8 results about "Isofraxidin" patented technology

The present application relates to a kind of based on isoglycyrrhizin's rice sheath blight plant source fungicide.The present application is through in-depth study the biological activity of plant source secondary metabolite, mechanism of action, mainly for rice sheath blight, develops a kind of new biological pesticide of efficient, environmental protection, safe and cost controllable, through scientific proportioning and formula optimization, significantly improves its field application effect and stability, simultaneously reduces production cost and environmental pollution risk, provides strong support for the sustainable development of agriculture and safeguard food security.

The invention relates to an optimization method for a pressing process of folium isatidis mouth decoction pieces, which can overcome the defects of leaf medicinal materials in production, transportation and application, and can be used for preparing the folium isatidis mouth decoction pieces by taking a single-factor test as a basis, combining a Box-Behnken design-response surface method and taking indirubin, tryptanthrin, isovitexin and water-soluble extracts as comprehensive evaluation indexes. Four factors including pressing time, pressure, baking temperature and baking time are investigated, an analytic hierarchy process and an entropy weight method are utilized to calculate weight coefficients and comprehensive scores of all indexes to determine the optimal pressing process of the folium isatidis mouth decoction pieces, and the optimal pressing process is close to a predicted value of a result obtained by actual operation, which shows that the process optimization method is good in predictability and high in practicability. The technology is stable and feasible, actual production can be directly guided, the problems of fuzzy technological parameters, large decoction piece quality fluctuation and the like in production are solved, key technical reference can be provided for standardized formulation of the folium isatidis mouth decoction piece pressing technology, and the practical application and popularization value is achieved.

The invention relates to the technical field of medicines, in particular to application of isofraxin in treatment of neurodegenerative diseases. The medicine prepared from the product disclosed by the invention has the effects of improving cognitive function and inhibiting neurodegenerative change by reducing neuron loss and improving synaptic plasticity.

The invention belongs to the technical field of tea production and fermentation, and particularly discloses a phlomis spp. Strain capable of improving tea quality and application of the phlomis spp. Strain, the classification name of the phlomis spp. Strain is Diaporthe masrevicii, and the preservation number of the phlomis spp. Strain is CGMCC No.42364. The strain is reported for the first time in the field of tea and belongs to a rare tea tree endophyte. Experiments prove that the strain can significantly improve the brightness and the brilliance degree of tea soup, and has a certain adjusting effect on the taste of the tea soup; metabonomics analysis shows that the strain can promote mass conversion and synthesis of functional components such as methyl caffeate, methyl gallate, ethyl gallate, hesperidin, isoschaftoside and the like in a tea soup fermentation process; the conversion and synthesis of beneficial components such as dihydromyricetin, leucocyanidin, isochlorogenic acid A, plantaginin, malic acid, sorbic acid and gluconic acid can be promoted in an exogenous sugar addition environment.

The present application belongs to the technical field of pharmaceutical preparation and use, and particularly relates to a composition of isofraxidin and application thereof in preparation of a medicine for treating thyroid cancer. The present application explores the role of isofraxidin in treating anaplastic thyroid cancer, and fully proves that isofraxidin can significantly inhibit the proliferation of anaplastic thyroid cancer cells, induce the apoptosis of anaplastic thyroid cancer cells, up-regulate the expression of apoptosis-related proteins cleaved-caspase3 and cleaved-PARP of anaplastic thyroid cancer cells, and inhibit the migration of anaplastic thyroid cancer cells by using a model of cell line xenograft tumor nude mice and cell in-vitro and in-vivo combination.

The invention discloses a thin-layer identification method for isofraxidin in Yao medicine four monsoon, and belongs to the technical field of medicine analysis. Aiming at the problems of difficulty in separation, high false positive rate, low extraction efficiency and the like in thin-layer identification of isofraxidin in the Yao medicine four monsoon in the prior art, the key points of the technical scheme provided by the invention are as follows: firstly, preparing a four monsoon standard reference medicinal material solution, a to-be-detected product solution and an isofraxidin reference substance solution; wherein the preparation of the first two comprises the steps of ethanol extraction, step-by-step extraction with petroleum ether and dichloromethane and the like, and dissolving a reference substance solution with methanol to a constant volume; respectively taking 4-6 microliters of each solution, and spotting the solutions on a silica gel G thin-layer plate; and finally, developing by taking a mixed solvent prepared from dichloromethane, methanol and formic acid according to a specific volume ratio as a developing solvent, observing fluorescent spots under the ultraviolet wavelength of 300-305nm, and developing by iodine vapor fuming. The method is mainly used for qualitative identification of isofraxidin in the Yao medicine 4 monsoon, and ensures the quality of the medicinal material.

The invention provides a method for determining the content of multiple components in an Aidi preparation, and belongs to the technical field of medicines. The Aidi preparation is prepared from traditional Chinese medicinal materials including ginseng, cantharides, astragalus membranaceus and acanthopanax. The content determination method comprises the following steps: simultaneously determining cantharidin, ginsenoside Rg1, ginsenoside Re, ginsenoside Rb1, ginsenoside Rc, ginsenoside Rd, isofraxidin, syringin, formononetin, astragaloside, chlorogenic acid, eleutheroside E, calycosin-7-glucoside, astragaloside II, neochlorogenic acid, cryptochlorogenic acid and eleutheroside E1 in the Aidi preparation by adopting liquid chromatography-mass spectrometry; the composition is prepared from effective components such as ginsenoside F3, ginsenoside Rg2, azelaic acid and the like. Compared with the prior art, the method has the advantages that the contents of the 20 effective components in the Aidi preparation are simultaneously measured under the same chromatographic condition through liquid chromatography-mass spectrometry, the method is convenient and rapid, the requirement for product quality detection is greatly improved, the method is more suitable for quality control of drugs in the future, and the drug quality and the clinical drug effect are guaranteed.