60 results about "Pharmaceutical manufacturing" patented technology

This utility model relates to the field of pharmaceutical manufacturing technology, and in particular to a packaging, conveying, and positioning device for pharmaceutical boxes. It includes a first conveyor belt and a second conveyor belt arranged sequentially. A packaging machine is installed at the junction of the first and second conveyor belts. An inkjet printer is installed next to the first conveyor belt. A box-turning mechanism is installed on the end of the second conveyor belt away from the first conveyor belt. A sensor mechanism for measuring the conveying speed of the second conveyor belt is installed on the other end of the second conveyor belt away from the first conveyor belt. The sensor mechanism includes an encoder for electrical connection to a control system that controls the inkjet printer. A roller is mounted on the encoder for rolling friction contact with the surface of the second conveyor belt. The conveying speed of the second conveyor belt is measured by the encoder and roller, and the result is fed back to the control system to control the inkjet printer's inkjet timing, thereby ensuring the consistency of the inkjet printing position for each box.

The utility model discloses a kind of visual microinvasive injectors for living body cultivation gall, belong to the technical field of pharmaceutical manufacturing.A kind of visual microinvasive injector for living body cultivation gall, including upper shell, lower shell, limit ring, sealing plate, bottom plate, sealing ring, buckles and support block, the upper shell is sleeved in the surface of lower shell and limit ring, the limit ring is sleeved in the surface of injector barrel, limit ring one end extends to the outside of upper shell, and the other end is penetrated to the inside of lower shell.The utility model is designed as integrally-formed injector, minimally invasive surgery and visualization technology are integrated, simplify surgical procedure, even non-professional technical personnel can quickly master operation method.Integrally-formed design reduces different tools needed to switch or use in cooperation in surgery, reduces surgery time, reduces operation complexity, improves surgery efficiency and safety.

Techniques for monitoring a pharmaceutical manufacturing process and making determinations regarding the release of radiopharmaceuticals to health care providers. A data processing system collects data across multiple batches of radiopharmaceuticals, across multiple entities, and / or across multiple stages of the manufacturing process, processes the data, and provides feedback to entities involved in the manufacturing process. In scenarios where quality assurance tests are conducted, data is collected from radiopharmaceutical products before they are shipped, and the data is analyzed to provide the recipients with an indication of whether the radiopharmaceutical products satisfy quality assurance standards. Techniques for analyzing information about a batch manufacturing process and, when a problem occurred during a manufacture of a batch, determining whether to continue to manufacture a next batch in time for delivering and administering to a patient. The detected problem may be investigated and remedied before or during the synthesis of the next batch.

This application discloses a method and system for information-based diagnosis of production batches in pharmaceutical manufacturing enterprises, belonging to the interdisciplinary field of artificial intelligence and pharmaceutical information technology. The method includes: unifying the time base of multi-source equipment; collecting equipment operating status, process parameters, and event data to construct a multi-dimensional array; establishing process constraints in the dimensions of product, process, and operational equipment flow; using a binning method to logically combine equipment status parameters into different operating status categories; training a random forest model using labeled historical batch data to obtain a batch diagnosis model; inputting the start time of the batch to be diagnosed into the model to derive the equipment operating time period, matching it with the operating status category, and statistically analyzing the classified operating time of each piece of equipment. This application solves the problem of statistical efficiency and validity in calculating the net operating time of each piece of equipment within a batch in pharmaceutical enterprises.

The utility model discloses a mildew-free activated carbon box for waste gas treatment, which belongs to the field of pharmaceutical manufacturing and comprises a box body, an activated carbon layer is arranged in the box body, the box body is mounted on the ground through a support, a cavity enclosed by the box body is divided into an upper cavity and a lower cavity by the activated carbon layer, a waste gas inlet pipe is communicated with the lower cavity, and an exhaust pipe is communicated with the upper cavity. The box body is connected with at least one drainage pipe, the upper end of each drainage pipe is communicated with the bottom of the lower cavity, the lower end of each drainage pipe is inserted into the ground and communicated with an enterprise drainage pipeline, and each drainage pipe is provided with a check valve. According to the utility model, water generated in the box body is drained in time, and the activated carbon is free from mildewing.

This invention provides a capsule pharmaceutical manufacturing machine, relating to the technical field of pharmaceutical manufacturing. The capsule pharmaceutical manufacturing machine includes a frame, a conveying device, a lower capsule shell placement device, an upper capsule shell placement device, and a feeding device. The conveying device is mounted on the frame; the lower capsule shell placement device is mounted on the frame, and the upper capsule shell placement device is mounted on the frame, located at the output end of the conveying device relative to the lower capsule shell placement device. The feeding device includes a hopper, a first motor, a hollow rotating shaft, a movable rod, and an adjusting component. The hopper is located between the upper and lower capsule shell placement devices. The first motor is mounted on the frame, the hollow rotating shaft is located below the hopper, and the movable rod is located inside the hollow rotating shaft and connected to a connecting column. The connecting column passes through a movable slot and is connected to a movable feeding component. This capsule pharmaceutical manufacturing machine solves the technical problem of existing capsule pharmaceutical manufacturing machines, which can only adapt to single-dose capsule filling operations and have difficulty adjusting the filling dosage.

This utility model relates to the field of pharmaceutical drying technology, and more particularly to a multi-layer drying oven for pharmaceutical manufacturing; comprising: a tank body, a pipe assembly, and trays; by centrally placing the medicine into the inner tube, and then the upper ends of the second opening and the first opening are connected, when the transmission plate rises, it pushes the medicine in the inner tube to distribute to multiple trays, and after the medicine is dried, the lower ends of the second opening and the first opening are connected, and the medicine in the multiple trays falls into the medicine receiving box along the inner tube. The above method facilitates the placement and removal of medicine, and when the medicine is stirred, the revolution of the stirring rod generates a certain centrifugal force on the medicine, causing the medicine to move from the center of the tray to the edge, the medicine moves to the end of the stirring rod, and then the medicine slides back to the center of the tray. This is repeated to stir the medicine, so that the medicine can be close to the heat source, thereby being heated evenly in the tank.

This utility model belongs to the field of water treatment technology, specifically relating to a water dispenser and equipment for pharmaceutical production using a full membrane process. The water dispenser includes: a water pretreatment system suitable for treating raw water into drinking water, and includes: a filtration module and a sterilization module; the filtration module includes: a first buffer tank suitable for receiving and conveying raw water; a first dosing unit suitable for adding chemicals to the raw water conveyed from the first buffer tank; and a filtration unit equipped with a nanofiltration membrane, suitable for receiving the raw water conveyed from the first buffer tank, filtering it through the nanofiltration membrane, and returning it to the first buffer tank to form a cycle, and suitable for conveying the filtered raw water to the sterilization module after a corresponding cycle time; the water pretreatment system treats the raw water into drinking water, and the water treatment system treats the drinking water into water for injection, and a first loop pipe keeps the water flowing during the treatment process to prevent bacterial growth.

This invention relates to the field of pharmaceutical manufacturing technology, specifically to an integrated machine for rumen-treated guanidinoacetic acid granulation, coating, and drying. It includes a positioning component, with a first processing device fixedly mounted on the left front end of the positioning component, and a second processing device fixedly mounted on the rear end of the first processing device. The first processing device includes a flow guiding cavity, a negative pressure extraction device, a drug press, and a connecting pipe. The negative pressure extraction device is fixedly mounted inside the top of the drug press, and the connecting pipe is fixedly connected to the top of the negative pressure extraction device. The flow guiding cavity is fixedly mounted inside the rear end of the drug press. The second processing device includes an extension support, a closed slide plate, a front partition, an alignment sealing plate, a rotating cavity, and a support base. The front partition is fixedly mounted at the front end of the rotating cavity, and the closed slide plate is slidably inserted into the center of the front partition. Through the positioning component, the dryer achieves the purpose of guiding and synchronously guiding the drug powder.

The invention discloses a pharmaceutical manufacturing enterprise emergency management capability evaluation index system and an evaluation method, and belongs to the technical field of enterprise safety management. The method comprises the following steps: constructing an emergency management capability evaluation index system comprising a target layer, a criterion layer and an index layer, wherein the criterion layer covers dimensions such as an organization system, disposal drill and training guarantee; scientifically calculating the weight of each index based on an attribute hierarchy model (AHM); enterprise data is collected to score the indexes; performing weighted calculation to obtain a comprehensive evaluation value and a score of each level of dimension; weak links are identified based on results, and targeted improvement suggestions are generated. According to the invention, systematized, quantitative and precise assessment of the emergency management capability of the pharmaceutical manufacturing enterprise is realized, the defects of strong subjectivity, single dimension and weak diagnosis function of the existing method are effectively overcome, and a scientific decision tool is provided for the enterprise to improve the emergency management level.

This invention discloses a preparation process for a homogeneous immunomodulatory polysaccharide from *Gynostemma pentaphyllum* and its application in the preparation of anti-melanoma drugs and immunomodulators, relating to the field of pharmaceutical manufacturing technology. The preparation process includes four steps: compound enzyme-ultrasound synergistic extraction, fractional alcohol precipitation to remove proteins, DEAE-52 ion exchange column chromatography, and Sephacryl S-400 gel permeation chromatography purification. The resulting homogeneous polysaccharide (GOP-3) has a weight-average molecular weight of 12±1 kDa and is composed of mannose, glucose, and galactose in a specific ratio. The GOP-3 of this invention has a weight-average molecular weight (Mw) of 12.8 kDa, a dispersion (Mw / Mn) < 1.2, a uronic acid content of 23.5%, a well-defined structure, and is suitable for drug application. Furthermore, GOP-3 can significantly promote the secretion of IL-12 by dendritic cells and induce the differentiation of naive T cells into Th1 cells. Simultaneously, compared with a full-dose PD-1 monoclonal antibody, the combination of GOP-3 and a half-dose monoclonal antibody not only reduces the risk of immune-mediated pneumonia caused by antibody drugs but also increases the tumor inhibition rate by more than 40%.

This invention relates to the field of pharmaceutical manufacturing, specifically to a method for preparing naturally sourced injectable cholesterol. The method includes the following steps: taking egg yolk oil, allowing it to settle, centrifuging the lower sediment at high speed, adding an organic solvent to the centrifuged solid for low-temperature extraction to remove residual glycerol lipids, taking the filtered extract, adding a first crystallization solvent for recrystallization and purification twice, taking the crude cholesterol product after recrystallization, adding a second crystallization solvent for further recrystallization and purification, and drying under reduced pressure to obtain the injectable cholesterol product. This invention solves the technical problem of preparing injectable cholesterol from egg yolk, is suitable for large-scale industrialization of cholesterol, and can be applied to the preparation of complex formulations such as liposomes, improving the safety of drug use.

The present invention relates, in general, to a method for predicting water loss from a sample. In particular, the present invention relates to modeling water loss from a drug substance in a silicone tube based on the properties of the tube and the drug substance.

The application relates to the technical field of pharmaceutical manufacturing equipment, in particular to a lyophilized microsphere dispensing device and a control method thereof. The rotating disc unit comprises a rotating disc, a first material dropping hole group is arranged on the bottom plate of the rotating disc, the first material dropping hole group comprises a plurality of first material dropping holes which are uniformly distributed along the circumference of the rotating disc, the driving unit is in transmission cooperation with the rotating disc unit to drive the rotating disc to rotate, the ball arranging unit comprises a ball arranging pipe connected with the air source, the ball arranging pipe is used for blowing air into the rotating disc, the discharging unit is used for sending each material ball in the first material dropping hole group at the discharging unit out of the rotating disc, the detection unit is in communication connection with the controller, and the detection unit is used for detecting the state of each first material dropping hole in the first material dropping hole group at the discharging unit and the state of each material ball. The application relates to the technical field of pharmaceutical manufacturing equipment, in particular to a lyophilized microsphere dispensing device and a control method thereof.

A pharmaceutical manufacturing information management device is capable of accessing multiple databases. The device includes: a searcher to search for related information items, when an information item is selected from results of searching information items related to pharmaceutical manufacturing and stored across multiple database servers, as information items related to the selected information item, and a display controller to display the related information items. The searcher searches one or more database servers of the multiple database servers, depending on the selected information item, for the related information items.

This application relates to the field of pharmaceutical manufacturing technology and discloses a pharmaceutical anti-stratification vibrating sieve, including a frame and a rocking plate. Connecting plates are fixedly connected to both ends of the rocking plate. Multiple sets of clamping components are provided on the rocking plate. Each connecting plate is configured as an inverted L-shaped structure, and a vertical rod is fixedly connected to the horizontal portion of each connecting plate. A sliding sleeve is fitted onto the outer surface of each vertical rod. A moving mechanism is provided on each vertical rod, allowing relative movement between the vertical rod and the sliding sleeve. The sliding sleeve is fixedly connected to the frame via a rotating shaft. This invention, by providing multiple sets of clamping components on the rocking plate, can simultaneously fix multiple pharmaceutical containers, improving efficiency. A motor can drive the sliding sleeve, connecting plates, and rocking plate to rotate back and forth around the rotating shaft. Furthermore, by providing the moving mechanism, the vertical rod and rocking plate can move radially back and forth along the rotating shaft, thereby vibrating the pharmaceuticals in multiple directions, improving the vibration effect, and preventing pharmaceutical stratification.

This invention belongs to the field of peptide drugs, specifically relating to an anti-drug-resistant bacterial peptide and its application in pharmaceutical manufacturing. Using Rink amide MBHA amino resin as a solid-phase support, the amino acid sequence of the template peptide raniseptin PL:Ac-GVFDTVKKIGKAVGKFALGVAKNYLNS-NH2 was modified, with amino acid residues 9I and 16F replaced by R8 and S5, respectively, to obtain the target stapling peptide PL-11. Compared to the template peptide PL-0, the stapling peptide PL-11 significantly enhances the antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Staphylococcus epidermidis.

The utility model discloses a packaging processing device for enteric-coated tablet production, and relates to the technical field of medicine production. The device comprises a belt type conveying device, a plurality of supporting legs are installed at the bottom of the belt type conveying device, a plurality of supports are installed at the top of the belt type conveying device, a material storage box is installed at the tops of the supports, a discharging pipe is installed at the bottom of the material storage box, and a piece adding cylinder is fixedly connected to the bottom of the discharging pipe. Two tablet plates are arranged at the top of the belt type conveying device, and the positioning part is installed in the belt type conveying device. According to the utility model, the positioning part is arranged, specifically, the motor is started to drive the two-way threaded rod to rotate clockwise, so that the two movable frames and the positioning plates on the outer surface of the two-way threaded rod are close to each other, the motor is closed after the width of the tablet plate is adjusted to a proper position, and the right sides of the two positioning plates are V-shaped, so that the tablet plate can be guided to enter between the two positioning plates to be aligned with the tablet adding cylinder; and the mode can flexibly adapt to tablet plates with different widths, so that the applicability is improved.

The utility model relates to the technical field of pharmaceutical manufacturing, concretely to a drying device for granule forming processing, including drying box body, drying box body one end is equipped with the discharge gate, drying box body one end fixedly connected with the box cover, the box cover one end fixedly connected with the feed inlet, the box cover middle part fixedly connected with the hair drier, drying box body middle part fixedly connected with the slow falling subassembly, the drying device for granule forming processing that the utility model puts forward mainly is through setting up the hair drier that carries out the heating hair drier to the box in the upper portion of drying box body, setting up the slow falling subassembly in drying box body realizes the time that increases granule sliding and stays in the inside of drying box body, through the motor on the slow falling subassembly drive rotation and intermittent extrusion protruding piece below the blanking plate, realize the extrusion vibration of blanking plate, avoid the phenomenon that the granule stacking and partial granule bonding blanking plate on blanking plate cause drying heating uneven, also avoided the situation that the granule production quality is influenced to scatter the granule with stirring device.

This invention belongs to the field of peptide drugs, specifically relating to an anti-drug-resistant bacterial peptide and its application in pharmaceutical manufacturing. Using Rink amide MBHA amino resin as a solid-phase support, the amino acid sequence of the template peptide raniseptin PL:Ac-GVFDTVKKIGKAVGKFALGVAKNYLNS-NH2 was modified, with amino acid residues 6V and 13V replaced by R8 and S5, respectively, to obtain the target stapling peptide PL-10. Compared to the template peptide PL-0, the stapling peptide PL-10 significantly enhances the antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Staphylococcus epidermidis.

This invention relates to the field of chemical pharmaceutical manufacturing technology, and discloses a process for preparing compound sodium bicarbonate to improve acid-base balance. The process includes: preparing an alkaline sodium bicarbonate raw material solution and an acidic raw material solution containing calcium and magnesium salts; dispersing the alkaline raw material solution into droplet clusters using a coaxial gas-liquid atomizing nozzle and a carbon dioxide gas source; allowing the droplet clusters to absorb carbon dioxide and pre-regulate their own hydrogen ion concentration during vertical vector descent; introducing the droplet clusters into the acidic raw material solution to form a homogeneous system and dispensing them; sterilizing the pharmaceutical packaging containers using a terminal overpressure compensation method; and injecting carbon dioxide into the sterilization chamber during the heating stage to establish an external pressure barrier. This invention solves the contradiction of high-concentration calcium and magnesium ions and bicarbonate ions precipitation in a single homogeneous system by blocking the precipitation formation pathway through microscale acidification modification, achieving long-term physical stability and coexistence of the formulation.

The present invention provides processes for the preparation 2-(t-butoxy)-4-(3-methyl-3-(5-methylsulfonyl)isoindolin-2-yl)butyl)phenol The disclosed processes overcome drawbacks of prior art methods by providing safer, more efficient synthetic routes with improved yields and reduced impurity levels. A key improvement includes a novel photochemical bromination process using continuous flow technology. The invention also encompasses novel intermediates including compounds of Formula 12 and 13. The processes eliminate the use of hazardous reagents, reduce reaction times, and provide better control over product purity, making them suitable for large-scale pharmaceutical manufacturing.

The utility model relates to the technical field of medicine manufacturing, and discloses a medicine intermediate raw material mixing cylinder which comprises a base plate, a supporting column is fixedly installed at the bottom of the base plate, a cylinder body is clamped in the center of the top end of the base plate, a support is fixedly installed at the top of the base plate, and a mixing assembly is arranged at the top end of the base plate. And the mixing assembly comprises a servo motor, the servo motor is fixedly installed at the top of the support, and a rotating shaft is fixedly installed at the output end of the bottom end of the servo motor. According to the medical intermediate raw material mixing barrel, in order to achieve a better material mixing effect, the mixing assembly is arranged, after multiple medical intermediate raw materials are added into the barrel body, a servo motor is started, a rotating shaft rotates, and thus a rotating rod revolves in cooperation with a connecting rod, and meanwhile the rotating rod drives a ball to move on a support; a driving gear, a fixed column and a bevel gear disc are matched, so that a rotating rod drives a bottom rod and a stirring rod to rotate, and the material mixing effect is better.

This invention belongs to the field of peptide drugs, specifically relating to an antibacterial peptide and its application in pharmaceutical manufacturing. Using Rink amide MBHA amino resin as a solid-phase support, the amino acid sequence of the template peptide raniseptin PL:Ac-GVFDTVKKIGKAVGKFALGVAKNYLNS-NH2 was modified, with amino acid residues 13V and 20V replaced by R8 and S5, respectively, to obtain the target stapling peptide PL-13. Compared to the template peptide PL-0, the stapling peptide PL-13 significantly enhances the antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, and Staphylococcus epidermidis.

The invention relates to a pharmaceutical manufacturing apparatus (12) and a method of operating a pharmaceutical manufacturing apparatus (12).

This invention discloses a precise differential pressure control system and method for clean areas in pharmaceutical production workshops, including a supply fan, an exhaust fan, a return air volume detection device, an air volume control valve, a differential pressure gauge, a gas flow meter, an angle sensor, and a monitoring module. The monitoring module stores a preset pressure range and a preset adjustment time for each clean area. When the monitoring module detects that the actual pressure value of the clean area is outside the preset pressure range, it generates a corresponding control command based on the magnitude of the deviation and the preset adjustment time. The control module receives the control command and adjusts the speed of the exhaust fan and the opening of the air volume control valve accordingly. This invention achieves intelligent adjustment of clean room pressure by controlling the air volume of the clean room through the monitoring module. Furthermore, the monitoring module can intelligently adjust the speed of the exhaust fan according to the actual pressure, thereby achieving rapid adjustment of the negative pressure clean room pressure.

This invention discloses a dynamic weighted multimodal pharmaceutical equipment fault diagnosis reasoning method and system, belonging to the interdisciplinary field of artificial intelligence and intelligent pharmaceutical manufacturing. Addressing the technical bottlenecks in existing pharmaceutical equipment fault diagnosis methods, such as insufficient robustness of multimodal fusion, weak long-term fault feature mining capabilities, and susceptibility to illusions in large-model reasoning, which fail to meet GMP compliance requirements, this invention proposes a layered collaborative diagnostic scheme: at the method level, accurate diagnosis is achieved through synchronous acquisition of multimodal data, robust feature extraction, dynamic weighted fusion using DWFF, structured cue word construction, and GraphRAG-enhanced large-model causal reasoning; at the system level, a bottom-up four-layer collaborative architecture is adopted, which adaptively allocates fusion weights based on the quality of each modality's data, combines knowledge graph retrieval to suppress illusions in output, and finally outputs an interpretable compliance diagnostic report. This invention effectively improves the accuracy, stability, and interpretability of fault diagnosis, ensuring efficient operation of pharmaceutical equipment and adapting to the actual production needs of the pharmaceutical industry.

The application discloses a dust recovery device for pharmaceutical equipment and belongs to the technical field of pharmaceutical production and environmental protection. The pharmaceutical dust recovery device comprises a pre-coagulation part, a filter assembly, a pre-coagulation shell and a filter shell. The pre-coagulation part comprises a collection body arranged in the pre-coagulation shell, the collection body is internally provided with a conveying cavity, an aggregation and combination area is formed at the center of the conveying cavity, the filter assembly comprises a filter cloth bag, and a shaking component is arranged between the filter cloth bag and a support framework. The aggregation and combination area with a smaller central space can make the mutual adsorption and mutual adhesion of the pharmaceutical dust, increase the number of dust with a large particle size before being filtered by the filter cloth bag, improve the blocking and capturing of the filter cloth bag, reduce the amount of dust embedded in the fiber of the filter cloth bag per unit time, and reduce the plugging rate of the filter cloth bag and the pressure loss in the whole dust removal system per unit time.

Advanced methods, apparatuses, and systems are presented for the real-time monitoring and precise control of substances undergoing phase transitions within a vacuum system, in particular, for lyophilization processes. Utilizing sophisticated interfaces, these techniques enable the visualization of phase diagrams depicting the equilibrium conditions of temperature and pressure for distinct substances. Real-time temperature and pressure data are seamlessly integrated and graphically represented on these phase diagrams. Furthermore, the methodology incorporates advanced regression models to accurately estimate mass quantities and employs dynamic environmental control curves for system parameter adjustments. These techniques encompass real-time data analysis, responsive adjustment inputs, intuitive graphical representations that ensure meticulous control and monitoring of phase transitions, thereby optimizing process monitoring and outcomes. The applications span diverse fields including chemical processing, materials science, food science, and pharmaceutical manufacturing, where precise control over phase transitions is paramount.

The utility model discloses an intelligent heat preservation water tank controlled by an industrial sensor, and relates to the technical field of temperature control equipment in the industrial field. The intelligent heat preservation water tank controlled by the industrial sensor comprises a heat preservation water tank body, the heat preservation water tank body comprises an outer shell, high-density polyurethane foam and an inner tank body, a water storage cavity is formed in the inner tank body, a water inlet pipe and a water outlet pipe are fixedly connected to the outer surface of the inner tank body, and a water level detection device is arranged in the water storage cavity; according to the water tank, the energy utilization rate is remarkably improved, the operation cost is reduced, the safety is greatly enhanced, the water tank can be applied to industries with strict requirements on water temperature, such as food processing, pharmaceutical manufacturing and printing and dyeing spinning, and the water tank has a wide application prospect. The practicability of the water tank is improved.