11 results about "Relative correction" patented technology

The invention relates to the technical field of component detection, in particular to a method for determining five components in quisqualis family medicinal materials based on quantitative analysis of multi-components by single marker. According to the method for simultaneously and quantitatively detecting the five components in the medicinal materials of the Quisqualis family based on the quantitative analysis of multi-components by single marker, the contents of index components of the five components are simultaneously determined by the quantitative analysis of multi-components by single marker, and the content of chebulaic acid, 1, 2, 3, 4-tetramethyl-3, 5-dichlorphenoxyacetic acid and 1, 2, 3, 4-tetramethyl-3, 5-dichlorphenoxyacetic acid can be calculated through relative correction factors only by using one reference substance of chebulaic acid as an internal reference substance. According to the method, the specific content of the galloylglucose, the 1, 2, 3, 4, 6-O-tetragalloylglucose, the 1, 2, 3, 4, 6-O-pentagalloylglucose and the ellagic acid can be measured, and the method has the advantages of being easy to operate, high in sensitivity, accurate in measurement and high in applicability.

The application discloses a refinery gas composition determination method and related device, and relates to the field of gas analysis. The absolute correction factor of nitrogen and the relative correction factor corresponding to each stable gas are determined, and the absolute correction factor of the stable gas with relatively stable content in air is determined. Similarly, the absolute correction factor of each alkane is determined according to the absolute correction factor of methane and the relative correction factor of each alkane relative to methane, and the absolute correction factor of hydrogen is determined according to the content of hydrogen in the production sample containing hydrogen and the chromatographic peak area of hydrogen, wherein the chromatographic peak area of hydrogen is obtained by processing the production sample by a thermal conductivity detector. The determination of the absolute correction factor of each gas component is realized, and on the basis, the concentration of each component in the sample can be determined by combining the detection of the chromatographic peak area of each component of the refinery gas sample, thereby providing a reliable reference for subsequent resource utilization.

The present invention belongs to the technical field of Chinese medicine preparation detection, and specifically relates to a quality control method for Jindan Fuyan granules. The quality control method uses UHPLC-MS / MS-QAMS technology to determine the content of multiple components of Corydalis in Jindan Fuyan granules. A test solution and a reference solution are first prepared, and then the test solution and the reference solution are respectively measured by UHPLC-MS / MS, and the peak area is recorded. Corydalis butylene is used as an internal reference to calculate the relative correction factor and content of each component. The present invention uses UHPLC-MS / MS-QAMS to determine corydalis butylene by a one-measurement-multiple-evaluation method, and realizes indirect determination of multiple other related components. The method has low detection cost, high sensitivity, strong specificity, and short analysis time. It can well distinguish whether the Corydalis butylene slices used in the production of Jindan Fuyan granules are mixed with summer maltose, and provide a basis for quality monitoring of Jindan Fuyan granules.

The invention discloses a method for establishing andrographis paniculata quality control by using a QAMS (quantitative analysis of multi-components by single marker) method. Comprising the following steps: preparing a test sample solution, preparing a reference solution, determining chromatographic conditions and mass spectrum conditions, determining main components of a test sample, establishing a standard curve, performing methodological investigation by using an external standard method, determining an internal reference and a relative correction factor of the quantitative analysis of multi-components by single marker, and investigating the durability of the relative correction factor and positioning of a chromatographic peak. And comparing and verifying the content of the measured sample. The invention further discloses an andrographis paniculata quality control method. According to the method, relative correction factors of an internal reference substance and other to-be-detected components are established on the basis of an ultra-high performance liquid chromatography-tandem mass spectrometry-based quantitative analysis of multi-components by single marker, and the contents of four components including desoxidized andrographolide, andrographolide, dehydroandrographolide and andrographolide in andrographis paniculata are determined as a quality control method of the andrographis paniculata medicinal material, so that the quality of the andrographis paniculata medicinal material is improved. The calculated value and the measured value meet the requirements of quantitative methodology, the requirements of reference substances are reduced, and the quality control level of andrographis paniculata is improved.

The invention provides an HPLC-QAMS (High Performance Liquid Chromatography-Quantitative Analysis Mass Spectrometry) synchronous quantitative detection method for four rare ginsenosides in cooked pseudo-ginseng, and belongs to the technical field of traditional Chinese medicine detection. According to the method, ginsenoside 20 (R)-Rg3 is taken as an internal reference, an HPLC-QAMS (High Performance Liquid Chromatography-Quantitative Amplified Mass Spectrometry) method is adopted, and simultaneous quantification of four ginsenosides is realized through verified relative correction factors; rSDlt; the method has the advantages of high accuracy (the recovery rate is 91.95-101.34%, RSDlt, 1.8%), high linearity (Rgt, 0.9997) and high stability (RSDlt, 3.5%), and the reference standard cost can be reduced by 75%. The QAMS method is excellent in green analysis score and blue applicability grade index. By analyzing 15 batches of samples, the consistency (relative to ESM, RE% lt, 5%) of the samples is confirmed, and the transfer rate of 20 (R) G-Rg3 is 85.82% by optimizing the extraction condition.

The invention discloses a method for determining the content of five components in a white jade ointment based on quantitative analysis of multi-components by single marker, and relates to the technical field of medicine detection. According to the method, tanshinone IIA is used as an internal standard substance for quantitative analysis of multi-components by single marker, relative correction factors of 1, 4-di [4-(glucose oxygen) benzyl]-2-isobutyl malate, tanshinone I, 6-gingerol and beta, beta '-dimethylacryloyl alkannin are established, and the content of each component in the white jade ointment is calculated through the relative correction factors. The method comprises the following specific steps: preparing a test solution; preparing a reference substance solution; performing chromatographic condition and system adaptability test; and measuring and calculating. According to the method, the oneness and one-sidedness of quality control of the white jade ointment are overcome, and the method has important significance in further improving the quality control level of the white jade ointment, ensuring the clinical curative effect and improving a related evaluation system.

This invention relates to the field of aerosol analysis technology, and in particular to a method for predicting and quantitatively detecting the relative correction factor of monomeric raw materials in aerosols. The prediction method includes: obtaining the molecular structure of the target monomeric raw material; calculating multiple predefined molecular structure descriptors; and substituting the molecular structure descriptors into a prediction model established through multivariate quadratic regression fitting to calculate the predicted relative correction factor of the target monomer. This invention also provides a quantitative detection method based on the prediction model. This method requires only molecular structure information to accurately predict the relative correction factor, completely eliminating dependence on expensive and scarce chemical standards, significantly reducing detection costs, simplifying the process, and improving the efficiency of quantitative analysis of aerosol components and product development.

The application discloses a method for determining the content of five components in Baiyu ointment based on a quantitative analysis of multiple components, and relates to the technical field of drug detection. ′ The method uses tanshinone II A as an internal standard for quantitative analysis of multiple components, establishes the relative correction factors of 1,4-di[4-(glucose oxygen) benzyl]-2-isobutyl malonic acid ester, tanshinone I, 6-gingerol, beta, beta The content of each component in the Baiyu ointment is calculated through the relative correction factors, and the specific steps include: preparation of a test sample solution; preparation of a reference sample solution; chromatographic conditions and system suitability test; determination and calculation. The application overcomes the single and one-sided quality control of the Baiyu ointment, and has important significance for further improving the quality control level of the Baiyu ointment, guaranteeing the clinical curative effect and improving the related evaluation system.

The invention provides a method for detecting multiple rare ginsenosides in health-care food by quantitative analysis of multi-components by single marker (QAM), and solves the problem of insufficient rare ginsenoside reference substances when the rare ginsenosides are detected by an external standard method. Ginsenoside Rd is used as an internal reference substance for quantitative analysis of multiple components by single marker, and relative correction factors between the ginsenoside Rd and ginsenoside Rg2, ginsenoside Rh1, ginsenoside F2, ginsenoside 20-(S)-Rg3, ginsenoside Rk3, ginsenoside Rk1, ginsenoside Rh4, ginsenoside 20-(R)-Rg3 and ginsenoside Rg5 are established. And calculating the content of each rare ginsenoside in the health food through the relative correction factor. The method has the advantages of high practicability, strong operability, cost saving and the like.

This invention relates to the field of e-liquid analysis technology, and in particular to a method for component analysis and formulation of e-liquids. The invention uses GC-FID to obtain chromatographic data of the sample, combines this with a retention index prediction model for qualitative analysis, and combines a relative correction factor prediction model with an internal standard method for quantitative analysis. This invention overcomes the technical bottlenecks of traditional GC-FID, which relies on standard comparison for qualitative analysis and on individual calibration for quantification, achieving rapid, accurate, and low-cost analysis of all components of e-liquids. Based on this method, the complete formulation of the target e-liquid can be obtained efficiently, enabling rapid flavor blending. This invention also provides specific formulations for two e-liquid compositions: strawberry ice cream flavor and Pocari Sweat flavor. This invention provides efficient and reliable technical support for product imitation, new product development, and quality control of e-liquids.

The invention provides a construction method of a high-performance liquid-phase fingerprint spectrum of Souqin capsules. The invention also provides a method for simultaneously determining the contents of six flavone components in the Souqinqin capsule by quantitative analysis of multi-components by QAMS (quantitative analysis of multi-components by QAMS). According to the present invention, the quantitative analysis of multi-components by single marker is adopted, the low-price baicalin is adopted as the alternative internal standard substance, and the relative correction factor is adopted to detect the contents of the six flavone components such as tectoridin, tectoridin A, tectoridin B, baicalin, wogonoside and tectorigenin in the Souqin capsule, such that the multi-component quantification is achieved, the method is simple, and the cost is controllable.