Ribavirin dissolvable tablet for infant

A tablet-dissolving and pediatric technology, which is applied in pill delivery, respiratory diseases, organic active ingredients, etc., can solve problems such as difficult dosage operation, and achieve high bioavailability and fast onset of effect

Inactive Publication Date: 2008-06-04
何德义
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the "administration and dosage" items in the instruction manuals of various ribavirin preparations on the domestic pharmaceutical market all stipulate that when used in children, 10 mg to 15 mg per kilogram of body weight per day s...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0030] The focus of the present invention is to allow each child who needs to take ribavirin preparations to easily obtain the most suitable dosage for them through innovative specifications and styles of products, so as to achieve the purpose of safe, effective and convenient treatment . Relatively, the types and dosages of excipients under specific specifications, and even whether they are soluble tablets, effervescent tablets, or buccal tablets, are not the most important.

[0031] (1) Take 5g to 10g of ribavirin, feed certain excipients in an appropriate proportion, carry out wet or dry granulation in a certain way, and then press into 1000 tablets, or mix all the main ingredients and The dry powder of the auxiliary material is directly mixed and pressed into 1000 tablets. The tablets made according to this plan are taken 2 times a day, 1 tablet per 1 kg of body weight each time.

[0032] (2) Take 10g to 15g of ribavirin, feed certain excipients in an appropriate proport...

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PUM

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Abstract

The invention relates to a ribavirin soluble tablet which is a specification special for children, the components of which include effective dosage of ribavirin and the water-soluble medicinal excipient which can rapidly disintegrate in water and release medicine. When the tablet is taken by patients, the dosage of administration can be determined according to the weights of patients, therefore, the intake dosage of medicine can be more accurate and the safety can be improved. The invention is a beverage with sweet and sour taste when being dissolved, so the invention is easy to be accepted by children in term of the way of administration. Meanwhile, the solution of the medicine is beneficial for full absorption and is high in bioavailability.

Description

1. Technical field [0001] The invention belongs to the field of pharmaceutical preparations. It specifically relates to an oral formulation of ribavirin specially designed for children, specifically a soluble tablet of ribavirin for children. 2. Background technology [0002] The chemical name of ribavirin is 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide. It is a colorless or white crystalline powder, odorless and tasteless, and is a broad-spectrum antiviral drug. Its mechanism of action is mainly through the inhibition of inosine dehydrogenase, blocking the conversion of inosine-phosphate to xanthine-phosphate, inhibiting nucleic acid synthesis, and preventing virus replication. Clinically, it is mainly used to prevent and treat a variety of viral respiratory infections and other viral infections, such as influenza and herpes zoster. [0003] At present, the "administration and dosage" items in the instruction manuals of various ribavirin preparations on the domestic ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/7056A61P31/12A61P11/00
Inventor 何德义
Owner 何德义
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