119 results about "Pregelatinized starch" patented technology

The invention relates to the technical field of pharmaceutical preparations, in particular to a stable perindopril amlodipine tablet and a preparation method thereof, and the tablet comprises the following components in percentage by weight: 5.0% of arginine perindopril; 3.5% of amlodipine besylate; 20%-40% of pregelatinized starch; 40%-68% of a microcrystalline cellulose colloidal silicon dioxide compound; 2.5%-6% of a disintegrating agent, wherein the disintegrating agent is selected from one or more of ion exchange resin, sodium alginate and croscarmellose sodium; the pregelatinized starch and the microcrystalline cellulose colloidal silicon dioxide compound are selected as main diluents, so that the Maillard reaction possibly occurring between the lactose and the active pharmaceutical ingredients is completely avoided, the problem of increase of related substances is fundamentally solved, and the stability and the safety of the product are remarkably improved.

The invention provides a closed-loop control method for viscosity in a pregelatinized starch production process, and relates to the technical field of intelligent control, which comprises the following steps: acquiring real-time viscosity data and real-time temperature data of pregelatinized starch slurry, calculating a viscosity deviation value, calculating a temperature compensation coefficient by adopting an improved Arrhenius viscosity-temperature equation, and calculating the viscosity deviation value according to the temperature compensation coefficient. A compensated viscosity deviation value is obtained, the compensated viscosity deviation value and the change rate of the compensated viscosity deviation value are input into a double-variable fuzzy controller, and the stirring speed adjusting amount is calculated according to a fuzzy rule; according to the compensated viscosity deviation value and the change rate of the viscosity deviation value, an incremental PID control algorithm is adopted to calculate the adjusting amount of the opening degree of a steam valve, and cooperative control over steam heating and mechanical shearing is formed. According to the method, accurate compensation of the nonlinear relation between the viscosity and the temperature is achieved, by introducing a dynamic correction factor and a multi-protection mechanism, adaptability and stability under complex working conditions are enhanced, and the regulation and control efficiency and the product quality stability in the pregelatinized starch production process are effectively improved.

The invention discloses a rice cake capable of regulating postprandial blood sugar and inhibiting starch aging, and belongs to the field of food processing and preservation. The rice cake is prepared from the following raw materials in parts by mass: 100 to 300 parts of polished round-grained rice flour, 100 to 200 parts of glutinous rice flour, 5 to 30 parts of pre-gelatinized corn starch, 5 to 30 parts of wheat type B starch granules and 100 to 300 parts of water. The pre-gelatinized corn starch-wheat type B starch composite preservative prepared by mixing the pre-gelatinized starch and the wheat type B starch in proportion can effectively inhibit hardness increase caused by starch aging and retrogradation in the storage process of the rice cake and avoid taste deterioration. Meanwhile, by adding the composite starch, the digestibility rate of the rice cake is remarkably reduced, and the metabolic regulation characteristic similar to that of low glycemic index food is endowed to the product. The characteristic of a cleaning label formed by natural components of the rice highly conforms to the development trend of healthy food, and the rice is especially suitable for functional rice product development of people needing to control postprandial blood sugar fluctuation.

The invention discloses a mixed auxiliary material for traditional Chinese medicine film coated tablets and a preparation method of the mixed auxiliary material. The mixed auxiliary material comprises the following components in percentage by weight: 50-60% of etherified crosslinked starch, 15-20% of pregelatinized starch, 10-15% of sodium carboxymethyl starch, 0.6-0.8% of magnesium stearate and 2-3% of talc. The etherified cross-linked starch is used for replacing a traditional polymer, a cross-linked structure of the etherified cross-linked starch blocks water molecule permeation, pre-gelatinized starch improves powder fluidity, crushed talcum powder is mixed with the pre-gelatinized starch, microgaps are filled, a friction system is reduced, and the situation that the sheet surface is rough and prone to sticking is avoided; the dynamic balance of sodium carboxymethyl starch and magnesium stearate ensures the synergism of disintegration and lubrication, and completely avoids the problems of poor tablet hardness, slow disintegration and large weight difference of traditional Chinese medicine film-coated tablets.

The invention belongs to the field of refractory materials, and provides a light heat-insulating refractory brick and a preparation method thereof. The light heat-insulating refractory brick comprises particles, mixed powder and an additional binding agent, the particles comprise, by weight, 10-15 parts of expanded vermiculite and 30-45 parts of closed cell perlite, and the mixed powder comprises, by weight, 15-25 parts of spherical quartz powder and 5-15 parts of perlite dust collecting powder. The raw materials comprise, by weight, 5-10 parts of waste silica brick powder, 5-10 parts of siliceous pyrophyllite powder, 10-15 parts of Jiaozhou white clay, 5-15 parts of sodium montmorillonite powder and 5-15 parts of limonite powder; the additional binding agent comprises the following raw materials in parts by weight: 3-5 parts of binding slurry and 3-5 parts of pre-gelatinized starch. The refractory brick disclosed by the invention is a light heat-insulating refractory brick which is small in volume density, small in heat conductivity coefficient and capable of meeting the requirement of heat insulation in a high-temperature kiln at 900-1000 DEG C in normal-temperature compressive strength.

The invention relates to the technical field of silicon carbide ceramics, in particular to an in-situ induced low-temperature eutectic silicon carbide porous ceramic and a preparation method thereof. The material is prepared by mixing and sintering the following materials: silicon carbide, a synergistic sintering system, a dispersing agent, a plasticizer and water, wherein the synergistic sintering system comprises the following components: pregelatinized starch, a silicate mineral material, aluminum oxide, calcium carbonate, glass powder and rare earth oxide; the pregelatinized starch is adopted as an adhesive, the thermal decomposition behavior of the pregelatinized starch and the chemical reaction activity of the glass powder and the calcium carbonate form synergy in the process, seamless connection of the whole process from the room temperature to the sintering temperature is achieved, the sintering temperature is greatly reduced, meanwhile, the glue discharging step is omitted, and the silicon carbide porous ceramic product with good performance and few defects is obtained.

The present disclosure provides pregelatinized pea starch (PPS) compositions and processes for producing pregelatinized pea starch. The PPS of the invention has several distinguishing attributes, including relatively alkaline pH when dissolved in water, high water absorption index water solubility index relative to known pregelatinized pea starches. The PPS of the invention is also highly viscous at low temperature without heating, providing for abundant uses in the food and beverage industry.

The invention discloses an ibuprofen composition suspension and a preparation method thereof, the preparation method comprises the following steps: adding purified water accounting for 60% of the prescription dosage into a liquid preparation tank, slowly adding pregelatinized starch in a stirring state, and stirring for more than or equal to 10 minutes after the addition is finished; heating is started, so that the pregelatinized starch is gelatinized; adding a prescription amount of cane sugar into the liquid preparation tank, and stirring for 10 minutes to completely dissolve the cane sugar; starting a tank body for cooling, when the temperature of the liquid medicine is cooled to be less than or equal to 50 DEG C, slowly adding xanthan gum into the stirring tank through a 40-mesh screen under a stirring state, after the xanthan gum is added, continuously stirring for more than or equal to 30 minutes, starting self-circulation to pass through a 5mm screen for 30 minutes, and then replacing a 20-mesh screen to continuously and circularly stir; the xanthan gum and the raw material medicine are added into the stirring tank in a sieving mode, then the liquid medicine is subjected to continuous circulating sieving to ensure that the xanthan gum is completely swelled and the raw material medicine is uniformly dispersed, finally, the content uniformity RSD% of the liquid medicine at different positions is within 2%, and the uniformity of the liquid medicine is good; the feeding process is simplified to a certain extent, the use of equipment is reduced, the cleanness is realized, and the production efficiency is improved.

The invention provides a composition for improving the thrombolysis capacity of a human body, a preparation method and application thereof.The composition is prepared from, by weight, 5-30 parts of earthworm protein, 30-120 parts of hippophae rhamnoides total flavone extract, 50-150 parts of silymarin extract, 20-80 parts of maltodextrin and 15-60 parts of pregelatinized starch, the earthworm protein activates a fibrinolytic system to promote t-PA to release and dissolve thrombus, and the hippophae rhamnoides total flavone extract activates the fibrinolytic system to promote t-PA to release and dissolve thrombus; the hippophae rhamnoides total flavonoids regulate the ratio of PGI2 / TXA2 to inhibit platelet aggregation and reduce blood fat, the silymarin protects the liver function to enhance LDL-C metabolism clearing, the hippophae rhamnoides total flavonoids, the silymarin and the hippophae rhamnoides total flavonoids cooperate to form a thrombolysis-antithrombosis-metabolism regulation three-dimensional intervention system, a whole-course low-temperature mixing direct tabletting process is adopted

The application relates to the technical field of medicine preparation, and particularly discloses a levodopa-benserazide tablet, a preparation method and application thereof, which comprises levodopa granules, benserazide hydrochloride granules, cross-linked polyvinylpyrrolidone and magnesium stearate; the levodopa granules are composed of levodopa, anhydrous calcium hydrogen phosphate, pregelatinized starch, cross-linked polyvinylpyrrolidone, red iron oxide and sodium docusate; and the benserazide hydrochloride granules are composed of benserazide hydrochloride, mannitol, microcrystalline cellulose, colloidal silicon dioxide, red iron oxide and ethyl cellulose. The related substances and the friability of the levodopa-benserazide tablet meet the production requirements, the stability is high, and the tablet is suitable for large-scale production.

The invention relates to the field of herbal fragrant moxibustion, in particular to an edible and medicinal inhalation type atomized moxibustion material and a preparation method thereof. The invention relates to an edible and medicinal inhalation type moxibustion atomized material which comprises the following raw materials in parts by weight: 8-11 parts of astragalus membranaceus, 5-6 parts of pericarpium citri reticulatae, 6-10 parts of radix puerariae, 10-12 parts of agilawood, 8-12 parts of poria cocos, 7-9 parts of radix ophiopogonis, 20-25 parts of a carrier, 2-3 parts of an adhesive and the balance of water, wherein the total weight part is 100; the carrier comprises at least one of lotus leaves and loquat leaves; the adhesive comprises at least one of guar gum and pregelatinized starch. According to the application, the medicine taking astragalus membranaceus as a main medicine is prepared into the edible and medicinal inhalation type moxibustion atomized material, and the medicine can be absorbed in an aerosol inhalation mode during use. And after the moxibustion atomized material is prepared, the medicine medium has higher penetrability, can reach blood capillaries of a human body more easily, and has a stronger conditioning effect.

A novel compound complex that has no side effects on a liver and is used to alleviate the toxicity of an acetaminophen (APAP) drug to the liver. The composition of the compound consists of (a) acetaminophen in a pharmaceutically effective amount and (b) a commonly-used safe and pharmaceutically acceptable excipient that can be combined with one or more of two drugs to reduce the toxicity of a drug metabolized by the hepatic enzyme CYP2E1 in the liver.The compound is selected from the following group: Tween 20, microcrystalline cellulose, dicalcium phosphate, polyoxyethylene 23 lauryl ether, saccharin, mannitol, polyoxyethylene alkyl ether, sucralose, pyrrolidone, sodium starch glycolate, S100 acrylic resin, sodium carboxymethylcellulose, polyoxyethylene polyoxyethylene, menthol, low-substituted propylcellulose hydrocarbon, pregelatinized starch, Dextrates NF hydrate, citric acid, polyoxyethylene castor oil, colloidal silicon, aliphatic polyethylene glycol monostearate ester, sorbic acid, lemon oil, hydroxypropylcellulose, sorbitol, acesulfame potassium, hypromellose phthalate, lactose monohydrate, maltodextrin, Brij 58, Brij 76, Tween 80, Tween 40, PEG 400, Peg 4000, PEG 2000, and the like, so as to reduce the side effects caused by acetaminophen on the liver.

The invention discloses dust-free putty which is prepared from the following components in parts by mass: 985 to 1000 parts of heavy calcium powder, 2 to 3 parts of pregelatinized starch, 3.2 to 3.5 parts of cellulose ether, 1.4 to 2 parts of polyvinyl alcohol, 8 to 10 parts of bentonite, 0.4 to 0.6 part of starch ether and 3 to 5 parts of dust suppressant. The invention also discloses a preparation method thereof. By adding the specific pregelatinized starch, the cellulose ether, the polyvinyl alcohol, the bentonite, the starch ether and the mineral oil into the heavy calcium carbonate powder, the obtained putty has good constructability, bonding strength and stability, meanwhile, the putty is endowed with certain thixotropy and water-retaining property, the tensile bonding strength and the construction performance of the putty are guaranteed, and the putty has the advantages of being simple in preparation process and low in cost. And meanwhile, a good dust inhibition effect is achieved.

This invention discloses a flocculant for treating fracturing flowback fluid, relating to the field of oilfield wastewater treatment technology. The flocculant comprises modified starch and organic acid. The preparation method of the modified starch includes the following steps: reacting allyl alcohol glycidyl ether with 1,4,7-trimethyldiethylenetriamine; after the reaction, separating and purifying to obtain an intermediate product; taking the intermediate product and dissolving it, adding an alkyl halide to perform a quaternization reaction; after the reaction, separating and purifying to obtain a cationic monomer; taking pregelatinized starch and dispersing it in water, then adding the cationic monomer, acrylamide, and an initiator to perform free radical polymerization; after the reaction, drying to obtain the final product. The flocculant for treating fracturing flowback fluid provided by this invention not only has strong salt resistance, making it suitable for the high-salt environment of fracturing flowback fluid, but also effectively removes oil, turbidity, color, and suspended solids from the fracturing flowback fluid, and has a strong COD removal capacity.

This invention, entitled "Antibacterial Food Packaging Film Containing Propolis Extract, Preparation Method, and Application," belongs to the field of food packaging films. The technical problem to be solved is the poor mechanical properties, antibacterial properties, and antioxidant properties of the packaging film. The antibacterial food packaging film provided by this invention is made from the following raw materials: tamarind gum, pregelatinized starch, glycerin, and propolis extract. Xyloglucan in the tamarind gum is extracted by rapid high-temperature heating, and the propolis extract is integrated into the film-forming solution through simple blending. After drying, the film is obtained. The antibacterial food packaging film prepared by this invention solves the problem of poor mechanical properties in traditional tamarind gum-based packaging films and endows the packaging film with antibacterial and antioxidant functions, which can inhibit food spoilage and thus extend the shelf life of food.

The invention relates to a high-content 5-aminolevulinic acid sustained-release pellet, which comprises the following components: 5-aminolevulinic acid phosphate; microcrystalline cellulose (MCC PH-102); hydroxypropyl cellulose (HPC-SL); 2-5% of pregelatinized starch; sodium carboxymethyl starch (CMS-Na); sucrose; the drug loading capacity is 60 + / -2%, and the bulk density is 0.65-0.75 g / cm < 3 >.

This invention relates to a choleretic traditional Chinese medicine composition, its preparation method, and its application, belonging to the field of traditional Chinese medicine preparation technology. The microcapsules prepared from this choleretic traditional Chinese medicine composition consist of a core and a coating. The core contains a traditional Chinese medicine extract, pregelatinized starch, sodium alginate, and croscarmellose sodium. The coating contains hydroxypropyl cellulose and hydroxypropyl methylcellulose E5, PEG4000, and talc. The traditional Chinese medicine extract is made from Artemisia capillaris, Lysimachia christinae, Rheum palmatum, Scutellaria baicalensis, Taraxacum mongolicum, Forsythia suspensa, Curcuma longa, Curcuma longa, Bupleurum chinense, Citrus aurantium, and Aucklandia lappa. This choleretic traditional Chinese medicine composition has the effects of promoting bile flow and expelling gallstones, detoxifying and reducing swelling, with a stable drug release rate, definite efficacy, and few toxic side effects. It can be used for the prevention and / or treatment of acute and chronic gallstones and / or cholecystitis.

This invention provides a cat litter additive, its preparation method, and its application. The preparation method includes the following steps: dripping a liquid component onto a solid base material, causing the solid base material to automatically agglomerate into granules, then separating and collecting the granules, and freeze-drying them to obtain the cat litter additive; the liquid component includes water; the solid base material, by weight, includes 5-10 parts of binder, 40-60 parts of pregelatinized starch, and 40-45 parts of microcrystalline cellulose. The preparation method provided by this invention is simple to operate, requires little liquid component, has low cost, and produces an additive with low density, good water absorption, resistance to breakage, and high quality.

The present invention relates to a pharmaceutical composition and use thereof. The pharmaceutical composition comprises a substance Z and pharmaceutical excipients. The substance Z is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. The pharmaceutical excipients comprise a binder, a disintegrant, and a filler. The content of the compound represented by formula I accounts for at least 5% of the mass of the pharmaceutical composition. The filler is selected from one or more of lactose, microcrystalline cellulose, mannitol, starch, sucrose, and pregelatinized starch. The pharmaceutical composition has stable pharmaceutical properties, and exhibits the characteristics of low effective dose, safety, superior efficacy, and the like in clinical applications for gout and hyperuricemia.

The invention provides a torasemide dispersible tablet as well as a preparation method and application thereof, and relates to the technical field of pharmaceutical preparations, the torasemide dispersible tablet comprises the following components: torasemide, microcrystalline cellulose, lactose, pregelatinized starch, cross-linked sodium carboxymethyl cellulose and magnesium stearate, the technical problem that a patient is difficult to swallow is solved, and the torasemide dispersible tablet is suitable for clinical application. The technical effects of high stability, rapid disintegration and high dissolution rate are achieved. The torasemide dispersible tablet is stable, easy to swallow, high in disintegration speed after entering a human body and high in bioavailability.

The application provides a high-efficiency growth-promoting and regulating type compound fertilizer as well as a preparation method and application thereof, and belongs to the technical field of biological compound fertilizers.The raw materials of the compound fertilizer include biological bacteria, biological bacteria protective agent, slow-release carrier, nitrogen fertilizer, phosphorus fertilizer, potassium fertilizer, slow-release regulator microcapsule and diatomite; the compound fertilizer has a three-layer structure; the inner core of the compound fertilizer is a core particle coated by polyvinylpyrrolidone, which is prepared by granulating biological bacteria mixed with biological bacteria protective agent by using starch and pregelatinized starch; the middle layer is a middle coating layer bonded by polyvinyl alcohol, which is prepared by mixing diatomite, nitrogen fertilizer, phosphorus fertilizer and potassium fertilizer; and the outer layer is an outer coating layer bonded by polyvinyl alcohol, which is prepared by mixing diatomite and slow-release regulator microcapsule.In the application, the biological bacteria and protective agent core particle are combined with the chemical fertilizer in the middle layer and the slow-release regulator microcapsule in the outer layer, so that the effects of nutrient supply, plant growth regulation and soil improvement are achieved.

The application relates to the field of biological medicine, and discloses a tripterygium glycosides tablet and a preparation method thereof; the preparation method comprises the following operation steps: uniformly mixing tripterygium glycosides, corn starch, pregelatinized starch and low-substitution hydroxypropyl cellulose, adding a binder to mix and granulate, integrating the granules, mixing the granules with magnesium stearate and silicon dioxide, pressing the granules to obtain a tablet core; step 2: (1) spraying a pregelatinized starch aqueous solution on the surface of the tablet core through a bottom-spraying type fluidized bed to form a wet adhesion layer, and then spraying probiotic microcapsules to form a probiotic microcapsule inlaid layer, so as to obtain a probiotic tablet core; (2) spraying a gastric-soluble coating liquid to form a coating layer, and obtaining the tripterygium glycosides tablet.

The invention belongs to the technical field of solid beverage preparation, and particularly relates to a heart-nourishing and mind-tranquilizing solid beverage and a preparation method thereof. The active ingredients of the solid beverage are prepared by mixing and decocting tremella, Chinese yam, hawthorn, spina date seed, poria cocos, astragalus membranaceus and fructus alpiniae oxyphyllae and fermenting with streptococcus thermophilus and bifidobacterium animalis compound zymophyte, and the effects of nourishing heart and tranquilizing mind are synergistically enhanced by nourishing heart and spleen, soothing liver and regulating qi, calming heart and stabilizing mind and the like; the active components are embedded by adopting a modified polyethylene glycol and stearic acid compound and can be quickly dissolved in warm water, and then pregelatinized starch with relatively strong hydrophilicity is sprayed as a shell, so that the particles can be quickly wetted in water, powder floating is avoided, and the particles are quickly dissolved; the inner layer modified polyethylene glycol and stearic acid compound and the outer layer pre-gelatinized starch cooperate to realize moisture resistance at normal temperature and quick dissolution in warm water, so that the preservation time is prolonged, and the capsule is convenient and quick to take after being mixed with water.

To provide a seasoning liquid for heat cooking, an ingredient-containing seasoning and a food, capable of reducing astringency even in vegetables having strong astringency in heat cooking or heat processing, and further suppressing grassy smell peculiar to the vegetables.SOLUTION: A seasoning liquid or an ingredient-containing seasoning containing the seasoning liquid contains a seasoning component, 0.08 to 2% by mass of gelatinized rice flour and / or rice flour-derived gelatinized starch, 0.8 to 20% by mass of fats and oils, 1 to 10% by mass of starch and / or processed starch (excluding rice flour-derived gelatinized starch) in total, and 0.05 to 1.5% by mass of gums in total, and satisfies the following Mathematical Formula (I) when the total content of the starch and the processed starch is x% by mass and the total content of the gums is y% by mass: The food is obtained by cooking or heat-processing vegetables.SELECTED DRAWING: None

The invention provides a moxa cone formula adaptive to automatic production and a preparation method, the moxa cone formula adaptive to automatic production comprises the following components in parts by mass: 91-95 parts of moxa, 1-3 parts of a flow aid, and 3-8 parts of a composite binder; the flow aid comprises a first flow aid and a second flow aid, the first flow aid comprises turmeric powder and bighead atractylodes rhizome powder, and the second flow aid comprises corncob powder; the composite binder comprises a first composite binder and a second composite binder, the first composite binder comprises agilawood powder and sandalwood powder, and the second composite binder comprises at least one of wormwood stalk extract, pregelatinized starch, rosin powder, pine needle powder and Chinese fir powder; wherein the number of parts of the first flow aid is larger than that of the second flow aid, and the number of parts of the first composite binder is larger than that of the second composite binder.

This invention provides a pharmaceutical composition containing hezemibrate and an HMG-CoA reductase inhibitor, and may further include one or more excipients selected from calcium carbonate, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, sodium lauryl sulfate, polysorbate, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, hydroxypropyl cellulose, lactose, pregelatinized starch, magnesium stearate, and talc. This composition can be formulated into various dosage forms, exhibiting good formulation stability and controllable quality.

The invention discloses a high-elasticity composite gel cat litter particle based on aeolian sand modification and a preparation method thereof. The dust suppressant is prepared from the following components in parts by weight: 60-90 parts of modified aeolian sand, 8-12 parts of super absorbent resin, 10-20 parts of bentonite, 3-7 parts of zeolite, 8-12 parts of corn pregelatinized starch and 0.5-1.5 parts of a dust suppressant. After the product encounters water or urine, a compound urine group with high-strength elastic gel characteristics is formed, when the compound urine group is in contact with the surface of a cat litter basin, an elastic interface is formed due to surface energy difference, the compound urine group is elastically deformed instead of rigid adhesion when being stressed, the compound urine group can be completely separated by slightly shoveling, and basin sticking is completely eradicated. A hydrophilic layer on the surface of the modified aeolian sand greatly shortens a moisture permeation path, capillary channels among aeolian sand particles and a super absorbent resin network form a double-channel water delivery system, the water absorption rate is high, and the water absorption rate is high.

The invention relates to the technical field of pharmaceutical preparations, in particular to a methylprednisolone pulse micro-tablet and a preparation method thereof. The methylprednisolone pulse microtablet comprises a quick release tablet core and a coating layer, the quick-release tablet core comprises methylprednisolone, a filler, an antistatic agent A, an antistatic agent B, an adhesive and a lubricant; the coating layer comprises a coating material and a plasticizer; wherein the antistatic agent A is selected from at least one of a combination of organic acid and bicarbonate or ammonium carbonate; the antistatic agent B is selected from at least one of polyoxyethylene, carbomer, high-expansion type pregelatinized starch, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, croscarmellose sodium and crospovidone. The antistatic agent A and the antistatic agent B have a synergistic effect, so that the electrostatic phenomenon can be effectively reduced, and particle adhesion and microchip agglomeration are avoided.

The application discloses a pre-gelatinized starch / calcium-containing mineral-berberine compound and a preparation method and application thereof, and comprises the following steps: mixing an organic acid salt or an inorganic acid salt, starch and water, and performing microwave treatment to obtain a starch-salt colloid solution; mixing calcium salt, berberine and ethanol to obtain an ethanol solution containing berberine and calcium salt; adding the starch-salt colloid solution into the ethanol solution containing berberine and calcium salt, stirring and reacting, performing retrogradation treatment, centrifuging to obtain a precipitate, and drying to obtain the compound. The application combines the starch "gelatinization-retrogradation" mechanism and the calcium-containing mineral biomimetic mineralization method, completes the encapsulation of berberine, and prepares the berberine compound with the pre-gelatinized starch / calcium-containing mineral as a drug delivery system, so that the berberine compound has a high drug encapsulation rate, the gastrointestinal stability of the berberine is remarkably improved, a good sustained-release effect is generated, the bioavailability of the berberine is improved, and a new way is provided for the clinical application of the berberine.

The invention discloses an instant probiotic popping bead shrimp meat sausage which is prepared by chopping, stirring, mixing and filling the following components in parts by weight: 85-90 parts of shrimp meat, 10-13 parts of probiotic popping beads, 8-12 parts of auxiliary materials, 0.06-0.08 part of zinc gluconate, 0.0008-0.001 part of vitamin D3, 6-8 parts of pregelatinized starch, 1-3 parts of sodium alginate and 5-8 parts of ice water. Probiotic popping beads are added in the preparation process of the shrimp meat sausage, and the probiotic popping beads are prepared by performing double-layer embedding on probiotic suspension liquid prepared from three kinds of probiotic powder of bacillus coagulans, lactobacillus plantarum and bifidobacterium by using an embedding layer prepared from sodium alginate, chitosan and casein. The prepared instant probiotic popping bead shrimp meat sausage is high in protein content and low in fat content, the contained probiotic popping beads can regulate intestinal flora balance, nutrition and health are achieved, the preparation method is simple, and the instant probiotic popping bead shrimp meat sausage is suitable for large-scale production.