The invention discloses a preparation method of
glucosamine sulfate, relating to a compound containing
aminosugar. The preparation method of
glucosamine sulfate has the advantages that a great deal of
sulfate precipitation by-product is avoided being generated and a great deal of
organic solvent is avoided being used, the operation is in complete aqueous phase, the production processes are safe, the
sulfuric acid removed by the
membrane method can be recovered and used, the production cost is reduced, exhaust and waste residue are not produced, the prepared product does not contain
sodium,
potassium or
chlorine, the purity of the product reaches over 95 percent, and the
glucosamine sulfate can be used to treat
osteoarthritis without usage taboo. The preparation method is characterized in that
chitin is adopted as the
raw material, and a degradation agent of concentrated
sulfuric acid is used to cause the
chitin to generate
degradation reaction; diluted
sulfuric acid is used as a deacetylation agent to cause the degraded
chitin to generate deacetylation reaction; the chitin which is not reacted after the deacetylation reaction is filtered, and the unreacted sulfuric acid is removed by the
membrane method; and the solution, in which the unreacted sulfuric acid is removed, is decolorized, concentrated and dried, and
glucosamine sulfate is obtained.