64 results about "Benzylamine" patented technology

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of isoindolone. An N-methylbenzylamine compound as shown in a formula 1 and a 2-fluorobenzoic acid methyl ester compound as shown in a formula 2 are mixed with methyl tert-butyl ether in the presence of bis (trimethylsilyl) lithium amide and cesium fluoride, and the isoindolone as shown in a formula 3 is synthesized through reaction. The isoindolone derivative is synthesized through a one-pot method, and the method has the prominent advantages that raw materials are simple and easy to obtain, operation is easy and convenient, economy and environment friendliness are achieved, and the substrate applicability is wide.

The invention belongs to the technical field of organic synthesis, and particularly provides a preparation method of (trimethylsilyl) methylamine hydrochloride. The preparation method provided by the embodiment of the invention comprises the following steps: carrying out reduction reaction on N-[(trimethylsilyl) methyl] benzylamine, and salifying with hydrochloric acid to generate (trimethylsilyl) methylamine hydrochloride. According to the preparation method disclosed by the embodiment of the invention, milder reduction hydrogenation operation is selected, severe conditions such as high temperature and high pressure are avoided, and the reaction yield and the product purity are improved.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

This application relates to the field of waterborne cathodic electrophoretic coating technology, specifically disclosing a bisphenol A epoxy-polyetheramine composite matte electrophoretic emulsion and its preparation method. The bisphenol A epoxy-polyetheramine composite matte electrophoretic emulsion comprises the following raw materials in parts by weight: 30-40 parts E-51 epoxy resin, 8-10 parts bisphenol A, 9-11 parts bisphenol A polyoxyethylene ether, 0.08-0.12 parts benzylamine, 2.5-3.5 parts methylethanolamine, 0.8-1.2 parts diethylene glycolamine, and 2.5-3.5 parts ketimine. This application uses E-51 epoxy resin, bisphenol A, and bisphenol A polyoxyethylene ether as the matrix skeleton, and obtains an epoxy equivalent prepolymer after chain extension catalyzed by benzylamine. At the same time, toluene diisocyanate is reacted with diethylene glycol butyl ether, diethylene glycol ethyl ether, and trimethylolpropane polyoxyethylene ether to prepare a blocked crosslinking agent, thereby achieving a uniform internal matting effect without the addition of external matting powder.

The invention discloses a method for synthesizing 5-(N, N-dibenzyl amino acetyl) salicylamide, which comprises the following steps: by taking benzaldehyde and benzylamine as raw materials and ethanol as a solvent, heating to a reaction temperature by using a micro-channel reactor, and reacting to obtain N-benzylidene benzylamine after the reaction is finished; taking the prepared N-benzylidene benzylamine as a raw material, adding hydrogen and a palladium carbon catalyst, reacting, and discharging the hydrogen after the reaction to obtain dibenzylamine; 5-bromoacetyl salicylamide and the prepared dibenzylamine are taken as raw materials, K2CO3 is taken as an acid-binding agent (or a deep eutectic solvent is used for replacing the acid-binding agent), acetonitrile is taken as a solvent, the materials are dropwise added under a low-temperature condition, a temperature rise reaction is carried out after dropwise adding is completed, the pH value of an obtained solid is adjusted with diluted hydrochloric acid to be acidic, then filtering, washing and drying are carried out, and the target product 5-(N, N-dimethyl-N, N-dimethyl formamide) is obtained. The compound is N, N-dibenzyl amino acetyl) salicylamide. The method has the advantages that the method is simple, the microchannel reactor is used, the product yield is high, the purity is high, and industrial production is easy.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

The application discloses a crosslinking agent for degradable hydrogel and a preparation method of degradable polyacrylamide hydrogel based on the crosslinking agent; the crosslinking agent for degradable hydrogel is composed of hydantoin epoxy resin, N, N-dimethyl benzylamine and acrylamide; the degradable polyacrylamide hydrogel prepared by using the crosslinking agent comprises acrylamide, 1.8-4.6 parts of water, potassium persulfate and the crosslinking agent; the crosslinking agent for degradable hydrogel can realize the preparation of the degradable hydrogel by chemical crosslinking method, and by adjusting the crosslinking agent, the degradable hydrogel prepared based on the crosslinking agent is applicable in the temperature environment range of normal temperature to 150 DEG C, the degradable hydrogel has selectivity to gel breaking liquid, and can realize gel breaking only by adding alkaline gel breaking liquid, and the gel breaking time is adjustable in the range of 90 min to 72 h; in addition, the crosslinking agent and the preparation method of the hydrogel are simple, the conditions are easy to control, and have good market application and promotion prospect.

The invention provides an ultrahigh-base-number composite calcium salt detergent, a preparation method thereof and a lubricating oil complexing agent. The preparation method comprises the following steps: mixing solvent oil, base oil, an accelerant A, an accelerant B, sulfonic acid, salicylic acid, first inorganic calcium and an accelerant C for neutralization reaction; carbon dioxide is introduced, second inorganic calcium and water are added for a carbonation reaction, a product is purified after the reaction is finished, and the composite calcium salt detergent is obtained; the accelerant B is selected from a combination of two or more than three of polyisobutylene succinic anhydride, dodecenyl succinic anhydride, polymethacrylate, trimethylolpropane isooctoate, alkylphenol formaldehyde resin and benzylamine. The composite calcium salt detergent disclosed by the invention has the advantages of ultrahigh base number and better thermal stability, and can fundamentally improve the problem of precipitation when calcium sulfonate and calcium salicylate are compounded.

The application discloses a method for synthesizing N-hydroxyethyl methyl benzylamine, and belongs to the technical field of pharmaceutical intermediates. The method comprises the following steps: continuously pumping a mixed solution of N-methyl benzylamine and ethylene carbonate into a micro-channel reactor filled with a bifunctional MOF catalyst UiO-66-NH2; continuously performing a flow catalytic reaction under heating and pressurizing conditions; and achieving a supercritical state of byproduct carbon dioxide in the reaction system; and obtaining N-hydroxyethyl methyl benzylamine after separating the reaction effluent under reduced pressure. The method has high raw material conversion rate, product selectivity and space-time yield.

This invention discloses a liquid crystal polymer copper-clad laminate and its preparation method, relating to the field of liquid crystal polymer technology. The invention involves melt-blending and granulating a liquid crystal polymer, modified polyetheretherketone (PEEK), nanofillers, and a lubricant via twin-screw extrusion, followed by single-screw extrusion casting or blown film production to obtain a thin film, which is then hot-pressed with copper foil to produce the copper-clad laminate. This invention uses fluorinated benzylamine-modified PEEK, utilizing the π-π stacking and van der Waals forces between the fluorinated benzene rings and the liquid crystal polymer to enhance interfacial compatibility, improve melt strength and processing stability, and significantly enhance peel strength. Simultaneously, boron nitride hollow microspheres and diamond powder, after acid treatment, synergistically construct a thermally conductive pathway. The hollow microspheres introduce a trace amount of air to reduce dielectric loss, resulting in a copper-clad laminate that combines high peel strength, excellent thermal conductivity, and low dielectric properties.

This invention discloses a cobalt zeolite catalyst, its preparation method, and its application in the oxidation reactions of benzylamine, alcohols, and anisole sulfides, specifically relating to alcohol oxidation, amine oxidative coupling, and sulfide oxidation reactions. This invention further expands the application scope of cobalt zeolite catalysts, clarifying their suitability for the oxidation reactions of alcohols, amines, and sulfides. The catalyst is prepared via in-situ hydrothermal synthesis, and its catalytic performance can be optimized by precisely controlling pore size, cobalt species dispersion, and their existing forms. Under oxygen or air atmospheres, this catalyst can efficiently achieve highly selective oxidation of benzyl alcohols, while simultaneously promoting the oxidative coupling reactions of benzylamines and the selective oxidation reactions of sulfides. The cobalt zeolite catalyst provided by this invention has clearly defined application scenarios, mild reaction conditions, and demonstrates significant industrial application potential, providing important theoretical reference and practical direction for catalyst development in the field of green organic synthesis.

The invention discloses a formaldehyde probe as well as a preparation method and application thereof, and belongs to the technical field of fluorescent probe preparation. Dissolving benzylamine and potassium carbonate in anhydrous acetonitrile, adding 2-bromo-2-methyl propionate, and reacting to obtain a compound 3; dissolving the compound 3 and lithium hydroxide in a mixed solution of tetrahydrofuran and water, reacting for a period of time, and quenching the reaction with hydrochloric acid to obtain a carboxylic acid intermediate 4; and dissolving the carboxylic acid intermediate 4 in dichloromethane, then adding CDM, EDCI and DMAP, and carrying out a reaction to obtain the target product DPM. The DPM is a formaldehyde regeneration type fluorescent probe and can realize formaldehyde detection in a mode of disturbing an endogenous steady state to the minimum extent. The DPM is a steady-state maintenance type formaldehyde probe successfully applied to a spinal cord injury (SCI) model for the first time, and can realize visual monitoring on formaldehyde rise of a diseased region based on a non-invasive living imaging system (IVIS).

The invention discloses a catalyst and a preparation method and application thereof. The catalyst comprises a carrier and a metal active element, the carrier is an SBA-15 molecular sieve which is modified by diethylenetriamine propyl trimethoxy silane (NQ-62); the metal active element is selected from at least one of Mn, Cr, Fe, Mg and Zr; the mass content of the metal active element in the catalyst is 0.5-5wt%. A simple precipitation method is adopted for preparation, the process route is simple, the equipment investment is low, and the method is suitable for large-scale and long-period continuous production; the catalyst can be used for preparing benzylamine from methyl ether, is a new reaction path, and has good selectivity.

The invention discloses a modified bismuth oxybromide composite photocatalyst as well as a preparation method and application thereof, and belongs to the technical field of photocatalytic organic synthesis. The preparation method comprises the following steps: mixing Bi (NO3) 3, KBr and Cu (NO3) 2, adding chlorophyll, and stirring to obtain the modified bismuth oxybromide composite photocatalyst. The Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is synthesized, the Cu-doped chlorophyll co-regulated nano bismuth oxybromide photocatalyst is used for photocatalysis of bimolecular oxidative coupling of benzylamine and methylamphetamine, bimolecular coupling of methylamphetamine and benzylamine is carried out under 10W visible light for the first time, the conversion rate can reach 99.5%, the product is alpha-methyl-N-(benzylidene) phenylethylamine, and the product has a wide application prospect. The method realizes detoxification treatment of methylamphetamine, realizes efficient and green synthesis of an imine compound under a noble metal-free condition, and can efficiently photocatalyze oxidative coupling of methylamphetamine and chemically degrade pollutants in water.

The present application relates to copper-clad plate material technical field, specifically to a kind of high transparent low expansion coefficient resin composition for copper-clad plate, copper-clad plate and preparation method thereof.The present application discloses a kind of high transparent low expansion coefficient resin composition for copper-clad plate, copper-clad plate and preparation method thereof, its resin composition includes epoxy modified polysiloxane, hydroxyl-terminated polyphenyl ether, phosphorus-containing epoxy resin, methyl hexacyanophthalic anhydride, polyhedral oligomeric silesquioxane, vinyl silane modified hollow SiO2, spherical fused SiO2, benzoxazine-siloxane bifunctional interface compatibilizer and N,N-dimethyl benzylamine.The preparation method is to synthesize key component first, then resin and pre-dispersed filler slurry are gently compounded to obtain glue solution, then impregnated, dried to prepare prepreg, finally with copper foil is stacked and is cured to obtain copper-clad plate product, the obtained copper-clad plate substrate has high light transmittance, low thermal expansion and excellent high-frequency performance.

A naphthalene-type compound, preparation method therefore and use therefore are provided. The naphthalene-type compound has a molecular structure substituted with polyhydroxyl, polybenzylamine, and quaternary ammonium or multiple quaternary ammonium functional groups, and compared with a raw material, the naphthalene-type compound has greatly improved water solubility in an acidic aqueous solution. An electrochemical reaction has low raw material costs and a high reaction yield, is carried out under a normal temperature and pressure condition without adding additional catalysts, and is carried out under air conditions without inert gas protection.

The application discloses an acid-resistant anion exchange membrane, a preparation method and application thereof, and relates to the technical field of ion exchange membranes. The acid-resistant anion exchange membrane is prepared by the following steps: taking N-allyl benzylamine as a monomer, copolymerizing the monomer with a crosslinking agent in a solvent, coating the copolymer on a base film, and further crosslinking the copolymer in a hot press through a Friedel-Crafts reaction. The anion exchange membrane prepared through the above technical means is suitable for use in nitric acid (salt) system electrodialysis for acid concentration or acid production, and has the advantages of good acid resistance, low surface resistance, stable long-term performance and long service life.

The invention belongs to the technical field of biocides, and particularly relates to a bactericide for oil and gas field water injection and a preparation method thereof.The preparation method comprises the steps that 1, 4-butanediol diglycidyl ether and N-methyl-N-dodecyl benzylamine are synthesized into epoxy quaternary ammonium salt, then caffeine is connected to the epoxy quaternary ammonium salt, and biquaternary ammonium salt is obtained; 1, 4-butanediol diglycidyl ether is used as a linking group, so that the overall stability of the biquaternary ammonium salt can be improved, and the service life of the biquaternary ammonium salt can be prolonged to a certain extent; the caffeine can significantly reduce the drug resistance of bacteria to the biquaternary ammonium salt.

The invention provides a preparation method of an ilastrant intermediate. The preparation method of the intermediate compound G comprises the following steps: by taking a compound C as a raw material, sequentially carrying out reduction, dehydroxylation, coupling with benzylamine and debenzylation on a catalyst RuPHOX-Ru in a hydrogen atmosphere, thereby obtaining the intermediate compound G. The chiral intermediate obtained by the method disclosed by the invention is high in yield, good in chiral purity, low in catalyst consumption and low in cost, and is very suitable for industrial large-scale production.

This invention provides (η) 4 (-Cyclopentadienyl)osmium-pentadienylene, its preparation method and application: Starting from osmium-pentadienylbenzene 1, it reacts with lithium triisopropylsilylacetylene to generate osmium-pentadienylbenzene 2, which is then reacted with lithium phenylacetylene to prepare the catalyst (η). 4 (-cyclopentadienyl)osmium-heptapentane 3; the preparation of this catalyst requires only two steps. Under light and oxygen atmosphere, under irradiation with a 48 W blue LED lamp, 1 mol% (η 4 (-Cyclopentadienyl)osmium pyropentadiene 3 can convert benzylamine into the target imine with a 76% NMR yield after 7 hours at room temperature.

This invention belongs to the field of carbon materials technology, and discloses a high-nuclear-core copper fullerene complex, its preparation method, and its applications. The chemical formula of this high-nuclear-core copper fullerene complex is 6(C7H). 10 N) + [Cu 30 Cl 36 (C 60 (C7H9N) 12 ] 6‑ ·3C7H9N. In this high-nuclearity copper fullerene complex, C 60 Provides a copper source with C=C double bonds, cuprous oxide as a monovalent copper ion, benzylamine, and Cl. ‑ To assist in coordination, high-nuclear copper fullerene complexes can absorb most of the near-infrared light, and the non-radiative transitions of the molecules are greater than the radiative transitions. They have high photothermal conversion efficiency and good electrical conductivity, as well as good photothermal stability, and can be recycled multiple times.

This invention discloses a porphyrin-based porous organic salt (Por-POS), its preparation method, and its photocatalytic application. Its chemical structure is shown in Formula 3. The preparation method is as follows: using the organic base 5,10,15,20-tetra(4-aminophenyl)-21H,23H-porphyrin (Formula 1) and the organic acid 1,5-naphthalenedisulfonic acid (Formula 2) as raw materials, Por-POS material is synthesized through charge-assisted hydrogen bond self-assembly and acid-base neutralization reaction. This method has advantages such as simple process, no need for external catalyst, mild reaction conditions, and short reaction time. The prepared Por-POS can serve as a highly efficient heterogeneous photocatalyst, exhibiting excellent photocatalytic activity and stability in the photocatalytic oxidative coupling reaction of benzylamine under blue light irradiation.

The application discloses a preparation method of a Ledipasvir intermediate (S)-5-(tert-butoxycarbonyl)-5-azaspiro[2,4]heptane-6-carboxylic acid and an intermediate compound thereof, and belongs to the technical field of synthesis of pharmaceutical intermediates. The method uses N-tert-butoxycarbonyl glycine and (R)-alpha-methyl benzylamine as starting materials, and generates a diastereoisomer mixture of (S)-3A and (R)-3B through amide condensation and intramolecular N-alkylation ring closure reaction, and obtains the target configuration intermediate compound (S)-3A through solvent recrystallization and mother liquor racemization reaction and recrystallization. Further, (S)-3A is further subjected to one-pot deprotection of double protection groups and amino protection to obtain the target product. The yield of the target intermediate configuration obtained by the application can reach 86.7%, the chiral purity of the product is greater than 99%, the operation is simple, the conditions are mild, the reaction stability is high, the recycling of non-target configuration compounds is realized, and the industrialized production is easy.

The application discloses a synthesis method of 4-(aminoalkyl) benzene sulfonic acid compound and relates to the technical field of organic synthesis. Benzylamine or phenethylamine is dissolved in a halogenated hydrocarbon solvent, the temperature is lowered to 0-5 DEG C, chlorosulfonic acid is added dropwise for sulfonation reaction, after dropwise addition is completed, the temperature is raised to 40-65 DEG C for reaction until the raw material is completely reacted, the temperature is lowered to 0-5 DEG C, then C1-C4 alcohol solvent containing trace moisture is added into the reaction system as a quenching agent for quenching, after quenching, the halogenated hydrocarbon solvent is recovered by distillation, the remaining substance is cooled, crystallized, filtered and dried, and 4-(aminoalkyl) benzene sulfonic acid is obtained. In the application, n-butanol containing trace moisture (0.5-8%) is used as a quenching agent, the reaction of chlorosulfonic acid and water is diluted and buffered by alcohol, the heat release is gentle, there is no risk of material shock, and the operation safety is far superior to traditional ice water quenching.

The application belongs to the technical field of photovoltaic cells, and relates to a perovskite layer interface processing method based on BTB in-situ proton transfer and a photovoltaic device. The method comprises the following steps: 3,5-bis(trifluoromethyl)benzylamine is dissolved in a first organic solvent and stirred to obtain a BTB solution; the BTB solution is spin-coated on a perovskite layer containing formamidine and then annealing treatment is performed, so that interface processing of the perovskite layer is realized. The perovskite layer after the processing has a smooth and dense interface and a hydrophobic protective layer, the long-term operation stability of the photovoltaic device is effectively enhanced, and the method is suitable for industrialized production of large-area and flexible components.

The invention relates to a continuous synthesis process of 1-(2-chlorphenyl)-3-(1-methyl-1-phenylethyl) urea, and relates to the technical field of organic synthesis.The continuous synthesis process comprises the following steps that o-chlorobenzyl chloride serves as an initial raw material, a continuous reaction device I is filled with sodium cyanate, o-chlorobenzyl chloride is added for a reaction, and reaction liquid is obtained; and introducing the reaction liquid into a continuous reaction device II to react with alpha, alpha-dimethyl benzylamine, and transferring into a continuous reaction device III to perform curing reaction, thereby obtaining the 1-(2-chlorphenyl)-3-(1-methyl-1-phenylethyl) urea. The o-chlorobenzyl chloride serving as an initial raw material is changed into o-chlorobenzylamine without an amino substitution reaction and directly reacts with sodium cyanate to obtain o-chlorobenzyl isocyanate, so that the use of highly toxic phosgene in a traditional process is avoided, the synthesis steps are few, a multi-stage tubular filler reactor is adopted, efficient continuous production is realized, and the product has high yield and purity.

The application provides an ambroxol oral dissolving film composition, a preparation method and application thereof. The ambroxol oral dissolving film composition comprises an active drug, a film forming material and a taste masking agent, and the active drug is 2-amino-3,5-dibromo-N-(trans-4-hydroxycyclohexyl) benzylamine and / or a pharmaceutically acceptable salt thereof, for example, ambroxol hydrochloride. The ambroxol oral dissolving film composition provided by the application has the advantages of thin thickness, good taste, stable properties, immediate dissolution in the oral cavity without drinking water, and fast oral absorption speed. Moreover, the ambroxol oral dissolving film composition has the advantages of simple process, high drug loading, good drug content uniformity, and good market prospect.

A composite quaternary ammonium salt cationic collector and its preparation method and uses involve: adding a halogenated alkyl group into an alkyl tertiary amine containing amido group to carry out a quaternization reaction to obtain an intermediate; and adding a catalyst into the intermediate to carry out a catalytic reaction to obtain a first mixture; adding an alkyl benzylamine into the first mixture to carry out an amidation reaction to obtain a second mixture; and desalting the second mixture to obtain a composite quaternary ammonium salt cationic collector; a molar ratio of the alkyl tertiary amine, the halogenated alkyl group, and the alkyl benzylamine is (1-1.4):(0.8-1.2):(1-1.4).

The invention relates to the technical field of molecular fluorescence, in particular to a polarity-sensitive fluorescent probe based on ICT and a preparation method and application of the polarity-sensitive fluorescent probe. The preparation method of the polarity sensitive type fluorescent probe comprises the following steps: enabling 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine, and enabling the 4, 7-dibromobenzo [c]-1, 2, 5-thiadiazole to react with [4-[bis (4-methoxyphenyl) amino] phenyl] boric acid to obtain 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine. The preparation method comprises the following steps: enabling 4-(7-bromo-2, 1, 3-benzothiadiazole-4-yl)-N, N-bis (4-methoxyphenyl) benzylamine and (6-nitropyridine-3-yl) boric acid to react, so as to prepare the polarity sensitive type fluorescent probe. The polarity-sensitive fluorescent probe can be used as an effective tool for detecting the polarity change of the lipid droplet, and provides auxiliary diagnosis for diagnosis of some diseases related to the lipid droplet by dynamically monitoring the continuous process of the lipid droplet from generation to maturation to decomposition.

The application discloses a preparation method of ethyl-1-oxygen-4-azaspiro [5.5] undecane-9-carboxylic acid ethyl ester and homologues thereof. The method uses a compound 1 as an initial raw material, and the compound 1 is prepared into an intermediate of a compound 13 through a reaction, an epoxy ring of the compound 13 is opened, a required benzyl amine part is introduced, a cyclization reaction is then carried out, the benzyl amine part is reduced, and finally a target product is obtained. The preparation method has the advantages of low cost, simple synthesis steps, good reaction repeatability, easy separation of a target product of each step, industrial production, and high yield of the target product.