266results about How to "Retain efficacy" patented technology

Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

Shaped articles made with a partially crystalline, cycloolefin elastomer of norbornene and ethylene typically having at least one glass transition temperature (Tg) in the range of from −10° C. to 15° C. and a crystalline melting temperature in the range of from 60° C. to 125° C. and a % crystallinity by weight in the range of from 5% to 40%. The shaped articles may be in the form of medical tubing; a contact lens mold or component thereof; a container such as a bottle, a squeeze bottle or a squeeze tube; an eyedropper or eyedropper component; an elastomeric closure, optionally a pierceable elastomeric closure or the shaped article is selected from shrink film and/or shrink tubing.

The invention discloses rose vinegar. A process method of the rose vinegar includes: subjecting roses serving as raw materials to dry crushing, extraction by edible alcohol, alcoholic strength adjustment, acetic fermentation, clarifying, ageing, filtering, mixing, filling and sterilization so that a rose vinegar finished product is obtained. The rose vinegar fully retains nutrition and efficacy of the roses, is rich in multiple amino acids, vitamins, mineral substances and antioxidant components of polyphenol, flavone and the like, and has the efficacy of detoxification, keeping young, promoting qi to activate blood, inducing resuscitation, removing stasis, soothing the liver, refreshing the mind, promoting biliation, easing digestion and regulating mechanism. The rose vinegar is free from addition of any spice and chemical component, rich in nutrition, sweet in aroma and suitable for ladies to drink and has the efficacy of maintaining beauty and keeping young.

Corticosteroid microparticle formulations are provided for use for treating pain, including pain caused by inflammatory diseases such as osteoarthritis or rheumatoid arthritis, and for slowing, arresting or reversing structural damage to tissues caused by an inflammatory disease, for example damage to articular and/or peri-articular tissues caused by osteoarthritis or rheumatoid arthritis. Corticosteroid microparticle formulations are administered locally as a sustained release dosage form (with or without an immediate release component) that results in efficacy accompanied by clinically insignificant or no measurable effect on endogenous cortisol production.

Disclosed herein are novel siRNA-cochleate and morpholino-cochleate compositions. Also disclosed are methods of making and using siRNA-cochleate and morpholino-cochleate compositions.

The invention discloses an all-shaddock fermentation drink and a production method thereof. The production method comprises the steps of separating the pulp and peels of shaddock, separately adding acid and enzyme for treatment, then adding sugar, heating for sterilizing, then leading into lactobacillus and active dry yeast, and fermenting to obtain fermentation liquor; mixing the pulp fermentation liquor and peel fermentation liquor, then adding gum, a sour agent, a sweetening agent, dietary fiber and vitamin C, and heating for sterilizing to obtain the all-shaddock fermentation drink. After being fermented by the lactobacillus and saccharomyces cerevisiae, the shaddock peel and pulp not only maintain the original flavor and effect of the shaddock, but also are endowed with the fermented flavor effect of the lactobacillus and saccharomyces cerevisiae. In addition, soluble dietary fiber is further added into the fermentation drink and plays roles in smoothing intestinal tract and detoxifying and the like. The all-shaddock fermentation drink is proper in sour taste, mellow and clear and sweet, has special aroma and mouthfeel, as well as the effects of wetting the throat and smoothing the intestinal tract.

The invention discloses a brewing method of grapefruit wine. The brewing method is characterized in that the whole grapefruit is used as the raw material, soluble solid, alcohol content and sensory evaluation are used to research influence of different pretreatment methods and yeasts on fruit wine fermentation, and strain capability evaluation tests show that yeasts SY and BV818 which are high in fermentation capability, high in wine yield and good in taste have high acid resistance, potassium metabisulfite resistance, sugar resistance and alcohol content resistance and are optimal strains for brewing the grapefruit wine. The free radical removing ability of the grapefruit wine brewed by the method reaches 73.69%, and the FRAP value of the grapefruit wine reaches 196.60mmol Fe<2+>/L; the grapefruit wine has the special fragrance and taste of the grapefruit and has effects of moistening the throat and dredging the intestines. The brewing method has the advantages that resources are utilized reasonably, grapefruit processing is further deepened, fruit wine varieties are enriched, grapefruit peel resources are utilized comprehensively, and the method is good in social and economic benefits.

Compounds and methods for utilizing compounds comprising a superoxide dismutase mimetic covalently linked to polyethylene glycol. Methods are also provided for preparing a superoxide dismutase mimetic covalently linked to a polyethylene glycol, the methods comprising reacting an activated polyethylene glycol with a superoxide, dismutase mimetic, or alternatively, reacting a superoxide dismutase mimetic with an activated polyethylene glycol. A method is also provided for preventing or treating a disease or disorder in which superoxide anions are implicated, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound comprising a superoxide dismutase mimetic covalently linked to a polyethylene glycol. Methods of determining the safety and efficacy of the compounds ere also provided. Methods for determining the safety and efficacy can include methods in lab animals and humans.

The invention discloses snow pear-osmanthus fragrans jam which is prepared from the following raw materials in percentage by weight: 30-40% of snow pears, 20-30% of high fructose syrup, 10-20% of water, 20-30% of white granulated sugar, 0.6-0.8% of osmanthus fragrans, 3-10% of a thickener, 0.2-0.8% of citric acid, 0.2-0.8% of malic acid, 0.05-0.5% of sodium citrate, 0.01-0.1% of a preservative, 0.001-0.01% of a pigment, 0.1-0.8% of pear essence and 0.1-0.8% of osmanthus fragrans essence, wherein the ratio of the snow pears to the osmanthus fragrans is 50:1. The invention further discloses a preparation method and application of the snow pear-osmanthus fragrans jam. During preparation, the snow pears with health efficacy is added for being matched with the fresh osmanthus fragrans, so that the snow pear-osmanthus fragrans jam is bright in color and lustre, fresh in fragrance, fine in taste, sour and sweet, and delicious; through scientific compatibility of the snow pears, the osmanthus fragrans and other raw materials, not only are the double fragrant tastes of the snow pears and the osmanthus fragrans kept, but also the tastes and the efficacy of the osmanthus fragrans and the snow pears are perfectly combined; meanwhile, the health function of moistening the lung to arrest cough is improved. Therefore, the snow pear-osmanthus fragrans jam has high values of nutrition and health, and serves as environment-friendly, healthy and natural food with a novel taste.

The invention discloses a flavoniodes processing technology which comprises the following steps of: (1) timely cleaning and selecting fresh picked flavoniodes; (2) loading the flavoniodes in the same day according to the loading amount of 2-8 kg/m2, and performing hot air drying treatment on the flavoniodes within 3 hours under the condition of setting the temperature at 60-80 DEG C and the wind speed of 2.0-3.0 m/s, regularly measuring the real-time mass of the material in a drying process, and calculating dry-basis water content until the water content of a sample is less than 12 percent, wherein the drying time is 3-6 hours; (3) detecting effective components, the water content, the total ash amount, acid non-soluble ash and extracts, and after the values reach set indexes, performing the step (4); and (4) packaging and storing the flavoniodes. By the processing technology for obtaining the flavoniodes, the drying time is short, and energy is saved; the sanitation degree is high; the limitation caused by the weather condition is avoided; the phenomena of difficult in harvesting and yield reduction are avoided; the original colors of fresh flowers are greatly retained; and the medicinal effects and the active components of the flavoniodes are well retained.

The invention relates to randia cochinchinensis paste for stimulating the appetite. The randia cochinchinensis paste is prepared from the following medicines in parts by weight: 135-145 parts of randia cochinchinensis fruits, 80-95 parts of dried orange peel, 65-70 parts of water chestnuts, 50-65 parts of collybia albuminosa, 45-60 parts of haws, 40-55 parts of pseudo-ginseng, 40-45 parts of radix astragali, 30-35 parts of chili paste, 30-40 parts of red jujubes, 35-50 parts of Chinese wolfberry fruits, 5-10 parts of a soy sauce, 5-10 parts of distilled liquor, 1-5 parts of rice vinegar, 5-10 parts of vegetable oil, 10-15 parts of garlic cloves, 10-15 parts of fresh ginger and 1-5 parts of table salt. The invention further discloses a preparation method of the randia cochinchinensis paste. The randia cochinchinensis paste disclosed by the invention is outstanding in mouth feel, outstanding in nutrition, unique in taste, rich in mouth feel and appropriate in pepperiness; the eating field of randia cochinchinensis is greatly extended, and the randia cochinchinensis paste can be widely used for cooking means of steaming, frying, mixing, dipping and the like; the randia cochinchinensis paste has the effects of stimulating the appetite and promoting digestion; and the preparation method is simple and practicable, and convenient to operate, and specific efficacies and fragrance of the randia cochinchinensis are reserved.

The invention discloses a Noni handmade soap having bacterium resistance and acne removal functions and a preparation method thereof. The handmade soap comprises the following raw materials in parts by weight: 0.5-6 parts of Noni extract, 0.25-3 parts of peppermint leaf extract, 8-18 parts of brown sugar, 19-43 parts of glycerol, 8-18 parts of deionized water, 10-35 parts of coconut oil, 6-16 parts of olive oil, 10-26 parts of shea butter and 240-380 parts of natural soap base. The preparation method comprises the following steps: primary mixing, secondary mixing, curing and demolding. The handmade soap disclosed by the invention can be used for face skin cleaning, has the effects of removing acne, sterilizing, diminishing inflammation and nourishing skin, and causes no irritation to skin; and the preparation method disclosed by the invention furthest retains the effects and nutrients of the components.

The invention discloses pomegranate effervescent tablets and a preparation method thereof. The pomegranate effervescent tablets comprise the components of pomegranate powder or pomegranate juice, nutrient supplements, a filling agent, a disintegrating agent, a lubricating agent, a sweetener and aromatic. The tablets are quick in disintegration and high in solubility, the active ingredients are fully utilized, the mouthfeel, color and effect of the pomegranate are kept, and the tablets has the characteristics that the tablets are convenient to carry, instant to drink and suitable for the old and the young. According to the pomegranate effervescent tablets, the additional value of the pomegranate is increased, so that the utilization value is effectively improved, and the market prospect is wide.

The invention discloses camel blood polypeptide effervescent tablets and a preparation method thereof. Camel blood polypeptides serve as a raw material, citric acid or/and malic acid, sodium bicarbonate, polyvinylpyrrolidone, lactose or/and mannitol, stevioside or aspartame and polyethylene glycol 8000 serve as auxiliary materials, and after mixing, blending, sterilizing and tabletting are performed, the camel blood polypeptide effervescent tablets are obtained. The camel blood polypeptide effervescent tablets have the immunity enhancing function, the anti-oxidation function, the anti-fatigue function and other functions and have the advantages of being sour and sweet in taste, capable of being easily absorbed by the human body, convenient to preserve and carry, high in bioavailability and the like.

The invention relates to a co-production method of polyphenols, pigments, tannin, procyanidins and wood powder through Chinese chestnut buds. Chinese chestnut buds are smashed into 30-80 meshes, Chinese chestnut bud powder and alkaline deionized water are added into a tank, subjected to microwave radiation and stirred and extracted for three times, a water extract solution is separated through various films, polyphenols, pigments, tannin, procyanidins and wood powder are obtained after concentration and drying, and filter residues are dried into wood powder. By means of the scheme, comprehensive utilization of waste Chinese chestnut bud resources can be achieved, and the method belongs to the clean and efficient pollution-free ecological mode industry.

The invention discloses a method for reducing loss of anthocyan of blueberry fruit juice in a processing course. The method comprises the following steps of (1) cleaning blueberries, and performing mashing to obtain blueberry slurry; (2) regulating the pH value of the blueberry slurry, adding zinc lactate, malic acid, glutathione, tea polyphenols and a grape seed extract to the blueberry slurry, and then adding complex enzymes; (3) after performing enzymolysis on the blueberry slurry, performing filtering, adding cane sugar, lactose, sodium citrate, trehalose, beta-cyclodextrin, arabic gum, xanthan gum and sodium carboxymethyl cellulose and performing allocation; (4) homogenizing the allocated fruit juice, and then performing vacuum degassing; and (5) sterilizing the degasses blueberry fruit juice and performing filling. In accordance with special functional components of the anthocyan in the blueberries, in the processing course of the blueberry fruit juice, in two respects that processing factors are controlled, and the self molecular structure stability is improved, the degradation loss of the anthocyan in the blueberries is reduced, the efficacy is reserved, the color deterioration is alleviated, the product quality is improved, and a blueberry fruit juice product high in anthocyan content is developed.

The invention discloses a nymphaea hybrid extract and application of a nymphaea hybrid extract composition. The application includes preparation of food, healthy food and medicines for inhibiting pancreatic lipase activity and improving intestinal flora and preparation of food, healthy food and medicines for preventing obesity or reducing weight, wherein preventing obesity or reducing weight and lipid includes inhibiting pancreatic lipase activity, improving weight, regulating blood lipid and improving intestinal flora, and improving intestinal flora includes improving intestinal microorganism abundance and diversity and improving intestinal flora structures. The nymphaea hybrid extract composition is formed by combination of at least one of nymphaea hybrid extract, lotus leaf extract, green tea extract, semen cassiae extract and grape seed extract, wherein the weight content of the nymphaea hybrid extract in the compositiosn is larger than or equal to 20%.

The invention relates to a preparation process of a stomach invigorating and digestion helping tablet. The preparation process comprises the following steps of: extracting tangerine peel by using 75% ethanol, replacing half-quantity extraction of radix pseudostellariae and Chinese yam by combined extraction of full-quantity medicinal materials and other medicinal materials, further pelletizing by taking extractum as an adhesive through a one-step pelletizing technology, mixing and tabletting. According to the preparation process of the stomach invigorating and digestion helping tablet, the stomach invigorating and digestion helping tablet is prepared by carrying out full-quantity medicinal material extraction on the Chinese yam and the radix pseudostellariae and alcohol extraction on the tangerine peel, and the disadvantages of products produced by using the original processes are effectively avoided; effective constituents of the stomach invigorating and digestion helping tablet are easily absorbed and utilized by human bodies; the microbial limit standard exceeding problem of a finished product is effectively avoided, and the mouth feel of the stomach invigorating and digestion helping tablet is improved; by adopting the extraction by using the 75% ethanol, the content of aurantiamarin is nearly doubled or more, so that the content of the aurantiamarin which is a functional constituent in the preparation and the treatment effect of the tablet are substantially improved; all the medicinal materials are prepared into the extractum and pelletized by spraying, the fluidity of prepared particles is good, the appearance of the tablet is neat, the uniformly pressed tablet surface is uniform in color and luster and free of pocking marks and colored patches, and the appearance quality of the tablet is improved; and the quality is stable.

A honey based composition is described. The composition includes a mixture of honey, a short chain fatty alcohol and a fatty ester or wax. The composition has applications for use in wound dressings and in one embodiment may be a gel. The composition has a higher than expected storage stability, remaining stable for many weeks when held at elevated temperatures and retains all of the other desirable characteristics including anti-microbial activity.