28 results about "Epidermal barrier" patented technology

The invention relates to the technical field of biological polypeptides, in particular to cyclic pentapeptide-4, a preparation method thereof and a polypeptide cosmetic. The cyclic pentapeptide-4 has a chemical structural formula as shown in a formula I in the specification. Compared with the existing palmitoyl pentapeptide-4, the cyclopentapeptide-4 provided by the invention has good ability to penetrate through an epidermal barrier, so that the cyclopentapeptide-4 can penetrate into skin tissues more deeply, thereby significantly improving the anti-wrinkle and anti-aging ability of the skin. Meanwhile, the expression level of anti-aging genes in human skin fibroblasts can be remarkably improved. Therefore, the cyclic pentapeptide-4 disclosed by the invention can be used for preparing an anti-aging preparation so as to improve the expression level of an anti-aging gene in human skin fibroblasts and further relieve skin aging. # imgabs0 #

A use of tetrahydropalmatine in the preparation of a drug for treating atopic dermatitis. The treatment of atopic dermatitis with tetrahydropalmatine is researched. The research shows that tetrahydropalmatine can significantly improve atopic dermatitis caused by calcipotriol and inhibit skin epidermal barrier damage, pruritus factor release and inflammatory factor release caused by tetrahydropalmatine, so that tetrahydropalmatine can be used for the treatment of atopic dermatitis.

The application belongs to the technical field of medicines, and specifically provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases include atopic dermatitis and skin epidermal barrier damage. The application finds that Phanginin A can reduce atopic dermatitis lesion scores, improve atopic dermatitis skin pathological thickening and inflammatory cell infiltration, reduce spleen inflammatory response, inhibit volume increase, promote thymus function recovery, down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the application also finds that Phanginin A can promote keratinocyte scratch healing, and can be used for repairing skin epidermal barrier damage.

The invention relates to the technical field of skin care products, in particular to a turnip extracting solution and a preparation method and application thereof. The preparation method comprises the following steps: mixing turnip with water, decocting to obtain a decoction, decolorizing, filtering and concentrating to obtain the turnip extracting solution. The turnip extracting solution is used for effectively inhibiting B16 cells from generating melanin and inhibiting the activity of tyrosinase in a melanin synthesis path; the increase of the active oxygen level in HaCaT cells is effectively prevented, and the antioxidant effect is obvious; the inflammation of the SDS surfactant on HaCaT cells is effectively prevented, and the generation of an inflammatory factor TNF-alpha is reduced; the expression of cell natural moisturizing factors, ceramide de novo synthesis rate-limiting enzymes and epidermal barrier related genes is up-regulated; the composition can effectively promote the generation of cell collagen and elastin, reduces the synthesis of matrix metalloproteinase 1 for degrading collagen under ultraviolet radiation, and has an anti-aging effect.

To utilize action of amplifying expression of an epidermal barrier function-related gene by a diacylglycerol polyethylene glycol adduct.SOLUTION: An agent for amplifying expression of epidermal barrier function-related gene comprises a diacylglycerol polyethylene glycol adduct as an active ingredient, the diacylglycerol PEG adduct having a following structural formula, in which the number of carbon atoms of R in a long-chain fatty acid is in the range from 11 to 23 and n in a polyethylene glycol chain is in the range from 11 to 46.SELECTED DRAWING: Figure 1

The present invention relates to the field of microorganisms, and in particular to Lactococcus lactis, a microbial agent, and a preparation method and application thereof. The present invention provides Lactococcus lactis JWA32 (Lactococcus lactis JWA32), and its deposit number is: CCTCC No.M 20221851. The present invention provides Lactococcus lactis, a microbial agent, and a preparation method and application thereof. The present invention provides a strain of Lactococcus lactis with excellent efficacy in preparing a skin microecological preparation, which can alleviate the oxidative damage of HaCaT cells and repair the epidermal barrier.

The present invention relates to isocetyl stearoyl stearate for its use in strengthening and / or preventing a decrease in the epidermal barrier function, in particular for enhancing the skin's protection against pollution. The present invention also relates to a cosmetic or dermatological composition comprising isocetyl stearoyl stearate and at least one cosmetically or dermatologically acceptable excipient for its use in strengthening and / or preventing a decrease in the epidermal barrier function, in particular for enhancing the skin's protection against pollution.

The invention belongs to the technical field of biology, and particularly relates to application of DPP4 in treatment or diagnosis of inflammatory skin diseases characterized by skin barrier injury. According to the application disclosed by the invention, key effects of dipeptidyl peptidase-4 (DPP4) in regulating and controlling keratinocyte differentiation and maintaining normal skin barrier structures and functions are analyzed, and on the basis of AAV-mediated skin tissue keratinocyte DPP4 gene therapy, the conditions of abnormal epidermis thickening and abnormal differentiation caused by skin damage can be relieved by inducing normal differentiation of keratinocytes, so that the curative effect of the skin tissue keratinocyte DPP4 is improved, and the curative effect of the skin tissue keratinocyte DPP4 is improved. The traditional Chinese medicine composition provided by the invention can be used for promoting the repair of an epidermal barrier and improving and maintaining the steady state of the skin barrier so as to effectively improve psoriasis-like dermatitis, and a new scheme is provided for treating inflammatory dermatosis characterized by skin barrier injury. In addition, the expression level of DPP4 can be used as a diagnostic marker for inflammatory skin diseases characterized by skin barrier injury.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with whitening, brightening and anti-saccharification functions, a preparation method of the sialic acid composition and cosmetics. The sialic acid composition is prepared from the following components in parts by mass: 4 to 10 parts of sialic acid, 8 to 15 parts of carnosine and 15 to 25 parts of nicotinamide. According to the sialic acid composition with the whitening, brightening and anti-saccharification functions, sialic acid, nicotinamide and carnosine are matched and synergistically exert effects, and the sialic acid composition can enhance the epidermal barrier function, promote permeation of active ingredients, remove AGEs, block generation of saccharification end products, inhibit melanin transport and regulate cell metabolism, so that the skin whitening, brightening and anti-saccharification functions are achieved. Finally, the three components form a synergistic pathway of blocking saccharification, inhibiting melanin and transdermal permeation promotion; therefore, the problems of uneven skin color and darkness of the skin are fundamentally solved.

The invention provides a method for analyzing an anti-eczema effect target spot of traumatology based on network pharmacology. The method comprises the following steps: firstly, screening out seven representative active components through a SwisSADME platform, predicting by integrating SwisTarget Prediction, SEA and ChEMBL databases to obtain 367 drug targets, and analyzing to obtain 82 intersection targets; a PPI network is constructed based on an STRING database, and 10 core targets such as IL6, TNF and EGFR are screened out through topology analysis. GO / KEGG enrichment analysis reveals that the GO / KEGG is significantly enriched in the processes of IL-17 signal pathway, epidermal barrier repair and the like. Molecular docking verification proves that isofraxidin, scopoletin and verbenin are strongly combined with EGFR (epidermal growth factor receptor) targets. According to the method, a multi-component-multi-target-multi-channel synergistic eczema treatment mechanism of traumatology is systematically analyzed, and a theoretical basis is provided for preparation optimization.

The invention relates to the technical field of materials, and discloses an inorganic material with sunscreen and skin barrier repair functions and a preparation method thereof, the preparation method comprises the following steps: S1, preparing zinc oxide sol; s2, coating is carried out; s3, filtering, washing and primary drying; s4, ultraviolet ozone and oxygen treatment and curing are conducted, and the inorganic material with the sunscreen and skin barrier repairing functions is obtained. The preparation method is simple, energy-saving and environmentally friendly, and the material has the sunscreen and skin barrier repairing dual effects.

The application discloses a kind of total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug composition in transdermal drug preparation application.In transdermal drug preparation the application advantage of this composition is in:(1) the active epidermal barrier and stratum corneum barrier of skin is the main obstacle of total glycosides of Paeonia lactiflora transdermal absorption.The non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of skin, if it is used with the skin stratum corneum barrier of penetration enhancer and can significantly improve the transdermal penetration performance of total glycosides of Paeonia lactiflora in this transdermal drug preparation, it is a kind of with simple preparation process, easy industrial production, skin non-invasive characteristics can safely, efficiently improve the method for the transdermal penetration ability of total glycosides of Paeonia lactiflora;(2) total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug combination in transdermal drug preparation, in the curative effect of treating primary dysmenorrhea and rheumatoid arthritis disease has obvious synergistic effect, curative effect is excellent.

The present disclosure is directed to dermatological formulations and their use for treating a variety of dermatological diseases and disorders, and for repairing and restoring a disrupted epidermal barrier, inhibiting inflammation, restoring a proper environment for maintaining a balanced symbiotic microbiome, and inhibiting the growth of pathogenic microorganisms in the epidermis—the outer layer of mammalian skin.

The present invention aims to provide an epidermal barrier function improving agent and an aromatic hydrocarbon receptor activator containing Artemisia princeps extract and / or vitamin K as active ingredients. [Solution] The present invention provides an epidermal barrier function improving agent and an aromatic hydrocarbon receptor activator containing Artemisia princeps extract and / or vitamin K as active ingredients.

The present invention discloses an anti-aging composition, which is composed of the following components by weight: 0.5 to 3 parts of Meconopsis pilosula extract; 0.0005 to 0.0025 parts of nonapeptide-1 or acetyl hexapeptide; 0.0001 to 0.0005 parts of palmitoyl hexapeptide-12; 0.005 to 0.01 parts of mulberry root extract; 0.5 to 3 parts of supramolecular schizonepeta tenuifolia extract; 0.15 to 0.5 parts of peony root bark extract; and 0.5 to 3 parts of arginine / lysine polypeptide. The novel anti-aging composition of the present invention is based on the comprehensive anti-aging solution that takes into account the epidermis, dermis, and muscle layers proposed in the early stage. It is further designed from the perspectives of epidermal barrier repair, basement membrane repair, dermal repair, and mitochondrial ROS clearance, and does not use strong active ingredients that are irritating to the skin, ensuring that the product itself will not damage the skin barrier and cause skin inflammation.

The invention discloses an application of a pharmaceutical composition consisting of total glucosides of paeony and a non-steroidal anti-inflammatory drug in a transdermal drug delivery preparation. The application of the composition in a transdermal drug delivery preparation has the advantages that (1) the active epidermal barrier and the cuticle barrier of the skin are main barriers of transdermal absorption of total glucosides of paeony; the non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of the skin, and if the non-steroidal anti-inflammatory drug is matched with a penetration enhancer for opening the cuticle barrier of the skin, the transdermal permeability of the total glucosides of paeony in the transdermal drug delivery preparation can be remarkably improved; the method has the characteristics of simple preparation process, easiness in industrial production and non-invasive skin, and can safely and efficiently improve the percutaneous permeability of the total glucosides of paeony; and (2) the total glucosides of paeony and the non-steroidal anti-inflammatory drug in the transdermal drug delivery preparation are combined for use, so that the total glucosides of paeony and the non-steroidal anti-inflammatory drug have an obvious synergistic effect in the aspect of curative effect on primary dysmenorrhea and rheumatoid arthritis, and the curative effect is excellent.

The present invention relates to isocetyl stearyloxy stea rate for use in enhancing and / or preventing a decrease in epidermal barrier function, in particular for use in enhancing the protection of the skin against pollution. The present invention also relates to a cosmetic or dermatological composition comprising isocetyl stearyloxy stearate and at least one cosmetically or dermatologically acceptable excipient for use in enhancing and / or preventing a decrease in epidermal barrier function, in particular for use in enhancing the protection of the skin against pollution.

To provide a skin care preparation synergistically improved in moisturizing effect and epidermal barrier function-improving effect by using specific components in combination.SOLUTION: The skin care preparation for external use comprises a citron extract, especially a sphingolipid-containing citron extract, a Rosa rugosa Thunberg flower extract and a fennel extract. The skin care preparation contains one or more kinds of extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract.SELECTED DRAWING: None

The invention discloses anti-aging collagen essence powder and a preparation method and application thereof, and belongs to the technical field of cosmetics, the essence powder maintains high activity of recombinant III-type humanized collagen and recombinant I-type humanized collagen through a freeze-drying protection system, and ingredients such as an oligopeptide synergist, hyaluronic acid and bifidus yeast are supplemented, so that the anti-aging collagen essence powder is prepared. The full-layer anti-aging effects of repairing epidermis barriers, enhancing dermis support, reducing wrinkles, moisturizing, resisting oxidation and the like are realized; the preparation method adopts a low-temperature dissolution-sterilization-freeze-drying process, and the product is suitable for application of skin care essence and the like, is clinically verified to remarkably improve the skin aging sign, and has important market value and application prospect.

The invention provides a medical sodium hyaluronate composite solution and a preparation method thereof. The sodium hyaluronate composite solution is prepared from the following raw materials in parts by weight: 6 to 8 parts of sodium hyaluronate, 12 to 18 parts of mussel mucoprotein compound, 1.5 to 2 parts of vitamin C ethyl ether, 0.5 to 1.5 parts of sodium chloride and 150 to 160 parts of water for injection. Through the synergistic effect of the sodium hyaluronate, the mussel mucoprotein compound and the vitamin C ethyl ether, a hydrated film protection barrier can be formed on the skin surface in the use process to resist the damage of an external bad environment, a sensitization source, bacteria and the like, meanwhile, a non-chronic micro-wound moist environment can be kept, the moisture loss is slow, and the skin care effect is good. The inflammatory reaction is effectively reduced, secondary inflammation infection of the wound surface is avoided, and migration and growth of cells at the wound can be improved; moreover, part of active substances can permeate into the skin, the moisture content in the skin is maintained, the recovery of the epidermis barrier function is promoted, and the healing of the wound surface is effectively promoted from inside to outside.

The present invention relates to isocetyl stearoyl stearate for its use in reinforcing and / or preventing a decrease in epidermal barrier function, in particular for enhancing the skin's protection against pollution. The present invention also relates to a cosmetic or dermatological composition comprising isocetyl stearoyl stearate and at least one cosmetically or dermatologically acceptable excipient for its use in reinforcing and / or preventing a decrease in epidermal barrier function, in particular for enhancing the skin's protection against pollution.

The invention belongs to the technical field of medicines, and particularly provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases comprise atopic dermatitis and skin epidermal barrier injury. It is found that Phanginin A can reduce the skin lesion score of atopic dermatitis, improve dermatological thickening and inflammatory cell infiltration of atopic dermatitis, relieve spleen inflammatory response, inhibit volume increase of spleen, promote thymus function recovery and down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the invention also finds that Phanginin A can promote the healing of cutin cell scratches, and can be used for repairing skin epidermal barrier injury.

The invention provides propionibacterium acnes and application of metabolites of the propionibacterium acnes to regulation of skin barriers. Specifically, the invention provides application of propionibacterium acnes and / or propionibacterium acnes metabolites in preparation of drugs, and the drugs are used for at least one of the following: activating an AhR signal channel; the expression of the ALDH1A3 is promoted or the activity of the ALDH1A3 is improved; the synthesis of retinoic acid is promoted; the expression of skin barrier functional genes is promoted; the epidermal barrier integrity is promoted. The discovery of the relationship between the propionibacterium acnes and the AhR provides a new mechanism for the subsequent research on the promotion of the completeness of the host skin barrier function by the skin symbiotic bacteria.

The present invention relates to the cosmetic use of an oil derived from the achenes of Silybum marianum (L.) Gaertn. to prevent a decrease and / or strengthen the epidermal barrier function.

The invention discloses a goat milk extract with anti-wrinkle and repairing effects and an enzymolysis biological preparation method, and particularly relates to the technical field of cosmetics, the goat milk extract is prepared by performing low-temperature vacuum de-odoring treatment and treating easily-sensitized protein by adopting plant protease and microbial protease, and the goat milk extract is free of goaty flavor and sensitization, and has no side effects. Nutritional ingredients and effects of goat milk are reserved; the preparation method comprises the steps of goat milk pretreatment, low-temperature vacuum de-odoring, enzymolysis, centrifugal separation and the like. The extract is applied to cosmetic compositions, contains various components such as goat milk extract, other functional skin care product additives, nicotinamide and the like, and can synergistically promote collagen synthesis, enhance epidermis barrier repair capability and realize anti-wrinkle and repair effects.

The present invention discloses a method for preparing a double-layer microneedle patch for atopic dermatitis. The method comprises the following steps: using double templates to replicate a double-layer microneedle; using methacrylate gelatin, forming an inner needle tip layer by ultraviolet curing; then transferring the formed microneedle into a large template; using sodium hyaluronate, forming an outer needle tip layer by drying, thereby preparing the double-layer microneedle patch. The double-layer microneedle patch prepared by the present invention has excellent mechanical properties and can successfully penetrate the thickened skin of atopic dermatitis patients. After penetration, the needle tip and the backing layer quickly separate, and the outer needle tip quickly dissolves under the action of tissue fluid, leaving the inner needle tip with strong biocompatibility and capable of sustained-release therapeutic drugs. While providing anti-inflammatory effects, it also repairs the epidermal barrier, thereby alleviating the symptoms of atopic dermatitis. The double-layer microneedle patch prepared by the present invention has diverse functions, significant efficacy, and a wide range of applications.

The invention relates to a skin anti-aging composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition is prepared from the following components: a recombinant human source type I collagen, a recombinant human source type III collagen, a recombinant human source type IV collagen, a recombinant human source type VI collagen, ceramide, a barrier repair signal peptide, panthenol and sodium hyaluronate. According to the invention, a corium layer and a basilar membrane structure are reconstructed through cooperation of a plurality of collagens, ceramide and a barrier repair signal peptide jointly repair and consolidate an epidermal barrier, panthenol promotes metabolism and synthesis functions of skin cells, and sodium hyaluronate provides effects of deep hydration and immediate filling. The composition can effectively improve multiple aging signs of skin laxity, wrinkles, dryness, lack of elasticity and the like, and synergistic intervention aiming at multiple key levels of skin aging is realized.

The present invention relates to isocetyl stearoyl stearate for use in enhancing and / or preventing the deterioration of the epidermal barrier function, particularly for enhancing protection of the skin against contamination. The present invention relates to a cosmetic or dermatological composition comprising isocetyl stearoyl stearate and at least one cosmetic or dermatologically acceptable excipient for use in enhancing and / or preventing the deterioration of the epidermal barrier function, particularly for enhancing protection of the skin against contamination.