The invention belongs to the field of chemical pharmacy, and in particular relates to an effervescent preparation of isatidis vitamin C and a preparation method thereof. The invention is prepared by adding Radix Radix Radix Extract Powder and vitamin C with auxiliary materials such as acid, alkali, filler, flavoring agent and lubricant. Through optimization and screening, the present invention determines the reasonable ratio of the main drug, auxiliary materials and disintegrants. The preparation has strong stability, high effective content, short effervescent time, and the liquid medicine after effervescence has good clarity and taste. Well, the preparation process of the present invention is simple, the method is controllable, and the quality is stable. The effervescent tablet of the present invention can be compressed into a large round plain tablet or coated with a film, or compressed into a special-shaped tablet or a slow-controlled effervescent preparation. It is proved by experiments that the preparation of the invention can significantly increase the solubility of the drug, has good solubility, can be better absorbed by the human body, and has good market development prospects.