435 results about "Amine derivatives" patented technology

A heteroaryl amine derivative is provided that contributes to a substantial improvement in the lifespan of an organic electroluminescent device by effectively absorbing high-energy external light in the UV region to minimizes damages to organic materials inside the organic electroluminescent device. An organic electroluminescent device according to the present invention comprises: a first electrode; a second electrode; at least one organic material layer disposed between the first electrode and the second electrode; and a capping layer, wherein the capping layer contains a heteroaryl amine derivative represented by chemical formula 1 according to the present invention.

The invention discloses 4-(pyridine-4-yl)-1H-imidazole-2-amine derivatives and compositions of a machine for assembling key proteins on an outer membrane of targeted gram-negative bacteria, and belongs to the technical field of chemical medicines. The invention provides a small molecule compound as shown in a formula (I): # imgabs0 #, the small molecule compound can be used as a brand new targeting gram-negative bacterium inner membrane lipoprotein positioning machine (LolCDE) and has bacteriostatic activity, and a new way is provided for specific antibacterial treatment of gram-negative bacteria.

The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

The nanofiltration membrane comprises a base membrane and a functional layer, the functional layer comprises a polymer, polymerization unit monomers of the polymer comprise amine monomers and cyanuric chloride, the amine monomers comprise aliphatic amine and aromatic amine derivatives, the aliphatic amine comprises at least two primary amine or secondary amine groups, and the aromatic amine derivatives comprise at least two aromatic amine derivatives. The aromatic amine derivative comprises at least two reaction functional groups and at least one hydrophilic group, the reaction functional groups comprise at least one of amino groups and hydroxyl groups, and the hydrophilic group comprises at least one of sulfonic acid groups, amino groups, hydroxyl groups, carboxyl groups and phosphate groups. Therefore, the nanofiltration membrane provided by the invention has relatively high desalination rate and stable alkali resistance.

The invention relates to a pyrrolo [2, 3-d] pyrimidine-4-amine derivative and application thereof in medicine, in particular to a compound shown in a formula (I) or a stereoisomer, a tautomer, a deuterated compound, a solvate, a prodrug, a metabolite, pharmaceutically acceptable salt or eutectic of the compound, and application of the compound in preparation of medicines for treating sGC-related diseases.

The present invention relates to isoxazoline compounds of formula I, wherein the variables have the meanings as defined in the description; to a composition comprising the same; to active compound combinations comprising the same; and to the use thereof for protecting growing plants and animals from infestation or infestation by invertebrate pests; furthermore, to seeds comprising such compounds. Preferred compounds are, for example, N-(3-(aminomethyl)-4-fluorophenyl)-5-(4-fluorophenyl)-5-(trifluoromethyl)-4, 5-dihydroisoxazole-3-amine derivatives. # imgabs0 #

The invention discloses a chiral alpha-hydroxyamide derivative as well as a synthesis method and application thereof. The synthesis method comprises the following steps: in the presence of a chiral thiourea catalyst, aromatic amine and alpha-carbonyl acyl silane are subjected to a catalytic asymmetric nucleophilic addition reaction in a solvent under illumination, and the chiral alpha-hydroxyamide derivative is generated. The reaction takes illumination as driving force, so that green synthesis is realized; and secondly, due to the introduction of the chiral thiourea catalyst, the enantioselectivity is remarkably improved, the use of a metal catalyst is avoided, and the concept of green chemistry is met. In addition, the reaction substrates alpha-carbonyl acyl silane and aromatic amine are cheap and easily available chemicals, so that the synthesis cost is reduced, and the feasibility and practicability of the method are improved.

The invention discloses a ketoazine-based polymer, an anion exchange membrane and a preparation method and application of the ketoazine-based polymer and the anion exchange membrane. A first linking group and a second linking group are mixed and then mixed with an aryl monomer A in an aprotic solvent of halogen atoms; slowly adding a super acid mixture; performing polymerization reaction in an environment of-5 to 3 DEG C to obtain a reaction solution; pouring the reaction liquid into a first mixed solvent to obtain PAAz; carrying out primary quaternization reaction on PAAz through carbonate, bicarbonate or hydroxide salt of alkali metal, and adding an organic base catalyst to assist the primary quaternization reaction; in the first quaternization reaction, a quaternization reagent is added; and pouring into a second mixed solvent, and precipitating to obtain purified PAAz. Under the condition of super acid catalysis, two or more alicyclic amine derivatives containing ketone groups react with one or more aromatic fused rings to generate a polymer containing secondary or tertiary amine. And carrying out quaternization treatment to finally form the cationic polymer.

The present disclosure relates to an OLED that includes a first electrode; a second electrode facing the first electrode; a first emitting material layer including a first host being an anthracene derivative and a first dopant being a pyrene derivative and positioned between the first and second electrodes; and a first electron blocking layer including an electron blocking material of a heteroaryl-substituted amine derivative and positioned between the first electrode and the first emitting material layer, wherein at least one of hydrogen atoms in the anthracene derivative and the pyrene derivative is deuterated.

The invention belongs to the technical field of friction power generation, and particularly relates to a microcrystalline cellulose triboelectric composite film, a preparation method thereof and a triboelectric nano-generator. Comprising the following steps: adding soluble trivalent iron salt into microcrystalline cellulose dispersion liquid, uniformly dispersing, and adding polyethyleneimine in a stirring state to form a dispersion system; adjusting the pH value of the dispersion system, adding a cross-linking agent for activation to obtain a mixture, carrying out a cross-linking reaction to cross-link microcrystalline cellulose and a liquid amine derivative, complexing with ferric ions to obtain a composite film precursor, and drying the composite film precursor to obtain the microcrystalline cellulose triboelectric composite film. According to the invention, microcrystalline cellulose is taken as a matrix, polyethyleneimine and microcrystalline cellulose are crosslinked and complexed with Fe < 3 + >, and a recyclable, biodegradable and biocompatible composite film is constructed, so that the triboelectricity output and humidity adaptability of the cellulose-based triboelectricity material are improved, and the energy efficiency of the material in a self-powered process in a high-humidity environment is enhanced.

The invention relates to the field of medicinal chemistry, and discloses application of cyclobutene amide compounds in antiviral drugs. The structural characteristics of the compounds are as shown in a general formula (I), wherein EWG is an electron withdrawing group and is selected from aryl-substituted sulfonyl; r1 is selected from alkyl or aryl; r2 is selected from alkyl or aryl; and n represents the number of carbon atoms and may be 1 or 2. In-vitro pharmacodynamic studies show that the series of compounds have a remarkable inhibition effect on influenza A virus (H1N1 subtype), and the antiviral efficacy of the compounds is obviously superior to that of a clinical common antiviral drug ribavirin. In addition, toxicological evaluation proves that the compounds have ideal safety characteristics. The cyclobuteneamide derivative can be used as an effective component for developing an anti-influenza A virus drug, and a new candidate drug molecule is provided for clinical treatment of influenza virus infection. # imgabs0 #

The use of certain alkanolamines in hair treatment compositions as an alternative to some or all ammonium hydroxide is disclosed. These compositions are useful in curling and straightening applications. Benefits include similar or reduced hair damage; relatively mild alkalinity; the curling or straightening efficiency and the shape retentivity are very good; heating is not needed; and useful results have been obtained using different hair races.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a synthesis method of a thiophene naphthenic amine derivative. The method comprises the following steps: reacting with benzylamine to generate a halogenated thiophene imine derivative, carrying out cyclization reaction in the presence of alkali to generate a thiophene naphthenic imine derivative, and reacting with organic acid to generate the product thiophene naphthenic amine derivative, so that the reaction conditions are mild, the yield is high, and the method is more suitable for industrial production.

The present invention provides a method for producing a compound represented by formula (I) suitable for mass synthesis as API. Provided according to one aspect of the present invention is a method for producing a compound represented by formula (I) or a salt thereof, the method including deprotecting a protecting group represented by R1 in formula (II) under basic conditions to thereby form a compound represented by formula (I) or a salt thereof.

The present invention is directed to (phthalazin-3-yl)amine derivatives of formula (I) as BFL-1 inhibitors for use in methods of treatment of leukemias, lymphomas and other cancers.

The invention provides an aldehyde insect pheromone derivative, which takes a compound containing at least one primary amine group as a carrier, and aldehyde insect pheromone forms an imine derivative with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the aldehyde insect pheromone derivative. According to the aldehyde insect pheromone derivative provided by the invention, aldehyde insect pheromones are treated in a chemical reaction manner, the stability of the aldehyde insect pheromones can be remarkably improved, slow release and controlled release of the pheromones can also be realized, the carrier material is wide in source, more in selectivity, convenient and economical, and in addition, the aldehyde insect pheromone derivative has good application prospects. The aldehyde insect pheromone derivative provided by the invention can also realize combined fixation and release of various pheromones, so that trapping, prevention and control of various insects can be realized.

A substituted pyrazolo[1,5-a]pyrimidine-7-amine derivative having a structure as shown in formula (I) or a pharmaceutically acceptable salt, solvate, stereoisomer, prodrug, or pharmaceutical composition thereof. The derivative has significant CDK9 selective inhibitory activity. #imgabs0#

The present invention discloses a photo-generated chiral radical molecule based on a triarylamine derivative with circularly polarized luminescence properties, and its preparation and application. It is prepared by subjecting tris(4-aminophenyl)amine to an amide condensation reaction with an aryl-containing chiral isocyanate or an aryl-containing chiral carboxylic acid. The triarylamine derivative molecule of the present invention has the characteristics of being easy to generate and detect chiral radicals. In addition to being detected by ultraviolet-visible absorption spectroscopy and CD spectroscopy, the generation of radicals can also be judged by color change. The planarization of the conformation of the triarylamine molecule itself after the generation of radicals makes it easy to undergo self-aggregation, thereby amplifying the chiral signal. The positive charge carried can also interact with other negatively charged molecules through charge interaction to generate chiral transfer or induce self-assembly. The amide bond and urea bond components contained in the molecule enable the regulation of hydrogen bond interaction and hydrophilic-hydrophobic effect by solvents to change the circularly polarized luminescence intensity and direction brought by its aromatic group part.

The invention belongs to the technical field of organic dyes, and particularly relates to an anti-ultraviolet dye taking tannic acid as a coupling component as well as a preparation method and application of the anti-ultraviolet dye. Under a stirring condition, adding a diazonium salt solution of an arylamine derivative into the mixed solution for reaction, and continuously stirring for reaction after the diazonium salt solution is added, so as to obtain a reaction solution; adjusting the pH value of the reaction liquid, evaporating, filtering and drying to obtain the anti-ultraviolet dye taking tannic acid as the coupling component. The uvioresistant dye taking tannic acid as a coupling component can endow real silk with color and uvioresistant function during dyeing; the dyeing process is simple and short in time, damage to real silk is small, dye liquor composition is simple, follow-up wastewater is easy to treat, and the whole dyeing process is low-carbon and environment-friendly.

The present invention provides novel drug-linker conjugates and antibody-drug conjugates of imidazo quinoline amine derivatives, which have agonistic activity against Toll-like receptors (TLRs), in particular TLR7 and / or TLR8, also provided are pharmaceutical compositions and methods of treatment against certain diseases or conditions mediated by or associated with TLR7 and / or TLR8 (e.g., graft rejection, autoimmunity, inflammation, allergy, asthma, infection, sepsis, cancer, and immunodeficiency).

The invention discloses water-based paint for a magnesium alloy robot shell and a preparation method and a coating method of the water-based paint, and relates to the technical field of paints.The water-based paint for the magnesium alloy robot shell comprises 55-80 parts of modified epoxy dispersoid and 1-10 parts of adhesion promoter; wherein the modified epoxy dispersoid is used as a main film forming substance, and the compatibility and reaction activity of the modified epoxy dispersoid and the surface of the magnesium alloy can be improved through chemical modification, so that the adhesion performance of the coating is enhanced; the adhesion promoter comprises modified molybdate, a rare earth compound, an amine derivative and a heterocyclic compound; the modified molybdate can form a stable complex or deposition layer; the rare earth compound can form a uniform and compact oxide layer on the surface of the magnesium alloy; the amine derivative can generate a three-dimensional network structure; the heterocyclic compound can increase the affinity between the coating and the base material; therefore, the technical problem of poor binding force between the water-based paint and the magnesium alloy is solved.

The invention provides compounds of formula (IA) and compounds of formula (IB) and pharmaceutically acceptable salts thereof; wherein A is selected from group (A1) and group (A2): wherein #1 is attached to the carbon atom forming the oxime moiety and wherein group (A1) is optionally substituted by one or two R10 and group (A2) is optionally substituted by one R10, and wherein R1, X, R2 and R10 are as defined in the claims, as well as methods of using the compounds to treat neoplastic diseases, in particular cancer.

The present invention discloses a chiral α -hydroxyamide derivative, and its synthesis method and application. The synthesis method includes: in the presence of a chiral thiourea catalyst, an aromatic amine and α -carbonyl acylsilane undergo a catalytic asymmetric nucleophilic addition reaction under light in a solvent to form a chiral α -hydroxyamide derivative. The reaction of the present invention uses light as the driving force to achieve green synthesis; secondly, the introduction of the chiral thiourea catalyst not only significantly improves the enantioselectivity but also avoids the use of metal catalysts, which conforms to the concept of green chemistry. In addition, the reaction substrates α -carbonyl acylsilane and aromatic amine are both inexpensive and easily accessible chemicals, thereby reducing the synthesis cost and improving the feasibility and practicality of the method.

The present invention relates to pharmaceutical compounds, compositions, and methods, particularly as they relate to compositions and methods for treating and / or preventing proliferative disorders associated with TGFβR1 activity, such as cancer or fibrosis. The present invention provides compounds of Formula (I) and Formula (II) as further described herein, which have an acidic moiety that enhances tissue specificity to target tissues and organs. The present invention includes pharmaceutical compositions, pharmaceutical combinations, and methods of using these compounds to treat disorders including cancer or fibrosis.