90 results about "Benzylamine" patented technology

The invention provides an anti-aging composition as well as a preparation method, a skin care product and application thereof. The anti-aging composition is prepared from a C6-C3-C6 skeleton compound, cationic amino acid and beta-alanyl hydroxyprolyl diaminobutyric acid benzylamine. The C6-C3-C6 structural compound is natural plant extracts such as quercetin, baicalin and the like, and has excellent oxidation resistance and high safety. Cell and in-vitro experiments prove that the combined action of the three components can effectively reduce the generation of reactive oxygen species (ROS) and enhance the anti-inflammatory action, thereby delaying the cell senescence process. On the basis, carbon dioxide is injected into the anti-aging composition, so that the anti-oxidation and anti-inflammatory capacities of the anti-aging composition are further improved. In addition, the preparation process of the anti-aging composition is simple, the safety and the anti-aging performance of the anti-aging composition are evaluated through various cell experiments and human body trials, and the anti-aging composition is suitable for human skin and can be widely added into various skin care products such as face cream, emulsion and essence.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of isoindolone. An N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 are mixed with methyl tert-butyl ether in the presence of bis (trimethylsilyl) lithium amide and cesium fluoride, and the isoindolone as shown in a formula 3 is synthesized through reaction. The isoindolone derivative is synthesized through a one-pot method, and the method has the prominent advantages that raw materials are simple and easy to obtain, operation is easy and convenient, economy and environment friendliness are achieved, and the substrate applicability is wide.

The invention belongs to the technical field of synthesis of organic compounds, and particularly relates to a synthesis method of a thiophene naphthenic amine derivative. The method comprises the following steps: reacting with benzylamine to generate a halogenated thiophene imine derivative, carrying out cyclization reaction in the presence of alkali to generate a thiophene naphthenic imine derivative, and reacting with organic acid to generate the product thiophene naphthenic amine derivative, so that the reaction conditions are mild, the yield is high, and the method is more suitable for industrial production.

The invention belongs to the technical field of catalyst preparation, and particularly relates to a novel lignin-based copper catalyst and a preparation method and application thereof. The preparation method comprises the following steps: mixing lignin with cyanuric chloride, heating for reaction, and carrying out suction filtration and washing to obtain cyanuric chloride functionalized lignin; mixing the cyanuric chloride functionalized lignin with benzylamine, reacting, and carrying out suction filtration and washing to obtain benzylamine functionalized lignin; and adding the benzylamine functionalized lignin and cuprous iodide into a solvent, reacting, carrying out suction filtration, and washing to obtain the lignin-based copper catalyst. The lignin-based copper catalyst prepared by the method is low in preparation cost, can be recycled, and has the advantages of mild catalytic conditions, high catalytic efficiency and high yield.

The invention belongs to the technical field of organic synthesis, and particularly provides a preparation method of (trimethylsilyl) methylamine hydrochloride. The preparation method provided by the embodiment of the invention comprises the following steps: carrying out reduction reaction on N-[(trimethylsilyl) methyl] benzylamine, and salifying with hydrochloric acid to generate (trimethylsilyl) methylamine hydrochloride. According to the preparation method disclosed by the embodiment of the invention, milder reduction hydrogenation operation is selected, severe conditions such as high temperature and high pressure are avoided, and the reaction yield and the product purity are improved.

The present invention discloses a method for enzymatically synthesizing ethyl 2-N-benzylamino-4-phenylbutyrate, wherein ethyl 2-oxo-4-phenylbutyrate and benzylamine are used as substrates, and an asymmetric reductive amination reaction is performed by two mutants of a reductive aminase. The reaction is carried out under mild conditions, and a product is obtained by a series of treatments after the reaction. The present invention shortens the synthetic route, reduces costs, reduces material loss, has high conversion rate and high stereoselectivity, conforms to the concept of green development, provides an effective method and theoretical guidance for the synthesis of potential ACEI drugs, and determines the gene sequence and amino acid sequence of the relevant mutants.

The invention provides a method for performing defluorination cyclization reaction on perfluoroalkyl tetralone and benzylamine under the promotion condition of potassium phosphate, and a series of polyfluoroalkyl pyridine compounds are synthesized. According to the reaction, six C (sp3)-F bonds of three carbon sites on a perfluoroalkyl chain are selectively activated, accurate synthesis of the fluoroalkyl-containing substituted pyridine compound is achieved, and the method has the advantages of being mild in condition, good in functional group tolerance, simple in aftertreatment, green in step, low in pollution, high in economic benefit and the like.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

The present invention belongs to the technical field of synthesis of metal organic complexes, and specifically relates to a nitrogen heterocyclic carbene-Schiff base type C sp2 ^N sp2 Bidentate cyclic palladium complexes and their synthesis methods and applications. This type of complex is formed by in situ oxidation and chelation of benzylamine or substituted benzylamine in the presence of palladium acetate in air, and then coordinated by nitrogen heterocyclic carbene. This type of Schiff base type C sp2 ^N sp2 The bidentate ligand has a strong electron-donating ability, which increases the electron cloud density of the metal center and more effectively catalyzes the Suzuki-Miruaya coupling reaction.

This application relates to the field of waterborne cathodic electrophoretic coating technology, specifically disclosing a bisphenol A epoxy-polyetheramine composite matte electrophoretic emulsion and its preparation method. The bisphenol A epoxy-polyetheramine composite matte electrophoretic emulsion comprises the following raw materials in parts by weight: 30-40 parts E-51 epoxy resin, 8-10 parts bisphenol A, 9-11 parts bisphenol A polyoxyethylene ether, 0.08-0.12 parts benzylamine, 2.5-3.5 parts methylethanolamine, 0.8-1.2 parts diethylene glycolamine, and 2.5-3.5 parts ketimine. This application uses E-51 epoxy resin, bisphenol A, and bisphenol A polyoxyethylene ether as the matrix skeleton, and obtains an epoxy equivalent prepolymer after chain extension catalyzed by benzylamine. At the same time, toluene diisocyanate is reacted with diethylene glycol butyl ether, diethylene glycol ethyl ether, and trimethylolpropane polyoxyethylene ether to prepare a blocked crosslinking agent, thereby achieving a uniform internal matting effect without the addition of external matting powder.

The invention discloses a method for synthesizing 5-(N, N-dibenzyl amino acetyl) salicylamide, which comprises the following steps: by taking benzaldehyde and benzylamine as raw materials and ethanol as a solvent, heating to a reaction temperature by using a micro-channel reactor, and reacting to obtain N-benzylidene benzylamine after the reaction is finished; taking the prepared N-benzylidene benzylamine as a raw material, adding hydrogen and a palladium carbon catalyst, reacting, and discharging the hydrogen after the reaction to obtain dibenzylamine; 5-bromoacetyl salicylamide and the prepared dibenzylamine are taken as raw materials, K2CO3 is taken as an acid-binding agent (or a deep eutectic solvent is used for replacing the acid-binding agent), acetonitrile is taken as a solvent, the materials are dropwise added under a low-temperature condition, a temperature rise reaction is carried out after dropwise adding is completed, the pH value of an obtained solid is adjusted with diluted hydrochloric acid to be acidic, then filtering, washing and drying are carried out, and the target product 5-(N, N-dimethyl-N, N-dimethyl formamide) is obtained. The compound is N, N-dibenzyl amino acetyl) salicylamide. The method has the advantages that the method is simple, the microchannel reactor is used, the product yield is high, the purity is high, and industrial production is easy.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

The application discloses a crosslinking agent for degradable hydrogel and a preparation method of degradable polyacrylamide hydrogel based on the crosslinking agent; the crosslinking agent for degradable hydrogel is composed of hydantoin epoxy resin, N, N-dimethyl benzylamine and acrylamide; the degradable polyacrylamide hydrogel prepared by using the crosslinking agent comprises acrylamide, 1.8-4.6 parts of water, potassium persulfate and the crosslinking agent; the crosslinking agent for degradable hydrogel can realize the preparation of the degradable hydrogel by chemical crosslinking method, and by adjusting the crosslinking agent, the degradable hydrogel prepared based on the crosslinking agent is applicable in the temperature environment range of normal temperature to 150 DEG C, the degradable hydrogel has selectivity to gel breaking liquid, and can realize gel breaking only by adding alkaline gel breaking liquid, and the gel breaking time is adjustable in the range of 90 min to 72 h; in addition, the crosslinking agent and the preparation method of the hydrogel are simple, the conditions are easy to control, and have good market application and promotion prospect.

The invention provides an ultrahigh-base-number composite calcium salt detergent, a preparation method thereof and a lubricating oil complexing agent. The preparation method comprises the following steps: mixing solvent oil, base oil, an accelerant A, an accelerant B, sulfonic acid, salicylic acid, first inorganic calcium and an accelerant C for neutralization reaction; carbon dioxide is introduced, second inorganic calcium and water are added for a carbonation reaction, a product is purified after the reaction is finished, and the composite calcium salt detergent is obtained; the accelerant B is selected from a combination of two or more than three of polyisobutylene succinic anhydride, dodecenyl succinic anhydride, polymethacrylate, trimethylolpropane isooctoate, alkylphenol formaldehyde resin and benzylamine. The composite calcium salt detergent disclosed by the invention has the advantages of ultrahigh base number and better thermal stability, and can fundamentally improve the problem of precipitation when calcium sulfonate and calcium salicylate are compounded.

The application discloses a method for synthesizing N-hydroxyethyl methyl benzylamine, and belongs to the technical field of pharmaceutical intermediates. The method comprises the following steps: continuously pumping a mixed solution of N-methyl benzylamine and ethylene carbonate into a micro-channel reactor filled with a bifunctional MOF catalyst UiO-66-NH2; continuously performing a flow catalytic reaction under heating and pressurizing conditions; and achieving a supercritical state of byproduct carbon dioxide in the reaction system; and obtaining N-hydroxyethyl methyl benzylamine after separating the reaction effluent under reduced pressure. The method has high raw material conversion rate, product selectivity and space-time yield.

This invention discloses a liquid crystal polymer copper-clad laminate and its preparation method, relating to the field of liquid crystal polymer technology. The invention involves melt-blending and granulating a liquid crystal polymer, modified polyetheretherketone (PEEK), nanofillers, and a lubricant via twin-screw extrusion, followed by single-screw extrusion casting or blown film production to obtain a thin film, which is then hot-pressed with copper foil to produce the copper-clad laminate. This invention uses fluorinated benzylamine-modified PEEK, utilizing the π-π stacking and van der Waals forces between the fluorinated benzene rings and the liquid crystal polymer to enhance interfacial compatibility, improve melt strength and processing stability, and significantly enhance peel strength. Simultaneously, boron nitride hollow microspheres and diamond powder, after acid treatment, synergistically construct a thermally conductive pathway. The hollow microspheres introduce a trace amount of air to reduce dielectric loss, resulting in a copper-clad laminate that combines high peel strength, excellent thermal conductivity, and low dielectric properties.

The invention discloses an application of an esterase response cationic polymer in preparation of an anti-tumor immunotherapy drug. The esterase response cationic polymer is an esterase response cationic polymer containing (p-phenolic ester group) benzyl amine or (p-phenolic ester group) benzyl ester. The compound can kill tumor cells, induce immunogen cell death (ICD), promote the tumor cells to release tumor-associated antigens, induce antigen-presenting cells to gather in tumors and present tumor antigens, activate killer T cells, inhibit tumor neovascularization, improve the tumor microenvironment, inhibit tumor cell apoptosis, inhibit tumor cell apoptosis, inhibit tumor cell apoptosis and inhibit tumor cell apoptosis after intratumor injection. Therefore, the organism obtains the anti-tumor immunity capability.

This invention discloses a cobalt zeolite catalyst, its preparation method, and its application in the oxidation reactions of benzylamine, alcohols, and anisole sulfides, specifically relating to alcohol oxidation, amine oxidative coupling, and sulfide oxidation reactions. This invention further expands the application scope of cobalt zeolite catalysts, clarifying their suitability for the oxidation reactions of alcohols, amines, and sulfides. The catalyst is prepared via in-situ hydrothermal synthesis, and its catalytic performance can be optimized by precisely controlling pore size, cobalt species dispersion, and their existing forms. Under oxygen or air atmospheres, this catalyst can efficiently achieve highly selective oxidation of benzyl alcohols, while simultaneously promoting the oxidative coupling reactions of benzylamines and the selective oxidation reactions of sulfides. The cobalt zeolite catalyst provided by this invention has clearly defined application scenarios, mild reaction conditions, and demonstrates significant industrial application potential, providing important theoretical reference and practical direction for catalyst development in the field of green organic synthesis.

The invention discloses a formaldehyde probe as well as a preparation method and application thereof, and belongs to the technical field of fluorescent probe preparation. Dissolving benzylamine and potassium carbonate in anhydrous acetonitrile, adding 2-bromo-2-methyl propionate, and reacting to obtain a compound 3; dissolving the compound 3 and lithium hydroxide in a mixed solution of tetrahydrofuran and water, reacting for a period of time, and quenching the reaction with hydrochloric acid to obtain a carboxylic acid intermediate 4; and dissolving the carboxylic acid intermediate 4 in dichloromethane, then adding CDM, EDCI and DMAP, and carrying out a reaction to obtain the target product DPM. The DPM is a formaldehyde regeneration type fluorescent probe and can realize formaldehyde detection in a mode of disturbing an endogenous steady state to the minimum extent. The DPM is a steady-state maintenance type formaldehyde probe successfully applied to a spinal cord injury (SCI) model for the first time, and can realize visual monitoring on formaldehyde rise of a diseased region based on a non-invasive living imaging system (IVIS).

The invention discloses an N-aryl quinazoline thio-imidazolinone compound and a preparation method and application thereof.The N-aryl quinazoline thio-imidazolinone compound is prepared by the steps that 2-amino benzylamine and a phenyl isothiocyanate compound serve as raw materials and react in dichloromethane under the action of triethylamine to generate a 1-(2-aminobenzyl)-3-phenylthiourea compound, and the 1-(2-aminobenzyl)-3-phenylthiourea compound is subjected to post-treatment to obtain the N-aryl quinazoline thio-imidazolinone compound. And reacting the 1-(2-aminobenzyl)-3-phenylthiourea compound with ethyl glyoxylate, so as to obtain the N-aryl quinazoline and thioimidazolinone compound. The preparation method comprises the following steps of: reacting the 1-(2-aminobenzyl)-3-phenylthiourea compound with ethyl glyoxylate; the raw materials for synthesis of the compound are easy to obtain, the synthesis method is simple, and meanwhile, the compound has a good inhibition effect on the activity of crop germs, especially on sclerotinia sclerotiorum, phytophthora germs, gibberellic disease germs, magnaporthe oryzae, botrytis cinerea and rhizoctonia solani.

The invention discloses a catalyst and a preparation method and application thereof. The catalyst comprises a carrier and a metal active element, the carrier is an SBA-15 molecular sieve which is modified by diethylenetriamine propyl trimethoxy silane (NQ-62); the metal active element is selected from at least one of Mn, Cr, Fe, Mg and Zr; the mass content of the metal active element in the catalyst is 0.5-5wt%. A simple precipitation method is adopted for preparation, the process route is simple, the equipment investment is low, and the method is suitable for large-scale and long-period continuous production; the catalyst can be used for preparing benzylamine from methyl ether, is a new reaction path, and has good selectivity.

The invention discloses a modified bismuth oxybromide composite photocatalyst as well as a preparation method and application thereof, and belongs to the technical field of photocatalytic organic synthesis. The preparation method comprises the following steps: mixing Bi (NO3) 3, KBr and Cu (NO3) 2, adding chlorophyll, and stirring to obtain the modified bismuth oxybromide composite photocatalyst. The Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is synthesized, the Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is used for photocatalysis of bimolecular oxidative coupling of benzylamine and methylamphetamine, bimolecular coupling of methylamphetamine and benzylamine is carried out under 10W visible light for the first time, the conversion rate can reach 99.5%, the product is alpha-methyl-N-(benzylidene) phenylethylamine, and the product has a wide application prospect. The method realizes detoxification treatment of methylamphetamine, realizes efficient and green synthesis of an imine compound under a noble metal-free condition, and can efficiently photocatalyze oxidative coupling of methylamphetamine and chemically degrade pollutants in water.

The present application discloses a naphthalene-type compound, preparation method therefore and use therefore. The naphthalene-type compound has a molecular structure substituted with polyhydroxyl, polybenzylamine, and quaternary ammonium or multiple quaternary ammonium functional groups, and compared with a raw material, the naphthalene-type compound has greatly improved water solubility in an acidic aqueous solution. An electrochemical reaction has low raw material costs and a high reaction yield, is carried out under a normal temperature and pressure condition without adding additional catalysts, and is carried out under air conditions without inert gas protection.

The present application relates to copper-clad plate material technical field, specifically to a kind of high transparent low expansion coefficient resin composition for copper-clad plate, copper-clad plate and preparation method thereof.The present application discloses a kind of high transparent low expansion coefficient resin composition for copper-clad plate, copper-clad plate and preparation method thereof, its resin composition includes epoxy modified polysiloxane, hydroxyl-terminated polyphenyl ether, phosphorus-containing epoxy resin, methyl hexacyanophthalic anhydride, polyhedral oligomeric silesquioxane, vinyl silane modified hollow SiO2, spherical fused SiO2, benzoxazine-siloxane bifunctional interface compatibilizer and N,N-dimethyl benzylamine.The preparation method is to synthesize key component first, then resin and pre-dispersed filler slurry are gently compounded to obtain glue solution, then impregnated, dried to prepare prepreg, finally with copper foil is stacked and is cured to obtain copper-clad plate product, the obtained copper-clad plate substrate has high light transmittance, low thermal expansion and excellent high-frequency performance.

A naphthalene-type compound, preparation method therefore and use therefore are provided. The naphthalene-type compound has a molecular structure substituted with polyhydroxyl, polybenzylamine, and quaternary ammonium or multiple quaternary ammonium functional groups, and compared with a raw material, the naphthalene-type compound has greatly improved water solubility in an acidic aqueous solution. An electrochemical reaction has low raw material costs and a high reaction yield, is carried out under a normal temperature and pressure condition without adding additional catalysts, and is carried out under air conditions without inert gas protection.

The application discloses an acid-resistant anion exchange membrane, a preparation method and application thereof, and relates to the technical field of ion exchange membranes. The acid-resistant anion exchange membrane is prepared by the following steps: taking N-allyl benzylamine as a monomer, copolymerizing the monomer with a crosslinking agent in a solvent, coating the copolymer on a base film, and further crosslinking the copolymer in a hot press through a Friedel-Crafts reaction. The anion exchange membrane prepared through the above technical means is suitable for use in nitric acid (salt) system electrodialysis for acid concentration or acid production, and has the advantages of good acid resistance, low surface resistance, stable long-term performance and long service life.

The invention belongs to the technical field of biocides, and particularly relates to a bactericide for oil and gas field water injection and a preparation method thereof.The preparation method comprises the steps that 1, 4-butanediol diglycidyl ether and N-methyl-N-dodecyl benzylamine are synthesized into epoxy quaternary ammonium salt, then caffeine is connected to the epoxy quaternary ammonium salt, and biquaternary ammonium salt is obtained; 1, 4-butanediol diglycidyl ether is used as a linking group, so that the overall stability of the biquaternary ammonium salt can be improved, and the service life of the biquaternary ammonium salt can be prolonged to a certain extent; the caffeine can significantly reduce the drug resistance of bacteria to the biquaternary ammonium salt.

The application belongs to the technical field of organic synthesis, and discloses a method for synthesizing 2,3,6-triphenylpyridine compounds. The Pd / ETS-10 catalyst is prepared first, and then benzyl acetylene compounds and benzylamine compounds are used as substrates to realize the oxidative coupling-cycloaddition reaction of terminal acetylene and benzylamine under the action of the Pd / ETS-10 catalyst in an oxygen atmosphere, so as to synthesize the triphenylpyridine compounds by one-pot method. The synthesis method has high atom economy, the catalyst can be recycled for multiple times, and has good stability and high economic value.

The invention provides a preparation method of an ilastrant intermediate. The preparation method of the intermediate compound G comprises the following steps: by taking a compound C as a raw material, sequentially carrying out reduction, dehydroxylation, coupling with benzylamine and debenzylation on a catalyst RuPHOX-Ru in a hydrogen atmosphere, thereby obtaining the intermediate compound G. The chiral intermediate obtained by the method disclosed by the invention is high in yield, good in chiral purity, low in catalyst consumption and low in cost, and is very suitable for industrial large-scale production.

This invention provides (η) 4 (-Cyclopentadienyl)osmium-pentadienylene, its preparation method and application: Starting from osmium-pentadienylbenzene 1, it reacts with lithium triisopropylsilylacetylene to generate osmium-pentadienylbenzene 2, which is then reacted with lithium phenylacetylene to prepare the catalyst (η). 4 (-cyclopentadienyl)osmium-heptapentane 3; the preparation of this catalyst requires only two steps. Under light and oxygen atmosphere, under irradiation with a 48 W blue LED lamp, 1 mol% (η 4 (-Cyclopentadienyl)osmium pyropentadiene 3 can convert benzylamine into the target imine with a 76% NMR yield after 7 hours at room temperature.