7 results about "Phellodendrine" patented technology

This invention proposes a method for rapid determination of the content of Phellodendron amurense charcoal slices processed at different temperatures using near-infrared spectroscopy. Near-infrared spectroscopy is used to collect spectral information of Phellodendron amurense charcoal slices processed at different temperatures. Background interference is eliminated through preprocessing methods such as baseline correction, standard normal variable transformation, multivariate scattering correction, and first derivative. Combined with competitive adaptive reweighted sampling, CARS combined with iterative retention of information variables, and iterative combination optimization, a partial least squares regression quantitative prediction model is established. This model achieves accurate prediction of the content of five key components: 5-O-FQA, 3-O-FQA, berberine, berberine, and berberine, with prediction correlation coefficients all exceeding 0.90. This invention combines spectral information with chemometric methods to establish a digital content prediction model based on near-infrared spectroscopy for online monitoring of the Phellodendron amurense charcoal slice processing process. It has the advantages of objectivity, speed, non-destructive nature, and reliability, effectively solving the technical problem of lack of objectivity in existing technologies based on human judgment.

The invention relates to the technical field of pet disinfection, and particularly provides pet disinfection gel and a preparation method thereof, and the pet disinfection gel comprises iodine, nano-silver, matrine, phellodendrine, palmatine and other components. According to the pet disinfection gel disclosed by the invention, on one hand, iodine, nano-silver, sophocarpidine, phellodendrine and palmatine are combined for sterilization and bacteriostasis, so that infection is avoided, and recovery of an immune system is accelerated; on the other hand, the nano pearl powder, the frankincense, the aloe freeze-dried powder and the rhizoma bletillae are used for stopping bleeding, promoting tissue regeneration, promoting wound repair and accelerating healing, and finally the effects of inhibiting bacteria and promoting healing are achieved.

The invention belongs to the technical field of biological medicine, and discloses application of phellodendrine in preparation of medicine for treating or improving acute lung injury. Through systematic animal experiment verification, the research finds that the phellodendrine (PDE) has a remarkable and comprehensive technical effect in improving the acute lung injury (ALI) induced by lipopolysaccharide (LPS), the effect of the phellodendrine (PDE) covers multiple dimensions such as overall state improvement, tissue injury repair, inflammation regulation and control, signal channel regulation and the like, and the phellodendrine (PDE) shows definite dose dependence and has the optimal effect under the dose of 12 mg / kg. Through the multi-dimensional synergistic effect of improving the overall state, repairing tissue damage, protecting the barrier function, inhibiting inflammatory response and regulating and controlling a signal channel, the phellodendrine effectively improves ALI induced by LPS, the safety is good, and a new effective medicine and an action target are provided for treatment of acute lung injury.

The application discloses a composition for treating stubborn skin infection, ulcer and inflammation and a preparation method and application thereof, and belongs to the technical field of functional compositions. The composition is prepared from components containing baicalin 1-5 parts, antibacterial alkaloids 0.5-3 parts, asiaticoside 2-6 parts, salvianolic acid B 3-8 parts, gallic acid 1-4 parts, white plant polysaccharide 5-10 parts, konjac glucomannan 3-10 parts, chitosan 3-5 parts, glycerol 8-20 parts, genipin 0.5-2 parts, calcium chloride 1-3 parts, laurazepam 1-3 parts and water 40-80 parts. The antibacterial alkaloids include berberine or phellodendrine. The application scientifically matches the above components based on deep understanding of the stubborn skin pathological mechanism, and the composition exhibits a significant synergistic effect in in-vitro antibacterial, antibiofilm and anti-inflammatory experiments. The preparation process is simple, the cost is low, and the application is suitable for industrial production.

According to a sepsis mouse model, it is found that phytolaccin can reduce the liver necrosis area and the inflammatory focus caused by sepsis by reducing the content of alanine aminotransferase, glutamic oxalacetic transaminase, serum creatinine and lactic dehydrogenase, so that the application of phytolaccin to preparation of the medicine for treating sepsis is achieved, and the application of phytolaccin to preparation of the medicine for treating sepsis is achieved. The lung inflammation, alveolar wall thickening and inflammatory cell infiltration are improved, so that the organ injury caused by sepsis is relieved. Meanwhile, the phytolaccin can also regulate the polarization state of macrophages to a balanced state in an inflammatory storm state, so that the release of proinflammatory factors is inhibited, and the effect of preventing and treating sepsis is achieved.

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a Phellodendron amurense extract. Based on the total mass of the extract, it comprises no less than 10% berberine and no less than 1% berberine. This extract shows significant efficacy in an animal model of ulcerative colitis, increasing colon length and reducing DAI scores. Animal efficacy and mechanism of action studies indicate that the combination of berberine and berberine has a synergistic effect, exhibiting superior efficacy compared to either berberine or berberine alone, demonstrating promising application prospects.

The application discloses a method for simultaneously determining the contents of 12 components in Longqing capsules by HPLC. The method comprises simultaneously determining the contents of paeoniflorin, paeonol, chlorogenic acid, caffeic acid, berberine hydrochloride, coptisine, jatrorrhizine hydrochloride, gallic acid, rutin, kaempferol, luteolin and phellodendrine hydrochloride in the Longqing capsules, gradient elution is carried out by adopting a chromatographic column with octadecylsilane-bonded silica gel as a filler, 0.1% phosphoric acid as mobile phase A and a methanol solution as mobile phase B, the column temperature is 35 DEG C, and the detection wavelength is 270 nm, and the HPLC content determination method is established, so that a multi-index quality control method of the Longqing capsules is established. The method is simple, stable and reliable, has high detection efficiency, and has reference value for establishing the quality standard and control system of the Longqing capsules based on the theory of traditional Chinese medicine.