Hydroxyalkyl cellulose

A technology of hydroxyalkyl cellulose and solid preparations, which is applied in the field of hydroxyalkyl cellulose, can solve the problems of reduced binding force and lower drug layering efficiency, achieve sufficient tablet strength, good disintegration time, and improve drug quality. The effect of stacking efficiency

Active Publication Date: 2013-07-31
NIPPON SODA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if a coating agent with low binding force is used, the binding force between the core particles and the drug particles becomes smaller, and the drug particles coated on the core particles are easy to peel off, which reduces the drug layering efficiency.

Method used

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  • Hydroxyalkyl cellulose
  • Hydroxyalkyl cellulose
  • Hydroxyalkyl cellulose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Hydroxypropyl cellulose having a viscosity of 2.2 mPa·s in a 2% concentration aqueous solution at 20° C. was dissolved in water at a concentration of 15%. The aqueous solution was heated to about 62°C. Part of the hydroxypropyl cellulose was gelled and precipitated. Aliquot the supernatant. Dilute the supernatant with water to obtain a 2% aqueous solution of hydroxypropyl cellulose. The viscosity at 20°C was 1.70 mPa·s. Water was removed from the above supernatant to obtain hydroxypropylcellulose.

Embodiment 2

[0098] By the same method as in Example 1 except that the heating temperature was changed to 58° C., hydroxypropyl cellulose having a viscosity of 1.84 mPa·s in a 2% aqueous solution at 20° C. was obtained.

Embodiment 3

[0100] By the same method as in Example 1 except that the heating temperature was changed to 55° C., hydroxypropyl cellulose having a viscosity of 1.93 mPa·s in a 2% aqueous solution at 20° C. was obtained.

[0101] Evaluation of the coated particles was carried out in the following manner.

[0102] (agglomeration rate)

[0103] The particle size distribution of the CCSS-coated particles was measured using an electromagnetic shaker (manufactured by Tsutsui Chemical Instruments Co., Ltd., sample input amount: 1 g). Particles in each portion were observed with a digital microscope, and as a result, the portion above the inflection point in the log-normal probability graph of the cumulative % under sieve was confirmed to be an aggregate. Therefore, the ratio of the amount of particles sieved above the inflection point to the total amount of particles was set as the aggregation rate.

[0104] (drug layering efficiency)

[0105]10 mg of the CCSS-coated particles were placed in a...

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Abstract

The present invention provides a hydroxyalkyl cellulose having a viscosity of 1.10 to 1.95 mPas in a 2%-concentration aqueous solution at a temperature below 20 DEG C, and a solid preparation containing the same.

Description

technical field [0001] The present invention relates to hydroxyalkylcelluloses. It relates to a hydroxyalkylcellulose suitable for the production of an orally disintegrating agent, a gastric-soluble solid preparation, an enteric-soluble solid preparation, a sustained-release solid preparation, and a bitterness-suppressing solid preparation. [0002] this application claims priority based on Japanese Patent Application No. 2010-270172 for which it applied to Japan on December 3, 2010, The content is used here. Background technique [0003] Oral disintegrants, etc., have been developed and manufactured in pursuit of the bitterness masking and ease of administration of dry syrups by using coated particles that coat core particles with a particle size of 100 μm or less with drug particles. In addition, the use of core particles with a particle size of 100 μm or less has attracted attention as a drug delivery system for oral administration, injections, and the like. [0004] A ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B11/08A61K9/20A61K47/38
CPCC09D101/284A61K9/5078C08B11/20A61K9/1652A61K9/20C08L1/284A61K9/2054A61K47/38C08B11/08A61K9/1676A61K9/2866A61K9/5047
Inventor 阿部悟加藤隆
Owner NIPPON SODA CO LTD
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