The invention relates to a
rebamipide TBPH
ion pair compound freeze-dried flash release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Comprising the following components in parts by weight: 80-90 parts of a
rebamipide TBPH
ion pair compound, 60-100 parts of a proppant, 8-20 parts of a stabilizer, 8-15 parts of an
acidulant, 1-5 parts of a
sweetening agent and 3-8 parts of a flavoring agent. The
rebamipide TBPH
ion pair compound has the advantages that in order to improve the
solubility and
bioavailability of rebamipide, the rebamipide is firstly prepared into the rebamipide TBPH ion pair compound, so that the hydrophilicity and
lipophilicity of the rebamipide TBPH ion pair compound are effectively improved, the
solubility of the rebamipide TBPH ion pair compound in water or lipid can be remarkably improved, and then quick release and
dissolution are realized through a freeze-
drying technology; the tablet can be rapidly disintegrated and dissolved in a short time, is good in molding, free of
cracking and collapse phenomena, free of water during taking, convenient to take, instant to dissolve in the mouth, good in taste, free of grit feeling, free of peculiar smell, convenient to take by a patient, rapid in effect taking, capable of reducing
waiting time after taking, and capable of improving the
bioavailability of the tablet.