The application belongs to the technical field of biological
medicine, and specifically discloses application of
jatrorrhizine in preparation of a
medicine for preventing and treating intestinal
radiation injury, and a
medicine for preventing and treating intestinal
radiation injury.The application verifies the effect of
jatrorrhizine on resisting intestinal
radiation injury by using an intestinal
organ model, wherein the
jatrorrhizine can obviously improve the changes in
survival rate,
bud number and organ size of the intestinal organ caused by
radiation injury, and eliminate the adverse effects caused by the intestinal
radiation injury.After abdominal
irradiation injury of experimental mice, jatrorrhizine is injected into the
abdominal cavity, the intestinal length is obviously increased, the
survival rate is improved, and HE
staining of small intestinal sections shows that the crypt depth and villus structure are improved.It is proved that the jatrorrhizine can promote the regeneration and repair of the intestinal organ after radiation, improve the
survival rate, and improve the morphological changes of the intestinal caused by
radiation injury.The medicine containing the jatrorrhizine provided by the application can improve the intestinal lesions caused by radiation injury, relieve the
intestinal injury symptoms, and improve the survival rate of individuals.