36results about How to "Good disintegration time" patented technology

Pharmaceutical compositions comprising one or more medicaments in a pharmaceutically acceptable effervescent formulation. The effervescent formulation includes a first gas-dispersing component and a second gas-generating effervescent component, wherein at least one first gas is released from the first gas-dispersing component and at least one second gas is generated and evolved from the second gas-generating effervescent component, upon contact with a minimal amount of water. The formulation is placed in an aqueous vehicle wherein the formulation effervesces gases causes penetration, dispersion and distribution of the medicaments in the vehicle. The vehicle, which may be any ordinary food or beverage chosen by the patient, is then ingested by the patient for delivery of a dosage of the medicaments.

The invention provides a glyphosate dry suspension and a preparation method and application thereof. The glyphosate dry suspension is prepared by using the following components in percentage by mass: 30-85 percent of glyphosate, 2-20 percent of wetting agent, 1-20 percent of dispersing agent, 0.1-5 percent of defoaming agent, 1-5 percent of bonding agent, 1-10 percent of disintegrating agent and balance of carrier, wherein the disintegrating agent comprises one or a plurality of urea, sodium chloride, sulfate, carbonate and sodium carboxymethylcellulose. The glyphosate dry suspension provided by the invention has relatively excellent stability and disintegrating property through the proportioning of the components with the contents; the content of effective components is higher; the control efficiency is higher; according to experimental results, after 14-day heated storage, no particles occur in more than 60 percent of the glyphosate dry suspension after screening; the suspension rate highly reaches 96.4 percent; the disintegrating time is 29-124s; the control efficiency is 88-99.05 percent after 14 days after application; the control efficiency is 88-99.72 percent after 28 days after application.

The invention discloses lyophilized orally disintegrating tablets of trelagliptin succinate and a preparation method thereof. Trelagliptin succinate is used as a medicament active component, and the tablets comprise the following raw materials and auxiliary materials by weight: 2-75% of trelagliptin succinate, 10-85% of a frame supporting agent, 2-55% of an adhesive, 0.5-55% of a suspending agent, 0.5-30% of an anti-oxidant, 0.2-10% of a corrigent, a proper amount of a pH regulator, and a proper amount of injection water. The lyophilized orally disintegrating tablets are prepared by a lyophilization device. The lyophilized orally disintegrating tablets has the advantages of fast disintegration speed, high dissolution rate, good stability, usage convenience, portability, and substantially enhanced medication compliance of patients.

The invention discloses a vortioxetine freeze-dried orally disintegrating tablet and a preparation method thereof. The vortioxetine freeze-dried orally disintegrating tablet with the vortioxetine as an active pharmaceutical ingredient comprises, by weight, 2%-75% of vortioxetine, 10%-85% of a skeleton supporting agent, 2%-55% of binder, 0.5%-55% of a suspending agent, 0.5%-30% of antioxidant, 0.2%-10% of corrigent, a defined amount of pH regulator and a defined amount of injection water. The vortioxetine freeze-dried orally disintegrating tablet is prepared through a freeze-drying device and has the advantages of being high in disintegrating speed, high in dissolution rate, good in stability and convenient to take and carry, and the compliance of a patient to take medicine is greatly improved.

Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions using solventless mixing methods. Excess coating material that is not bound to a coated API particle may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Specifically, a coating ratio and/or a dosing ratio can be used to minimize the residual amount of excess unbound coating material to minimize agglomeration of coating material during storage. In some embodiments, a pharmaceutical composition is provided, the pharmaceutical composition comprising: 65-85 % w/w API particles; 15-30 % w/w coating material coating the API particles; and 3-15 % w/w matrix surrounding the coated API particles, wherein the pharmaceutical composition comprises a disintegration time rate of less than 10 seconds for at least six months under storage conditions of at least 25° C. and at least 60 % relative humidity.

Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising Ibuprofen using solventless mixing methods. Excess coating material that is not bound to coated Ibuprofen may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Additionally, the compositions can be formulated to preserve the functional coating of coated Ibuprofen and to minimize aeration of Ibuprofen when mixed into suspension.

The invention belongs to the field of medicinal preparations, and particularly relates to a honeysuckle throat clearing formula and a tablet preparation method thereof. The honeysuckle throat clearing tablets contain medicament extract and pharmaceutically acceptable diluting agent, lubricating agent and disintegrating agent. The honeysuckle throat clearing tablets prepared by the invention have a better treatment effect on acute pharyngitis.

The invention discloses a preparation method of a soft capsule for treating hysteritis, including the following steps: three medicines, namely, 167 parts of callicarpa kwangtungensis dry extract, 44 parts of motherwort dry extract and 39 parts of radix linderae dry extract are ground into fine powder and evenly blended to obtain dry extract powder; the dry extract powder is added with the mixture of polyethylene glycol 400 and polyethylene glycol 4,000 which accounts for 8% of the total weight of finished products, the proportion of the dry extract to the mixture of polyethylene glycol 400 and 8% polyethylene glycol 4,000 is 1:1.5 to 2; the preparation of a capsule shell is as follows: gelatin liquid is prepared according to the proportion that gelatin: water: glycerin is 1:1:0.4, put into a gelatin dissolving tank and the temperature is set to be 70-80 DEG C; when the gelatin liquid is completely melted, the temperature is set to be 55-65 DEG C and is maintained for about 8 hours. Then pelleting, shaping, drying and packaging are carried out. The soft capsule can prevent air oxidation and moisture absorption and has the advantages of short disintegration time, no leakage of medicine, good stability, high utilization rate and good curative effect.

The invention provides buccal tablets. The buccal tablets contain plant exosome components, antioxidant components, whitening components, stearic acid, hydroxyproline and pectin. The buccal tablets provided by the invention have significantly shortened disintegrating time; and the buccal tablets are very good in antioxidant effects, anti-wrinkle effects and whitening effects.

The present invention provides a hydroxyalkyl cellulose having a viscosity of 1.10 to 1.95 mPas in a 2%-concentration aqueous solution at a temperature below 20 DEG C, and a solid preparation containing the same.

The invention provides a water-soluble tablet of a fluorescent brightener 351. The water-soluble tablet contains the fluorescent brightener 351, a binder, a wetting agent, a disintegrating agent, a dispersing agent, an effervescing agent and a filling agent. All the components are mixed and crushed and are tabletted by using a direct powder compression method. Compared with the traditional dosage form, the water-soluble tablet is better in whitening effect, safe and convenient in use and transportation, beneficial to storage and container configuration and little in environment pollution.

The present invention relates to rapidly disintegrating oral dosage forms, more particularly to rapidly disintegrating tablets containing (1S ,2S ,3R,5S)-3-[7-{[1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-3H-[1,2,3]-triazolo[4,5-d]pyrimidin-3-yl]-55-(2-hydroxyethoxy)cyclopentane-1,2-diol and a disintegrating excipient. Blister packs suitable for use with the rapidly disintegrating oral dosage form are also disclosed.

The invention relates to the technical field of soft capsule shell materials, in particular to a plant-based soft capsule shell and a preparation method and application thereof. The plant-based soft capsule shell comprises a hydroxypropyl starch/lactic acid graft copolymer, a cellulose/polylactic acid graft copolymer, a plasticizer, gel, edible pigment and water, wherein the substitution degree ofthe hydroxypropyl starch is not higher than 0.58, and the grafting rate of lactic acid to the hydroxypropyl starch is 14-25%. The main material of the soft capsule shell is derived from plants, and has extremely excellent disintegration time limit, and is beneficial to rapid release of the capsule in an organism. The soft capsule shell has excellent performance in the aspects of friability, disintegration time, tensile strength, elongation at break and the like, and meanwhile, and has excellent ageing resistance and remarkably-prolonged storage life.

Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions comprising coated API. Excess coating material that is not bound to coated API may be removed by a sieving process. Coating and dosing ratios can also be optimized to minimize the amount of excess unbound coating material. Additionally, the compositions can be formulated to preserve the functional coating of coated API and to minimize aeration of API when mixed into suspension.

The invention discloses a method for preparing a spleen-tonifying stomach-harmonizing healthcare product. The method comprises a step of weighing an excipient, lalang grass rhizome, radix bupleuri, astragalus membranaceus, gynostemma pentaphylla, carthamus tinctorius, nepal dock leaves, rhizoma anemarrhenae, phyllodium elegans, geranium robertianum, alum, motherwort fruits, scindapsus officinalisschott, sage and radix scrophulariae. The product is capable of tonifying spleen and harmonizing stomach, clearing lung and brightening eyes, nourishing spleen and tonifying stomach, brightening facecolor and prolonging life as well as tonifying kidney and strengthening yang, is simple in preparation method, low in cost, good in operability, free of environment pollution, safe and environmentallyfriendly, short in disintegration time, good in decomposition state, easy to absorb, rapid in effect taking and free of conspicuous toxic or side effect; due to synergetic effects of the radix scrophulariae and the lalang grass rhizome, functions of generating body fluid and tonifying lung, refreshing mind and clearing dizziness, expelling wind and removing coldness, improving vigor, protecting liver and preventing cancer and preventing dementia can be achieved; due to the synergetic functions of the components in the formula, effects of nourishing spleen and tonifying stomach, replenishing vital essence and improving eyesight and improving vigor can be achieved, and the product can be adopted to treat mouth sore, cough and excessive phlegm, chronic diarrhea and movement disability, and can be widely produced to replace conventional materials continuously.