13 results about "Phellodendrine" patented technology

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

The application discloses a kind of compositions for treating radiation enteropathy and application thereof, belong to medical technology field.The composition includes the following components: anemarrhena asphodeloides B4, obakunine, berberine, aesculetin, fraxinellone and fraxinellin.The composition has no toxic side effects, has good safety, can reduce the inflammatory infiltration of intestinal epithelial cells, reduce intestinal epithelial cell apoptosis, protect intestinal barrier and protect intestinal oxidative damage by regulating NF-κB, Caspase 9 / 3 and NRF2 pathway, and then multi-component, multi-pathway jointly play the efficacy of treating radiation enteropathy.The problem that there is no effective drug for treating radiation enteropathy in the prior art is solved.

This invention proposes a method for rapid determination of the content of Phellodendron amurense charcoal slices processed at different temperatures using near-infrared spectroscopy. Near-infrared spectroscopy is used to collect spectral information of Phellodendron amurense charcoal slices processed at different temperatures. Background interference is eliminated through preprocessing methods such as baseline correction, standard normal variable transformation, multivariate scattering correction, and first derivative. Combined with competitive adaptive reweighted sampling, CARS combined with iterative retention of information variables, and iterative combination optimization, a partial least squares regression quantitative prediction model is established. This model achieves accurate prediction of the content of five key components: 5-O-FQA, 3-O-FQA, berberine, berberine, and berberine, with prediction correlation coefficients all exceeding 0.90. This invention combines spectral information with chemometric methods to establish a digital content prediction model based on near-infrared spectroscopy for online monitoring of the Phellodendron amurense charcoal slice processing process. It has the advantages of objectivity, speed, non-destructive nature, and reliability, effectively solving the technical problem of lack of objectivity in existing technologies based on human judgment.

The invention relates to the technical field of pet disinfection, and particularly provides pet disinfection gel and a preparation method thereof, and the pet disinfection gel comprises iodine, nano-silver, matrine, phellodendrine, palmatine and other components. According to the pet disinfection gel disclosed by the invention, on one hand, iodine, nano-silver, sophocarpidine, phellodendrine and palmatine are combined for sterilization and bacteriostasis, so that infection is avoided, and recovery of an immune system is accelerated; on the other hand, the nano pearl powder, the frankincense, the aloe freeze-dried powder and the rhizoma bletillae are used for stopping bleeding, promoting tissue regeneration, promoting wound repair and accelerating healing, and finally the effects of inhibiting bacteria and promoting healing are achieved.

The invention belongs to the technical field of biological medicine, and discloses application of phellodendrine in preparation of medicine for treating or improving acute lung injury. Through systematic animal experiment verification, the research finds that the phellodendrine (PDE) has a remarkable and comprehensive technical effect in improving the acute lung injury (ALI) induced by lipopolysaccharide (LPS), the effect of the phellodendrine (PDE) covers multiple dimensions such as overall state improvement, tissue injury repair, inflammation regulation and control, signal channel regulation and the like, and the phellodendrine (PDE) shows definite dose dependence and has the optimal effect under the dose of 12 mg / kg. Through the multi-dimensional synergistic effect of improving the overall state, repairing tissue damage, protecting the barrier function, inhibiting inflammatory response and regulating and controlling a signal channel, the phellodendrine effectively improves ALI induced by LPS, the safety is good, and a new effective medicine and an action target are provided for treatment of acute lung injury.

The application discloses a composition for treating stubborn skin infection, ulcer and inflammation and a preparation method and application thereof, and belongs to the technical field of functional compositions. The composition is prepared from components containing baicalin 1-5 parts, antibacterial alkaloids 0.5-3 parts, asiaticoside 2-6 parts, salvianolic acid B 3-8 parts, gallic acid 1-4 parts, white plant polysaccharide 5-10 parts, konjac glucomannan 3-10 parts, chitosan 3-5 parts, glycerol 8-20 parts, genipin 0.5-2 parts, calcium chloride 1-3 parts, laurazepam 1-3 parts and water 40-80 parts. The antibacterial alkaloids include berberine or phellodendrine. The application scientifically matches the above components based on deep understanding of the stubborn skin pathological mechanism, and the composition exhibits a significant synergistic effect in in-vitro antibacterial, antibiofilm and anti-inflammatory experiments. The preparation process is simple, the cost is low, and the application is suitable for industrial production.

According to a sepsis mouse model, it is found that phytolaccin can reduce the liver necrosis area and the inflammatory focus caused by sepsis by reducing the content of alanine aminotransferase, glutamic oxalacetic transaminase, serum creatinine and lactic dehydrogenase, so that the application of phytolaccin to preparation of the medicine for treating sepsis is achieved, and the application of phytolaccin to preparation of the medicine for treating sepsis is achieved. The lung inflammation, alveolar wall thickening and inflammatory cell infiltration are improved, so that the organ injury caused by sepsis is relieved. Meanwhile, the phytolaccin can also regulate the polarization state of macrophages to a balanced state in an inflammatory storm state, so that the release of proinflammatory factors is inhibited, and the effect of preventing and treating sepsis is achieved.

The invention discloses application of phellodendrine in preparation of a medicine for preventing and / or treating acute pancreatitis, and belongs to the technical field of biological medicine. The invention discloses a key link in acute pancreatitis pathogenesis that phellodendrine directly acts on neutrophil-mediated excessive inflammatory response and upstream regulation of extracellular trap formation (NETs) for the first time, and reduces the generation of active oxygen by inhibiting the generation of neutrophil extracellular traps of pancreatic tissues, thereby reducing the damage degree of acinus cells. As a small molecule compound, phellodendrine has better tissue permeability and metabolic stability. Compared with a synthetic NETs inhibitor, the natural product has more advantages in the aspect of reducing immunotoxicity. Therefore, the invention proves that the phellodendrine (PHE) realizes the effects of relieving the inflammatory response of the acute pancreatitis and reducing the severity of the acute pancreatitis by targeting immune cells (inhibiting the formation of extracellular traps of neutrophils).

This invention belongs to the field of traditional Chinese medicine technology, specifically relating to a Phellodendron amurense extract. Based on the total mass of the extract, it comprises no less than 10% berberine and no less than 1% berberine. This extract shows significant efficacy in an animal model of ulcerative colitis, increasing colon length and reducing DAI scores. Animal efficacy and mechanism of action studies indicate that the combination of berberine and berberine has a synergistic effect, exhibiting superior efficacy compared to either berberine or berberine alone, demonstrating promising application prospects.

The present invention relates to a method for simultaneously determining seven index components in Fengtong'an capsules and constructing a characteristic spectrum and its application, belonging to the field of detection and analysis technology. The present invention adopts a high performance liquid chromatograph and a gradient elution method. By switching different wavelengths under the same elution conditions, the contents of phellodendronine (284nm), loganin (236nm), fangchinoline, tetrandrine (280nm), forsythin (277nm), berberine (265nm), and curcumin (430nm) in a prescription can be simultaneously determined and a characteristic spectrum (254nm) can be constructed. The measured components are well separated, achieving the practical purpose of one measurement and multiple evaluations, high efficiency, low consumption and easy popularization. According to the polarity differences of each substance, a gradient elution program is adopted to achieve separation and accurate detection. To date, no report on the simultaneous determination of these seven components in Fengtong'an capsules has been found. This method fills the gap in the quality control of multiple medicinal materials in prescriptions and the research on fingerprints.

The invention discloses an anti-bladder cancer traditional Chinese medicine compound tablet based on function modularization and a preparation method. Comprising the following components: a body resistance strengthening module: an astragaloside-selenium nano-composite, an ophiopogonin-selenium nano-composite and rehmannia lipidosome; an evil eliminating module: spreading hedyotis herb PLGA nanoparticles and phellodendrine / coix seed oil microemulsion; and the collateral dredging module comprises centipede-salvia miltiorrhiza sustained release microspheres and achyranthes bidentata-lysimachia christinae According to the invention, a three-module design of strengthening body resistance, eliminating evil and dredging collaterals is created for the first time, and the action mechanism of each path is clear. When the drug is combined with a chemotherapeutic drug gemcitabine, the synergistic interaction index reaches 1.31, and the tumor volume reduction rate is increased to 89% from 62% of single drug treatment.

The application discloses a method for simultaneously determining the contents of 12 components in Longqing capsules by HPLC. The method comprises simultaneously determining the contents of paeoniflorin, paeonol, chlorogenic acid, caffeic acid, berberine hydrochloride, coptisine, jatrorrhizine hydrochloride, gallic acid, rutin, kaempferol, luteolin and phellodendrine hydrochloride in the Longqing capsules, gradient elution is carried out by adopting a chromatographic column with octadecylsilane-bonded silica gel as a filler, 0.1% phosphoric acid as mobile phase A and a methanol solution as mobile phase B, the column temperature is 35 DEG C, and the detection wavelength is 270 nm, and the HPLC content determination method is established, so that a multi-index quality control method of the Longqing capsules is established. The method is simple, stable and reliable, has high detection efficiency, and has reference value for establishing the quality standard and control system of the Longqing capsules based on the theory of traditional Chinese medicine.

The invention relates to a quality evaluation method of a cortex phellodendri medicinal material and application thereof. Based on a multi-component alkaloid-phenolic acid-limonin synergistic effect mechanism of cortex phellodendri, berberine hydrochloride (alkaloid) and 3-O- / 5-O-feruloylquinic acid (phenolic acid) are introduced into a synchronous detection system for the first time; the defect that only two alkaloids, namely berberine hydrochloride and phellodendrine hydrochloride, are monitored in the existing pharmacopoeia, but key active components with remarkable anti-inflammatory and antioxidant activity, such as phenolic acids, are ignored, is overcome. The invention discloses a variable importance projection (VIP) algorithm based on a PLS-DA model. According to the method, 9 components are taken as the screening standard of symbolic components, core characteristic components including berberine hydrochloride and 3-O- / 5-O-feruloylquinic acid which contribute to the quality difference are intelligently screened from the 9 components, and the quality grades of different batches of cortex phellodendri medicinal materials are distinguished, so that the quality difference identification sensitivity is greatly improved; and a precise target spot is provided for producing area traceability and process regulation and control. By adopting the quality evaluation method provided by the invention, not only is the overall chemical substance basis of the medicinal materials comprehensively reflected, but also the quality grades of different batches of cortex phellodendri medicinal materials can be distinguished and the high-quality production area of cortex phellodendri can be locked through the VIP characteristic components.