The invention discloses dextral ibuprofen amino acid salt tablets and a preparation method thereof. The tablets are prepared from the following raw materials in part by weight: 1 part of dextral ibuprofen amino acid salt, 0.2 to 20 parts of diluent (or filler), 0.01 to 1 part of adhesive, 0.01 to 1 part of disintegrating agent, 0.01 to 1 part of flavoring agent and 0.001 to 0.1 part of lubricating agent. Wet granulation, dry granulation and tabletting or direct powder tabletting and tablet coating are adopted in the preparation process of the tablets. Based on the dextral ibuprofen, the specification of the tablets can be 30 to 300 milligrams, preferably 37.5 milligrams or integral multiple of 37.5 milligrams. The dextral ibuprofen amino acid salt serving as an effective ingredient of the tablets has the advantages of quick response, accurate dose, low side effect and small individual difference. The tablets can be prepared into common tablets, chewable tablets, effervescent tablets, soluble tablets, oral fast dissolving tablets, sugar coated tablets, film coated tablets and the like.