14 results about "Anabolism" patented technology

The application discloses creatine composition for improving exercise endurance and strength, and a preparation method and application thereof. The creatine composition comprises creatine, black pepper extract and oyster peptide. The scheme has the effects of significantly enhancing energy systems, promoting anabolism, inhibiting catabolism, reducing oxidative damage and accelerating recovery through the combination of components, and can be effectively used for improving exercise endurance and strength.

This invention belongs to the field of biomedical technology, specifically involving the application of the MRPL41 gene / protein in the preparation of drugs for treating age-related sarcopenia. This invention is the first to demonstrate that MRPL41 is a key rate-limiting factor in the assembly of mitochondrial ribosomes in aging muscle satellite cells, establishing it as a core target for the treatment of age-related sarcopenia. Overexpression of MRPL41 can promote the assembly of mitochondrial 55S holoenzymes, improve the translation efficiency of mitochondrial-encoded proteins, repair mitochondrial dysfunction at its source, thereby promoting muscle repair, improving muscle atrophy, and achieving the treatment of age-related sarcopenia. This invention provides a precise microscopic target for the treatment of age-related sarcopenia, overcoming the limitations of existing clinical therapies (such as hormone replacement and simple nutritional supplementation) due to significant side effects and "anabolism resistance," providing a new direction for the development of innovative drugs specifically for the treatment of age-related sarcopenia, and has excellent application prospects.

Provided is a promoter, which has a nucleotide sequence shown in SEQ ID NO. 1. The promoter is obtained by means of rationally designing the promoter of a dapA gene, has obviously reduced transcriptional activity and can be used for the weakened expression of microorganism genes. Substituting the original promoters of the dapA gene, a ddh gene, an ilvA gene, a tdcB gene and a gltA gene in Corynebacterium glutamicum by using the promoter enables the expression levels of these genes to be significantly reduced, the carbon metabolic in a recombinant microorganism constructed thereby flows more to a threonine anabolism pathway, and the recombinant microorganism has a significantly improved production of threonine in comparison with an original strain and has good growth performance.

Disclosed in the present invention are a 4-sulfamoylphenylpropanamide compound and the use thereof. Provided in the present invention are a compound as represented by formula (I), an isotopically labeled substance thereof, a solvate thereof, a pharmaceutically acceptable salt thereof, a solvate of the pharmaceutically acceptable salt thereof, or a prodrug thereof. The compound can promote ALP expression in osteoblasts, exhibit a relatively good activity for promoting osteoblast differentiation, and has potential therapeutic effects in promoting bone anabolism and treating bone-related diseases.

The invention belongs to the technical field of biological medicines, and particularly relates to application of rubimaillin in preparation of a medicine for delaying intervertebral disc degeneration. Compared with the limitations of inexact conservative treatment effect and high surgical intervention risk in the prior art, the invention reveals for the first time that rubimaillin (MO) can effectively regulate and control a PI3K-AKT / NF-kappa B signal channel through targeted inhibition of EGFR phosphorylation, alleviates nucleus pulposus cell metabolic disorder caused by an inflammatory microenvironment from the source, significantly improves the expression of anabolism markers, and provides a new application for the treatment of the inflammatory microenvironment. The compound inhibits the release of catabolic enzymes and inflammatory factors, delays the processes of cell aging and apoptosis, and shows a clear effect of delaying the progress of IDD in animal and cellular levels. Compared with the traditional treatment, the traditional Chinese medicine composition has the advantages of good effect, low side effect and the like, so that a new way can be provided for preventing and treating the IDD.

The invention provides a tandem gene for biosynthesizing astaxanthin in rape seeds, an expression cassette and an expression method, and belongs to the technical field of gene engineering. The invention provides a tandem gene for biosynthesis of astaxanthin, and four carotenoid anabolism genes are firstly constructed into the tandem gene for a biosynthesis path of astaxanthin. The four carotenoid anabolism genes are driven based on the rape seed specific NAPIN promoter to construct an astaxanthin biosynthesis path in the rape seeds and synthesize the astaxanthin, so that the biosynthesis efficiency of the astaxanthin is improved; the expression of the astaxanthin biosynthetic gene and the accumulation of the astaxanthin in the seeds do not influence the growth, development and reproduction of the rape; in addition, fat-soluble carotenoid and astaxanthin are naturally integrated with grease in the rape seeds, and astaxanthin rapeseed oil is directly used as a product, so that the activity of astaxanthin is maintained, and the later astaxanthin extraction production cost can be reduced.

The invention discloses a long-acting parathyroid hormone receptor stimulant fusion protein and application thereof. The fusion protein can inhibit the activity of RANKL and promote PTHR-mediated bone anabolism, and comprises a first arm and a second arm, the first arm comprises a functional region targeting RANKL and an Fc region, and the second arm comprises a functional region capable of activating PTHR and an Fc region. The long-acting parathyroid hormone receptor stimulant fusion protein has the advantages of better drug effect, more lasting effect, better safety, higher structural stability, higher expression quantity and the like, and the comprehensive performance of the long-acting parathyroid hormone receptor stimulant fusion protein is superior to that of the existing or potential treatment means such as teriparatide, PEG-PTH, anti-RANKL monoclonal antibody, romomonoclonal antibody or a control sample synPTH-alpha RANKL-1.

The invention discloses a 4-sulfamoyl phenylpropanamide compound and an application of the 4-sulfamoyl phenylpropanamide compound. The invention provides a compound as shown in a formula (I), an isotope label thereof, a solvate thereof, a pharmaceutically acceptable salt thereof, a solvate of the pharmaceutically acceptable salt thereof or a prodrug thereof. The compound can promote ALP expression of osteoblasts, has good promotion activity on differentiation of osteoblasts, and has potential treatment effects in the aspects of promotion of bone anabolism and treatment of bone related diseases.

The invention discloses application of a SiMC1 gene in regulation and control of anabolism of millet carotenoid, and belongs to the technical field of genetic engineering breeding. According to the invention, the SiMC1 gene for regulating and controlling metabolism of carotenoid in millet is screened, and the nucleotide sequence of the SiMC1 gene is shown as SEQ ID NO. 1. Experimental results show that compared with a wild plant (WT), the millet yellowness and the carotenoid content of the SiMC1 gene knockout strain (KO) are remarkably increased, the SiMC1 gene negatively regulates synthesis of millet carotenoid, and the SiMC1 gene is a potential efficient millet breeding gene and can be used for improving the appearance character and the eating quality of millet. Gene modification targets and theoretical basis are provided for screening and cultivating high-quality millet varieties, and new millet germplasm which has both appearance and taste and is rich in natural antioxidant nutritional ingredients is expected to be obtained.

The polypeptide feed is prepared from the following raw materials in percentage by mass: 35%-40% of a plant crude extract, 35%-45% of a protein source, 5%-8% of microbial flora and 15%-20% of a fermentation auxiliary material, wherein the plant extract is prepared from the following raw materials in percentage by mass: 50% of an astragalus membranaceus crude extract, 30% of a codonopsis pilosula crude extract and 20% of an angelica sinensis crude extract. The feed contains various plant and animal-derived amino acids, can supplement various nutrients in animal bodies, maintain amino acid balance, and is beneficial to enhancing protein fat absorption, promoting muscle and fat growth and improving meat quality and flavor, and meanwhile, the rich peptide contains various beneficial bacteria and free fatty acids, so that vasoactive intestinal peptide causes vasodilatation of mesentery, and the meat quality and flavor are improved. Protease and digestive enzymes are secreted in quantity, intestinal tract movement is enhanced, digestive absorption and anabolism of the body are enhanced, and therefore growth of the body is promoted.

The invention relates to the technical field of aquatic product quality safety, in particular to a saxitoxin risk formation chain characterization monitoring system, which comprises a data acquisition module, a data processing module, a data processing module and a display module, the risk chain association module is used for constructing a multi-factor toxin association mechanism model, analyzing and quantifying influence weights of environmental factors through a causal inference algorithm and a random forest weight, and identifying key regulation points and threshold values of toxin synthesis; the risk chain mechanism analysis module carries out deduction through a digital twin simulation platform and a dynamic Bayesian network, simulates the dynamic change of a toxin anabolism pathway under different environment scenes, and obtains a risk formation chain and a risk change rule thereof; and the risk monitoring and intervention module constructs a global risk prediction model to obtain a risk level, obtains an emergency scheme from the emergency decision library according to the risk level and the toxin type, and performs intervention according to the emergency scheme. Therefore, the problems of monitoring lag, unknown causality, low intervention efficiency and the like are solved.

The present invention relates to a pharmaceutical composition for preventing or treating muscle diseases, comprising an extract of Brassica juncea as an active ingredient. Inhibitory activity against myotube cell atrophy, a muscle anabolic factor expression promoting activity, and an effect of recovering from dexamethasone-induced enhancement of muscle cell catabolism and inhibition of anabolism of the Brassica juncea extract have been analyzed, and the effects of the Brassica juncea extract on recovery of reduced muscle tissue size, weight and muscle fiber size, biostability, a serum LDH level recovery effect, and an effect of reducing CK and creatinine levels in animal models have been analyzed, and thus it has been identified that the Brassica juncea extract can be used for preventing or treating sarcopenia or muscle atrophy.

The invention relates to an application of an indoleamine 2, 3-dioxygenase 1 inhibitor in preparation of a medicine for treating cancer cachexia. The indoleamine 2, 3-dioxygenase 1 is determined as a core therapeutic target of cancer cachexia for the first time, and it is proved that palmatine hydrochloride shows an exact therapeutic effect in cell and animal models through a multi-channel synergistic mechanism of metabolic reprogramming, protein degradation inhibition, anabolism signal recovery and muscle regeneration promotion. And sufficient experimental basis and theoretical support are provided for clinical transformation.

The invention relates to the technical field of fertilizers, in particular to a method for preparing a functional microbial organic fertilizer preparation from Chinese herbal medicines. According to the invention, the gynostemma pentaphylla dregs, the lindera aggregata dregs and the buckwheat straws are adaptively selected as complementary stacking materials and are stacked by a layered alternating method before the first turning; meanwhile, trichoderma harzianum, bacillus subtilis and streptomyces microflavus are constructed to serve as a composite flora, the flora is added step by step to prepare a microbial fermentation material with the high nutrient content, and the microbial fermentation material is used for preparing an organic fertilizer preparation finished product and has a positive effect on growth and quality improvement of crops. In addition, the marigold extract, the artemisia annua extract and the origanum vulgare extract are also added to construct a multi-aspect nematode-resistant system with the functions of repelling, protecting, blocking anabolism and damaging the integrity of a membrane, so that the prepared microbial organic fertilizer preparation can effectively have an excellent nematode-resistant effect.