17 results about "Epidermal barrier" patented technology

The application belongs to the technical field of medicines, and specifically provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases include atopic dermatitis and skin epidermal barrier damage. The application finds that Phanginin A can reduce atopic dermatitis lesion scores, improve atopic dermatitis skin pathological thickening and inflammatory cell infiltration, reduce spleen inflammatory response, inhibit volume increase, promote thymus function recovery, down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the application also finds that Phanginin A can promote keratinocyte scratch healing, and can be used for repairing skin epidermal barrier damage.

The invention relates to the technical field of skin care products, in particular to a turnip extracting solution and a preparation method and application thereof. The preparation method comprises the following steps: mixing turnip with water, decocting to obtain a decoction, decolorizing, filtering and concentrating to obtain the turnip extracting solution. The turnip extracting solution is used for effectively inhibiting B16 cells from generating melanin and inhibiting the activity of tyrosinase in a melanin synthesis path; the increase of the active oxygen level in HaCaT cells is effectively prevented, and the antioxidant effect is obvious; the inflammation of the SDS surfactant on HaCaT cells is effectively prevented, and the generation of an inflammatory factor TNF-alpha is reduced; the expression of cell natural moisturizing factors, ceramide de novo synthesis rate-limiting enzymes and epidermal barrier related genes is up-regulated; the composition can effectively promote the generation of cell collagen and elastin, reduces the synthesis of matrix metalloproteinase 1 for degrading collagen under ultraviolet radiation, and has an anti-aging effect.

The invention belongs to the technical field of biology, and particularly relates to application of DPP4 in treatment or diagnosis of inflammatory skin diseases characterized by skin barrier injury. According to the application disclosed by the invention, key effects of dipeptidyl peptidase-4 (DPP4) in regulating and controlling keratinocyte differentiation and maintaining normal skin barrier structures and functions are analyzed, and on the basis of AAV-mediated skin tissue keratinocyte DPP4 gene therapy, the conditions of abnormal epidermis thickening and abnormal differentiation caused by skin damage can be relieved by inducing normal differentiation of keratinocytes, so that the curative effect of the skin tissue keratinocyte DPP4 is improved, and the curative effect of the skin tissue keratinocyte DPP4 is improved. The traditional Chinese medicine composition provided by the invention can be used for promoting the repair of an epidermal barrier and improving and maintaining the steady state of the skin barrier so as to effectively improve psoriasis-like dermatitis, and a new scheme is provided for treating inflammatory dermatosis characterized by skin barrier injury. In addition, the expression level of DPP4 can be used as a diagnostic marker for inflammatory skin diseases characterized by skin barrier injury.

The invention relates to the field of cosmetics, in particular to a sialic acid composition with whitening, brightening and anti-saccharification functions, a preparation method of the sialic acid composition and cosmetics. The sialic acid composition is prepared from the following components in parts by mass: 4 to 10 parts of sialic acid, 8 to 15 parts of carnosine and 15 to 25 parts of nicotinamide. According to the sialic acid composition with the whitening, brightening and anti-saccharification functions, sialic acid, nicotinamide and carnosine are matched and synergistically exert effects, and the sialic acid composition can enhance the epidermal barrier function, promote permeation of active ingredients, remove AGEs, block generation of saccharification end products, inhibit melanin transport and regulate cell metabolism, so that the skin whitening, brightening and anti-saccharification functions are achieved. Finally, the three components form a synergistic pathway of blocking saccharification, inhibiting melanin and transdermal permeation promotion; therefore, the problems of uneven skin color and darkness of the skin are fundamentally solved.

The invention provides a method for analyzing an anti-eczema effect target spot of traumatology based on network pharmacology. The method comprises the following steps: firstly, screening out seven representative active components through a SwisSADME platform, predicting by integrating SwisTarget Prediction, SEA and ChEMBL databases to obtain 367 drug targets, and analyzing to obtain 82 intersection targets; a PPI network is constructed based on an STRING database, and 10 core targets such as IL6, TNF and EGFR are screened out through topology analysis. GO / KEGG enrichment analysis reveals that the GO / KEGG is significantly enriched in the processes of IL-17 signal pathway, epidermal barrier repair and the like. Molecular docking verification proves that isofraxidin, scopoletin and verbenin are strongly combined with EGFR (epidermal growth factor receptor) targets. According to the method, a multi-component-multi-target-multi-channel synergistic eczema treatment mechanism of traumatology is systematically analyzed, and a theoretical basis is provided for preparation optimization.

The invention relates to the technical field of materials, and discloses an inorganic material with sunscreen and skin barrier repair functions and a preparation method thereof, the preparation method comprises the following steps: S1, preparing zinc oxide sol; s2, coating is carried out; s3, filtering, washing and primary drying; s4, ultraviolet ozone and oxygen treatment and curing are conducted, and the inorganic material with the sunscreen and skin barrier repairing functions is obtained. The preparation method is simple, energy-saving and environmentally friendly, and the material has the sunscreen and skin barrier repairing dual effects.

The application discloses a kind of total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug composition in transdermal drug preparation application.In transdermal drug preparation the application advantage of this composition is in:(1) the active epidermal barrier and stratum corneum barrier of skin is the main obstacle of total glycosides of Paeonia lactiflora transdermal absorption.The non-steroidal anti-inflammatory drug in the composition can reversibly open the active epidermal barrier of skin, if it is used with the skin stratum corneum barrier of penetration enhancer and can significantly improve the transdermal penetration performance of total glycosides of Paeonia lactiflora in this transdermal drug preparation, it is a kind of with simple preparation process, easy industrial production, skin non-invasive characteristics can safely, efficiently improve the method for the transdermal penetration ability of total glycosides of Paeonia lactiflora;(2) total glycosides of Paeonia lactiflora and non-steroidal anti-inflammatory drug combination in transdermal drug preparation, in the curative effect of treating primary dysmenorrhea and rheumatoid arthritis disease has obvious synergistic effect, curative effect is excellent.

The present invention aims to provide an epidermal barrier function improving agent and an aromatic hydrocarbon receptor activator containing Artemisia princeps extract and / or vitamin K as active ingredients. [Solution] The present invention provides an epidermal barrier function improving agent and an aromatic hydrocarbon receptor activator containing Artemisia princeps extract and / or vitamin K as active ingredients.

The present invention discloses an anti-aging composition, which is composed of the following components by weight: 0.5 to 3 parts of Meconopsis pilosula extract; 0.0005 to 0.0025 parts of nonapeptide-1 or acetyl hexapeptide; 0.0001 to 0.0005 parts of palmitoyl hexapeptide-12; 0.005 to 0.01 parts of mulberry root extract; 0.5 to 3 parts of supramolecular schizonepeta tenuifolia extract; 0.15 to 0.5 parts of peony root bark extract; and 0.5 to 3 parts of arginine / lysine polypeptide. The novel anti-aging composition of the present invention is based on the comprehensive anti-aging solution that takes into account the epidermis, dermis, and muscle layers proposed in the early stage. It is further designed from the perspectives of epidermal barrier repair, basement membrane repair, dermal repair, and mitochondrial ROS clearance, and does not use strong active ingredients that are irritating to the skin, ensuring that the product itself will not damage the skin barrier and cause skin inflammation.

The present invention relates to isocetyl stearyloxy stea rate for use in enhancing and / or preventing a decrease in epidermal barrier function, in particular for use in enhancing the protection of the skin against pollution. The present invention also relates to a cosmetic or dermatological composition comprising isocetyl stearyloxy stearate and at least one cosmetically or dermatologically acceptable excipient for use in enhancing and / or preventing a decrease in epidermal barrier function, in particular for use in enhancing the protection of the skin against pollution.

To provide a skin care preparation synergistically improved in moisturizing effect and epidermal barrier function-improving effect by using specific components in combination.SOLUTION: The skin care preparation for external use comprises a citron extract, especially a sphingolipid-containing citron extract, a Rosa rugosa Thunberg flower extract and a fennel extract. The skin care preparation contains one or more kinds of extracts selected from melissa extract, calendula extract, chamomile extract, horsetail extract, horse chestnut extract, hop extract, carrot extract, mistletoe extract, yarrow extract, sage extract, cornflower extract and rosemary extract.SELECTED DRAWING: None

The invention discloses anti-aging collagen essence powder and a preparation method and application thereof, and belongs to the technical field of cosmetics, the essence powder maintains high activity of recombinant III-type humanized collagen and recombinant I-type humanized collagen through a freeze-drying protection system, and ingredients such as an oligopeptide synergist, hyaluronic acid and bifidus yeast are supplemented, so that the anti-aging collagen essence powder is prepared. The full-layer anti-aging effects of repairing epidermis barriers, enhancing dermis support, reducing wrinkles, moisturizing, resisting oxidation and the like are realized; the preparation method adopts a low-temperature dissolution-sterilization-freeze-drying process, and the product is suitable for application of skin care essence and the like, is clinically verified to remarkably improve the skin aging sign, and has important market value and application prospect.

The invention belongs to the technical field of medicines, and particularly provides application of Phanginin A in preparation of medicines for preventing and / or treating skin diseases. The skin diseases comprise atopic dermatitis and skin epidermal barrier injury. It is found that Phanginin A can reduce the skin lesion score of atopic dermatitis, improve dermatological thickening and inflammatory cell infiltration of atopic dermatitis, relieve spleen inflammatory response, inhibit volume increase of spleen, promote thymus function recovery and down-regulate expression of atopic dermatitis related inflammatory factors IL-6 and TNF-alpha, and can be used for preventing and / or treating atopic dermatitis. In addition, the invention also finds that Phanginin A can promote the healing of cutin cell scratches, and can be used for repairing skin epidermal barrier injury.

The present invention relates to the cosmetic use of an oil derived from the achenes of Silybum marianum (L.) Gaertn. to prevent a decrease and / or strengthen the epidermal barrier function.

The present invention discloses a method for preparing a double-layer microneedle patch for atopic dermatitis. The method comprises the following steps: using double templates to replicate a double-layer microneedle; using methacrylate gelatin, forming an inner needle tip layer by ultraviolet curing; then transferring the formed microneedle into a large template; using sodium hyaluronate, forming an outer needle tip layer by drying, thereby preparing the double-layer microneedle patch. The double-layer microneedle patch prepared by the present invention has excellent mechanical properties and can successfully penetrate the thickened skin of atopic dermatitis patients. After penetration, the needle tip and the backing layer quickly separate, and the outer needle tip quickly dissolves under the action of tissue fluid, leaving the inner needle tip with strong biocompatibility and capable of sustained-release therapeutic drugs. While providing anti-inflammatory effects, it also repairs the epidermal barrier, thereby alleviating the symptoms of atopic dermatitis. The double-layer microneedle patch prepared by the present invention has diverse functions, significant efficacy, and a wide range of applications.

The invention relates to a skin anti-aging composition and a preparation method thereof, and belongs to the technical field of cosmetics. The composition is prepared from the following components: a recombinant human source type I collagen, a recombinant human source type III collagen, a recombinant human source type IV collagen, a recombinant human source type VI collagen, ceramide, a barrier repair signal peptide, panthenol and sodium hyaluronate. According to the invention, a corium layer and a basilar membrane structure are reconstructed through cooperation of a plurality of collagens, ceramide and a barrier repair signal peptide jointly repair and consolidate an epidermal barrier, panthenol promotes metabolism and synthesis functions of skin cells, and sodium hyaluronate provides effects of deep hydration and immediate filling. The composition can effectively improve multiple aging signs of skin laxity, wrinkles, dryness, lack of elasticity and the like, and synergistic intervention aiming at multiple key levels of skin aging is realized.

The present invention relates to isocetyl stearoyl stearate for use in enhancing and / or preventing the deterioration of the epidermal barrier function, particularly for enhancing protection of the skin against contamination. The present invention relates to a cosmetic or dermatological composition comprising isocetyl stearoyl stearate and at least one cosmetic or dermatologically acceptable excipient for use in enhancing and / or preventing the deterioration of the epidermal barrier function, particularly for enhancing protection of the skin against contamination.