The present invention belongs to the technical field of
traditional Chinese medicine research, and particularly relates to a
traditional Chinese medicine composition for treating Alzheimer's
disease, its preparation method and application. The raw materials of the
traditional Chinese medicine composition of the present invention and their dosages include: 5-15 parts by weight of
Desmodium styracifolium, 10-15 parts by weight of
Salvia przewalskii Maxim. var. kansuensis, 9-15 parts by weight of
Erythrina arborescens Roxb., 8-20 parts by weight of
Euphorbia hirta L., 6-12 parts by weight of
Murraya exotica L., and 5-9 parts by weight of Luffa cylindrica (L.) Roem. The traditional Chinese
medicine composition has the basic effects of removing dampness and promoting
blood circulation to remove stasis, expelling wind and detoxifying, and promoting qi circulation and dredging collaterals. Animal experimental studies have shown that the high-
dose and medium-
dose of the traditional Chinese
medicine composition can improve the learning ability, memory ability, learning and
memory retention ability, hippocampal inflammatory mediators, β-
amyloid transport
enzyme gene and
protein expression of Alzheimer's
disease Kunming mice. At the same time, the traditional Chinese
medicine composition has no effect on the main organ indexes and related body weights of Kunming mice. The proposal of the present invention provides a new technical means for further developing new traditional Chinese medicine drugs for the prevention and treatment of AD.