds of formula (IB) and pharmaceutically acceptable salts thereof; wherein A is selected from group (A1) and group (A2): wherein #1 is attached to the carbon atom forming the oxime moiety and wherein group (A1) is optionally substituted by one or two R10 and group (A2) is optionally substituted by one R10, and wherein R1, X, R2 and R10 are as defined in the claims, as well as methods of using the compounds to treat neoplastic diseases, in particular cancer.

The present invention relates to pharmaceutical compounds, compositions, and methods, particularly as they relate to compositions and methods for treating and / or preventing proliferative disorders associated with TGFβR1 activity, such as cancer or fibrosis. The present invention provides compounds of Formula (I) and Formula (II) as further described herein, which have an acidic moiety that enhances tissue specificity to target tissues and organs. The present invention includes pharmaceutical compositions, pharmaceutical combinations, and methods of using these compounds to treat disorders including cancer or fibrosis.

The invention belongs to the field of biological medicines, and discloses an (R)-3-(1-([1, 1 '-biphenyl]-2-yl) ethyoxyl) pyridine-2-amine derivative as well as a synthesis method and application thereof. A compound with a structure as shown in a general formula I of the derivative or pharmaceutically acceptable salt, hydrate, solvate, polymorphic substance, tautomer, stereoisomer, isotope derivative or prodrug thereof has higher ROS1 or ALK protein kinase inhibitory activity; the compound has high anti-proliferative activity on human non-small cell lung cancer and solid tumors such as brain metastatic tumors, glioblastoma and breast cancer, and can be used for preparing drugs for treatment and / or prevention and / or delay and / or adjuvant treatment and / or treatment of tyrosine protein kinase, especially diseases mediated by ROS1 and ALK kinase and mutant kinase thereof.

The application belongs to the field of pharmaceutical chemistry, and specifically discloses a benzimidazole amine derivative, a preparation method thereof and application of the benzimidazole amine derivative as a beta2-adrenergic receptor allosteric antagonist. In the benzimidazole amine derivative, R1 is a hydrogen atom or a bromine atom; and R2 is a substituted benzoyl group or a substituted benzyl group. Pharmacological results show that the benzimidazole amine derivative has good antagonistic activity on beta2AR and can negatively allosterically regulate the functional activity of isoprenaline (ISO).

Provided in the present invention are a solid form of a cyclic amine derivative, a preparation method therefor, and a pharmaceutical composition, specifically relating to a solid form of a compound of formula I or a salt thereof, a preparation method therefor, and a pharmaceutical composition. The compound of formula I or the salt thereof provided by the present invention has strong binding ability to apo(a) and high stability, and can be better used in clinical practice.

The invention belongs to the technical field of medicines, and relates to a compound as shown in a formula I, a stereoisomer, a prodrug and a pharmaceutically active metabolite thereof, pharmaceutically acceptable salt, a solvate and a hydrate thereof, a pharmaceutical composition containing the compound, and application of the compound in preparation of medicines for preventing and / or treating diseases or symptoms related to virus infection.

The application relates to a method for preparing a beta-heteroaryl ethylamine derivative by utilizing photocatalytic energy transfer, and belongs to the technical field of catalytic synthesis, in particular to a method for preparing a beta-heteroaryl ethylamine derivative by utilizing photocatalytic energy transfer. The application is to solve the technical problems of the existing synthesis method, such as being too complicated, needing pre-activation and expensive metal catalysts. One, an oxime ester compound, an olefin compound and TXT are added into a solvent to obtain a mixed solution; two, the mixed solution obtained in the step one is irradiated by using an LED light source, the solvent is removed by rotary evaporation, and separation and purification are carried out. Compared with the prior art, the application is more green, mild, atom-economical, simple and efficient in a metal-free catalytic energy transfer strategy to construct aryl tertiary amine compounds. The method can be used for preparing a beta-heteroaryl ethylamine derivative.

The present invention relates to a 5-cyclopropylpicolinamide derivative represented by chemical formula I or II, and the like. The compound and the like according to the present invention have an inhibitory ability against HPK1, and thus can be effectively used in the prevention, amelioration, and / or treatment of diseases related thereto.

To provide a novel organic compound.SOLUTION: An organic compound herein is a triarylamine derivative, wherein one aryl group in the organic compound is an aryl group including a skeleton in which a naphthyl group is bonded to a naphthylene group. The other two aryl groups are each independently a phenyl group, a biphenyl group, or a terphenyl group. These groups may each have a substituent. As the substituent, an alkyl group having 1 to 6 carbon atoms or a cycloalkyl group having 3 to 6 carbon atoms can be selected.SELECTED DRAWING: None

The present invention aims to provide a novel compound having SF-1 antagonist activity and a polyfunctional molecule containing a moiety corresponding to the compound, particularly an SF-1 degrader. The present invention relates to a 3-phenylpropylamine derivative compound represented by the formula (1) and the like, and a polyfunctional molecule containing a moiety corresponding to the compound represented by the formula (1) and the like.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

The application provides a triamine derivative and an organic light-emitting device thereof, and relates to the technical field of organic photoelectric materials. The application mainly solves the problems of low light-emitting efficiency and short service life of most current organic light-emitting devices. The derivative of the application takes benzene as a center, and at least one or two alkyl groups are connected to the center benzene. The derivative has good film-forming property and thermal stability on one hand, and has good hole mobility, appropriate HOMO energy level and T1 value on the other hand. When the derivative is applied to an organic light-emitting device as a hole transport layer material, the light-emitting efficiency of the device can be effectively improved, and the service life of the device can be prolonged. The derivative of the application is combined with a heterocyclic compound represented by formula II and applied to the device, so that the maximum recombination of carriers is realized, thereby improving the light-emitting efficiency and service life of the device. The application can be widely applied to the fields of panel display, lighting source, organic solar cell, organic photoreceptor or organic thin film transistor and the like.

The present invention relates to macrocyclic diamine derivatives of Formula II, including pharmaceutically acceptable salts and solvates thereof. The compounds of the present invention are inhibitors of ENT family transporters, particularly ENT1, and are useful as therapeutic compounds for the treatment of cancer. The present invention also relates to the combination of a macrocyclic diamine derivative with an adenosine receptor antagonist for the treatment of cancer. JPEG2023521351000310.jpg36123