184 results about "Glucosamine Sulfate" patented technology

The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid, said method comprising orally administering to a mammalian species a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof. Additionally, compositions containing hyaluronic acid; chondroitin sulfate, and glucosamine sulfate in a paste formulation are also disclosed which can be administered on their own or can be used as a feed additive.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

A topical skin rejuvenation preparation to relieve wrinkles, increase the skin's natural production of hyaluronic acid, reverse the lack of suppleness, hydrate from within, erase spider veins, reduce varicose veins, lighten aging dark blotches (“liver spots” / Lentigos, Senile Lentigines), decrease acne, and reduce under eye puffiness includes Glucosamine (2-amino-2-deoxy-alpha-D-glucose), a hexosamine (6 carbon amino sugar), including its derivative and precursor compounds: Glucosamine Sulfate, Glucosamine Hydrochloride, Glucose-6-Phosphate, Acetyl Glucosamine, Fructose-6-phosphate, Glucosamine-6-Phosphate, to increase production of Hyaluronic acid and collagen from Glucosamine Sulfate, its precursors and derivatives and to increase skin muscle tone by Dimethylaminoethanol (DMAE) while over coming deficiency it creates in each cell's production of PhosphatidylCholine, whose deficiency damages cell membranes, as well as mitochondrial and lysosome membranes.

The present invention relates to compositions of and methods for producing timed or retarded release formulations that contain glucosamine sulfate, beta-(1,4)-2-amino-2-deoxy-D-glucose, and chondroitin, (C14H19NO14SNa2)n; N-acetylchondrosanine (2-acetamide-2-deoxi-D-galactopiranose) and D-gluoronic acid copolymer and / or their dietary and nutraceutically acceptable salts of the same and / or hydrates of the active substance that provide a timed release formulation of the active substance.

This invention is directed to a dietary regimen and a unique combination of nutritional supplements and a method. More specifically, this invention is directed to a unique combination of nutritional supplements which provides symptomatic relief from arthritis. The unique combination of nutritional supplements of this invention is believed to function by both increasing the available (effective blood level) of anti-inflammatory agents and promotion of the healing / regenerative process in the effected joints, thus, producing unexpected and lasting symptomatic relief from the debilitating effects of both osteoarthritis and rheumatoid arthritis. The essential nutritional supplements of the dietary regimen of this invention are as follows: (a) gamma linolenic acid (unrefined), hereinafter "GLA"(b) a mixture of eicosapentaenoic acid and docosahexaneoic acid, hereinafter collectively "EPA"(c) a mixture of chondroitin sulfate, N-acetyl glucosamine sulfate, glucosamine sulfate and manganese aspartate, hereinafter collectively "CHONDROX"The regimen is adjusted based upon the weight of the individual, and once symptomatic relief is achieved, the individual remains essentially free from the debilitating effects of arthritis so as long the daily regimen is faithfully followed.

Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the following: an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles; an effective amount of a cooling component; an effective amount of a heat minimizing or blocking component; an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves; and an effective amount of a soothing and anti-inflammatory complex for the joints and / or muscles comprising Glucosamine sulfate or HCl, Zingiber officiniale (Ginger Root) extract, Methyl sulfonylmethane (MSM), Polygonum cuspidatum (Mexican Bamboo) extract, Aloe barbadensis leaf, and Salix alba (white willow) bark extract. Additionally, the composition includes an encapsulation or entrapment system for a timed release delivery.

Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biochemicals from the activated mast cells, the compositions containg one or more of a flavone or flavonoid glycoside a heavily sulfated, non-bovine proteoglycan, an unrefined olive kernel extract that increases absorption of these compositions in various routes of administration, a hexosamine sulfate such as D-glucosamine sulfate, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, a long-chain unsaturated fatty acid, a phospholipid, Krill oil, a polyamine, glutiramer acetate and interferon. Certain of the present compositions are useful in protecting against the neuropathological components of multiple sclerosis and similar inflammatory neurological diseases.

Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the following: an effective amount of an inflammation control component which is designed to reduce immediate pain and discourage future pain in the joints and muscles; an effective amount of a cooling component; an effective amount of a heat minimizing or blocking component; an effective amount of a circulation increasing component which effectuates better penetration of the actives to the skin and nerves; and an effective amount of a soothing and anti-inflammatory complex for the joints and / or muscles comprising Glucosamine sulfate or HCl, Zingiber officiniale (Ginger Root) extract, Methyl sulfonylmethane (MSM), Polygonum cuspidatum (Mexican Bamboo) extract, Aloe barbadensis leaf, and Salix alba (white willow) bark extract. Additionally, the composition includes an encapsulation or entrapment system for a timed release delivery.

The invention discloses a preparation method of glucosamine sulfate, relating to a compound containing aminosugar. The preparation method of glucosamine sulfate has the advantages that a great deal of sulfate precipitation by-product is avoided being generated and a great deal of organic solvent is avoided being used, the operation is in complete aqueous phase, the production processes are safe, the sulfuric acid removed by the membrane method can be recovered and used, the production cost is reduced, exhaust and waste residue are not produced, the prepared product does not contain sodium, potassium or chlorine, the purity of the product reaches over 95 percent, and the glucosamine sulfate can be used to treat osteoarthritis without usage taboo. The preparation method is characterized in that chitin is adopted as the raw material, and a degradation agent of concentrated sulfuric acid is used to cause the chitin to generate degradation reaction; diluted sulfuric acid is used as a deacetylation agent to cause the degraded chitin to generate deacetylation reaction; the chitin which is not reacted after the deacetylation reaction is filtered, and the unreacted sulfuric acid is removed by the membrane method; and the solution, in which the unreacted sulfuric acid is removed, is decolorized, concentrated and dried, and glucosamine sulfate is obtained.

In one embodiment, a composition containing ergothioneine and / or synthesized l-ergothioneine and one or more compounds selected from the group consisting of vitamin B-12, glucosamine sulfate, calcium ascorbate, turmeric extract, black pepper extract, hyaluronic acid, collagen, glycosaminoglycans, cat's claw extract, acai berry; and white willow bark extract is provided to a mammal to improve a variety of health related factors, including but not limited to brain health, joint health, eye health, mitondchorial optimization / improvement and reduction of inflammation and pain in a mammal.

A dietary supplement for benefitting human bone health includes a calcium source, a source of vitamin D activity, and an osteoblast stimulant. A preferred calcium source is microcrystalline hydroxyapatite, which also contains protein (mostly collagen), phosphorus, fat, and other minerals. A preferred source of vitamin D activity is cholecalciferol, and a preferred osteoblast stimulant is ipriflavone. In addition to these basic ingredients, the composition can further include various other minerals known to occur in bone, vitamin C, and glucosamine sulfate, all of which exert beneficial effects on growth and maintenance of healthy bone. A method for benefitting human bone health involves administering a daily regimen of the dietary supplement.

A fertility-enhancing supplement contains a balance of compositions and ingredients that will enhance the reproduction system in the female and male to help support conception, while also supporting the anti-aging of the reproductive system, taken in balance to aid in the uptake by the body of certain and particular compositions that are included in this invention. The supplement can include ingredients to assist the female reproductive system to conceive and in the male to aid in the production of more healthy sperm. Such ingredients as glucosamine sulfate are included separately or in conjunction to help the female reproductive system to maintain a youthfulness in the female and are important to the maintaining of the vitality of eggs and reducing the aging process in the development of fertilized eggs, embryos and facilitating the implantation of embryos. The supplement will help in the preservation of the eggs and the reproductive system and the overall reproductive health, as the female ages, and assist the male in sperm production throughout the child bearing years.

The invention provides a preparation method of glucosamine sulfate. According to the hydrolysis in the preparation method, chitosan and a bisulfate-containing acidic ionic liquid undergo a hydrolysis reaction in water for 2-5 hours, wherein the quality and volume ratio of chitosan to the bisulfate-containing acidic ionic liquid is 1:3-5, the water amount is 3-6 times the weight of chitosan, and the reaction temperature is 80-140 DEG C. According to the method, there is no acid fog and tail gas during the production process; and the product contains no chloride ion and is safe with no pollution. With the use of the bisulfate-containing acidic ionic liquid, the reaction time is short, the yield is high, the ionic liquid can be repeatedly used, the whole production technology is simple, the purity and the yield of the product obtained is high, the cost is low, and the preparation method provided by the invention is a green, environmentally friendly and high efficient production technology.

Compositions with synergistic anti-inflammatory effect in inflammatory diseases resulting from activation and consequent degranulation of mast cell and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as chondroitin sulfate C and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, a special organic extra virgin kernel seed olive oil, S-adenosylmethionine and diphenhydramine.

An oral supplement or topical supplement containing glucosamine sulfate and oleocanthal provides relief of pain and reduces inflammation in joints. The topical supplement is used in conjunction with a heat patch.

The invention relates to a composition for increasing bone mineral density, a preparation agent containing the composition, and the preparation method of same. The composition comprises the following raw materials according to the weight portions: 0.5 to 35 portions of calcium carbonate, 0.5 to 30 portions of sulfuric acid dextrosamine, 0.05 to 2 portions of sulfuric acid chondroitin, 0.1 to 10 portions of collagen, and 0.08 to 5 portions of turmeric yellow extractive. In the composition, except a calsium supplement and a calcium absorbing promoting agent, the composition further comprises nutrients and anti-inflammatory mitigative, and can be used for preventing and treating osteoporotic symptom from multiply angles and ways.

The invention discloses a compound preparation used for joint care and a preparation method thereof. The compound preparation comprises active ingredients and auxiliary materials, wherein the active ingredients comprise glucosamine, chondroitin sulfate, dimethyl sulfone and collagen, and the glucosamine is glucosamine sulfate or glucosamine hydrochloride or glucosamine phosphate or mixture of theglucosamine sulfate and the glucosamine hydrochloride and the glucosamine phosphate; and the auxiliary materials comprise excipient, disintegrant, lubricant, bonding agent and wetting agent. The invention has better treatment and prevention functions on arthritis and joint injury; the prepared tablet has good disintegration property, rapid digestion, quick effect taking, strengthened stability andhigh absorption and utilization ratio; and the consumption of the raw materials and the auxiliary materials achieves the optimal proportion.

A triple natural polymer viscoelastic composition is disclosed. By combining glucosamine sulfate (“GS”), sodium hyaluronate (“HA”) and chondroitin sulfate (“CS”), the triple natural polymer viscoelastic compositions of this invention can provide a viscoelastic agent at a surgical site that not only serves as a protective agent to ocular tissues, but that can also act as an agent to alleviate pain and inflammation associated with ocular surgery. Embodiments of this invention can comprise GS combined with existing HA / CS viscoelastic agents. Embodiments of this invention can also comprise GS and CS in combination with an irrigation solution. Further, to enhance retention time at the site of an intra-articulate application of an embodiment of this invention, the following biodegradable polymers may also be included in an embodiment of the compositions of the present invention: cellulose derivatives (e.g., hydroxypropylmethylcellulose, ethylcellulose, caboxymethylcellulose, etc.), carbopol, citosan, and collagen.

The invention discloses a preparation method for preparation containing glucosamine and an application thereof. The preparation is characterized in that the major component is one or the combination of more of the glucosamine, glucosamine hydrochloride, glucosamine sulfate sodium chloride double salt or potassium chloride double salt, and chondroitin sulfate. The preparation method is simple, convenient and time-saving to operate and is easy for large industrialized production.

The invention discloses a glucosamine chewable tablet used for relieving and preventing osteoarthritis and a preparation method thereof. The glucosamine chewable tablet comprises active ingredients and auxiliary materials, wherein the active ingredients comprise glucosamine, vitamin C and dimethyl sulfone, the glucosamine is glucosamine sulfate or glucosamine hydrochloride or glucosamine phosphateor mixture of the glucosamine sulfate and the glucosamine hydrochloride and the glucosamine phosphate; and the auxiliary materials comprise excipient, bonding agent, flavouring agent and lubricant. The glucosamine chewable table is slowly disintegrated and released without entering the gastrointestinal tract through the chewing and is absorbed through the increment of the taking number, therefore, the medicine effect is improved, and the discomfort of a patient with poor gastrointestinal tract function, caused by a deglutible tablet accelerating the gastrointestine load, is reduced. The glucosamine chewable tablet has the advantages of good mouth feel, high bioavailability, more convenient taking, convenient carrying and the like, and can fully play a role of the product.

The invention is an ingestible wellness one time daily dosage made of a large quantity of rapid absorbing glucosamine sulfate, glucosamine hydrochloride, and an n-acetyl glucosamine and combinations thereof, a large quantity of chondroitin sulfate, chondroitin hydrochloride and combinations thereof, a vasodialating sulfonate with at least one methyl group, and a buffer to reduce adverse symptoms from large amounts of glucosamine and chondroitin selected from the family of araliaceae and a B3 vitamin, wherein the invention is also a wellness beverage that involves a fluid combined with the ingestible wellness dosage.

The invention discloses a compound combined formulation for preventing and treating osteoarthrosis and a preparation method thereof. The compound and composite formulation comprises an active component and auxiliary materials, wherein the active component is glucosamine or a combination of the glucosamine and more than one or two of other active components, i.e. chondroitin sulfuric acid, dimethyl sulfone and collagen, and the glucosamine is glucosamine sulfate or hydrochloride or phosphate or a mixture of the glucosamine sulfate, the hydrochloride and the phosphate; and the auxiliary materials include an excipient, a disintegrating agent, a lubricating agent, an adhesion agent, a stabilizing agent and a wetting agent. The invention has good treating and preventing effects on arthritis and articulate movement damage; a prepared tablet has good disintegrating property, fast dissolution and quick results and achieves the optimal proportion of the using amount of raw materials and various auxiliary materials; and in addition, the product has enhanced stability and high absorption utility ratio.

The invention relates to a preparation method for glucosamine sulfate. According to a technical scheme in the invention, the preparation method comprises the following steps: step 1, dispersing D-glucosamine hydrochloride in an alcoholic solvent; step 2, neutralizing D-glucosamine hydrochloride with alkali; step 3, adding sulfuric acid into a glucosamine solution drop by drop so as to form a salt; step 4, carrying out precipitation and separation; and step 5, carrying out refining by repeatedly washing a solid with a small amount of an organic solvent until no chloride ion is eluted and carrying out drying under reduced pressure, wherein the organic reagent is ethanol, propyl alcohol, acetone or the like with a concentration of 80 to 100%. With the technical scheme, glucosamine sulfate with low sodium or potassium content is obtained.

The invention relates to novel tobacco sense organ humectant and a using method of the novel tobacco sense organ humectant in tobacco. Pure water and glucosamine sulfate are adopted as raw material for the humectant which is evenly sprayed in tobacco leaves in the leaf-humidifying and moisture-regaining process or evenly sprayed in cut tobacco in the material adding process. Operation is easy, sense organ moisture degree of tobacco products is significantly improved under the condition that physical moisture absorption performance of the tobacco products is not changed evidently, dry feeling and pungency of the tobacco products are remarkably reduced when the tobacco products are smoked, tobacco gas is fruity and fine, and aroma of the tobacco products can be appropriately enriched.

The invention belongs to the field of bio-medicines, and relates to a preparation method of glycopeptide hydrogel containing a glucosamine unit. The glycopeptide hydrogel is formed by self-assembling the glycopeptide containing a glucosamine unit under physiological conditions. Because the glucosamine unit in the glycopeptide hydrogel has the function of inhibiting the postoperation scar from forming, the glycopeptide hydrogel is expected to be used as a gel inhibitor for inhibiting the postoperation scar from forming. The novel glycopeptide hydrogel has the two advantages that the gel is easily placed in an operation point through an injection method; and because glucosamine fixed inside the gel can not disperse in a wound region, once injection is needed during application, the treatment process is simplified and cost is saved.

The invention relates to a glucosamine sulfate production method. According to the invention, chitin is subjected to sulfuric acid acidolysis; the acidolysis liquid is subjected to discoloring, extracting, and re-crystallizing; sulfuric acid is removed through calcium hydroxide precipitation; and lyophilization is carried out, such that pure glucosamine sulfate is obtained. The production method has the advantages of simple process and low three-waste. The product does not contain metal ion and chloride ion. The process flow is clean.

A biological fermentation pig forage is prepared from the following raw materials in parts by weight: 45-53 parts of corn flour, 8-10 parts of herb of common nipplewort, 3-4 parts of konjac glucomannan, 3-4 parts of glucosamine sulfate, 35-40 parts of soybean meal, 35-40 parts of barley vinasse, 17-25 parts of wheat bran, 10-13 parts of euglena, 3-4 parts of spora lygodii, 1-1.5 parts of lactobacillus fermentum, 1-1.5 parts of aspergillus niger, 1.5-2 parts of lactobacillus plantaum, 1.5-2 parts of lactobacillus johnsonii, 0.2-0.3 part of sodium selenosulfate, 3-4 parts of vitamin e acetate, and 10-12 parts of illite powder. The biological fermentation pig forage is improved in digestion rate, and is capable of increasing digestion capability of animals on the forage and improving animal growth performance, especially is capable of enhancing immunity, possesses protrude effects on reducing pig cold and mycoplasma pneumoniae of swine, and is capable of improving pork tenderness and reducing muscle shearing force.

The invention discloses a health product for keeping joint health and increasing bone density and a preparation method thereof. The health product comprises the following active components: glucosamine, chondroitin sulfate, a calcium agent, a copper agent, a manganese agent and vitamins, wherein the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture; auxiliary materials comprise an excipient, a disintegrant, a lubricant, an adhesive, a wetting agent and a coating pre-mixing agent. The health product contains vitamin D3 which can be used for supplementing mineral matters, such as calcium and the like for human bodies and promoting absorption and have treating and preventing functions for rheumatoid arthritis, degenerative arthritis and damaged joint motion. A tabletprepared by the method has the advantages of good disintegrating performance, quick dissolution and effect taking, optimal proportion of use amount of raw materials and various auxiliary materials, product stability enhancement and high absorption utilization rate.