103 results about "Pharmaceutical manufacturing" patented technology

The present invention relates to a method for quantitatively evaluating the quality health of pharmaceutical manufacturing sites; specifically, the invention pertains to a method that measures audit readiness, data integrity compliance, and overall operational performance of the pharmaceutical manufacturing sites.

The embodiment of the invention discloses a training method, a prediction method, a device and equipment for a molecular attribute prediction model, and relates to the field of artificial intelligence assisted pharmacy. Comprising the steps that in a first training stage, in order to improve the interpretability of a sub-graph extraction model, the sub-graph extraction model and a sub-graph prediction model are trained based on a sample molecular graph, and the sub-graph extraction model obtained through training is used for extracting at least two interpretable key sub-graphs from the molecular graph; and in a second training stage, on the basis of the sub-graph extraction model obtained by training in the first training stage, training the sub-graph prediction model based on the sample sub-graph by taking improvement of the distribution external generalization ability of the sub-graph prediction model as a target, the sub-graph prediction model obtained through training is used for predicting molecular attributes of the molecular graph based on the at least two key sub-graphs of the molecular graph. By adopting the method provided by the invention, the interpretability of molecular attribute prediction and the generalization ability outside distribution can be improved.

This utility model relates to the field of pharmaceutical manufacturing technology, and in particular to a packaging, conveying, and positioning device for pharmaceutical boxes. It includes a first conveyor belt and a second conveyor belt arranged sequentially. A packaging machine is installed at the junction of the first and second conveyor belts. An inkjet printer is installed next to the first conveyor belt. A box-turning mechanism is installed on the end of the second conveyor belt away from the first conveyor belt. A sensor mechanism for measuring the conveying speed of the second conveyor belt is installed on the other end of the second conveyor belt away from the first conveyor belt. The sensor mechanism includes an encoder for electrical connection to a control system that controls the inkjet printer. A roller is mounted on the encoder for rolling friction contact with the surface of the second conveyor belt. The conveying speed of the second conveyor belt is measured by the encoder and roller, and the result is fed back to the control system to control the inkjet printer's inkjet timing, thereby ensuring the consistency of the inkjet printing position for each box.

The utility model discloses a kind of visual microinvasive injectors for living body cultivation gall, belong to the technical field of pharmaceutical manufacturing.A kind of visual microinvasive injector for living body cultivation gall, including upper shell, lower shell, limit ring, sealing plate, bottom plate, sealing ring, buckles and support block, the upper shell is sleeved in the surface of lower shell and limit ring, the limit ring is sleeved in the surface of injector barrel, limit ring one end extends to the outside of upper shell, and the other end is penetrated to the inside of lower shell.The utility model is designed as integrally-formed injector, minimally invasive surgery and visualization technology are integrated, simplify surgical procedure, even non-professional technical personnel can quickly master operation method.Integrally-formed design reduces different tools needed to switch or use in cooperation in surgery, reduces surgery time, reduces operation complexity, improves surgery efficiency and safety.

Techniques for monitoring a pharmaceutical manufacturing process and making determinations regarding the release of radiopharmaceuticals to health care providers. A data processing system collects data across multiple batches of radiopharmaceuticals, across multiple entities, and / or across multiple stages of the manufacturing process, processes the data, and provides feedback to entities involved in the manufacturing process. In scenarios where quality assurance tests are conducted, data is collected from radiopharmaceutical products before they are shipped, and the data is analyzed to provide the recipients with an indication of whether the radiopharmaceutical products satisfy quality assurance standards. Techniques for analyzing information about a batch manufacturing process and, when a problem occurred during a manufacture of a batch, determining whether to continue to manufacture a next batch in time for delivering and administering to a patient. The detected problem may be investigated and remedied before or during the synthesis of the next batch.

This application discloses a method and system for information-based diagnosis of production batches in pharmaceutical manufacturing enterprises, belonging to the interdisciplinary field of artificial intelligence and pharmaceutical information technology. The method includes: unifying the time base of multi-source equipment; collecting equipment operating status, process parameters, and event data to construct a multi-dimensional array; establishing process constraints in the dimensions of product, process, and operational equipment flow; using a binning method to logically combine equipment status parameters into different operating status categories; training a random forest model using labeled historical batch data to obtain a batch diagnosis model; inputting the start time of the batch to be diagnosed into the model to derive the equipment operating time period, matching it with the operating status category, and statistically analyzing the classified operating time of each piece of equipment. This application solves the problem of statistical efficiency and validity in calculating the net operating time of each piece of equipment within a batch in pharmaceutical enterprises.

The present invention discloses a preparation process for polycarbophil calcium in the field of pharmaceutical manufacturing process technology. The preparation process comprises the following steps: (1) preparing a magnesium sulfate aqueous solution; (2) preparing an acrylic acid monomer mixture: fully mixing acrylic acid, butadiene glycol, an initiator, and a regulator; the initiator is one or both of di-tert-butyl azodicarboxylate and diisopropyl azodicarboxylate; (3) concentrating the magnesium sulfate aqueous solution, adding the acrylic acid monomer mixture, controlling the temperature at 45-60°C to carry out a polymerization reaction, and filtering to obtain polycarbophil after the reaction is completed; (4) washing and soaking the polycarbophil; (5) performing a calcification reaction: fully mixing the polycarbophil treated in step (4) with an aqueous solution of a weakly acidic calcium salt, and performing a calcification reaction at 40-50°C; (6) after the calcification reaction is completed, centrifuging, drying, and pulverizing to obtain the finished product polycarbophil calcium. The present invention has the advantage of improving the yield.

The images represented in the image diagrams are interactive graphical user interfaces (GUIs) that visually convey information to a user related to systems for (i) creating and / or modifying and / or analyzing unit operations and data generated therefrom in manufacturing processes, such as cell and gene therapy manufacturing processes, (ii) combining live data from databases with textual information, and (iii) interactive analysis of data (e.g., patient data visualization systems) and analysis of data related to manufacturing processes. (A. Graph-Based Visualization and Interactive Data Views for Pharmaceutical Manufacturing Process Data Reconciliation) For example, in certain embodiments, the images represented in the image diagrams are associated with graph-based visualization tools that enable a user to analyze data related to one or more experiments and / or manufacturing processes used to produce pharmaceutical products and / or variations thereof. In particular, the images for graph-based visualization and data analysis GUI tools represented in the image diagrams can be used in association with GUIs that enable a user to automatically and / or semi-automatically (e.g., in conjunction with user review and / or input) generate visualizations that facilitate the examination of experiments and / or manufacturing processes and reconcile data generated across multiple processes and / or process runs. For example, among other things, the interactive graph-based visualization tools and their images may be provided (e.g., rendered) individually or together via one or more GUIs or windows, sub-windows, panels, etc. (Process Graph) For example, the image diagram illustrates a GUI that provides a visualization of a process graph. In one embodiment, the graph-based visualization tool represented in the image diagram includes generating and / or rendering a process graph that displays an experimental and / or manufacturing process for the production of pharmaceutical products, including biologics such as cell-based therapeutics and biologic drugs. The process graph includes multiple nodes, each representing a data point corresponding to a unit operation in a particular experimental and / or manufacturing process where information is collected and / or an action is performed.The image diagrams further illustrate various approaches for capturing and / or displaying these data points and how users interact with them. (Comparing and Reconciling Multiple Processes) In certain embodiments, the images depicted in the image diagrams are used as GUIs to provide graph-based visualization tools that provide comparison and / or reconciliation of data from multiple experiments and / or manufacturing processes, e.g., in an automated and / or semi-automated manner (e.g., coupled with user interactions such as review and selection actions). Among other things, the images depicted in the image diagrams include designs that overlay multiple graph processes, structurally compare them, and reconcile them based on data points. For example, the images depicted in the image diagrams may provide rendering data created by process comparison and reconciliation tools that (e.g., automatically) identify and address discrepancies, missing data, or anomalies, which can be used to generate a harmonized data set for further analysis, such as mathematical modeling. Thus, among other things, the graph-based visualization tools provided in the images depicted in the image diagrams address the challenges presented by unreconciled data across multiple experiments and / or manufacturing processes and / or within a single process that may be performed under varying conditions. Achieving automated reconciliation of such data is a significant challenge that, if not addressed, hinders effective and accurate analysis, which, in turn, can dramatically impact a user's and / or organization's ability to optimize and / or maintain manufacturing process quality and / or develop new processes. In particular, the images presented in the graph-based visualizations and the graphical representations that present them aid in adjusting sampling points to maximize overlay for effective comparisons and / or, in certain embodiments, identify overlapping points in existing data for effective real-time analysis. For example, the graphical representations show examples of multiple levels of data views and clickable / expandable pop-ups. In particular, in certain embodiments, the graphical representations are associated with GUIs that integrate the ability to collect and link actual data with process diagrams.For example, multiple levels of data can be viewed in an interactive and dynamic manner. For example, images presented in pictorial diagrams provide a high-level view, and while not all data may be directly visible, they provide clickable / expandable, customized, dynamic nodes for each node type, allowing users to simultaneously inspect and analyze collected and / or input data. In this manner, images presented in pictorial diagrams facilitate the identification and analysis of differences between processes. In some embodiments, structural differences between different processes indicate variations in conditions (e.g., temperature, duration, chemical concentrations), as well as the sequence and / or presence of certain steps. While unit operations (basic steps or stages in a process) may be generally similar to other processes, unique conditions and / or sequences can significantly affect the outcome, or the nature of the product or result. Thus, images presented in pictorial diagrams that provide visual display tools can be extremely useful in process optimization, troubleshooting, and ensuring that a process meets desired specifications. For example, changing the device that performs a unit operation and / or certain parameter values ​​within the unit operation (e.g., rotation speed, total volume, duration, etc.) can have a significant impact on the quality, recovery, efficacy, etc. of the output of that unit operation, which in turn can affect characteristics such as the biological / potency of the product, and additionally or alternatively, factors such as the cost of production, the number of doses produced per manufacturing run, and the like. Thus, among other things, images depicted in pictorial diagrams can be associated with and provided with GUIs that present generated data, such as automatically generated data (e.g., using ontologies), which helps to identify commonalities and / or differences between studies and facilitates performing analyses to determine, for example, whether device or parameter changes have significant impacts.In particular, as described herein, a graph-based visualization tool represented in a pictorial diagram provides a user with a visual representation of one or more manufacturing processes via a graph-based approach that easily communicates and highlights differences in conditions and unit operations, as well as their nature. For example, an image represented in a pictorial diagram may include visual features that highlight unreconciled data points. This approach facilitates the identification and correction of data reconciliation issues, thereby streamlining data analysis for research and process development conducted in the creation and production of pharmaceuticals, such as cell-based therapeutics and biologic drugs. (i. Process Graph with Interactive Nodes) The pictorial diagram illustrates an example of a graph-based visualization of a manufacturing process. As shown in the pictorial diagram, a manufacturing process can be represented and displayed via a process graph. Each node in the process graph displays a data point corresponding to a unit operation in the particular manufacturing process that it (e.g., the process graph) represents. The node may include information about the current data state and content (e.g., in real time) of the data point it represents. Within a graph-based visualization, nodes can be dynamic, such that, for example, a user interaction with a particular node (e.g., a mouse hover, click, touchscreen tap or long press, etc.) triggers the display of a tooltip indicating the current data state for the displayed data point, including data collected at various stages of the manufacturing process. Process graphs can be rendered and used for experiment design and process execution to outline complex manufacturing experiments over multiple days of manufacturing procedures and to visualize and track different stages of a real-time experiment.Experimental Overview: In some embodiments, a graph is displayed as an experimental overview, providing a high-level overview of an experiment, including the process steps and (e.g., approximate) order in which they were performed, the dates particular process steps were performed, how the process steps relate to one another (e.g., the top half of FIG. 1A ), and an overview of the various states / arms evaluated during the experiment and how those states relate to one another (e.g., the bottom half of FIG. 1A ). Timeline: In some embodiments, a process graph may include a timeline, displaying multiple timepoints, such as the days, during which a particular experiment or manufacturing process represented by the graph was performed. As shown in the image depicted in the pictorial diagram, the timeline may be displayed along the horizontal axis, with labeled circular icons used to visually represent individual timepoints (e.g., days of execution from day 1 through day 21). Other ways of visually displaying the timeline may be used, for example, along the vertical axis and / or using other shaped icons, other units (e.g., hours, weeks, etc.). Process Unit Operations: In some embodiments, a process graph may visually identify individual process unit operations performed during a manufacturing process. Individual process unit operations may be displayed, for example, through a combination of text labels and icons or markings that convey the particular unit operations performed and, optionally, the time at which they are carried out and / or their (e.g., temporal) relationship with respect to other unit operations. For example, the graph-based visualization shown in the image depicted in the pictorial diagram includes a series of text labels along the top row (of nodes) identifying various unit operations such as "Material Preparation," "Start-Up," "Transduction," and "Compounding." In one embodiment, as shown in the image depicted in the pictorial diagram, for example, the text labels also include a numerical component and identify the particular day on which each unit operation is performed, and the text labels are arranged sequentially from left to right along the horizontal axis to mark the order in which the operations are performed over time.The vertical dotted lines extending downward from each text label provide a visual guide for the expected schedule for each unit operation and / or a temporal mapping of the manufacturing process. (Data Points (Nodes)) As shown in the images depicted in the pictorial diagrams, data points in the manufacturing process associated with a particular unit operation and from which pertinent information (measurements and / or recorded observations) is collected are represented via nodes. Nodes may be rendered as icons such as filled circles as shown in the images depicted in the pictorial diagrams. In the images depicted in the pictorial diagrams, each circle is a node and is positioned so as to be visually aligned with a particular unit operation. That is, in the images depicted in the pictorial diagrams, it is located on a vertical dotted line extending downward from a text label identifying a particular unit operation, thereby identifying the data point related to that particular unit operation. (Connectivity) In some embodiments, the process graph may display the dependency or sequence of material and / or data flow from one unit operation to another via rendered connections between the various nodes. For example, as shown in the image depicted in the pictorial diagram, node connectivity may be rendered as lines connecting nodes across a timeline. (Data Connection Points) Specific points along the process where data is collected are marked, such as important checkpoints for quality control or measurements required for process evaluation. (Arms) In some embodiments, a process graph may include and / or display one or more (e.g., separate) arms, each representing a different experimental condition and / or baseline process variation. For example, in the image depicted in the pictorial diagram, the arms are rendered as various smaller graphs positioned below the timeline. Each line in the arms section indicates a different arm / condition as defined by the operator.Labels are provided to help clarify the focus of these steps and / or to distinguish and identify nodes as belonging to one condition, so that corresponding data collected from the laboratory are placed in the correct node and we do not mix data across conditions. In this case, the base process may be the step following a standard or control process, while other processes are steps that make experimental changes to that process or supplement the base process (e.g., making media, preparing materials, etc.). (Baseline Process and Base Process Graph) A baseline process may be a control and / or standard procedure and may be rendered as a base process graph. Text labels, color schemes, icon styles, positioning, and the like may be used to visually identify the baseline process, such as in graph-based visualizations. For example, in images presented in pictorial diagrams, the baseline process is identified and displayed as a node line directly below the timeline. In process graphs of images presented in pictorial diagrams, the baseline process may be the standard process against which other variations are compared. Variations and Outputs / Endpoints In some embodiments, a graph-based visualization can include one or more auxiliary subgraphs, each corresponding to and representing variations to experimental conditions and / or baseline versions of a manufacturing process. For example, the image depicted in the image diagram shows auxiliary subgraphs displaying variations labeled as "Ver1.1," "Ver1.2," "Ver2.1," "Ver2.3," etc., and "Condition 1," "Condition 2," "Condition 3," etc., representing different experimental arms or conditions. In this manner, the graph-based visualization tool can be used to communicate variations in materials used, process conditions, or specific unit operations performed. Additionally or alternatively, endpoints and / or outputs of different processes can also be displayed (e.g., via endpoint graphs).For example, as shown in the image depicted in the pictorial diagram, a series of nodes labeled "Out.1" and "Out.2" represent different endpoints and / or outputs of a process, such as different ways of processing or storing a final product. For example, in the exemplary subgraph shown in the image depicted in the pictorial diagram, lines refer to experimental conditions or interrelated subsets of a process, such as preparing materials (e.g., media) to feed a cell-containing process. Arm / condition sections help orient operators to the specific task being performed, and by identifying various arms in a descriptive manner, data collected in the lab are entered into corresponding nodes, and numbers / quantities, etc., are not mixed between conditions. Process graphs therefore facilitate the visualization and management of complex manufacturing processes. Among other things, they allow researchers to track the progress of experiments, compare different conditions or variations side by side, and ensure that data is systematically collected at designated points throughout the process. The ability to visualize the entire process in this way helps identify bottlenecks, ensure consistency, and facilitate data-driven decision-making.

The utility model discloses a mildew-free activated carbon box for waste gas treatment, which belongs to the field of pharmaceutical manufacturing and comprises a box body, an activated carbon layer is arranged in the box body, the box body is mounted on the ground through a support, a cavity enclosed by the box body is divided into an upper cavity and a lower cavity by the activated carbon layer, a waste gas inlet pipe is communicated with the lower cavity, and an exhaust pipe is communicated with the upper cavity. The box body is connected with at least one drainage pipe, the upper end of each drainage pipe is communicated with the bottom of the lower cavity, the lower end of each drainage pipe is inserted into the ground and communicated with an enterprise drainage pipeline, and each drainage pipe is provided with a check valve. According to the utility model, water generated in the box body is drained in time, and the activated carbon is free from mildewing.

This invention provides a capsule pharmaceutical manufacturing machine, relating to the technical field of pharmaceutical manufacturing. The capsule pharmaceutical manufacturing machine includes a frame, a conveying device, a lower capsule shell placement device, an upper capsule shell placement device, and a feeding device. The conveying device is mounted on the frame; the lower capsule shell placement device is mounted on the frame, and the upper capsule shell placement device is mounted on the frame, located at the output end of the conveying device relative to the lower capsule shell placement device. The feeding device includes a hopper, a first motor, a hollow rotating shaft, a movable rod, and an adjusting component. The hopper is located between the upper and lower capsule shell placement devices. The first motor is mounted on the frame, the hollow rotating shaft is located below the hopper, and the movable rod is located inside the hollow rotating shaft and connected to a connecting column. The connecting column passes through a movable slot and is connected to a movable feeding component. This capsule pharmaceutical manufacturing machine solves the technical problem of existing capsule pharmaceutical manufacturing machines, which can only adapt to single-dose capsule filling operations and have difficulty adjusting the filling dosage.

This utility model relates to the field of pharmaceutical drying technology, and more particularly to a multi-layer drying oven for pharmaceutical manufacturing; comprising: a tank body, a pipe assembly, and trays; by centrally placing the medicine into the inner tube, and then the upper ends of the second opening and the first opening are connected, when the transmission plate rises, it pushes the medicine in the inner tube to distribute to multiple trays, and after the medicine is dried, the lower ends of the second opening and the first opening are connected, and the medicine in the multiple trays falls into the medicine receiving box along the inner tube. The above method facilitates the placement and removal of medicine, and when the medicine is stirred, the revolution of the stirring rod generates a certain centrifugal force on the medicine, causing the medicine to move from the center of the tray to the edge, the medicine moves to the end of the stirring rod, and then the medicine slides back to the center of the tray. This is repeated to stir the medicine, so that the medicine can be close to the heat source, thereby being heated evenly in the tank.

This utility model belongs to the field of water treatment technology, specifically relating to a water dispenser and equipment for pharmaceutical production using a full membrane process. The water dispenser includes: a water pretreatment system suitable for treating raw water into drinking water, and includes: a filtration module and a sterilization module; the filtration module includes: a first buffer tank suitable for receiving and conveying raw water; a first dosing unit suitable for adding chemicals to the raw water conveyed from the first buffer tank; and a filtration unit equipped with a nanofiltration membrane, suitable for receiving the raw water conveyed from the first buffer tank, filtering it through the nanofiltration membrane, and returning it to the first buffer tank to form a cycle, and suitable for conveying the filtered raw water to the sterilization module after a corresponding cycle time; the water pretreatment system treats the raw water into drinking water, and the water treatment system treats the drinking water into water for injection, and a first loop pipe keeps the water flowing during the treatment process to prevent bacterial growth.

This invention relates to the field of pharmaceutical manufacturing technology, specifically to an integrated machine for rumen-treated guanidinoacetic acid granulation, coating, and drying. It includes a positioning component, with a first processing device fixedly mounted on the left front end of the positioning component, and a second processing device fixedly mounted on the rear end of the first processing device. The first processing device includes a flow guiding cavity, a negative pressure extraction device, a drug press, and a connecting pipe. The negative pressure extraction device is fixedly mounted inside the top of the drug press, and the connecting pipe is fixedly connected to the top of the negative pressure extraction device. The flow guiding cavity is fixedly mounted inside the rear end of the drug press. The second processing device includes an extension support, a closed slide plate, a front partition, an alignment sealing plate, a rotating cavity, and a support base. The front partition is fixedly mounted at the front end of the rotating cavity, and the closed slide plate is slidably inserted into the center of the front partition. Through the positioning component, the dryer achieves the purpose of guiding and synchronously guiding the drug powder.

The invention discloses a pharmaceutical manufacturing enterprise emergency management capability evaluation index system and an evaluation method, and belongs to the technical field of enterprise safety management. The method comprises the following steps: constructing an emergency management capability evaluation index system comprising a target layer, a criterion layer and an index layer, wherein the criterion layer covers dimensions such as an organization system, disposal drill and training guarantee; scientifically calculating the weight of each index based on an attribute hierarchy model (AHM); enterprise data is collected to score the indexes; performing weighted calculation to obtain a comprehensive evaluation value and a score of each level of dimension; weak links are identified based on results, and targeted improvement suggestions are generated. According to the invention, systematized, quantitative and precise assessment of the emergency management capability of the pharmaceutical manufacturing enterprise is realized, the defects of strong subjectivity, single dimension and weak diagnosis function of the existing method are effectively overcome, and a scientific decision tool is provided for the enterprise to improve the emergency management level.

This invention discloses a preparation process for a homogeneous immunomodulatory polysaccharide from *Gynostemma pentaphyllum* and its application in the preparation of anti-melanoma drugs and immunomodulators, relating to the field of pharmaceutical manufacturing technology. The preparation process includes four steps: compound enzyme-ultrasound synergistic extraction, fractional alcohol precipitation to remove proteins, DEAE-52 ion exchange column chromatography, and Sephacryl S-400 gel permeation chromatography purification. The resulting homogeneous polysaccharide (GOP-3) has a weight-average molecular weight of 12±1 kDa and is composed of mannose, glucose, and galactose in a specific ratio. The GOP-3 of this invention has a weight-average molecular weight (Mw) of 12.8 kDa, a dispersion (Mw / Mn) < 1.2, a uronic acid content of 23.5%, a well-defined structure, and is suitable for drug application. Furthermore, GOP-3 can significantly promote the secretion of IL-12 by dendritic cells and induce the differentiation of naive T cells into Th1 cells. Simultaneously, compared with a full-dose PD-1 monoclonal antibody, the combination of GOP-3 and a half-dose monoclonal antibody not only reduces the risk of immune-mediated pneumonia caused by antibody drugs but also increases the tumor inhibition rate by more than 40%.

This invention relates to the field of pharmaceutical manufacturing, specifically to a method for preparing naturally sourced injectable cholesterol. The method includes the following steps: taking egg yolk oil, allowing it to settle, centrifuging the lower sediment at high speed, adding an organic solvent to the centrifuged solid for low-temperature extraction to remove residual glycerol lipids, taking the filtered extract, adding a first crystallization solvent for recrystallization and purification twice, taking the crude cholesterol product after recrystallization, adding a second crystallization solvent for further recrystallization and purification, and drying under reduced pressure to obtain the injectable cholesterol product. This invention solves the technical problem of preparing injectable cholesterol from egg yolk, is suitable for large-scale industrialization of cholesterol, and can be applied to the preparation of complex formulations such as liposomes, improving the safety of drug use.

The present invention relates, in general, to a method for predicting water loss from a sample. In particular, the present invention relates to modeling water loss from a drug substance in a silicone tube based on the properties of the tube and the drug substance.

The utility model discloses an environment-friendly self-cleaning boiling dryer for producing medical intermediates, and relates to the technical field of medical manufacturing equipment, in particular to an environment-friendly self-cleaning boiling dryer for producing medical intermediates, which comprises a boiling bed and a feeding bin positioned at the bottom of the boiling bed, an exhaust inlet is fixed to the right side of the heating bin, air can enter the boiling bed through the exhaust inlet, a filter layer is arranged in the heating bin, a dehumidification plate is arranged on the left side of the filter layer, and a heater which is located in an inner cavity of the heating bin and controlled by a control panel is installed on one side of the dehumidification plate. According to the environment-friendly self-cleaning type boiling dryer for medical intermediate production, water mist sprayed by a water mist atomizer arranged in the treatment layer is combined with impurities and dust in hot air to be treated, so that the impurities and the dust are gathered, then the gathered objects are adsorbed by a dust collection plate in the recycling barrel, and the impurities contained in air are reduced.

The application relates to the technical field of pharmaceutical manufacturing equipment, in particular to a lyophilized microsphere dispensing device and a control method thereof. The rotating disc unit comprises a rotating disc, a first material dropping hole group is arranged on the bottom plate of the rotating disc, the first material dropping hole group comprises a plurality of first material dropping holes which are uniformly distributed along the circumference of the rotating disc, the driving unit is in transmission cooperation with the rotating disc unit to drive the rotating disc to rotate, the ball arranging unit comprises a ball arranging pipe connected with the air source, the ball arranging pipe is used for blowing air into the rotating disc, the discharging unit is used for sending each material ball in the first material dropping hole group at the discharging unit out of the rotating disc, the detection unit is in communication connection with the controller, and the detection unit is used for detecting the state of each first material dropping hole in the first material dropping hole group at the discharging unit and the state of each material ball. The application relates to the technical field of pharmaceutical manufacturing equipment, in particular to a lyophilized microsphere dispensing device and a control method thereof.

A pharmaceutical manufacturing information management device is capable of accessing multiple databases. The device includes: a searcher to search for related information items, when an information item is selected from results of searching information items related to pharmaceutical manufacturing and stored across multiple database servers, as information items related to the selected information item, and a display controller to display the related information items. The searcher searches one or more database servers of the multiple database servers, depending on the selected information item, for the related information items.

This application relates to the field of pharmaceutical manufacturing technology and discloses a pharmaceutical anti-stratification vibrating sieve, including a frame and a rocking plate. Connecting plates are fixedly connected to both ends of the rocking plate. Multiple sets of clamping components are provided on the rocking plate. Each connecting plate is configured as an inverted L-shaped structure, and a vertical rod is fixedly connected to the horizontal portion of each connecting plate. A sliding sleeve is fitted onto the outer surface of each vertical rod. A moving mechanism is provided on each vertical rod, allowing relative movement between the vertical rod and the sliding sleeve. The sliding sleeve is fixedly connected to the frame via a rotating shaft. This invention, by providing multiple sets of clamping components on the rocking plate, can simultaneously fix multiple pharmaceutical containers, improving efficiency. A motor can drive the sliding sleeve, connecting plates, and rocking plate to rotate back and forth around the rotating shaft. Furthermore, by providing the moving mechanism, the vertical rod and rocking plate can move radially back and forth along the rotating shaft, thereby vibrating the pharmaceuticals in multiple directions, improving the vibration effect, and preventing pharmaceutical stratification.

This invention belongs to the field of peptide drugs, specifically relating to an anti-drug-resistant bacterial peptide and its application in pharmaceutical manufacturing. Using Rink amide MBHA amino resin as a solid-phase support, the amino acid sequence of the template peptide raniseptin PL:Ac-GVFDTVKKIGKAVGKFALGVAKNYLNS-NH2 was modified, with amino acid residues 9I and 16F replaced by R8 and S5, respectively, to obtain the target stapling peptide PL-11. Compared to the template peptide PL-0, the stapling peptide PL-11 significantly enhances the antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Staphylococcus epidermidis.

The utility model discloses a packaging processing device for enteric-coated tablet production, and relates to the technical field of medicine production. The device comprises a belt type conveying device, a plurality of supporting legs are installed at the bottom of the belt type conveying device, a plurality of supports are installed at the top of the belt type conveying device, a material storage box is installed at the tops of the supports, a discharging pipe is installed at the bottom of the material storage box, and a piece adding cylinder is fixedly connected to the bottom of the discharging pipe. Two tablet plates are arranged at the top of the belt type conveying device, and the positioning part is installed in the belt type conveying device. According to the utility model, the positioning part is arranged, specifically, the motor is started to drive the two-way threaded rod to rotate clockwise, so that the two movable frames and the positioning plates on the outer surface of the two-way threaded rod are close to each other, the motor is closed after the width of the tablet plate is adjusted to a proper position, and the right sides of the two positioning plates are V-shaped, so that the tablet plate can be guided to enter between the two positioning plates to be aligned with the tablet adding cylinder; and the mode can flexibly adapt to tablet plates with different widths, so that the applicability is improved.

The present invention relates to the technical field of bioengineering, and in particular to a double-pump harvesting method and apparatus. The double-pump harvesting method includes concentration and formulation. The concentration step involves using two pumps, a first pump connected at one end to an initial sample container and at the other end to a centrifuge container, and a second pump connected at one end to the centrifuge container and at the other end to an intermediate product container and a waste liquid container, and a continuous-flow concentration step in which the flow rate of the second pump is increased while the difference in flow rate between the second pump and the first pump during concentration is set as a flow rate threshold. The present invention achieves a cyclic continuous-flow concentration process using a specific double-pump process, and in combination with subsequent cyclic formulation, achieves the function of formulation in multiple formulation bags without manual operation, resulting in a cell formulation method that improves formulation efficiency and accuracy, and is of great significance in the field of cellular pharmaceutical manufacturing.

The invention provides a traditional Chinese medicine composition for diabetes and application, and relates to the technical field of traditional Chinese medicine pharmacy, the traditional Chinese medicine composition is composed of twelve traditional Chinese medicines of prepared rehmannia root, pulp of dogwood fruit, Chinese yam, rhizoma alismatis, poria cocos, cortex moutan, wolfberry fruit, semen cuscutae, rhizoma polygonati, radix polygonati officinalis, radices trichosanthis and mantis egg-case. Animal experiments show that the traditional Chinese medicine composition disclosed by the invention can be used for remarkably improving the weight loss trend of diabetic mice and improving the glucose metabolism disorder state by reducing fasting blood-glucose and 2h glucose tolerance; in addition, the traditional Chinese medicine composition can increase TP and GLB contents in serum of mice, reduce ALT and AST activity, effectively repair anabolism functions of livers of diabetic mice and inhibit inflammation and necrosis of hepatocytes, and a safe and efficient treatment scheme is provided for diabetes.

The utility model relates to the technical field of pharmaceutical manufacturing, concretely to a drying device for granule forming processing, including drying box body, drying box body one end is equipped with the discharge gate, drying box body one end fixedly connected with the box cover, the box cover one end fixedly connected with the feed inlet, the box cover middle part fixedly connected with the hair drier, drying box body middle part fixedly connected with the slow falling subassembly, the drying device for granule forming processing that the utility model puts forward mainly is through setting up the hair drier that carries out the heating hair drier to the box in the upper portion of drying box body, setting up the slow falling subassembly in drying box body realizes the time that increases granule sliding and stays in the inside of drying box body, through the motor on the slow falling subassembly drive rotation and intermittent extrusion protruding piece below the blanking plate, realize the extrusion vibration of blanking plate, avoid the phenomenon that the granule stacking and partial granule bonding blanking plate on blanking plate cause drying heating uneven, also avoided the situation that the granule production quality is influenced to scatter the granule with stirring device.

This invention belongs to the field of peptide drugs, specifically relating to an anti-drug-resistant bacterial peptide and its application in pharmaceutical manufacturing. Using Rink amide MBHA amino resin as a solid-phase support, the amino acid sequence of the template peptide raniseptin PL:Ac-GVFDTVKKIGKAVGKFALGVAKNYLNS-NH2 was modified, with amino acid residues 6V and 13V replaced by R8 and S5, respectively, to obtain the target stapling peptide PL-10. Compared to the template peptide PL-0, the stapling peptide PL-10 significantly enhances the antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Staphylococcus epidermidis.

The present application relates to the technical field of pharmaceutical manufacturing, and specifically discloses a kind of Yinzhihuang oral liquid and its preparation method. The preparation method of a kind of Yinzhihuang oral liquid provided by the present application, the steps are: take Artemisia capillaris, Gardenia jasminoides, honeysuckle and mix, add water to decoct, filter to obtain the first filtrate; add ethanol aqueous solution to the filter residue of the decoction, heat and reflux extraction, merge the ethanol extract, filter to obtain the second filtrate; merge the first filtrate and the second filtrate, concentrate, obtain Artemisia capillaris ‑ Gardenia jasminoides ‑ Honeysuckle extract; take Scutellaria baicalensis, add water to decoct, filter and concentrate; add ethanol to refrigerate, filter and concentrate, obtain Scutellaria baicalensis extract; take Artemisia capillaris ‑ Gardenia jasminoides ‑ Honeysuckle extract and Scutellaria baicalensis extract, add water and stir evenly; then add sweetener, stir evenly, refrigerate, adjust pH, stir evenly, let stand, filter, encapsulate, sterilize, obtain. The clarity of the medicinal liquid of the Yinzhihuang oral liquid provided by the technical solution of the present application is maintained well, without obvious precipitation, and has good stability.

The invention discloses an anti-crosslinking gelatin hollow capsule and a preparation method thereof, and belongs to the field of biological medicine manufacturing, and the preparation method comprises the following steps: adding purified water and gelatin into a sol tank according to a mass ratio of (3-5): 1, mixing, heating to 60-85 DEG C, and dissolving; adding 0.01-0.1% of a chelating agent, stirring, and adding a pH regulator to regulate the pH value of the glue solution to 4-6; based on the total mass of the gelatin, adding 1-4% of an antioxidant, 1-3% of a plasticizer and 0.5-3% of a filler into the gelatin dissolving tank, and uniformly mixing and dissolving to obtain a gelatin solution; the sol tank is vacuumized to be smaller than or equal to-0.05 MPa, and the vacuum condition is kept for 15-30 min; filtering, transferring to a glue barrel, and carrying out heat preservation defoaming treatment for 4-6 hours under the condition that the heat preservation temperature is less than or equal to 50 DEG C; and injecting the de-foamed gelatin solution into a mold, curing, drying, pulling, selecting and packaging to obtain the gelatin hollow capsule, so that the preparation process is simplified, and the anti-crosslinking effect of the gelatin hollow capsule is remarkably improved.

This invention relates to the field of chemical pharmaceutical manufacturing technology, and discloses a process for preparing compound sodium bicarbonate to improve acid-base balance. The process includes: preparing an alkaline sodium bicarbonate raw material solution and an acidic raw material solution containing calcium and magnesium salts; dispersing the alkaline raw material solution into droplet clusters using a coaxial gas-liquid atomizing nozzle and a carbon dioxide gas source; allowing the droplet clusters to absorb carbon dioxide and pre-regulate their own hydrogen ion concentration during vertical vector descent; introducing the droplet clusters into the acidic raw material solution to form a homogeneous system and dispensing them; sterilizing the pharmaceutical packaging containers using a terminal overpressure compensation method; and injecting carbon dioxide into the sterilization chamber during the heating stage to establish an external pressure barrier. This invention solves the contradiction of high-concentration calcium and magnesium ions and bicarbonate ions precipitation in a single homogeneous system by blocking the precipitation formation pathway through microscale acidification modification, achieving long-term physical stability and coexistence of the formulation.