36 results about "Glucosamine Sulfate" patented technology

The invention discloses an oral instant film suitable for pet nutrition intervention and a preparation method of the oral instant film, and belongs to the technical field of pet oral preparations. The instant film adopts a sandwich type multi-layer structural design, sequentially comprises a first food calling layer, a core layer and a second food calling layer, can be selectively provided with a functional layer and an interface middle layer, and constructs a staggered hot-pressing laminated structure, so that the structural stability and the function delivery efficiency of a film body are remarkably improved. The core layer contains multiple composite active ingredients such as L-carnitine, coenzyme Q10, beta-glucan, glucosamine sulfate and the like, chitosan-inulin-polyglutamic acid or starch is adopted for embedding to form a first microcapsule and a second microcapsule, and intelligent delivery of temperature / pH response and gastrointestinal controlled release is achieved. The food calling layer is composed of chicken powder, fish oil powder, fructo-oligosaccharide and the like, and the feeding compliance of pets is improved.

The present invention discloses an organic fertilizer for promoting plant growth and soil improvement and a preparation method thereof, and belongs to the technical field of organic fertilizers. The organic fertilizer comprises the following raw materials: decomposed chicken manure, soybean meal, straw powder, sweet potato vine, humic acid, composite microbial agent, rosmarinic acid, and a stimulant. The composite microbial agent is composed of Actinomyces millefolius, Pseudomonas stutzeri, and Bacillus velezensis, and the stimulant is a glucosamine sulfate solution. Rosmarinic acid, glucosamine sulfate solution, and composite microbial agent are added to the organic fertilizer of the present invention. These three components are compounded with straw, chicken manure, etc. to form an organic fertilizer. The synergistic effect of multiple substances promotes the growth of cabbage and increases yield on the one hand; on the other hand, it significantly improves the physical and chemical properties of the soil.

The invention discloses a capsule containing a glucosamine sulfate compound with low hygroscopicity and a preparation process of the capsule, the content of the capsule is composed of the glucosamine sulfate compound, a lubricant and a disintegrating agent, and an adopted capsule shell is a plant capsule with a certain proportion of surfactant; the glucosamine sulfate compound has the characteristics of low hygroscopicity, high purity and high solubility, and is prepared by compounding glucosamine sulfate, a water-soluble film-forming material and a plasticizer and then performing spray drying. Wherein the glucosamine sulfate accounts for more than 90% of the total weight, the water-soluble film-forming material accounts for 5-10%, and the plasticizer accounts for 1-5%. Various quality indexes and stability of the prepared glucosamine sulfate compound capsule are superior to those of an existing product, the safety and effectiveness of the medicine are improved, and the preparation process of the glucosamine sulfate compound capsule is more suitable for industrial production.

1.The name of the design product: packaging box (glucosamine sulfate capsule). 2.The use of the design product: packaging box for medicine. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best shows the design points: perspective view. 5.The design claimed contains color.

1. The name of the design product: packaging box (glucosamine sulfate capsule). 2. The use of the design product: for product outer packaging. 3. The design points of the design product: in the combination of shape and pattern. 4. The picture or photo that best indicates the design points: unfolded state reference drawing.

The invention relates to a method for determining related impurities of glucosamine sulfate capsules, which can effectively evaluate the quality and process level of preparations and ensure the effectiveness of drugs, and adopts the technical scheme that the method comprises the following steps: S1, preparing a test solution; s2, preparing a reference substance solution; s3, chromatographic condition setting; s4, determining related impurities; according to the related impurity determination method, the minimum separation degree of the impurities is 1.74 and larger than 1.5, the separation effect is good, it is indicated that specificity is high, fructosazine, 2, 5-deoxyfructosazine, pyrazine, 5-hydroxymethylfurfural, furfuryl alcohol, 2-methylpyrazine, furfural, pyrrole-2-formaldehyde and 5-methylfurfural can be accurately and quantitatively detected, and the content of fructosazine, 2, 5-deoxyfructosazine, pyrazine, 5-hydroxymethylfurfural, furfuryl alcohol, 2-methylpyrazine, furfural, pyrrole-2-formaldehyde and 5-methylfurfural can be accurately and quantitatively detected. According to the present invention, the 5-deoxyfructosazine, the pyrazine, the 5-hydroxymethylfurfural, the furfuryl alcohol, the 2-methylpyrazine, the furfural, the pyrrole-2-formaldehyde and the 5-methylfurfural can be sensitively detected, and the large influence on the experiment result due to the laboratory change can be avoided.

The invention provides a glucosamine and chondroitin sulfate pharmaceutical composition as well as a preparation method and application thereof, and belongs to the technical field of biological pharmaceutical preparations, the composition comprises sodium chondroitin sulfate, glucosamine sulfate, dimethyl sulfone, non-denatured type II collagen, frankincense extract and auxiliary materials in specific parts by mass, compared with the prior art, the composition provided by the invention has the advantages that by selecting the components, adding the composite synergist optionally and optimizing the ratio and synergistic effect of the components, the effects of the composition in promoting cartilage regeneration and inhibiting joint inflammation are remarkably improved, the anti-inflammatory and anti-oxidation effects are enhanced, and the bioavailability is also improved, so that a breakthrough progress is realized in the field of joint health.

The invention relates to a method for determining the dissolution rate and content of glucosamine sulfate capsules by a derivatization method, which can effectively evaluate the quality and process level of preparations and ensure the effectiveness of drugs, and adopts the technical scheme that the dissolution rate determination method comprises the following steps: S1, preparing a dissolution solution; s2, preparing a test solution; s3, preparing a reference substance solution; s4, preparing a derivatization reagent; s5, chromatographic condition determination; s6, determining the dissolution rate; the content determination method comprises the following steps: S1, preparing a test solution; s2, preparing a reference substance solution; s3, preparing a derivatization reagent; s4, chromatographic condition setting; s5, content determination; according to the method, the dissolution rate and content determination repeatability is good, absolute deviations of dissolution rate determination results in different laboratories all meet requirements, and experimental results cannot be greatly influenced due to changes of the laboratories.

1. The name of the product of this design: Packaging box (No. 8 Land Reclamation Calcium Carbonate Glucosamine Sulfate Chondroitin Glue). 2. Application of this design product: for health food packaging. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the key points of the design: main view. 5. The design for which protection is sought includes color. 6. The left view and the right view of this design are the same, so the left view is omitted; the bottom view and the top view are the same, so the bottom view is omitted.

1.The name of the design product: packaging box (glucosamine sulfate capsule). 2.The use of the design product: for packaging glucosamine sulfate capsules. 3.The design points of the design product: the combination of shape, pattern and color. 4.The picture or photo that best shows the design points: perspective view. 5.The design claimed contains color.

The present invention provides an operation monitoring and control system for glucosamine sulfate capsule preparation equipment, relating to the technical field of equipment operation monitoring. The system is configured to acquire historical sound data from the production system, perform frequency domain feature extraction based on operating parameters, and generate operation voiceprint feature data; collect real-time operation sound data from the production system and extract corresponding real-time voiceprint feature information and real-time operation parameter information; and perform monitoring and analysis based on the real-time operation parameter information and in combination with the operation voiceprint feature data and real-time voiceprint feature information to generate real-time operation monitoring and analysis result data. By combining voiceprint feature data, the system conducts timely and accurate comprehensive equipment fault analysis, enabling accurate and timely monitoring of comprehensive production system faults and ensuring efficient and orderly production.

The application provides a compound preparation for improving osteoporosis and osteoarthritis, a preparation method and application thereof, and belongs to the technical field of biological medicines. The compound preparation contains the following raw materials: glutathione, curcumin, calcium carbonate, vitamin D3, hydrolyzed collagen, and glucosamine sulfate; wherein the glutathione exists in the form of a cyclodextrin inclusion compound. The preparation method comprises the following steps: mixing the calcium carbonate, the hydrolyzed collagen, the glucosamine sulfate and excipients, then adding an equal amount of a premix of the glutathione cyclodextrin inclusion compound, the curcumin and the vitamin D3 in a stepwise manner, and performing dry granulation and tabletting to obtain the compound preparation. The compound preparation can simultaneously increase bone density, protect articular cartilage, reduce the levels of oxidative stress and inflammation, and can be used for preparing medicines or health foods for preventing or adjuvant treating osteoporosis and osteoarthritis. The application has a scientific formula, a stable process and a good application prospect.

The invention discloses a method for detecting glucosamine sulfate by using a liquid chromatography-mass spectrometry technology. The method comprises the following steps: adopting an octadecyl silane bonded silica gel column as a chromatographic column; an acidic aqueous solution is used as a mobile phase A; and carrying out gradient elution by using an organic solution as a mobile phase B. The detection method has the advantages of high sensitivity, strong specificity, high precision, strong accuracy and simple and rapid operation, and can greatly shorten the experiment time and realize rapid detection of the dissolution curves of the glucosamine sulfate capsule imitation medicine and the reference preparation.

The glucosamine sulfate extraction device comprises a base, buffer boxes are fixedly connected to the two ends of the interior of the base, an electric push rod is fixedly connected to the outer bottom of the base, the telescopic end of the electric push rod penetrates through the buffer boxes and is fixedly connected with a T-shaped lifting disc, and a sealing pipe is fixedly connected to the tops of the buffer boxes in an embedded mode; a pressure release valve is fixedly connected to the outer side of the buffer tank, and a discharge pipe is arranged at the center of the base; a reaction kettle is fixedly connected to the center of the top of the base, and a protection box is fixedly connected to the outer edge of the top of the base. Through mutual cooperation of the protection box, the pressure sensing module, the buffer box and the reaction kettle, when the reaction kettle performs pretreatment on a glucosamine sulfate raw material before extraction, if material leakage occurs, a worker can be warned in time, so that the worker can conveniently make a response in time, and working environment pollution caused by harmful gas leakage is prevented; and meanwhile, the personal safety of workers is protected.

This invention relates to the field of biomedical technology and discloses a low-moisture-content glucosamine sulfate tablet. By weight, the tablet comprises the following components: 28-32 parts glucosamine sulfate, 10-30 parts filler, 2-8 parts disintegrant, 0.5-3 parts binder, 0.3-2 parts lubricant, and 0.1-1 parts flow aid. The moisture content of the tablet is controlled below 6.0%, and the tablet hardness is 6-12 kg with a friability ≤0.5%. The filler is selected from one or more combinations of microcrystalline cellulose, lactose, mannitol, and pregelatinized starch. The disintegrant is selected from one or more combinations of crospovidone, sodium carboxymethyl starch, and low-substituted hydroxypropyl cellulose. Through a triple moisture control system of raw material pre-drying, segmented temperature-controlled drying, and low-humidity tableting, the common industry problems of glucosamine sulfate's hygroscopicity, moisture absorption and clumping during tablet storage, and content degradation are effectively solved, significantly improving the long-term storage stability of the tablet.

The invention discloses a pharmaceutical composition for preventing and treating joint inflammation / relieving pain and a preparation method thereof. The pharmaceutical composition comprises the following components: 1, glucosamine sulfate 2KCL (99%), 2, chondroitin sulfate, 3, methylsulfonylmethane (MSM), 4, type II collagen, 5, a morinda officinalis root extract, 6, a herba epimedii extract, 7, a sambucus williamsii extract, 8, a rhizoma drynariae extract, 9, a turmeric root extract, 10, hyaluronic acid and 11, chitosan. The pharmaceutical composition can be prepared into tablets, capsules, dispersible tablets, chewable tablets, effervescent tablets, buccal tablets and other oral preparations. The composition has the effect of preventing and relieving knee joint inflammation / pain.

The invention relates to a 3D printing resin, a preparation method and application thereof, a photocurable resin composition and a cured product thereof. The preparation method of the resin for 3D printing comprises the following steps: (1) reacting a glucosamine sulfate compound with (methyl) acryloyl halide to obtain a reaction mixture containing glucosamine (methyl) acrylamide; (2) bringing the reaction mixture into contact with an organic compound containing methyl (meth) acrylate, and extracting an organic phase from the resulting contact mixture, (3) mixing the organic phase with a photocurable compound, with the total mass of the resin for 3D printing being 100% by mass, and the content of the photocurable compound being 1% by mass or less relative to 100% by mass of the resin for 3D printing being 1% by mass or less relative to 100% by mass of the total mass of the resin for 3D printing. The content of the glucosamine (meth) acrylamide is from 3% by mass to 10% by mass (inclusive).

The utility model discloses a granulating device for glucosamine sulfate capsule production, which relates to the technical field of granulating devices and comprises a granulating machine body, a round box arranged at the bottom of a medicine outlet pipe of the granulating machine body, a connecting shaft rotatably arranged in the middle of the bottom surface of the round box, a driving motor arranged at the bottom of the connecting shaft, and a bumping post fixedly connected to the top of the connecting shaft. An annular plate is slidably arranged on the outer wall of the blocking column, a plurality of medicine screening openings are evenly formed in the annular plate, and a medicine outlet is formed in the bottom of the circular box; the driving motor drives the annular plate to rotate, qualified glucosamine sulfate capsules fall into the medicine screening opening when the annular plate rotates, then the qualified glucosamine sulfate capsules rotate along with the annular plate, and finally the glucosamine sulfate capsules fall from the medicine outlet. Therefore, screening of the glucosamine sulfate capsules is achieved, unqualified products in the glucosamine sulfate capsules are removed, operation is easy and convenient, and the working efficiency of screening of the glucosamine sulfate capsules is improved.

The invention relates to the technical field of medicines, and particularly discloses a glucosamine sulfate capsule and application thereof in preventing joint degeneration after sport injury. The content of the capsule is prepared from the following raw materials: glucosamine sulfate and sodium chloride double salt, corn starch, lactose, talcum powder, magnesium stearate and a chondroitin sulfate-chitosan nano-composite, by introducing the chondroitin sulfate-chitosan nano-composite, the common problems of easy moisture absorption and poor stability of the traditional glucosamine sulfate preparation are solved, the chondroitin sulfate-chitosan nano-composite has good interaction with the active ingredients of the main medicine, and a microscopic protection structure is formed on the particle surface, so that the physical and chemical stability of the final product is enhanced; the influence of environment humidity can be effectively resisted in the production, storage and subsequent use processes, good fluidity and uniformity of contents are maintained, and long-term stability of product quality is ensured.

The invention relates to the technical field of molecular biology and biomedicine, in particular to a separation and extraction method and application of extracellular vesicles derived from brucea javanica. The separation and extraction method comprises the following steps: S1, preparing supernate containing active ingredients of brucea javanica; s2, sequentially performing micron-scale filtration and nano-scale filtration on the supernate to obtain an extracellular vesicle concentrated solution; and S3, mixing the extracellular vesicle concentrated solution with a glucosamine sulfate solution, and performing freeze-drying to obtain freeze-dried powder of the extracellular vesicles derived from brucea javanica. The separation and extraction method is simple in operation process, mechanical damage to the vesicle structure caused by a traditional ultracentrifugation method is effectively avoided, and the extracted vesicles are uniform and good in form, uniform and concentrated in particle size distribution, good in stability and high in purity.

1. The name of the design product: packaging box (glucosamine sulfate capsule - anteban). 2. The use of the design product: used for the outer packaging of products. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best indicates the design points: unfolded state reference drawing.

The invention discloses an ion selective electrodialysis preparation device for preparing glucosamine, which comprises a main inlet pipe, a main outlet pipe and a plurality of electrodialysis units, the electrodialysis unit comprises a shell and a top cover, and a cation exchange membrane and an anion exchange membrane are arranged in the shell and divide the space in the shell into a cathode chamber, an anode chamber and a reaction chamber located between the cathode chamber and the anode chamber. The preparation method of the sulfate glucosamine is simpler, and continuous online preparation can be realized. According to the electrodialysis preparation device, regular cleaning of the cation exchange membrane and the anion exchange membrane can be realized, so that the electrodialysis unit works more efficiently. And a standard solution can be used for calibration, so that the device can be better checked, and maintenance can be prompted in time.

The present invention discloses an efficient nano-silica tackifier and its preparation method and application, which relates to the field of oilfield chemistry. The preparation method includes the following steps: taking nano-silica and ultrasonically dispersing it in a first solvent, then adding a small amount of a second solvent and a certain amount of a silane coupling agent to obtain preliminarily modified nano-silica; again, stirring and dispersing acrylic acid and ammonium persulfate in the second solvent to obtain polymer-modified silica; finally, dispersing it with glucosamine sulfate, NMI (N-methylimidazole), and TCFH (N,N,N,N-tetramethylchlorourea hexafluorophosphate) in a third solvent for reaction to obtain the product. The present invention can effectively increase the viscosity of crude oil under the conditions of high-salt and high-water-cut reservoirs, improve the oil displacement efficiency, the viscosity of the formed emulsion increases with the increase of the water cut, and the flow resistance can adapt to the change of the water cut, thereby increasing the swept volume and meeting the requirements of improving the recovery rate of high-salt and high-water-cut reservoirs.

The invention discloses a glucosamine sulfate composition, a capsule as well as a preparation method and application of the glucosamine sulfate composition and the capsule, and belongs to the technical field of pharmaceutical preparations, the glucosamine sulfate composition comprises the following components in percentage by mass: 80-90% of glucosamine sulfate sodium chloride double salt, 3-15% of modified corn starch, 2-6% of lactose and 2-4% of a lubricant. The glucosamine sulfate composition is obtained by compounding and screening auxiliary materials such as modified corn starch and lactose with glucosamine sulfate and sodium chloride double salt, so that the hygroscopicity of the glucosamine sulfate and sodium chloride double salt in a high-humidity environment can be improved, and the problem that water in gelatin capsules is easily reversely absorbed by glucosamine sulfate is solved; the prepared glucosamine sulfate capsule has good disintegration, dissolution rate and stability.

The invention discloses a glucosamine sulfate effervescent tablet composition and a preparation method thereof, and belongs to the technical field of biological medicines. The effervescent tablet contains glucosamine sulfate, and the effective drug content is high and is 1000mg / tablet; the soft capsule contains glucosamine sulfate, chondroitin sulfate and collagen which jointly maintain the stable state of cartilage, delay the development of osteoarthritis and relieve symptoms; glucosamine sulfate and vitamin C are reasonably matched, so that the joint discomfort recovery period is shortened; and moreover, the prescription contains sodium salt, is low in calorie, helps to maintain moisture balance, and is suitable for people with high-intensity metabolic movement. According to the method, the effervescent tablets obtained through step-by-step granulation and total pressure are high in dissolution speed during use, quick in active ingredient release, quick in effect taking, high in bioavailability and convenient to carry, and are particularly suitable for the old, children and users who cannot swallow solid preparations.

The present invention discloses a kind of aluminum-doped cobalt tetroxide and its preparation method, the preparation method comprises, mixing a cobalt salt solution, an aluminum salt solution, a precipitant solution, and a regulator solution to react, collecting insoluble matter; heat-treating the insoluble matter to obtain aluminum-doped cobalt tetroxide; wherein, the regulator in the regulator solution comprises at least one of D-glucosamine sulfate sodium salt and sodium benzoate. In the process of preparing aluminum-doped cobalt tetroxide by precipitation method, the present invention adds D-glucosamine sulfate sodium salt and sodium benzoate, effectively adjusting the micromorphology of aluminum-doped cobalt tetroxide, making the structure more uniform and the dispersibility better. At the same time, D-glucosamine sulfate sodium salt and sodium benzoate in a certain concentration range are also beneficial to improving the tap density of aluminum-doped cobalt tetroxide. Overall, the preparation method of the present invention is simple, the raw materials are easy to obtain, and it has good application prospects.

The utility model relates to the technical field of capsule filling, and discloses a filling device for glucosamine sulfate capsule production, which comprises a support table, the top of the support table is fixedly connected with a conveying component used for sending out a carrier, and the top of the support table is rotatably connected with a processing component used for processing. A conical block is fixedly connected to the bottom of the machining assembly, a plurality of placing blocks are fixedly connected to the outer portion of the conical block, clamping grooves are formed in the bottoms of the placing blocks, a fixing ring is fixedly connected to the top of the supporting table, a plurality of placing grooves are formed in the fixing ring, and a plurality of limiting blocks are fixedly connected to the interior of the fixing ring. According to the utility model, through the matching of the conical block and the fixing ring, the stability of the workbench is improved, and the reliability of the workbench in the working process is ensured. The safety and accuracy of the equipment are enhanced, meanwhile, the equipment is convenient to disassemble and replace, and the equipment can be convenient to maintain and repair.

1. The name of the design product: medicine box (glucosamine sulfate capsule). 2. The use of the design product: for packaging medicine. 3. The design points of the design product: the combination of shape and pattern. 4. The picture or photo that best shows the design points: perspective view.

1. The name of the design product: packaging box (glucosamine sulfate capsule). 2. The use of the design product: for packaging of glucosamine sulfate capsule. 3. The design points of the design product: in the combination of patterns and colors. 4. The picture or photo that best shows the design points: perspective view. 5. The design claimed contains colors.

1. Name of the product in this design: Packaging Box (Glucosamine Sulfate Capsules). 2. Application of this design: This design is used for pharmaceutical packaging boxes. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.