44 results about "Epidermal barrier" patented technology

The invention relates to the technical field of biomedicines, and particularly relates to an artificial skin and a preparation method thereof. The artificial skin comprises a dermal layer and an epidermal layer, wherein the dermal layer and the epidermal layer are fitted; the dermal layer comprises a timbering material and fibroblast; the epidermal layer consists of a timbering material and epidermal cells; the timbering material consists of DMEM / F12 culture media, I type mouse collagen, chitin, glycosaminoglycan and glutaraldehyde; the epidermal cells and fibroblast are produced by fat stem cell differentiation. No smearing is needed in use, the structure of the artificial skin is more suitable for the self-situations of patients, and the artificial skin can achieves a better therapeutic effect on the wound restoration, the heeling speed of the skin is faster, and the wound is more smooth after being healed. Furthermore, the artificial skin has small possibility of breaking in use due to good mechanical performance.

This invention relates to the use of 4-amidino benzylamine derivatives as cosmetic ingredients and to cosmetic compositions, as well as to non-therapeutic methods for the cosmetic treatment of the skin and the scalp. Said derivatives and compositions can be used as urokinase inhibitors to prevent and restore damage of the epidermal barrier. Barrier abnormalities and disruptions respectively are often the starting point of a dry skin state, of itching, of dandruff and of the perception of sensitive skin. These 4-amidino benzylamine derivatives can be used for topical skin and scalp care applications in form of creams, lotions, gels, shampoos and the like.

The invention belongs to the technical field of cosmetics, and particularly relates to a liposome of bionic vernix caseosa and a preparing method and application thereof. The liposome includes squalane, hydrogenated lecithin, antibacterial peptide and amino acids, and is prepared through emulsification to cover the antibacterial peptide within the inner layer of the liposome, thus improving stability of the antibacterial peptide and other activated proteins. When the liposome prepared by the method is applied onto skin, the absorption rate of activated compounds can be increased, thus reducingthe dosage of the activated compounds and reducing side effects of the activated compounds on human skin. In addition, the liposome prepared by the method has antibacterial, anti-infection, pH buffering and skin epidermal barrier maintaining functions, and can be widely applied in various skincare products in the field of cosmetics.

The invention relates to the technical fields of the biomedicine and the skin health-care and facial cosmetics, in particular to a composite nanoemulsion used for epidermis repair and a preparation method thereof. The product prepared in the invention can quicken the injured epidermis repair and the epidermis barrier function repair, can improve the stability of protein polypeptide drugs or efficacy compositions and enhance the dissolvability of the difficultly dissolved matter and the stability of the easily hydrolyzed matter by promoting the skin to permeate and absorb the efficacy compositions of the epidermis, can scientifically and reasonably match natural drugs, antioxidants and biological derived skin repair polypeptide, and can exert the better epidermis repair efficiency and speed by combining the high-efficiency skin delivery carrier blank nanoemulsion system. Moreover, the product prepared in the invention can also improve the nutrition and moisturizing capabilities of the skin greatly, create an appropriate micro-ecological environment for the epidermis repair and enhance the synergism of the efficacy compositions. In addition, the product prepared in the invention can not contain the preservative and the essence, lowers the toxicity, improves the safety and can be industrially produced without adopting special equipment and energy.

The invention discloses a bionic camellia extract-containing composition for repairing skin barrier and application of the composition. The composition is prepared from skin surface lipid film repairing components: squalene substances, fatty acid, triglyceride and cholesterol analogues; keratinocyte interstitial components: free fatty acid, ceramide and cholesterol analogues; synergistic interaction componentcomprises: a relieving and inflammation diminishing component, an anti-aging component, a whitening component and a skin penetrating agent; wherein the skin surface lipid film repairing and keratinocyte interstitial components are prepared from the camellia extract, camelina oil, oat kernel oil, squalane, phytosterol and ceramide 3. According to the composition for repairing the skin barrier, on the basis of the principle of the human skin barrier, keratinocyte interstitial components and skin surface lipid film repairing components which are similar to the human skin barrier in structure are subjected to bionic matching through a large number of formula tests and studies, the components in the skin barrier are safely simulated, and the complete and healthy epidermal barrier isremodeled.

Disorders of the skin and mucous membranes that have a disrupted or dysfunctional epidermal barrier are treated or prevented by topical application of compounds that are either activators of the farnesoid X receptor, activators of the peroxisome proliferator-activated receptor alpha , and oxysterol activators of the LXR alpha receptor. The same compounds are also effective in treating disorders of epidermal differentiation and proliferation.

The invention discloses an autologous whole blood homogenate compound for reconstruction of an autologous skin epidermis protective screen. After the autologous whole blood is homogenized, under the synergetic effects of multiple bioactive substances and cell growth factors released by the autologous whole blood, the autoblood is effectively applied to epidermis repair and reconstruction of the skin protective screen, thereby giving better play to the maximum value and biological effects of the autoblood in autologous application; and because the autologous whole blood homogenate liquid plays a mutually cooperative protective effect with other auxiliary components and strengthens the compounding effect of the cell factors in epidermis reconstruction, the autologous whole blood homogenate liquid compound has good effects on epidermis repair and functional reconstruction of the epidermis protective screen, can improve the functional problems of the human skin protective screen in multiple aspects at different levels, restores the health of skin, and basically solves the functional problems of the epidermis protective screen. In addition, the preparation method disclosed by the invention is simple, convenient to operate, easy to learn and popularize, and suitable for medical cosmetology institutions with legal qualification for medical cosmetology.

The invention provides an oral nanometer insulin micelle preparation, comprising a therapeutically effective amount of insulin, pegylated phosphatide and pharmaceutically acceptable adjuvant. The insulin micelle preparation is prepared by using a one-step self-assembly method; particles with a uniform size can be formed, and the entrapment rate of insulin reaches more than 99.0%. In the micelle preparation, polyethylene glycol long chains can be distributed on the surface of a hydrophobic nucleus of an entrapment drug to form a hydrophilic protection film, which is favorable for overcoming a slime layer barrier, an enzyme barrier and an epidermal barrier in an alimentary canal system and protecting smooth entering of insulin into a blood circulation system for performance of hypoglycemic activity.

Provided is a novel method capable of manufacturing an artificial skin model including dendritic cells. A method for manufacturing an artificial skin model includes the following: forming a dermal tissue layer by culturing coated cells in which a cell surface is coated with a coating film containing an extracellular matrix component, so that the coated cells are layered; forming a basal layer including type IV collagen on the dermal tissue layer by bringing type IV collagen into contact with the dermal tissue layer; and forming an epidermal layer by arranging epidermal cells on the basal layer. At least one of the dermal tissue layer and the epidermal layer includes dendritic cells.

The present invention provides a novel DNA microarray chip that can be used for simultaneous testing of transcriptional responses to cutaneous stressors in the context of neuro-endocrine-immune functions of the skin. The transcriptional responses to ultraviolet radiation in epidermal keratinocytes were tested using such microarray chip containing more than 700 neuro-endocrine-immune related genes. The gene expression pattern was non-random and time dependent; it included increased expression of genes involved in water and salt balance, prostaglandin synthesis, keratinocyte differentiation as well as genes coding for stress effectors, cytokines and metalloproteinases. In contrast, expression was decreased for genes coding for growth factors and their receptors, and for elements of extracellular matrix. This stochastic pattern suggests that transcriptional responses are coordinated and aimed at preservation of epidermal barrier function, prevention of early carcinogenic events and remodeling of extracellular matrix.

The invention discloses an anti-aging composition, which is prepared from the following components in parts by weight: 0.04 to 0.4 part of cordyceps sinensis extract; 0.0001 to 0.003 part of palmitoyl hexapeptide-12, 0.0001 to 0.003 0.002 to 0.01 part of a mulberry root extract; 0.001 to 0.01 part of beta-alanyl hydroxyprolyl diaminobutyric acid benzylamine, and 0.001 to 0.01 part of beta-alanyl 0.07 to 0.21 part of a chrysanthemum indicum extract; 0.002 to 0.1 part of a peony root bark extract; 0.004 to 0.01 part of ergothioneine and 0.056 to 0.168 part of kappaphycus alvarezii extract. The anti-aging composition disclosed by the invention is designed in the directions of epidermal barrier repair, dermis repair, nuclear gene telomere protection and mitochondrial ROS (reactive oxygen species) removal, anti-aging at epidermal, dermis and muscle levels is considered in the aspect of dermatology, and a strong-effect active matter with irritation to skin is not used, so that the safety of the product is ensured. The invention further discloses an anti-aging cosmetic containing the anti-aging composition.

The invention discloses skin-care product composition for sensitive skin and particularly relates to skin-care product composition containing a common St.John's wort herb extracting solution, a fructus lycii extracting solution and a pineapple leaf extracting solution. The composition is prepared from natural plant ingredients, can penetrate through the surface layer of skin well, performs the function of strengthening the skin epidermal barrier, improves the state of the sensitive skin and is safe, mild and free of irritation.

A topical composition comprising a mucilage plant extract is provided. The topical composition is formulated for administration to a subject, and may be provided in the form of a skin toner. Methods of preparing the topical composition are also provided, and include combining a mucilage plant extract and a pharmaceutically acceptable additive. The topical composition may be used to control the skin microbiome of a subject, and likewise for treating certain skin conditions involving pathogenic bacteria. A method of ameliorating a skin condition of a subject is therefore also provided. The method generally includes topically administering the topical composition to the skin of the subject, and may be used in ameliorating skin conditions including inflammation and / or decreased epidermal barrier function.

The present invention is directed to cosmetic and / or pharmaceutical compositions comprising at least one plant lipid, having as its main application the treatment of keratinous materials, particularly skin, hair, scalp, nails and eyelashes, by modulating the expression of genes responsible for ROS metabolism, lipid metabolism, skin integrity, cell renewal, cell differentiation, strengthening the skin barrier, calcium metabolism, cell proliferation, tissue healing and / or repair, cell adhesion, carbohydrate metabolism, hydration, skin homeostasis / maintenance, skin defense and / or protection, remodeling and / or extracellular matrix synthesis, skin peeling, tissue maintenance, cell signaling, normal development of the epidermis, epidermal barrier function, development of the skin, dermis-epidermis junction, anti-inflammatory or antioxidant action in keratinous materials, through the modulation of the expression of the genes involved in said functions. The present invention also teaches methods of modulating the expression of genes responsible for such functions of keratinous materials and the use of said plant lipids in the preparation of said compositions.

The invention discloses V-face mask, comprising mask essence. The mask essence comprises ethylenediaminetetraacetic acid disodium salt, allantoin, sodium hyaluronate, sodium polyglutamate, butanediol,glycerol, betaine, methylparaben, hydroxyethyl cellulose, polydimethylsiloxane cross-linked polymer, a skin toner, an anti-allergy restoration agent, beta-glucan, an anti-wrinkle agent, phenoxyethanol, ethylhexylglycerin, and purified water. The V-face mask with reasonable components and ratio can promote restoration of epidermal barrier, and can increase the size of fat cells in order to promotedifferentiation and proliferation of fat cells, to reduce fat degradation and to improve tightness of cells, thereby improving skin tightness and fullness and improving wrinkle removal effect.

Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein R1 represents C1-4 alkylene; R2 and R3 represent each liner or branched C1-8 alkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

The invention discloses an external preparation for treating facial seborrheic dermatitis, belongs to the technical field of medical, dental or dressing preparations, and in particular relates to an external preparation for treating facial seborrheic dermatitis. The external preparation disclosed by the invention at least comprises the following medicinal components: 0.05-0.1 part of chlorhexidine acetate, 0.05-0.15 part of ketoconazole, 0.05-0.15 part of ceramide, 8-12 parts of glycerin and 0.8-1.2 parts of glycyrrhizin. According to the external preparation disclosed by the invention, the staphylococcus epidermidis can be effectively killed by chlorhexidine acetate, the pityrosporum orbiculare is effectively inhibited by ketoconazole, the inflammatory reaction is inhibited by the glycyrrhizin, the natural moisturizing factors of cuticle are increased by the glycerin, and the epidermal barrier function is repaired by the ceramide. According to the comprehensive effects of the five medical components, the facial seborrheic dermatitis can be effectively treated.

The invention provides a repairing and aging resistance compound containing multiple plant extracts, a preparation method and application. The repairing and aging resistance compound containing multiple plant extracts is prepared from, by mass, 1%-10% of a moisturizing agent, 3%-10% of a repairing and aging resistance agent, 0.1%-5% of a preservative and the balance deionized water. The olive leafextract and the centalla asiatica extract are cooperatively used and can achieve a synergistic effect, the epidermal barrier capacity is effectively improved, the damaged skin is effectively repaired, and aging resistance is effectively improved. It is proved through an experiment result that cooperative use of the two extracts can achieve the best use effect.

The invention discloses facial mask liquid for repairing couperose skin and a preparation method of the facial mask liquid. The facial mask liquid is prepared from the following components in parts byweight: 16 to 24 parts of protein growth factor, 2 to 4 parts of licochalcone A, 30 to 50 parts of lactobacillus / vigna radiata seed extract / glutamic sodium fermented product filtrate, 6 to 10 parts of vitamin C ethyl ether, 8 to 12 parts of vitamin A, 4 to 6 parts of vitamin B2, 9 to 15 parts of ceramide, 3 to 5 parts of nicotinamide, 10 to 20 parts of rose hydrosol, 15 to 23 parts of lanolin, 4to 8 parts of arginine, 12 to 16 parts of butanediol, 7 to 11 parts of D-panthenol, 0.1 to 0.3 part of folic acid, 24 to 32 parts of hyaluronic acid, 0.5 to 3.5 parts of tea polyphenol, 1 to 14 partsof thickening agent and 80 to 100 parts of deionized water. The protein growth factor is prepared from the following components in percentage by weight: 20 to 28 percent of oligopeptide-1, 10 to 14 percent of oligopeptide-2, 18 to 22 percent of oligopeptide-3, 26 to 46 percent of oligopeptide-5 and 6 to 10 percent of palmitoyl tripeptide-8. The facial mask liquid disclosed by the invention has theadvantages that elasticity and functions of facial capillary are favorably restored and blood circulation is improved; in addition, intercellular matrix is replenished, cuticle is reconstructed, fibroblast proliferation is promoted and damaged epidermal barrier is repaired, so that the couperose skin can be cured from the root.

Compositions and methods for treating aged skin or skin otherwise suffering from abnormal epidermal barrier function are disclosed, where the compositions include hesperidin.

The invention belongs to the technical field of cosmetics, and discloses a moisturizing and soothing spray. The moisturizing and soothing spray comprises a group A preparation water, p-hydroxyacetophenone, a group B preparation 1, 2-pentanediol, a glycerol composition and a butanediol composition. A preparation method of the preparation comprises the following steps: S1, adding the group A preparation into a water phase pot, performing stirring and heating to 90 DEG C until no particles are dissolved, and performing sterilizing at constant temperature for 10 minutes; S2, after sterilization of the group A preparation is completed, starting the cooling; S3, performing cooling to 45 DEG C, adding the preparation B, and uniformly performing stirring; S4, performing cooling to 38 DEG C, performing filtering with 400-mesh filter cloth, and performing discharging. The moisturizing and soothing spray is used for after-sun first aid, thermal spring water and glacier water adopted in the formula have the effects of enhancing skin tolerance and repairing skin barrier, and component saccharide isomeride is very similar to the composition of NMF in human skin and can be combined with free amino to form a layer of water-locking film, TEWL is reduced, and water production of the skin is improved; The moisturizing and soothing spray has the effects of quickly and deeply combining and moisturizing, promoting the generation of NMF, improving the barrier function of an epidermis barrier and relieving the symptoms such as dryness, scurf and pruritus.

Skin external agent compositions and drugs characterized by containing fumaric acid diester derivatives represented by following general formula (1), wherein R<1 >represents C1-4 alkylene; R<2 >and R<3 >represent each liner or branched C1-8 alkyl; and n is an integer of 2 to 5; which provide epidermal barrier function potentiating agents and skin external agent compositions having a high safety, quickly relieving epidermal permeation barrier function failures and having an effect of maintaining the skin in a cosmetologically healthy state; agents to be used together with HB-EFG expression inducing agents accelerating epidermal turnover, amphiregulin expression inhibitors regulating excessive epidermal proliferation, and retinoic acid or its derivative preventing skin chapping caused by retinoic acid or its derivative; and skin aging relieving agents capable of ameliorating depression in the skin metabolism and thinning in association with aging.

The present invention relates to a composition for improving skin barrier damage and / or alleviating skin inflammation, wherein 3,5-dicaffeoylquinic acid isolated from an Aster glehni (AG) extract is introduced as an active ingredient of a cosmetic composition or a pharmaceutical composition for improving skim barrier damage and alleviating skin inflammation, thereby being effective in preventing and improving atopic dermatitis.

The invention discloses a preparation method of a double-layer microneedle patch for atopic dermatitis, which comprises the following steps: preparing a double-layer microneedle through double-template duplication; the preparation method comprises the following steps: forming a needle tip inner layer by adopting methacrylate gelatin through ultraviolet curing, then transferring a formed microneedle into a large template, and forming a needle tip outer layer by adopting sodium hyaluronate through drying, thereby preparing the double-layer microneedle patch. The prepared double-layer microneedle patch has excellent mechanical performance and can be successfully inserted into thickened skin of an atopic dermatitis patient, after the double-layer microneedle patch is inserted into the skin, the needle tip and the backing layer are rapidly separated, the outer-layer needle tip is rapidly dissolved under the action of tissue fluid, and the left inner-layer needle tip is high in biocompatibility and can slowly release treatment medicine; the traditional Chinese medicine composition is capable of resisting inflammation and repairing epidermal barrier, so that atopic dermatitis symptoms are relieved, and the traditional Chinese medicine composition is diversified in function, remarkable in curative effect and wide in application range.

The present invention discloses a calcium taurine chelate external application preparation for re-constructing skin barrier steady state, and applications thereof, wherein the external application preparation mainly comprises calcium taurine chelate, water, a penetrating promoter, and a preservative. According to the present invention, the calcium taurine chelate external application preparation mainly has the human body epidermal barrier system repair effect so as to achieve effects of skin protection, moisturizing, compacting, anti-allergy and the like, and can be adopted as cosmetic external application preparations, pharmaceutical external application preparations, health product external application preparations, medical and health external application preparations, and the like.

The invention discloses an external preparation for treating facial seborrheic dermatitis, belongs to the technical field of medical, dental or dressing preparations, and in particular relates to an external preparation for treating facial seborrheic dermatitis. The external preparation disclosed by the invention at least comprises the following medicinal components: 0.05-0.1 part of chlorhexidine acetate, 0.05-0.15 part of ketoconazole, 0.05-0.15 part of ceramide, 8-12 parts of glycerin and 0.8-1.2 parts of glycyrrhizin. According to the external preparation disclosed by the invention, the staphylococcus epidermidis can be effectively killed by chlorhexidine acetate, the pityrosporum orbiculare is effectively inhibited by ketoconazole, the inflammatory reaction is inhibited by the glycyrrhizin, the natural moisturizing factors of cuticle are increased by the glycerin, and the epidermal barrier function is repaired by the ceramide. According to the comprehensive effects of the five medical components, the facial seborrheic dermatitis can be effectively treated.

The invention relates to the technical field of biomedicines, and particularly relates to an artificial skin and a preparation method thereof. The artificial skin comprises a dermal layer and an epidermal layer, wherein the dermal layer and the epidermal layer are fitted; the dermal layer comprises a timbering material and fibroblast; the epidermal layer consists of a timbering material and epidermal cells; the timbering material consists of DMEM / F12 culture media, I type mouse collagen, chitin, glycosaminoglycan and glutaraldehyde; the epidermal cells and fibroblast are produced by fat stem cell differentiation. No smearing is needed in use, the structure of the artificial skin is more suitable for the self-situations of patients, and the artificial skin can achieves a better therapeutic effect on the wound restoration, the heeling speed of the skin is faster, and the wound is more smooth after being healed. Furthermore, the artificial skin has small possibility of breaking in use due to good mechanical performance.

The invention relates to a natural polysaccharide nano hydrogel mask based on hollow nanoparticles, the mask is prepared by forming hydrogel after hollow nanoparticles entrap natural polysaccharide mixed liquor, and the natural polysaccharide mixed liquor is prepared from the following components in percentage by mass: 30-50% of natural polysaccharide and 50-70% of gum oil component, the natural polysaccharide is a natural polysaccharide product extracted from motherwort herb, chia seeds, grape seeds, Chinese wolfberry fruits and tremella fuciformis. The polysaccharide nano hydrogel mask provided by the invention contains various natural polysaccharides, has no side effect, and has a relatively good protection effect on skin; natural polysaccharide components are entrapped in the hollow nanoparticles to prepare the polysaccharide nano hydrogel mask, so that the natural components can be better absorbed by skin, and the polysaccharide nano hydrogel mask has remarkable effects in the aspects of resisting oxidation and aging, maintaining epidermal barrier of cuticle, interrupting epidermal melanin, whitening and moisturizing, brightening skin color, making skin elastic and glossy and the like.