287 results about "Transfer factor" patented technology

The invention belongs to the field of power distribution systems, and relates to a method for estimating the power supply capacity of a power distribution system, which takes the 'N-1' Principle into account. The method comprises the following steps: (1) the data of the power distribution system is collected; (2) the topology of the power distribution system is simplified, and the contact information is acquired; (3) the interconnection relation of the main transformer is analyzed to form a main transformer communication relational matrix; (4) the 'N-1' analysis of a communication unit is performed; (5) the analysis result of the step (4) is integrated to obtain the maximum allowable load factor of the main transformer; and (6) the maximum power supply capacity of the system is calculated based on the analysis result in the step (5). The invention overcomes the defects that the conventional power distribution system is based on flow and iterative optimization, takes the capacity constraint of the actual line and the in-station priority transfer factor of a transformer station into account, provides the maximum power supply capacity of the power distribution system based on the 'N-1' Principle and the one-time calculation of the interconnection relation, and finds out the network bottleneck when in calculation, thereby providing the reference basis for optimization and planning of the power distribution system.

Compositions that include extracts from sources of immune modulators that include nanofraction immune modulator molecules (i.e., molecules having molecular weights of about 3,000 Da and less) are disclosed. These compositions may also include other immune modulators, such as transfer factor. Administration of compositions with extracts that include nanofraction immune modulator molecules modulates the cell-mediated immunity (e.g., down-regulates undesired T cell activity) of a subject to which such compositions are administered. When administered with transfer factor, the combination of nanofraction immune modulator molecules and transfer factor down-regulates undesired T cell activity while increasing, or up-regulating, T cell activity against pathogens and other undesirable entities, such as cancer cells and other aberrant or mutated cells. Assays and assay techniques for evaluating the immune modulation capabilities of various substances are also disclosed.

A composition for eliciting a T-cell mediated immune response in a subject includes transfer factor from at least two different types of source animals. For example, the composition may include mammalian transfer factor and nonmammalian transfer factor. An example of the composition includes a combination of a colostrum-derived product, which includes the mammalian transfer factor, and an egg-derived product, which includes the nonmammalian transfer factor. Additionally, the egg-derived product may be substantially free of fat. Methods for forming the composition and eliciting T-cell mediated immune responses in subjects that have been treated with the composition are also disclosed.

The invention relates to a method for preparing anti-influenza virus transfer factor, comprising following steps: preparing raw material, pre-treating, disintegrating, freezing and thawing, extracting, ultra-filtering, disinfecting and packing. The invention employs process of first immune and second extraction. The preparation time is reduced because of low-temperature freezing and thawing and hollow fiber tube ultra-filtering, so the substance activity will not be destroyed. It can be made into oral liquid.

The invention relates to a solving method for node marginal electricity price, and the method is based on the B coefficient transmission loss correction of a DC method and gives consideration to load-side quoted price. The method comprises the steps: a DC method B coefficient and a power transfer factor SF; building an economic dispatching model comprising an optimization target, unit constraints,and load flow constraints; deducing a node marginal electricity price model, and determining the node marginal electricity price; determining transmission loss micro-increasing rates of a generator node and a load node; determining a marginal node and a full-load circuit; determining an unknown full-load circuit shadow price Mu and system electric energy price lambda; and determining the node marginal electricity price of a non-marginal node. According to the technical scheme of the invention, the method is high in applicability, can be used for solving the node marginal electricity prices ofthe generator node, a quoted sensitive pure load node and a non-quoted rigid pure load node, and is suitable for market pricing at each stage of electricity market construction. The detailed solvingmethod provides references for the development of the solving software of the node marginal electricity price.

The invention discloses a method for preparing an anti-duck viral hepatitis transfer factor, which comprises the following steps of: firstly, inoculating duck viral hepatitis in a chick embryo allantoic cavity for multiplication and extracting a virus antigen from the chick embryo allantoic cavity; secondly, immunizing a healthy pig body with the extracted virus antigen; and thirdly, extracting the anti-duck viral hepatitis transfer factor from the spleen of the immune pig. In the invention, specific transfer factor is extracted from duck viral hepatitis viruses and can effectively suppress the duck viral hepatitis viruses and protect the cells of a normal body from being infected with the duck viral hepatitis viruses, so that the duck viral hepatitis is prevented and treated radically. Moreover, the preparation method of the invention is simple and feasible, short in production time and low in cost and has a promising application prospect.

The invention discloses a PMU-based low-frequency oscillation control method, which belongs to the technical field of the low-frequency oscillation control of a power system. In the method, a PMU is utilized to obtain the wide area information of a whole network; under the condition of not analyzing the oscillation mode of the system, an eigenvalue transfer factor theory and a synthetic mapping theory are utilized and a reconstruction solving method is also utilized to obtain a control influence matrix B; the advantages of circle mapping and linear mapping are combined to obtain an optimal eigenvalue transfer factor matrix F; and the system is subjected to closed-loop control through a BFBT feedback link. In the method, eigenvalues easily inducing the low-frequency oscillation of the system are directly transferred to a stable area, which increases system damping and further fulfills the aim of controlling the low-frequency oscillation of the system.

Various compositions containing transfer factor in combination with nutraceuticals are provided including transfer factor in combination with zinc and essential fatty acids and transfer factor in combination with lactic acid generating bacteria. Also provided are methods for treating animal diseases and syndromes using these compositions.

A composition for use in cardiovascular therapy includes transfer factor. The transfer factor may be nonmammalian transfer factor, such as that derived from eggs, or mammalian transfer factor, such as that derived from colostrum. The composition may also include one or more of the following: an LDL receptor-binding element; a blood flow-enhancing element; a cholesterol reducing element; a fat oxidation prevention element, and an antioxidant. Treatment methods include enlisting the immune system of a subject receiving therapy to attack pathogens that cause inflammation of blood vessels or to otherwise reduce inflammation of blood vessels.

The invention discloses a preparation method of a natural high-effective biological active substance anti-duck plague virus transfer factor. The preparation method comprises the following steps of: inoculating duck plague virus into an allantoic fluid obtained from a 10-day-aged chick embryo, and preparing duck plague virus antigen; extracting the duck plague virus antigen; immunizing a pig with the extracted duck plague virus antigen; and extracting the anti-duck plague virus transfer factor from the immunized pig. The inventive anti-duck plague virus transfer factor can prevent duck plague and protect normal body cells from being infected by the duck plague virus, so as to reduce incidence rate.

Compositions, vaccines and kits for cancer immunotherapy are described. The compositions, vaccines and kits may include transfer factor. The compositions, vaccines and kits also include modified monoclonal antibodies directed to cancer cells, other specific cancer receptor agonists, or viruses which infect cancer cells. The invention is also directed to methods of cancer immunotherapy using the compositions and vaccines of the invention.

The invention relates to a combined specific transfer factor for livestock and poultry and a preparation method of the combined specific transfer factor. The preparation method comprises the steps of: 1. immunizing; 2. taking materials; 3. processing and grinding tissues; 4. crushing cells; 5. centrifuging protein isoelectric points; 6. filtering supernate in a pressure filter, taking filtrate, wherein the pore size of a membrane is 0.22 microns; and 7. carrying out ultra-filtering on the filtrate by an ultrafilter, and collecting the filtrate, namely, a stock solution containing the combined specific transfer factor, wherein the molecular weight cut off of the ultrafilter is 5000-9000 Daltons. According to the preparation method, a time and labor-consuming program is eliminated, and thus the manpower and the time are greatly saved, and the industrialized production is facilitated.

The invention relates to an active power distribution network optimization scheduling model and method considering information system uncertainty. The method specifically includes the following stepsthat: a power generation transfer factor which can express a relationship between renewable energy power variation and flexibility provided by an upper-layer power grid and flexibility provided by a controllable load is constructed; a power distribution network conventional optimal power flow model is provided, the optimal solution of the power distribution network conventional optimal power flowmodel is solved, and a sensitivity factor matrix which can express a linear relationship between a node injection power variation quantity and the real part and imaginary part of node voltage, a branch power flow active power variation quantity and a reactive power variation quantity; and an opportunity constraint-based optimal power flow model is constructed based on the above steps, and the opportunity constraint-based optimal power flow model is transformed into a deterministic optimal power flow model, a deterministic optimal power flow problem is solved, and the sensitivity factor matrixis updated; whether the transformed deterministic optimal power flow model converges is judged, if the model converges, an optimal solution is solved; if the model does not converge, the method returns to the previous step.

The invention provides a transfer factor solution for livestock and poultry. Frozen pig spleens are washed clean by use of distilled water, cut into small pieces, added with distilled water free from heat source, subjected to cell disruption by use of a tissue bruiser and prepared into homogenate; the homogenate passes through a high-pressure homogenizer under the pressure of 60 kPa and then is added with a flocculating agent for flocculation; the flocculated homogenate is centrifuged at a centrifugation ambient temperature of 4 DEG C and at a speed of 7,000 r / min; precipitate is removed; supernatant is left on standby; the supernatant is filtered by use of a microporous filtering membrane 0.45 mu m in pore diameter, and then is ultrafiltered by use of a ultrafiltration membrane 5,000 Dalton in molecular weight cutoff so as to obtain a stock solution; after viruses are removed, nicotinamide is added as a stabilizer; the stock solution is subjected to aseptic filtration by use of the microporous filtering membrane; and the obtained product is added with glycerol as a heat-resisting protective agent and then is directly and separately packed. The transfer factor solution can be applied to livestock and poultry. The preparation method is characterized by directly using the pig spleen to extract the transfer factor solution so as to save manpower and materials and improve extraction efficiency. The preparation method combines a heat-resisting protection technique with transfer factors, thereby realizing the normal-temperature preservation of the transfer factors. The transfer factor solution can improve the disease-resisting capability of organisms, relieve immunologic suppression and immunologic tolerance, can play a role in emergency adjuvant treatment, and makes up for immunization blank after vaccination before antibody production.

Various compositions containing transfer factor in combination with nutraceuticals are provided including transfer factor in combination with zinc and essential fatty acids and transfer factor in combination with lactic acid generating bacteria. Also provided are methods for treating animal diseases and syndromes using these compositions.

The invention relates to a method for extracting transfer factors from animal spleens, and mainly aims at providing a method which is applicable to in-scale transfer factor production. The method comprises the following steps of firstly crushing spleen cells to prepare a homogenate, secondly eliminating cell residues in the homogenate, and subsequently extracting the transfer factors, wherein the step of eliminating the cell residues in the homogenate comprises adjusting the pH value to 7.2, adding polyaluminium chloride into the homogenate according to a mass volume ratio of 1%, uniformly stirring, acting for 30 minutes, centrifuging for not less than 30 seconds, repeating centrifuging for three times, adding 0.5% of, 0.4% of and 0.1% of polyaluminium chloride according to the mass volume ratio each time, all uniformly stirring after adding polyaluminium chloride, acting for 30 minutes, primarily filtering the centrifugate, and finely filtering the primary filtrate by using a filtering film with a filtering precision of 0.2 microns so as to obtain the transfer factors. According to the method, the polyaluminium chloride sediment is adopted to eliminate the spleen cell residues in a breakthrough, so that the production method is applicable to in-scale production of transfer factors which are high in effective content and good in biological activity.

The invention provides a method for extracting transfer factors from cattle spleen, which comprises the following steps of grinding cells by a high-pressure homogenizer, precipitating by a flocculating agent, filtering by a micro-pore filtration membrane, ultra-filtering by a macro-pore filtration membrane, wherein the flocculating agent is added when in shell breaking, so that the protein in solution can be precipitated, and the solution can become transparent, thereby reducing the possibility of blocking a hollow-fiber ultra-filtration column in the ultra-filtration process. The method can greatly shorten the production cycle, save large amount of manpower and material resources and improve the production efficiency of the transfer factors, so as to provide a feasible path for meeting the industrial large-scale production.

Belonging to the technical field of bio-medicine, the invention discloses a spleen immune factor and its preparation method. The spleen immune factor or specific spleen immune factor is prepared through an ultrafiltration or dialysis method. With a molecular weight less than 20000 Dalton, the spleen immune factor of the invention has proteins absent in a transfer factor as well as high bioactivity. Development and application of the spleen immune factor provided in the invention not only expands the utilization efficiency of animal (chicken, pig etc.) spleen resources, enhances the bioactivity of a spleen extract, but also provides a preparation raw material characterized by easily available crude materials, low cost and no toxic and side effect and used for treating human as well as animal refractory diseases like bird flu and tumors, etc. Therefore, the spleen immune factor of the invention is suitable for industrial production.

The invention discloses a preparation method of a swine vaccine specific swine spleen transfer factor (TF). The preparation method comprises the following steps: slaughtering a swine with a positive swine vaccine antibody to harvest the swine spleen; preserving the swine spleen at low temperature; unfreezing the swine spleen; removing fasciae; mincing the swine spleen; homogenizing the pulp; filling the homogenized pulp into a bottle and storing the pulp; repeatedly freezing and thawing the pulp; centrifuging the pulp; carrying out microfiltration; carrying out ultrafiltration; carrying out inactivation; regulating the pH value; regulating the osmotic pressure; removing bacteria; and detecting the quality. The preparation method has the advantages that the pH value of water for injection is regulated to 4-6 in the pulp homogenizing step, thus being beneficial to increasing of the yields of ribose and polypeptide; a box type membrane coating is adopted for tangential flow filtration, so that the dead volumes of system residues are small and linear amplification production is easy to achieve; a 1-3KD box type membrane coating is adopted to carry out tangential flow nanofiltration on a TF crude product, thus preparing the high-concentration TF and improving the using effects; phenol red is used as an acid-base indicator, thus being convenient for clients to observe the pH value of the TF; the TF uses beta-propiolactone for inactivation instead of traditional formaldehyde and an osmotic pressure regulation process is added, thus being beneficial to combined immunization of the TF and vaccines.

The embodiment of the invention provides a method and a device for monitoring the optical signal to noise ratio (OSNR). The method comprises the steps of respectively determining the actual signal power, the ideal signal power and the noise signal power of wavelength signals, which are received by two transmitting and receiving terminals acting as two communication parties and sent by the opposite party through the same channel to be monitored; calculating a signal power transfer factor and a noise power transfer factor of the channel to be monitored according to the determined actual signal power, the ideal signal power and the noise power of the two wavelength signals; and calculating the OSNR of the wavelength signal received by each transmitting and receiving terminal according to the actual signal power, the noise power, the calculated signal power transfer factor and the calculated noise power transfer factor of the wavelength signal received by each transmitting and receiving terminal. According to the embodiment of the invention, an existing OSNR calculation mode is modified through calculating the signal power transfer factor and the noise power transfer factor of the channel to be monitored so as to improve the accuracy of OSNR monitoring.

The invention provides a preparation method and applications of pig spleen transferfactor. According to the preparation method, frozen-breaking, freeze thawing breaking, and centrifugal process are combined for transferfactor production, yield is guaranteed, and at the same time production temperature is reduced, and the activity of the transferfactor can be guaranteed preferably. And in addition, the prepared transferfactor contains no protein, is a small molecular peptide, possesses no pyrogen, is a widely used immunomodulator, is capable of increasing vaccine titer, and can be used for improving animal immunity and improving production performance; the activity is not influenced by pancreatic enzymes; and no toxic reaction is caused. When the pig spleen transferfactor is combined with vaccine, animal immunity can be improved, vaccine titer is increased at the same time, body immune response period is shortened, and antibody lasting time is prolonged.

Methods of promoting reproductive health in an animal by administering an effective amount of a composition containing at least one transfer factor are provided.

The invention relates to a preparation method of pig spleen transfer factor injection. The preparation method comprises the following steps: performing pretreatment on a pig spleen which is inspected to be qualified, and then preliminarily mincing once to three times; finely mincing and grinding the pig spleen after preliminary mincing for 1.5-8 minutes to prepare a homogenate; adding a formaldehyde solution into the homogenate for inactivation; repeatedly freezing and thawing the inactivated homogenate 6-10 times; performing centrifugal separation, filtration and ultra-filtration on the homogenate which is repeatedly frozen and thawed to get a semi-finished product; and adding water for injection into the semi-finished product which is inspected to be qualified to get a finished product. The preparation method disclosed by the invention has the advantages of simple process and low cost, and can greatly shorten production cycle to 4 days, greatly save manpower and material resources and improve the production efficiency of a transfer factor.

Disclosed is a transfer factor solution for animals, wherein its preparing process consists of washing freeze chicken spleens and chopping, charging distilled water and comminuting cells to homogenate, freezing eight times at minus 30 deg C, centrifuging the homogenated liquid, separating deposition and filtering supernatant fluid with microporous filtering film, carrying out hyperfiltration with ultrafiltration membrane to obtain stock solution, removing viruses, charging niacinamide as stabilizer, filtering and degerming through microporous filtering film, charging glycerine and split charging directly.

The invention belongs to the technical field of biological pharmaceutical manufacturing, and particularly relates to a transfer faction solution and a preparation method thereof. The preparation method comprises the following steps: mixing animal spleen and NaCl solution according to a weight ratio of 1:(1.3-1.4), performing repeated freeze-thaw, adjusting the pH value to 6.2-7.2, and filtering to obtain the transfer faction solution. By the adoption of the method provided by the invention, the content of effective components in the transfer faction solution can be increased advantageously, the product yield is improved, and the stability and the safety of a medicine are improved.

The invention provides a preparation method of a pig spleen transfer factor. The preparation method comprises the steps of tissue mincing, breaking by homogenizing, microfiltration, ultrafiltration and the like. A high-pressure homogenizer is adopted to rapidly break cells and can effectively keep the activity of the transfer factor; besides, compared with the prior art, the technical scheme provided by the invention does not need a freezing-thawing step, therefore, the production period is shortened; the microfiltration-ultrafiltration technology is adopted to intercept effective constituents with appropriate molecular weight, so as to obtain a transfer factor stock solution, and compared with the traditional dialysis technology, the microfiltration-ultrafiltration technology is relatively high in efficiency. The method provided by the invention is suitable for scale production requirement, and the production period can be greatly shortened; the transfer factor solution prepared from the healthy pig spleen as a raw material through defatting, cell breakage, microfiltration and ultrafiltration is non-specific immunoregulator and is used for enhancing the immunological function of animal bodies.

The invention discloses a medicine combination for curing the recurrent ulcerative stomatitis and the chronic pharyngitis, and the application method. The invention mainly comprises transfer factors, carulon, vitamin B 12, and dolicaine. The invention has the functions of improving the nutrition and the metabolism of the local tissue, enhancing the cellular immunity and anti-inflammation of the local tissue, and improving the local symptoms, etc. The therapeutic method has the advantages that the curative effect is high, the material selection is convenient, the price is low, and the operation is simple and convenient. The injection is two times per week and six or eight times are taken as a course of treatment. Through the clinical verification, the effective rate reaches above 98 percent.

The invention discloses a numerical method of satellite electromagnetic scattering characteristics within a millimeter wave band. Aiming at such a metal and medium mixed structure of a satellite, an electric field integral equation is established only for the metal part of the satellite, an equation does not need to be established for the medium part, and finally, an equation with good conditions is formed, so as to be convenient for iterative solution. Mesh generation is performed only on the metal surface of the satellite, the mesh generation does not need to be performed on the medium coated part, and the strangeness is easily processed. Because of a structural feature of the inclined long satellite, the directionality of a transfer factor component is strong, an acceleration method is adopted for a far field effect on the basis of a multi-level fast multipole algorithm, computational memory requirements are effectively reduced, and the computing time is saved.

The invention discloses a method for preparing a natural high-efficiency swine fever-resistant transfer factor, which comprises the steps of preparing a virus antigen, extracting the virus antigen, immunizing a swine by the virus antigen, extracting the swine fever-resistant transfer factor from a spleen of the immunized swine and the like. The use of the transfer factor can play roles in preventing swine fever and protecting cells of normal organisms from being invaded by viruses of the swine fever, thereby reducing the disease rate. At the same time, swines infected by the viruses of the swine fever are treated by using the transfer factor, which can effectively improve clinical symptoms, improve cure rate, and reduce death rate.

The invention relates to a preparation method for obtaining blood used for preparing homologous antiserums and a spleen byproduct used for preparing transfer factors from the bodies of fur bearing animals such as foxes, raccoon dogs and minks; the furs of the foxes, the raccoon dogs and the minks are taken concentratedly in December and confirmed according to the fur-taking dates of different areas; healthy individuals are picked up 45 days before a predicated fur-taking date; the booster immunization of univalent vaccines or polyvalent vaccines of canine distemper, Canine parvovirus enteritis, adenovirus disease, corona virus laxness, parainfluenza, and pasteurellosis is carried out for 3 times by purified and condensed antigens on the foundation of carrying out immunization for once in summer; when the furs are taken, aseptic anticoagulation blood collection is carried out to a heart to improve the blood serum yield; and the spleens of the animals are collected for extracting specific or common transfer factors simultaneously. The blood can be conveniently prepared into the blood serums which resist communicable diseases, and the transfer factors can be extracted the spleen, thus providing guarantee for the healthy development of the breeding in the next year; the invention is used for curing the corresponding communicable diseases of the wild animals of the same species; and when a small amount of communicable disease cases appear in a breeding crowd, the corresponding pathogeny hyper-immune serums and transfer factors are mainly injected to a supposed healthy crowd after the pathogeny is confirmed so as to cure the affected animals in the early period of disease and control the spreading of the epidemic situations.