325 results about "Nutritional Supplementation" patented technology

The invention discloses a sheep flock accurate nutrition supply method based on an intelligent feeding algorithm, and the method comprises the following steps: collecting the body type, physiology, movement and environment data of sheep through a multi-modal sensing device, and constructing individual three-dimensional representation based on a neural radiation field model, historical growth data and a real-time health state are analyzed by utilizing an individual nutritional requirement calculation model, an optimal feed distribution strategy is determined by combining an intelligent sheep flock optimization algorithm, a feeding scheme is dynamically adjusted by adopting deep reinforcement learning, and through a cloud-side collaborative calculation architecture, the calculation efficiency is improved and a feeding decision is optimized. A non-intrusive health monitoring technology is combined, a group health evaluation model is constructed, the feed ratio is adjusted in real time, accurate matching of individual and group nutritional requirements is achieved, and through prediction of the individual and group nutritional requirements, self-adaptive adjustment is conducted on feeding parameters, and a dynamic nutrition supply strategy is optimized. The system effectively improves the feeding precision, reduces the feed waste, and optimizes the health management of the sheep flock.

Composition containing Nicotinamide and vitamin B6 are provided. The composition may be an oral nutritional composition, for example a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purpose (FSMP). The composition can be administered to an individual in need thereof for treating muscle injury, and / or promoting muscle repair, improving skeletal muscle regeneration, maintaining or increasing skeletal muscle function and / or skeletal muscle mass in an individual with muscle injury.

Provided are compositions comprising compounds or precursors to compounds which may be used for a variety of therapeutic applications including, for example, treating and / or preventing a disease or disorder related to reduced or inadequate mitochondrial activity, including aging or stress, diabetes, obesity, and neurodegenerative diseases. The compounds relate generally to urolithins and precursors thereof, including but not limited to ellagitannins and urolithin A. In certain embodiments the compositions are presented in or as food products or nutritional supplements. These same compounds and compositions can also be used advantageously in generally healthy individuals to increase or maintain metabolic rate, decrease percent body fat, increase or maintain muscle mass, manage body weight, improve or maintain mental performance (including memory), improve or maintain muscle performance, improve or maintain mood, and manage stress.

The invention belongs to the technical field of probiotics, and particularly relates to lactobacillus reuteri ShuiMian with a sleep aiding effect and application of the lactobacillus reuteri ShuiMian. A new ShuiMian strain is separated from feces of a healthy infant in Guangzhou city, Guangdong province, PTZ is adopted to construct a zebra fish insomnia model, and research finds that the strain can inhibit eye movement frequency, inhibit brain discharge, reduce dopamine secretion, promote GABA secretion and promote Gabra gene expression, and the zebra fish insomnia model can be used for treating insomnia. The effect of promoting sleep is achieved. Therefore, the strain has a unique sleep-promoting mechanism, can assist in developing novel sleep-promoting medicines in the field of medicines, and provides a safer and more effective treatment scheme for insomnia patients. In the health care industry, a nutritional supplement can be prepared, the mass sleep quality is improved, and the development of sleep health related industries is promoted.

The invention relates to an application of bifidobacterium breve i1088 or a postbiotic thereof in improvement of cognition. The bifidobacterium breve i1088 or the afterbiogen of the bifidobacterium breve i1088 is used for preparing a product for enhancing the oxidative stress capacity of mammalian cells, improving the in-vitro free radical scavenging level of mammals and changing at least one of the expression levels of mammalian cells Nrf2 and anti-oxidation related genes. The invention aims to explore the potential of the bifidobacterium breve in the aspect of improving the Alzheimer's disease and provide a safer and more effective nutritional supplement scheme for middle-aged and elderly people.

The invention belongs to the technical field of nano-enzymes, and particularly relates to a CuPH (at) KMO composite nano-enzyme material as well as a preparation method and application thereof. Aiming at the problems of poor catalytic activity, complex steps, high raw material cost and low biocompatibility of nano-enzyme prepared by the existing method, the preparation method comprises the following steps: by taking terephthalic acid and histidine as dual-coordination copper-based nano-enzyme as a precursor, introducing manganese oxide in situ under a hydrothermal condition; and the flower-like nano mimic enzyme which is uniform in size and has high laccase-like catalytic characteristics at the same time is synthesized. The composite nano-enzyme provided by the invention can catalytically oxidize phenol amine organic compounds under the condition that the pH value is 3-9, can realize the detection of the content of ergothioneine in cosmetics and nutritional supplement capsules, and can be applied to the field of cosmetic and food safety monitoring.

Solid lipid nanoparticles (SLNs) for delivery of bioactive compounds are disclosed. The SLNs comprise a lipid matrix and surfactant layer encapsulating at least one bioactive compound selected from vitamins, minerals, enzymes, algae-derived bioactives, proteins, peptides, amino acids, antioxidants, small synthetic molecules, plant-derived volatile compounds, or botanical extracts. The SLNs exhibit submicron particle size, low polydispersity, and sufficient surface charge to ensure colloidal stability and efficient delivery. In one embodiment, algae-based bioactives, such as phycocyanin or fucoxanthin, are encapsulated using only natural and sustainable lipids and surfactants to improve bioavailability and support environmentally friendly formulations. The SLNs may be formulated for oral, topical, transdermal, injectable, ophthalmic, mucosal, textile, veterinary, or agricultural administration. Applications include human and animal health, functional foods, skincare, nutrient supplementation, and crop treatment. The disclosed SLNs offer a biocompatible and scalable delivery system that protects sensitive compounds, enables sustained release, and enhances absorption across diverse industries.

The invention relates to the technical field of biomedicine, in particular to application of gastrodin in prevention and treatment of Alzheimer's disease. The invention provides application of gastrodin in prevention and treatment of the Alzheimer's disease, and provides a new way for preventing and treating the Alzheimer's disease. And gastrodin is from gastrodia elata, is used as a mild medicinal and edible raw material component, and has no toxic or side effect on the body. Gastrodin is adopted as a raw material, and a series of experimental studies prove that gastrodin has an inhibitory effect on GSK-3beta / P38MAPK, and can obviously improve various pathological changes of the Alzheimer's disease caused by APOE4. The invention verifies the effect of gastrodin on the Alzheimer's disease high-risk factor APOE4, and provides a brand-new technical scheme and theoretical basis for developing medicines, health-care foods or nutritional supplements which take gastrodin as a core component and are used for preventing or treating Alzheimer's disease.

The invention discloses application of animal bifidobacterium subsp. Lactis GOLDGUT-BB21 in preparation of products for relieving depression, and belongs to the technical field of biological medicine. The probiotics disclosed by the invention can be used for relieving depressive symptoms, improving related symptoms, assisting in treating depression and preventing depression, and also can be used as a nutritional supplement to help maintain the balance of intestinal microflora and promote intestinal health.

The invention belongs to the technical field of environmental engineering, and discloses a microbial agent for degrading malathion as well as a preparation method and application of the microbial agent. The microbial agent comprises the following raw materials: compound bacteria, a nutritional supplement and a biomass carrier material, wherein the compound bacteria comprise functional bacteria and synergistic bacteria, and the mass ratio of the functional bacteria to the synergistic bacteria is (1.2-1.8): 1; the functional bacteria comprise issatchenkia orientalis, nocardia, brevibacillus laterosporus and bacillus cereus; the synergistic bacteria comprise azospirillum brasilense, bacillus thuringiensis and lactobacillus buchneri. Functional bacteria with direct degradation capacity and synergistic bacteria with auxiliary functions are creatively compounded according to a specific proportion, meanwhile, the garlic straw powder is selected as a biomass carrier material, all the raw materials complement each other in function and have a synergistic effect, the degradation rate and thoroughness of malathion are remarkably improved, and the degradation efficiency of malathion is greatly improved. The defects of low degradation efficiency and poor environmental adaptability of a single strain are overcome.

The invention relates to the field of vinegar wine production, and discloses a vinegar wine formula with beauty maintaining and young keeping functions and a preparation method thereof.The preparation method comprises the following steps that S1, raw material pretreatment is conducted, specifically, finished rice wine fermented for one month is filtered through a filter screen to remove rice wine residues; s2, secondary fermentation: adding lactobacillus plantarum into the finished product rice wine for secondary fermentation; s3, tertiary fermentation: taking out the liquid after the secondary fermentation, and adding lactobacillus acidophilus for tertiary fermentation; and S4, post-treatment: disinfecting a filling container, and filling the finished product vinegar wine into the filling container by using a filling machine for storage. According to the present invention, the rice wine, the lactobacillus plantarum and the lactobacillus acidophilus are scientifically proportioned, and the double-bacterium step-by-step fermentation process is adopted, such that the synergistic output of a variety of active substances is achieved; lactic acid and gamma-aminobutyric acid (GABA) are enriched through secondary anaerobic fermentation, lactobacillus acidophilus is induced to generate exopolysaccharides through third-time micro-aerobic fermentation, and the effects of the product in the aspects of nutritional supplement, beauty maintaining and young keeping are remarkably enhanced.

The invention relates to the technical field of pomacea canaliculata trapping, killing and preventing, in particular to an efficient pomacea canaliculata trapping and killing method which comprises the following steps: pre-treating drug particles, specifically preparing drug particles for storing trapping and killing drugs, thickening duckweed dry powder, specifically, coating the drug particles with a duckweed dry powder coating with the thickness of 1mm to obtain inner sphere particles, the mikania micrantha ethanol dry powder thickening treatment means that the mikania micrantha ethanol dry powder tightly and uniformly covers the surface of the duckweed dry powder coating by adopting a spraying process on the outer layer of the inner sphere particles. According to the method, the pomacea canaliculata is actively induced to gather and feed by utilizing the rape straw pith core, and aquatic / terrestrial plant wastes are converted into a biological carrier with gradient inducing-poisoning functions; natural toxic components of mikania micrantha are used for replacing traditional chemical pesticides; the straw pith core is used as a universal skeleton, the duckweed dry powder plays the functions of ecological attraction and nutrition supplement, the mikania micrantha ethanol dry powder provides efficient poisoning ability, and the method is especially suitable for green prevention and control of ampullaria gigas in rice cropping areas of the Yangtze River basin.

The invention provides an ascorbic acid-S-glutathione conjugate, a derivative, a preparation method and application of the ascorbic acid-S-glutathione conjugate. The conjugate is obtained by activating ascorbic acid-6-hydroxyl by halogenation or sulfo group and then connecting the activated ascorbic acid-6-hydroxyl with sulfydryl of glutathione through thioether. The invention also discloses derivatives such as salts, esters, N-acylates, N-alkylates and the like of the compound. The stability of the series of compounds is greatly improved compared with that of vitamin C, and the whitening effect is obviously better than that of vitamin C and glutathione monomers. The invention also discloses a preparation method of the series of compounds and application of the series of compounds as antioxidants, whitening agents, nutritional supplements and the like in cosmetics, foods, feeds and medicines.

The invention discloses a method for imitating wild cultivation of dictyophora rubrovolvata by using a withered bamboo resource. The method comprises the following steps: digging a groove downwards in a soil layer in a gap of a square bamboo forest; stacking a water collecting layer at the bottom of the groove; a lower filling layer composed of broken bamboo residues is laid on the water collecting layer; a middle filling layer formed by uniformly mixing broken bamboo residues and humus soil is laid on the lower filling layer; a culture groove is erected on the middle filling layer in the length direction of the groove and used for cultivating dictyophora rubrovolvata; paving a layer of culture material prepared in advance in the culture tank, punching a plurality of holes in the periphery of a dictyophora rubrovolvata fungus stick, clamping the dictyophora rubrovolvata fungus stick in the middle of the culture material, and uniformly scattering the fungus material in the dictyophora rubrovolvata fungus stick on the surface of the culture material; covering the middle filling layer and the culture material with an upper filling layer formed by sandy loam; and a covering layer covers the surface of the upper filling layer. The method has the advantages of high resource utilization rate, obvious economic benefit and obvious ecological benefit, can realize long-acting moisturizing and nutritional supplement, and can produce mushrooms for many years.

The invention discloses a preparation method and application of oyster peptide for improving human fertility quality. Fresh oysters are used as raw materials, protease hydrolysis is utilized to release small molecule peptides, and then separation, purification and activity research are performed to explore the good utilization value of the oysters in the aspect of improving the reproductive function; the invention aims at innovating an oyster peptide extraction method to obtain the oyster peptide with high biological activity and high absorptivity, and discloses and introduces the application of the oyster peptide in the aspect of high human fertility quality. Meanwhile, the oyster peptide has the effects of improving the reproductive function, supplementing nutrition, mineral substances, protein, vitamins and the like, can be added into food, health care products, medicines and the like, and is a multifunctional biological peptide.

According to the atherosclerotic plaque reversal strategy recommendation method based on AI evaluation, comprehensive analysis of multi-modal data is realized through an AI large model algorithm, and a personalized intervention scheme based on dynamic risk grading is provided for doctors, so that acute cardiovascular events are reduced, and long-term prognosis of patients is improved. A set of intelligent risk grading system is constructed by using a large model algorithm and multi-modal data, and drug and nutritional supplement recommendation is performed through a large model, so that atherosclerotic plaque reversal of a patient is realized. Clinical artery image data of a patient can be processed, and risk assessment and grading are performed through the trained AI model to generate a personalized intervention scheme. Compared with a system based on rules, the AI algorithm has higher flexibility and robustness through large-scale data training, can dynamically predict the risk level of the patient according to the multi-dimensional features of the patient and provide an accurate intervention scheme, and meets the requirements of different patients.

The invention provides a composition. The composition consists of spirulina, astaxanthin, vitamin C and health food or food acceptable auxiliary materials. The composition has the advantages that the composition has a synergistic effect, and can effectively relieve cognitive impairment of a tested object and improve learning and memory functions, so that the composition can be used for preventing or adjunctively treating the Alzheimer's disease and can also be used for precise nutritional supplement of specific people. In addition, the multi-component compound form of the product can obviously improve the taking compliance of users, and the total use cost is saved.

The invention provides a pet hair decomposer with synergistic effect of bacillus subtilis and keratinase, the pet hair decomposer comprises bacillus subtilis ZYpet-015 and keratinase, the preservation number of the bacillus subtilis ZYpet-015 is CGMCC (China General Microbiological Culture Collection Center) No.34790, and the preservation date is June 6, 2025; the protease activity of the bacillus subtilis is greater than or equal to 129.92 U, the survival rate of the bacillus subtilis in simulated gastric juice within 3 hours is greater than 50%, and the tolerance rate of the bacillus subtilis in intestinal juice within 4 hours is greater than 90%. According to the pet hair decomposing agent, hair keratin is synergistically degraded through protease secreted by the bacillus subtilis ZYpet-015 and keratinase, and the hair decomposing efficiency reaches 28.07% + / -2.79% and is remarkably higher than that of a single treatment group. Meanwhile, experiments prove that the pet hair decomposer can effectively destroy the hair cuticle structure, is suitable for a pet hair-melting nutritional supplement and can relieve the hair ball symptom.

The invention provides a composition for promoting differentiation of intestinal immune cells as well as a preparation method and application of the composition. According to the composition, 1, 3-dioleic acid-2-palmitic acid triglyceride and breast milk oligosaccharide are used in a combined manner, so that monocytes can be effectively promoted to differentiate into intestinal macrophages, and inflammation is reduced to a certain extent. After the monocytes are differentiated into the intestinal macrophages, the intestinal immune homeostasis and intestinal microbiota inflammatory response can be regulated, so that the mucosal immune homeostasis and intestinal epithelial cell barrier function are maintained. Therefore, the composition provided by the invention can improve the intestinal immune barrier by promoting the monocytes to differentiate into the intestinal macrophages, and provides a new thought for improving the early intestinal barrier of infants through nutritional supplement.

A method of improving flavor of a combination of a composition for increasing circulating ketone levels is disclosed. A composition containing (D)-β-hydroxybutyric acid (D-BHB), (D)-β-hydroxyvaleric acid (D-BHV), and (D)-1,3 butanediol (D-1,3BD) is disclosed. Exemplary compositions may be incorporated into food, supplement, and beverage products.

The present invention relates to a process for the preparation of nicotinamide furan riboside salts, in particular pharmaceutically acceptable nicotinamide furan riboside salts. The invention also relates to nicotinamide furan riboside salts themselves, in particular carboxylic acid salts in crystalline form, and their use in nutritional supplements and pharmaceutical compositions.

The invention relates to the technical field of nutrition management, in particular to a newborn nutrition management method and system based on data analysis, and the method comprises the following steps: collecting newborn heartbeat, respiratory rate and body temperature physiological data, uploading the data to a central processing unit, checking the data with newborn age and historical growth data, correcting the change of physiological indexes, and obtaining a newborn nutrition management result. Preliminary physiological index data are obtained. According to the method, the preliminary physiological index data is deeply analyzed through time sequence analysis, the physiological change trend and nutritional requirements of newborns are accurately grasped, potential nutritional requirement modes can be recognized in real time and compared with existing nutritional plans, key nutritional insufficiency areas are quickly recognized, and the accuracy of the nutritional requirements of the newborns is improved. According to the method, a more personalized nutrition supplement scheme is provided for the newborns, the adaptability and effectiveness of the nutrition scheme are improved, the actual effect of the nutrition adjustment scheme can be effectively detected by monitoring and analyzing the adjusted physiological data difference, and it is ensured that the newborns obtain the optimal nutrition support in the key growth period.

The invention discloses application of a combination of probiotics GOLDGUT-M520 and GOLDGUT-LR99 in preparation of a product for relieving depression, and belongs to the technical field of biological medicines. The probiotics disclosed by the invention can be used for relieving depressive symptoms, improving related symptoms, assisting in treating depression and preventing depression, and also can be used as a nutritional supplement to help maintain the balance of intestinal microflora and promote intestinal health.

The utility model relates to the technical field of pet food processing, in particular to a freeze-drying pet nutritional supplement cold press forming machine device which comprises a cold press forming machine body, a first conveying belt is arranged at the output end of the cold press forming machine body, and a collector is fixedly connected to the side, close to the bottom of the first conveying belt, of the cold press forming machine body. And one side of the top of the collector is fixedly connected with a scraping plate. Compared with the prior art, the freeze-dried powder collecting device has the advantages that when the first conveying belt conveys freeze-dried powder to the tail end, most of the freeze-dried powder directly falls into the collector, part of the freeze-dried powder adhered to the first conveying belt is scraped by the scraping plate to enter the collector, and the freeze-dried powder entering the collecting tank at the top of the collector is shunted to enter the two discharging grooves; the two discharging grooves can evenly distribute the freeze-dried powder on the second conveying belt, the distance between the top face of the second conveying belt and the bottom face of the collector is two centimeters, and the probability that the freeze-dried powder splashes outwards can be reduced due to the small distance between the top face of the second conveying belt and the bottom face of the collector.

Some aspects of the disclosure relate to compositions comprising fermentates of bacterial strains capable of reducing volatile sulfur compounds (VSCs) in an environment, nutritional supplements, dental supplements, and food products containing such fermentates, and methods of use thereof.

Some aspects of the disclosure relate to compositions comprising fermentates of bacterial strains capable of reducing volatile sulfur compounds (VSCs) in an environment, nutritional supplements, dental supplements, and food products containing such fermentates, and methods of use thereof.

The invention relates to an application of a bioactive peptide YPFPGPIH derived from bovine casein in the aspect of anti-inflammation or immunoregulation. The peptide can be combined with TLR2 and TLR4 to inhibit the activation of NF-kappa B and MAPK signal channels, so that the levels of inflammatory factors such as IL-1beta, TNF-alpha and NO are remarkably reduced, the expression of IL-10 is up-regulated, and inflammation balance regulation is realized; the body inflammatory response is improved, and the immune organ injury is recovered. The peptide can be used for preparing anti-inflammatory drugs, immunomodulatory functional foods and nutritional supplements, and has good safety and application prospects.

The invention discloses a composition for resisting altitude stress and improving hypoxia tolerance, and belongs to the field of nutritional health-care food and functional compositions. The composition comprises the following components in parts by mass: 20-60 parts of beet root powder, 10-50 parts of cordyceps militaris powder, 5-40 parts of astragalus membranaceus powder, 0.5-5 parts of ginseng powder and 1-10 parts of Chinese wolfberry fruit powder. The composition can be prepared into foodstuffs such as soft sweets, tablets, powder, drinks, capsules and the like or other nutritional supplement forms, so that the problems of single effect, indefinite action mechanism and poor compliance of the existing product are solved, and multi-target regulation of hematopoiesis enhancement, energy metabolism improvement, oxidative stress inhibition and circulation improvement is realized.

This patent discloses a dual targeting lipid-based formulation designed for precise drug delivery to the thyroid gland, addressing the complexities of thyroid disorders. The formulation integrates two key technologies: the RGDFK Targeting Motif and Iodine Coupling. The RGDFK motif enhances specific binding to αvβ3 integrin receptors, facilitating internalization of therapeutic agents. Simultaneously, the Iodine Coupling technology leverages the thyroid gland's natural affinity for iodine, ensuring increased accumulation of lipid-based vesicles in thyroid tissue. Applications of this formulation extend to targeted treatment of diverse thyroid disorders, symptom-specific relief, and nutritional supplementation. The formulation serves as a fundamental component in pharmaceutical compositions, adaptable for various administration routes. The manufacturing process emphasizes scalability, reproducibility, and standardized quality. A comprehensive treatment kit has been devised, offering a convenient and tailored approach to thyroid drug delivery. In conclusion, this dual targeting lipid-based formulation signifies a paradigm shift in thyroid disorder therapeutics, promising precision, efficacy, and patient-centric care. As it advances towards clinical applications, it holds the potential to redefine the landscape of thyroid health management for enhanced patient outcomes.