44 results about "Epidermal barrier" patented technology

This invention relates to the use of 4-amidino benzylamine derivatives as cosmetic ingredients and to cosmetic compositions, as well as to non-therapeutic methods for the cosmetic treatment of the skin and the scalp. Said derivatives and compositions can be used as urokinase inhibitors to prevent and restore damage of the epidermal barrier. Barrier abnormalities and disruptions respectively are often the starting point of a dry skin state, of itching, of dandruff and of the perception of sensitive skin. These 4-amidino benzylamine derivatives can be used for topical skin and scalp care applications in form of creams, lotions, gels, shampoos and the like.

The invention relates to the technical fields of the biomedicine and the skin health-care and facial cosmetics, in particular to a composite nanoemulsion used for epidermis repair and a preparation method thereof. The product prepared in the invention can quicken the injured epidermis repair and the epidermis barrier function repair, can improve the stability of protein polypeptide drugs or efficacy compositions and enhance the dissolvability of the difficultly dissolved matter and the stability of the easily hydrolyzed matter by promoting the skin to permeate and absorb the efficacy compositions of the epidermis, can scientifically and reasonably match natural drugs, antioxidants and biological derived skin repair polypeptide, and can exert the better epidermis repair efficiency and speed by combining the high-efficiency skin delivery carrier blank nanoemulsion system. Moreover, the product prepared in the invention can also improve the nutrition and moisturizing capabilities of the skin greatly, create an appropriate micro-ecological environment for the epidermis repair and enhance the synergism of the efficacy compositions. In addition, the product prepared in the invention can not contain the preservative and the essence, lowers the toxicity, improves the safety and can be industrially produced without adopting special equipment and energy.

The invention discloses a bionic camellia extract-containing composition for repairing skin barrier and application of the composition. The composition is prepared from skin surface lipid film repairing components: squalene substances, fatty acid, triglyceride and cholesterol analogues; keratinocyte interstitial components: free fatty acid, ceramide and cholesterol analogues; synergistic interaction componentcomprises: a relieving and inflammation diminishing component, an anti-aging component, a whitening component and a skin penetrating agent; wherein the skin surface lipid film repairing and keratinocyte interstitial components are prepared from the camellia extract, camelina oil, oat kernel oil, squalane, phytosterol and ceramide 3. According to the composition for repairing the skin barrier, on the basis of the principle of the human skin barrier, keratinocyte interstitial components and skin surface lipid film repairing components which are similar to the human skin barrier in structure are subjected to bionic matching through a large number of formula tests and studies, the components in the skin barrier are safely simulated, and the complete and healthy epidermal barrier isremodeled.

Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor alpha , and oxysterol activators of the LXR alpha receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.

The invention provides an oral nanometer insulin micelle preparation, comprising a therapeutically effective amount of insulin, pegylated phosphatide and pharmaceutically acceptable adjuvant. The insulin micelle preparation is prepared by using a one-step self-assembly method; particles with a uniform size can be formed, and the entrapment rate of insulin reaches more than 99.0%. In the micelle preparation, polyethylene glycol long chains can be distributed on the surface of a hydrophobic nucleus of an entrapment drug to form a hydrophilic protection film, which is favorable for overcoming a slime layer barrier, an enzyme barrier and an epidermal barrier in an alimentary canal system and protecting smooth entering of insulin into a blood circulation system for performance of hypoglycemic activity.

Provided is a novel method capable of manufacturing an artificial skin model including dendritic cells. A method for manufacturing an artificial skin model includes the following: forming a dermal tissue layer by culturing coated cells in which a cell surface is coated with a coating film containing an extracellular matrix component, so that the coated cells are layered; forming a basal layer including type IV collagen on the dermal tissue layer by bringing type IV collagen into contact with the dermal tissue layer; and forming an epidermal layer by arranging epidermal cells on the basal layer. At least one of the dermal tissue layer and the epidermal layer includes dendritic cells.

The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700 neuro-endocrine-immune related genes. The gene expression pattern was non-random and time dependent; it included increased expression of genes involved in water and salt balance, prostaglandin synthesis, keratinocyte differentiation as well as genes coding for stress effectors, cytokines and metalloproteinases. In contrast, expression was decreased for genes coding for growth factors and their receptors, and for elements of extracellular matrix. This stochastic pattern suggests that transcriptional responses are coordinated and aimed at preservation of epidermal barrier function, prevention of early carcinogenic events and remodeling of extracellular matrix.

The invention discloses skin-care product composition for sensitive skin and particularly relates to skin-care product composition containing a common St.John's wort herb extracting solution, a fructus lycii extracting solution and a pineapple leaf extracting solution. The composition is prepared from natural plant ingredients, can penetrate through the surface layer of skin well, performs the function of strengthening the skin epidermal barrier, improves the state of the sensitive skin and is safe, mild and free of irritation.

A topical composition comprising a mucilage plant extract is provided. The topical composition is formulated for administration to a subject, and may be provided in the form of a skin toner. Methods of preparing the topical composition are also provided, and include combining a mucilage plant extract and a pharmaceutically acceptable additive. The topical composition may be used to control the skin microbiome of a subject, and likewise for treating certain skin conditions involving pathogenic bacteria. A method of ameliorating a skin condition of a subject is therefore also provided. The method generally includes topically administering the topical composition to the skin of the subject, and may be used in ameliorating skin conditions including inflammation and/or decreased epidermal barrier function.

The invention discloses V-face mask, comprising mask essence. The mask essence comprises ethylenediaminetetraacetic acid disodium salt, allantoin, sodium hyaluronate, sodium polyglutamate, butanediol,glycerol, betaine, methylparaben, hydroxyethyl cellulose, polydimethylsiloxane cross-linked polymer, a skin toner, an anti-allergy restoration agent, beta-glucan, an anti-wrinkle agent, phenoxyethanol, ethylhexylglycerin, and purified water. The V-face mask with reasonable components and ratio can promote restoration of epidermal barrier, and can increase the size of fat cells in order to promotedifferentiation and proliferation of fat cells, to reduce fat degradation and to improve tightness of cells, thereby improving skin tightness and fullness and improving wrinkle removal effect.

The invention discloses gentle cleansing cream containing natural antioxidant ingredients and a preparation method thereof. The cleansing cream is prepared from Inca peanut oil, bee pollen extract, ginkgol biloba extract, grape seed extract, a surfactant, a humectant, a chelating agent, a thickening agent, a preservative and water; the surfactant is prepared from soapnut saponin, tea saponin and sodium cocoyl apple amino acid; the bee pollen extract is bee pollen extract of fructus schisandrae chinensis. According to the cleansing cream disclosed by the invention, the Inca peanut oil is addedon the basis of the pure plant extract surfactant, so that skin permeability can be regulated and the cleansing cream is beneficial to skin permeation absorption of nutrient substances. With the addition of an ultra high antioxidant function of the well selected bee pollen extract of fructus schisandrae chinensis, other plant extracts are compounded, so that a coordinating synergistic effect of each ingredient of the cleansing cream is sufficiently played, the aim that one bottle of cream has multiple functions is fulfilled, skin quality is also improved, hydration is reinforced, skin microcirculation is improved, sebum balance is kept, an epidermal barrier is reinforced, and skin aging is retarded.

The invention provides a repairing and aging resistance compound containing multiple plant extracts, a preparation method and application. The repairing and aging resistance compound containing multiple plant extracts is prepared from, by mass, 1%-10% of a moisturizing agent, 3%-10% of a repairing and aging resistance agent, 0.1%-5% of a preservative and the balance deionized water. The olive leafextract and the centalla asiatica extract are cooperatively used and can achieve a synergistic effect, the epidermal barrier capacity is effectively improved, the damaged skin is effectively repaired, and aging resistance is effectively improved. It is proved through an experiment result that cooperative use of the two extracts can achieve the best use effect.

The invention discloses facial mask liquid for repairing couperose skin and a preparation method of the facial mask liquid. The facial mask liquid is prepared from the following components in parts byweight: 16 to 24 parts of protein growth factor, 2 to 4 parts of licochalcone A, 30 to 50 parts of lactobacillus/vigna radiata seed extract/glutamic sodium fermented product filtrate, 6 to 10 parts of vitamin C ethyl ether, 8 to 12 parts of vitamin A, 4 to 6 parts of vitamin B2, 9 to 15 parts of ceramide, 3 to 5 parts of nicotinamide, 10 to 20 parts of rose hydrosol, 15 to 23 parts of lanolin, 4to 8 parts of arginine, 12 to 16 parts of butanediol, 7 to 11 parts of D-panthenol, 0.1 to 0.3 part of folic acid, 24 to 32 parts of hyaluronic acid, 0.5 to 3.5 parts of tea polyphenol, 1 to 14 partsof thickening agent and 80 to 100 parts of deionized water. The protein growth factor is prepared from the following components in percentage by weight: 20 to 28 percent of oligopeptide-1, 10 to 14 percent of oligopeptide-2, 18 to 22 percent of oligopeptide-3, 26 to 46 percent of oligopeptide-5 and 6 to 10 percent of palmitoyl tripeptide-8. The facial mask liquid disclosed by the invention has theadvantages that elasticity and functions of facial capillary are favorably restored and blood circulation is improved; in addition, intercellular matrix is replenished, cuticle is reconstructed, fibroblast proliferation is promoted and damaged epidermal barrier is repaired, so that the couperose skin can be cured from the root.

Compositions and methods for treating aged skin or skin otherwise suffering from abnormal epidermal barrier function are disclosed, where the compositions include hesperidin.

The present invention relates to a composition for improving skin barrier damage and/or alleviating skin inflammation, wherein 3,5-dicaffeoylquinic acid isolated from an Aster glehni (AG) extract is introduced as an active ingredient of a cosmetic composition or a pharmaceutical composition for improving skim barrier damage and alleviating skin inflammation, thereby being effective in preventing and improving atopic dermatitis.

The invention relates to a natural polysaccharide nano hydrogel mask based on hollow nanoparticles, the mask is prepared by forming hydrogel after hollow nanoparticles entrap natural polysaccharide mixed liquor, and the natural polysaccharide mixed liquor is prepared from the following components in percentage by mass: 30-50% of natural polysaccharide and 50-70% of gum oil component, the natural polysaccharide is a natural polysaccharide product extracted from motherwort herb, chia seeds, grape seeds, Chinese wolfberry fruits and tremella fuciformis. The polysaccharide nano hydrogel mask provided by the invention contains various natural polysaccharides, has no side effect, and has a relatively good protection effect on skin; natural polysaccharide components are entrapped in the hollow nanoparticles to prepare the polysaccharide nano hydrogel mask, so that the natural components can be better absorbed by skin, and the polysaccharide nano hydrogel mask has remarkable effects in the aspects of resisting oxidation and aging, maintaining epidermal barrier of cuticle, interrupting epidermal melanin, whitening and moisturizing, brightening skin color, making skin elastic and glossy and the like.