Yinzhihuang oral liquid and preparation method thereof

Abstract

The present application relates to the technical field of pharmaceutical manufacturing, and specifically discloses a kind of Yinzhihuang oral liquid and its preparation method. The preparation method of a kind of Yinzhihuang oral liquid provided by the present application, the steps are: take Artemisia capillaris, Gardenia jasminoides, honeysuckle and mix, add water to decoct, filter to obtain the first filtrate; add ethanol aqueous solution to the filter residue of the decoction, heat and reflux extraction, merge the ethanol extract, filter to obtain the second filtrate; merge the first filtrate and the second filtrate, concentrate, obtain Artemisia capillaris ‑ Gardenia jasminoides ‑ Honeysuckle extract; take Scutellaria baicalensis, add water to decoct, filter and concentrate; add ethanol to refrigerate, filter and concentrate, obtain Scutellaria baicalensis extract; take Artemisia capillaris ‑ Gardenia jasminoides ‑ Honeysuckle extract and Scutellaria baicalensis extract, add water and stir evenly; then add sweetener, stir evenly, refrigerate, adjust pH, stir evenly, let stand, filter, encapsulate, sterilize, obtain. The clarity of the medicinal liquid of the Yinzhihuang oral liquid provided by the technical solution of the present application is maintained well, without obvious precipitation, and has good stability.

Description

Technical Field

[0001] The present application relates to the technical field of pharmaceutical manufacturing, and in particular to a Yinzhihuang oral liquid and a preparation method thereof. Background Art

[0002] Yinzhihuang Oral Liquid is a traditional Chinese medicine with the primary effects of clearing heat and detoxifying, promoting dampness and relieving jaundice. It is indicated for jaundice caused by damp-heat in the liver and gallbladder, with symptoms including sallow complexion, chest and flank pain, nausea and vomiting, dark yellow urine, and acute and chronic hepatitis. Its main ingredients include extracts of Artemisia capillaris, Gardenia jasminoides, Scutellaria baicalensis, and Honeysuckle, which work synergistically to achieve its therapeutic effect. Yinzhihuang Oral Liquid is a reddish-brown liquid with a sweet and slightly bitter taste.

[0003] Currently, the preparation method for Yinzhihuang oral liquid is relatively complex, involving multiple steps and ingredients, and therefore may be subject to certain instability. This instability may arise from multiple factors, including the quality of the raw materials, the extraction reagents used during the preparation process, the control of conditions such as temperature and pH, and the storage and transportation conditions of the product. Poor raw material quality or inappropriate extraction methods may lead to loss or changes in the active ingredients, thus affecting the stability of the product.

[0004] Therefore, it is necessary to provide a new method for preparing Yinzhihuang oral liquid to improve the overall stability and long-term storage performance of the oral liquid. Summary of the Invention

[0005] In order to solve the above technical problems, the present application provides a Yinzhihuang oral liquid and a preparation method thereof.

[0006] The present application provides a method for preparing Yinzhihuang oral liquid, which is characterized by comprising the following steps in sequence:

[0007] S1: Mix Artemisia capillaris, Gardenia jasminoides, and honeysuckle, add water and decoct 3-4 times, adding 8-12 times the weight of water each time, and decoct for 120-180 minutes each time; combine the decoctions and filter to obtain a first filtrate;

[0008] The residue obtained by filtering the decoction is added with 8-12 times by weight of an ethanol aqueous solution, and the mixture is heated under reflux for 2-3 times under sealed conditions. The alcohol extracts are combined and filtered to obtain a second filtrate;

[0009] The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of 1.15-1.20 / 60° C. to obtain an Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract;

[0010] S2: Take Scutellaria baicalensis, add water and decoct three times, adding 8-12 times the weight of water each time; combine the decoctions, filter, and concentrate the filtrate to a concentrate with a specific gravity of 1.10-1.20 / 60°C, add ethanol to a concentration of 60-80% alcohol, refrigerate for 8-16 hours, filter, recover the filtrate, and concentrate to a concentrate with a specific gravity of 1.15-1.20 / 60°C to obtain the Scutellaria baicalensis extract;

[0011] S3: Take 23-31 parts by weight of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 35-45 parts by weight of Scutellaria baicalensis extract, add 850-950 parts by weight of water, and stir evenly; then add 0.05-0.15 parts by weight of sweetener, stir evenly, refrigerate for 12-36 hours, adjust the pH value to 6.7-7.3, stir evenly, let stand, filter, fill, and sterilize to obtain the product.

[0012] The present application selects to use Artemisia capillaris, Gardenia jasminoides, and honeysuckle to mix to prepare Artemisia capillaris-gardenia-honeysuckle extract, decoct Scutellaria baicalensis in water alone to prepare Scutellaria baicalensis extract, and then mix 35-45 of Artemisia capillaris-gardenia-honeysuckle extract and Scutellaria baicalensis extract to prepare Yinzhihuang oral liquid, so that the prepared Yinzhihuang oral liquid can effectively maintain the clarity of the solution and stably ensure the stability of the content of baicalin and gardenoside when placed at 40°C for 6 months, solving the problems existing in existing products.

[0013] In order to improve the stability of Yinzhihuang oral liquid, the present application considers improving it by optimizing the extraction process. First, the Herba Artemisiae Scopariae, Gardeniae Fructus and Flos Lonicerae are mixed and extracted, and the decocted filter residue is subjected to ethanol extraction during the extraction process. This can fully integrate the effective ingredients of these three medicinal materials to form a complex component system and produce a new stabilizing effect. At the same time, the baicalin extract is extracted separately from Scutellariae Baicalensis, which can maximize the retention of its medicinal ingredients and avoid unnecessary chemical reactions with other medicinal materials during the extraction process. When preparing Yinzhihuang oral liquid, the Herba Artemisiae Scopariae-Gardeniae-Flos Lonicerae mixed extract is carefully proportioned with the Scutellariae Baicalensis extract, which may form a more stable dispersion system. In summary, the stability of Yinzhihuang oral liquid can be effectively improved by optimizing the extraction process and careful proportioning. These measures can not only extend the shelf life of the oral liquid, but also ensure the lasting stability of the drug efficacy, providing patients with better therapeutic effects.

[0014] Preferably, in step S1, in the method for preparing the Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract, the weight ratio of Artemisia capillaris, Gardenia jasminoides and Honeysuckle is 10-14:6-7.2:4.5-5.5.

[0015] Preferably, in step S1, in the method for preparing the Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract, the weight ratio of Artemisia capillaris, Gardenia jasminoides and Honeysuckle is 11-13:6.4-6.8:4.8-5.2.

[0016] Preferably, in step S1, the concentration of the ethanol aqueous solution is 45-55 wt%.

[0017] Preferably, in step S2, the specific method of decocting three times is: the first time, adjusting the pH value to 6.0-6.6 with 8-12wt% sodium hydroxide solution, and decocting for 60-90min; the second time, adjusting the pH value to 6.8-7.4 with 8-12wt% sodium hydroxide solution, and decocting for 120-180min; the third time, adjusting the pH value to 7.6-8.2 with 8-12wt% sodium hydroxide solution, and decocting for 200-260min.

[0018] Preferably, in step S2, the specific method of decocting three times is: the first time, adjusting the pH value to 6.2-6.4 with 8-12wt% sodium hydroxide solution, and decocting for 70-80min; the second time, adjusting the pH value to 7.0-7.2 with 8-12wt% sodium hydroxide solution, and decocting for 140-160min; the third time, adjusting the pH value to 7.8-8.0 with 8-12wt% sodium hydroxide solution, and decocting for 220-240min.

[0019] During the preparation of the Scutellaria baicalensis extract, the present application ensures the stable extraction of ingredients by carefully designing the pH value and extraction time of three decoctions, thereby further improving the stability of the Yinzhihuang oral liquid.

[0020] Preferably, in S3, the amount of the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract is 25-29 parts by weight, and the amount of the Scutellaria baicalensis extract is 37-40 parts by weight.

[0021] Preferably, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-1.5:0.5-1.5.

[0022] Preferably, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-0.8:1.2-1.5.

[0023] After experimental analysis, it is known that aspartame is used as a sweetener in the existing Yinzhihuang oral liquid. Although it can improve the taste, due to the unstable chemical properties of aspartame under a neutral environment (the residual aspartame in the finished product is only 0.82-6.20% of the added amount, with an average of only 2.5% residual), it is easy to decompose and produce aspartic acid, phenylalanine and methanol, which is a potential risk for patients with phenylketonuria. In addition, the instability of aspartame will also affect the overall stability and long-term storage performance of the oral liquid. The present application uses erythritol and Momordica grosvenori extract in the above-mentioned weight ratio as sweeteners to further improve the stability of Yinzhihuang oral liquid.

[0024] In a second aspect, the present application provides a Yinzhihuang oral liquid, which is prepared using the above-mentioned preparation method of Yinzhihuang oral liquid.

[0025] In summary, the technical solution of this application has the following effects:

[0026] The Yinzhihuang oral liquid provided by the technical solution of the present application not only retains a good taste, but is also more stable, not easily decomposed by heat, and extends the shelf life of the product.

[0027] After 6 months of acceleration, the content of the active ingredient in the Yinzhihuang oral liquid product provided by the technical solution of the present application decreased less than that in 0 months, the clarity of the liquid was maintained well, there was no obvious precipitation, and it had good stability. DETAILED DESCRIPTION

[0028] The present application is further described in detail below in conjunction with examples, comparative examples and performance testing experiments. These examples should not be construed as limiting the scope of protection claimed in this application.

[0029] Example

[0030] Examples 1-5

[0031] Examples 1-5 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0032] The difference between the above embodiments is that: in step S1, in the method for preparing the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract, the weight ratios of Artemisia capillaris, Gardenia jasminoides, and Lonicera japonica are different, as shown in Table 1.

[0033] The preparation method of Yinzhihuang oral liquid in the above embodiment is:

[0034] S1: According to Table 1, Herba Artemisiae Scopariae, Herba Gardeniae, and Herba Lonicerae were mixed and decocted with water three times, each time adding 10 times the weight of water, and each time decocting for 150 minutes; the decoctions were combined and filtered to obtain a first filtrate;

[0035] The residue obtained by filtering the decoction was added with 10 times by weight of a 50 wt% ethanol aqueous solution, and the mixture was heated under reflux for extraction twice under sealed conditions. The alcohol extracts were combined and filtered to obtain a second filtrate;

[0036] The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of 1.17 / 60° C. to obtain an Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract;

[0037] S2: 1 kg of Scutellaria baicalensis was decocted three times with water, each time adding 10 times the weight of water; the decoctions were combined, filtered, and the filtrate was concentrated to a specific gravity of 1.15 / 60°C. Ethanol was added to increase the alcohol content to 70%, and the mixture was refrigerated for 12 hours. The mixture was filtered, the filtrate was recovered, and concentrated to a specific gravity of 1.17 / 60°C to obtain the Scutellaria baicalensis extract;

[0038] The specific method of decocting three times is as follows: the first time, the pH value is adjusted to 6.2-6.4 with 10wt% sodium hydroxide solution, and decocted for 75 minutes; the second time, the pH value is adjusted to 7.0-7.2 with 10wt% sodium hydroxide solution, and decocted for 150 minutes; the third time, the pH value is adjusted to 7.8-8.0 with 10wt% sodium hydroxide solution, and decocted for 230 minutes.

[0039] S3: Take 27g of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 40g of Scutellaria baicalensis extract, add 900g of water, and stir well; then add 0.1g of sweetener (the sweetener is obtained by mixing erythritol and Momordica grosvenori extract in a weight ratio of 0.7:1.3), stir well, refrigerate for 24h, adjust the pH value to 7.0, stir well, let stand, filter, fill, and sterilize.

[0040] Table 1 Weight ratio of Artemisia capillaris, Gardenia jasminoides and Flos lonicerae in Examples 1-5

[0041] example The weight ratio of Artemisia capillaris, Gardenia jasminoides, and Honeysuckle Example 1 80g:78g:40g Example 2 100g:72g:45g Example 3 120g:66g:50g Example 4 140g:60g:55g Example 5 160g:54g:60g

[0042] Examples 6-10

[0043] Examples 6-10 provide a Yinzhihuang oral liquid and a preparation method thereof, respectively.

[0044] The difference between the above embodiment and embodiment 3 is that in step S2, the specific method of decocting three times is different, as shown below.

[0045] In Example 6, 1 kg of Scutellaria baicalensis was taken and decocted three times with water, each time adding 10 times the weight of water; the decoctions were combined, filtered, and the filtrate was concentrated to a concentrate with a specific gravity of 1.15 / 60°C, ethanol was added to make the alcohol content reach 70%, refrigerated for 12 hours, filtered, and the filtrate was recovered and concentrated to a concentrate with a specific gravity of 1.17 / 60°C to obtain a Scutellaria baicalensis extract (without pH adjustment).

[0046] In Example 7, the specific method of decocting three times is as follows: the first time, the pH value is adjusted to 7.8-8.0 with 10wt% sodium hydroxide solution, and decocted for 75min; the second time, the pH value is adjusted to 7.0-7.2 with 10wt% sodium hydroxide solution, and decocted for 150min; the third time, the pH value is adjusted to 6.2-6.4 with 10wt% sodium hydroxide solution, and decocted for 230min.

[0047] In Example 8, the specific method of decocting three times is as follows: the first time, the pH value is adjusted to 6.0 with 10wt% sodium hydroxide solution, and decocted for 230min; the second time, the pH value is adjusted to 7.4 with 10wt% sodium hydroxide solution, and decocted for 90min; the third time, the pH value is adjusted to 7.6 with 10wt% sodium hydroxide solution, and decocted for 75min.

[0048] In Example 9, the specific method of decocting three times is as follows: the first time, the pH value is adjusted to 6.0-6.2 with 10wt% sodium hydroxide solution, and decocted for 60min; the second time, the pH value is adjusted to 6.8-7.0 with 10wt% sodium hydroxide solution, and decocted for 180min; the third time, the pH value is adjusted to 7.6-7.8 with 10wt% sodium hydroxide solution, and decocted for 200min.

[0049] In Example 10, the specific method of decocting three times is as follows: the first time, the pH value is adjusted to 6.4-6.6 with 10wt% sodium hydroxide solution, and decocted for 90min; the second time, the pH value is adjusted to 7.2-7.4 with 10wt% sodium hydroxide solution, and decocted for 120min; the third time, the pH value is adjusted to 8.0-8.2 with 10wt% sodium hydroxide solution, and decocted for 260min.

[0050] The other process parameters in the above embodiment are the same as those in Example 3.

[0051] Examples 11-12

[0052] Examples 11-12 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0053] The difference between the above embodiment and embodiment 3 is that in step S3, the dosages of the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and the Scutellaria baicalensis extract are different, as shown below.

[0054] In Example 11: 23g of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 45g of Scutellaria baicalensis extract.

[0055] In Example 12: 31g of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 35g of Scutellaria baicalensis extract.

[0056] The other process parameters in the above embodiment are the same as those in Example 1.

[0057] Examples 13-16

[0058] Examples 13-16 respectively provide a Yinzhihuang oral liquid and a preparation method thereof.

[0059] The difference between the above embodiment and embodiment 3 is that the types of sweeteners are different, as shown below.

[0060] In Example 13, the sweetener is obtained by mixing sucrose and monk fruit extract in a weight ratio of 0.7:1.3.

[0061] In Example 14, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 1.3:0.7.

[0062] In Example 15, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5:1.5.

[0063] In Example 16, the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.8:1.2.

[0064] The other process parameters in the above embodiment are the same as those in Example 3.

[0065] Comparative Example

[0066] Comparative Example 1

[0067] Comparative Example 1 provides a Yinzhihuang oral liquid and a preparation method thereof.

[0068] The preparation method of Yinzhihuang oral liquid in this comparative example is prepared by the method recorded in the Chinese Pharmacopoeia.

[0069] Comparative Example 2

[0070] Comparative Example 1 provides a Yinzhihuang oral liquid and a preparation method thereof.

[0071] The preparation method of Yinzhihuang oral liquid in this comparative example is specifically as follows:

[0072] S1: According to Table 1, mix Artemisia capillaris, Gardenia jasminoides, Honeysuckle, and Scutellaria baicalensis in a weight ratio of 120 g: 66 g: 50 g: 100 g, add water and boil three times, adding 10 times the weight of water each time, and boil each time for 150 min; combine the decoctions and filter to obtain a first filtrate;

[0073] The residue obtained by filtering the decoction was added with 10 times by weight of a 50 wt% ethanol aqueous solution, and the mixture was heated under reflux for extraction twice under sealed conditions. The alcohol extracts were combined and filtered to obtain a second filtrate;

[0074] The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of the concentrated solution of 1.17 / 60° C. to obtain an extract;

[0075] S2: Take 37g of the extract, add 900g of water, and stir well; then add 0.1g of sweetener (the sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.7:1.3), stir well, refrigerate for 24h, adjust the pH value to 7.0, stir well, let it stand, filter, fill, and sterilize.

[0076] Comparative Example 3

[0077] Comparative Example 3 provides a Yinzhihuang oral liquid and its preparation method

[0078] The difference between Comparative Example 3 and Example 3 is that the preparation method of the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract is different, as shown below.

[0079] In Comparative Example 3: The filter residue of the water decoction in the preparation method of the Artemisia capillaris-gardenia-honeysuckle extract was not subjected to alcohol extraction, specifically: Artemisia capillaris, gardenia, and honeysuckle were mixed, decocted with water 3 times, adding 10 times the weight of water each time, and decocting for 150 minutes each time; the water decoctions were combined, filtered to obtain a filtrate, and concentrated to a concentrate with a specific gravity of 1.17 / 60°C to obtain the Artemisia capillaris-gardenia-honeysuckle extract.

[0080] The other process parameters in Comparative Example 3 are the same as those in Example 3.

[0081] Performance testing

[0082] Stability Assessment Method: Samples of Yinzhihuang Oral Liquid were placed in a constant temperature and humidity chamber at 40±2°C and 75±5%. The clarity, baicalin, and geniposide content of the Yinzhihuang Oral Liquid were measured at 0, 3, and 6 months. The baicalin and geniposide content were determined using the method specified in the Chinese Pharmacopoeia. The test results are shown in Table 2.

[0083] Table 2 Performance test results of Yinzhihuang oral solution in Examples 1-17 and Comparative Examples 1-3

[0084]

[0085]

[0086] Combined with Table 2, by comparing the test results of the examples and the comparative examples, it can be seen that in Comparative Example 1, the method of the Chinese Pharmacopoeia was used to prepare Yinzhihuang oral liquid, and the amount of baicalin and geniposide active ingredients obtained in the oral liquid was small, and the stability was poor. In Comparative Example 2, Artemisia capillaris, Gardenia jasminoides, honeysuckle, and Scutellaria baicalensis were mixed together for extraction, and the stability of the prepared Yinzhihuang oral liquid was poor. In Comparative Example 3, the filter residue of the water decoction in the preparation method of the Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract was not subjected to alcohol extraction, and the stability of the prepared Yinzhihuang oral liquid was poor.

[0087] In contrast, in the process of preparing Yinzhihuang oral liquid, the present application uses Artemisia capillaris, Gardenia jasminoides, and honeysuckle to mix to prepare Artemisia capillaris-gardenia jasminoides-honeysuckle extract, and the filter residue of the Artemisia capillaris-gardenia jasminoides-honeysuckle decoction is subjected to alcohol extraction. At the same time, Scutellaria baicalensis is decocted separately to prepare Scutellaria baicalensis extract, and then the Artemisia capillaris-gardenia jasminoides-honeysuckle extract and Scutellaria baicalensis extract are mixed to prepare Yinzhihuang oral liquid. The prepared Yinzhihuang oral liquid can effectively maintain the clarity of the solution and stably ensure the stability of the baicalin and gardenoside content when placed at 40°C for 6 months, solving the problems existing in existing products and achieving unexpected results.

[0088] Although the present invention has been described in detail above using general descriptions and specific embodiments, it will be apparent to those skilled in the art that modifications and improvements may be made based on the present invention. Therefore, such modifications and improvements, which do not depart from the spirit of the present invention, are intended to be within the scope of protection claimed herein.

Claims

1. A method for preparing Yinzhihuang oral liquid, characterized in that: Specifically, the following steps are performed in sequence: S1: Mix Artemisia capillaris, Gardenia jasminoides, and honeysuckle in a weight ratio of 10-14:6-7.2:4.5-5.5, add water and decoct 3-4 times, adding 8-12 times the weight of water each time, and decoct each time for 120-180 minutes; combine the decoctions and filter to obtain a first filtrate; The residue obtained by filtering the decoction is added with 8-12 times by weight of a 40-60 wt% ethanol aqueous solution, and the mixture is heated under reflux for 2-3 times under sealed conditions. The alcohol extracts are combined and filtered to obtain a second filtrate; The first filtrate and the second filtrate are combined to obtain a mixed solution, and the mixed solution is concentrated to a specific gravity of 1.15-1.20 / 60° C. to obtain an Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract; S2: Take Scutellaria baicalensis, add water and boil three times, adding 8-12 times the weight of water each time; combine the decoctions, filter, concentrate the filtrate to a concentrated solution with a specific gravity of 1.10-1.20 / 60°C, add ethanol to make the alcohol content reach 60-80%, refrigerate for 8-16 hours, filter, recover the filtrate, and concentrate to a concentrated solution with a specific gravity of 1.15-1.20 / 60°C to obtain the Scutellaria baicalensis extract; the specific method of boiling three times is: the first time, adjust the pH value to 6.0-6.6 with 8-12wt% sodium hydroxide solution, and boil for 60-90 minutes; the second time, adjust the pH value to 6.8-7.4 with 8-12wt% sodium hydroxide solution, and boil for 120-180 minutes; the third time, adjust the pH value to 7.6-8.2 with 8-12wt% sodium hydroxide solution, and boil for 200-260 minutes S3: Take 23-31 parts by weight of Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract and 35-45 parts by weight of Scutellaria baicalensis extract, add 850-950 parts by weight of water, and stir evenly; then add 0.05-0.15 parts by weight of sweetener, stir evenly, refrigerate for 12-36 hours, adjust the pH value to 6.7-7.3, stir evenly, let stand, filter, encapsulate, and sterilize to obtain the sweetener; the sweetener is obtained by mixing erythritol and Momordica grosvenori extract in a weight ratio of 0.5-1.5:0.5-1.

5.

2. The method for preparing Yinzhihuang oral liquid according to claim 1, wherein In step S1, in the preparation method of the Artemisia capillaris-Gardenia jasminoides-Honeysuckle extract, the weight ratio of Artemisia capillaris, Gardenia jasminoides, and Honeysuckle is 11-13:6.4-6.8:4.8-5.

2.

3. The method for preparing Yinzhihuang oral liquid according to claim 1, wherein In step S1, the concentration of the ethanol aqueous solution is 45-55 wt %.

4. The method for preparing Yinzhihuang oral liquid according to claim 1, wherein In step S2, the specific method of decocting three times is: the first time, the pH value is adjusted to 6.2-6.4 with 8-12wt% sodium hydroxide solution, and the decocting is 70-80min; the second time, the pH value is adjusted to 7.0-7.2 with 8-12wt% sodium hydroxide solution, and the decocting is 140-160min; the third time, the pH value is adjusted to 7.8-8.0 with 8-12wt% sodium hydroxide solution, and the decocting is 220-240min.

5. The method for preparing Yinzhihuang oral liquid according to claim 1, wherein In step S3, the amount of the Artemisia capillaris-Gardenia jasminoides-Lonicera japonica extract is 25-29 parts by weight, and the amount of the Scutellaria baicalensis extract is 37-40 parts by weight.

6. The preparation method of Yinzhihuang oral liquid according to claim 1, characterized in that The sweetener is obtained by mixing erythritol and monk fruit extract in a weight ratio of 0.5-0.8:1.2-1.

5.

7. A Yinzhihuang oral liquid, characterized in that: The product is prepared by the preparation method of the Yinzhihuang oral liquid according to any one of claims 1 to 6.

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