193results about How to "Maintain efficacy" patented technology

New methods and systems for manufacturing a three-dimensional form, comprising steps of providing a plurality of particulates; contacting the particulates with an activation agent; contacting particulates having the activation agent with a binder material that is activatable by the activation agent; at least partially hardening the binder for forming a layer of the three-dimensional form; and repeating these steps to form the remainder of the three-dimensional form. Following sequential application of all required layers and binder material to make the form, the unbound particles are appropriately removed (and optionally re-used), to result in the desired three-dimensional form. The invention also contemplates a novel method for preparing a form, where unbound particulates free of binder material are re-claimed.

New methods and systems for manufacturing a three-dimensional form, comprising steps of providing a plurality of particulates; contacting the particulates with an activation agent; contacting particulates having the activation agent with a binder material that is activatable by the activation agent; at least partially hardening the binder for forming a layer of the three-dimensional form; and repeating these steps to form the remainder of the three-dimensional form. Following sequential application of all required layers and binder material to make the form, the unbound particles are appropriately removed (and optionally re-used), to result in the desired three-dimensional form. The invention also contemplates a novel method for preparing a form, where unbound particulates free of binder material are re-claimed.

New methods and systems for manufacturing a three-dimensional form, comprising steps of providing a plurality of particulates; contacting the particulates with an activation agent; contacting particulates having the activation agent with a binder material that is activatable by the activation agent; at least partially hardening the binder for forming a layer of the three-dimensional form; and repeating these steps to form the remainder of the three-dimensional form. Following sequential application of all required layers and binder material to make the form, the unbound particles are appropriately removed (and optionally re-used), to result in the desired three-dimensional form. The invention also contemplates a novel method for preparing a form, where unbound particulates free of binder material are re-claimed.

A method of preventing or treating constipation in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.

Contact killing antimicrobial articles, devices and formulations are described which kill microorganisms on contact. The articles, devices or formulations contain a non-leaching antimicrobial material which is a unique combination of an organic matrix having biocidal metallic materials non-leachably associated with the matrix. The antimicrobial material may used to form an antimicrobial coating or layer on a surface of the article or device, or may be dispersed in a vehicle or carrier to form a topical antiseptic or disinfectant, or solid shape having contact killing antimicrobial properties. When a microorganism contacts the article, device, or formulation, the biocidal metallic material is transferred to the microorganism in amounts sufficient to kill it.

A method of encoding a digital image signal comprising a plurality of samples. The method comprises the following steps, applied during the encoding of each sample with a view to its storage in a buffer. The level of occupancy of the buffer is determined, and the level of occupancy is compared with a predetermined threshold. An encoding mode is determined from among a plurality of encoding modes when the level of occupancy is above the predetermined threshold, and encoding the sample according to the determined encoding mode, and the sample is encoded according to a default encoding mode when the level of occupancy is below the predetermined threshold.

The present invention relates to a snack food-pumpking seed and its processing method. Said invention uses pumpking seed as raw material, uses jasmine flower as main ingredient and uses tea, licorice, edible salt, sweetening agent and water as auxiliary material, and makes them undergo the processes of screening, peeling, cooking, drying, stir-frying, cooling, spraying flavouring material, air-separating and packaging so as to obtain the invented product.

The binding specificity of the murine OKT3 has been transferred into a human antibody framework in order to reduce its immunogenicity. “Humanized” anti-CD3 mAbs, such as gOKT3-5 and gOKT3-7, have been shown to retain, in vitro, all the properties of native OKT3, including T cell activation which has been correlated, in vivo, with the severe side-effects observed in transplant recipients after the first administration of the mAb. Disclosed are modified versions of humanized anti-CD3 mAbs that do not have the property of T cell activation. Further dislosed are methods of using such mAbs.

Described are injectable formulations of nanoparticulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise nanoparticulate olanzapine.

An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and / or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The phytases of the invention can be thermotolerant and / or thermostable at low temperatures, in addition to higher temperatures. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate. The foods or feeds of the invention can be in the form of pellets, liquids, powders and the like. In one aspect, phytases of the invention are stabile against thermal denaturation during pelleting; and this decreases the cost of the phytase product while maintaining in vivo efficacy and detection of activity in feed.

The present invention provides an aqueous ophthalmic solution having an effective amount of ketorolac which includes carboxymethyl cellulose in an aqueous solution wherein the concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.

The invention provides a cosmetic composition containing a TCM (traditional Chinese medicine) extracting solution. The TCM extracting solution is composed of the following Chinese herbal medicines in parts by weight: ginseng, angelica sinensis, snow lotus herbs, folium artemisiae argyi, panax notoginseng, olibanum, fortune eupatorium herbs, radix pseudostellariae, agrimonia pilosa ledeb, radix polygonati officinalis, corn cervi pantotrichum, radix gentianae, flos magnolia, selaginella tamariscina, peony, Chinese herbaceous peony, herba centellae, pogostemon cablin, rhizoma ligustici wallichii, poria cocos, radix aucklandiae, anthemis tinctoria, and fructus lycii. The invention also provides a preparation method of the cosmetic composition containing a TCM extracting solution. The cosmetic composition disclosed by the invention is a cosmetic product which is implemented by the collaborative application of multiple TCM skin care products, and is good in extraction effect and high in quality, and each product reaches the international standards.

The invention discloses a processing method of fried fructus trichosanthis seed. The fried fructus trichosanthis seed is prepared from a raw material of fructus trichosanthis seed and a variety of accessories, by steps of cleaning, sorting, stir-frying, dipping, cooling, detecting and packaging. The fructus trichosanthis seed fried by the method provided by the invention has advantages of smooth and soft taste, crispness, full seed and easy cracking, maintains nutrition and drug efficacy of the fructus trichosanthis seed, and at the same time is added with materials of cane leaf and mulberry with the function of reducing blood sugar, so as to enhance the health care effect of the fructus trichosanthis seed.

The invention relates to a method for processing semen trichosanthis. The method is characterized in that ingredient is prepared from semen trichosanthis serving as raw material and anise, fennel, liquorice, tangerine peel, clove, salt, sweetener and water serving as auxiliary materials by selecting, frying, dipping in soup, cooling and seasoning, winnowing and packaging. As the semen trichosanthis is fried by mechanical equipment, the nutrition and drug effect of the semen trichosanthis are maintained, and due to the aroma of spice mixed therein, the fried semen trichosanthis has rich toasty taste and good mouthfeel. Moisture control is performed during the frying so that the fried semen trichosanthis is easy to crack; and meanwhile, the antioxidant prolongs the shelf life of the product. The invention has the advantages of reasonable and practical processing method, simple operation and good effect and is favorable for wide popularization.

This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and isolation of such polynucleotides and polypeptides. In particular, the invention provides polypeptides having phytase activity under high temperature conditions, and phytases that retain activity after exposure to high temperatures. The invention further provides phytases which have increased gastric lability. The phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be formulated as foods or feeds or supplements for either to, e.g., aid in the digestion of phytate.

A health-care mulberry leaf tea in the form of small blocks is prepared from mulberry leaf (40-70 wt.%) and tea leaf (30-60 wt.%). Its advantages are sure health-care function in reducing blood sugar, blood pressure, urine sugar and blood fat, and no by-effect.

The binding specificity of the murine OKT3 has been transferred into a human antibody framework in order to reduce its immunogenicity. “Humanized” anti-CD3 mAbs, such as gOKT3-5 and gOKT3-7, have been shown to retain, in vitro, all the properties of native OKT3, including T cell activation which has been correlated, in vivo, with the severe side-effects observed in transplant recipients after the first administration of the mAb. Disclosed are modified versions of humanized anti-CD3 mAbs that do not have the property of T cell activation. Further dislosed are methods of using such mAbs.

The invention relates to a method for processing green beans, which is characterized by comprising the following processes of selecting, soaking, deactivating, freezing, vacuum frying, stirring, cooling and packaging by taking the green beans as raw materials and taking garlic, ginger, monosodium glutamate, salt, water and palm oil as auxiliary materials. According to the method for processing the green beans, the green beans is fried by vacuum frying equipment, so the nutrition and the medicinal effect of the green beans can be remained; at the same time, the aroma of the auxiliary materials is melted into the green beans, so the produced green beans has a delicious crispy taste and a good mouth feel. Due to the vacuum frying technique and antioxidant which is used in the frying process, so the shelf life of the products is prolonged. The method for processing green beans is reasonable and practical, simple in operation and good in effect, and is suitable to be widely popularized.

An improved method for manufacture of chewing gums containing active ingredient(s) that preserves the efficacy of the active ingredient(s) by avoiding exposure to high heat and extreme cold during milling that can otherwise degrade the active's efficacy. A chewing gum base is used, along with one or more therapeutically-active ingredients, one or more sweeteners (alcohol-based and / or natural), and one or more flavorings and optional flavor modifiers. The method generally comprises heating the gum base in ovens to melt the gum base. Separately, the active ingredient(s), sweeteners and flavorings are combined in a mixer. The melted gum base is added to the mixer and cools to produce a particulate mixture. As mixing continues the mass cools to room temperature and forms granular pieces. The granular pieces are ground into a powder at room temperature, mixed at room temperature with tableting excipients, and tableted. Several variations on the foregoing are also described.

The invention relates to a multipurpose polyester film and a preparation method thereof. The preparation method adopts a biaxial orientation technique and comprises the following steps: 1. preparation of functional assistants; 2. precrystallization and drying; 3. melt extrusion: the precrystallized and dried PET (polyethylene terephthalate) slices and the functional assistants are heated and molten by an extruder, and the melt is uniformly delivered to a die head for slab casting under the push of extrusion pressure; 4. slab casting: the uniform and stable melt from the extrusion system runs on rotating quenching rollers through the die head to form an amorphous slab; 5. longitudinal stretching and lateral stretching: the cast slab is subjected to longitudinal stretching after entering a longitudinal stretching machine, and subjected to lateral stretching after entering a lateral stretching machine; and 7. pulling, slicing, corona treatment, rolling and inspection. The method has wide application range, such as environment-friendly films, twist wrap films, high-brightness films, insulation films, capacitive films, car protecting films, bronzing films, aluminizing films and composite packaging films.

The invention provides a method for planting dendrobium officinale on a tree, and belongs to the technical field of dendrobium officinale planting. The method comprises the steps of selecting and treating an adnascent tree, pretreating seedlings, treating moss, binding the tree and fixing planting, performing water and fertilizer management after fixing planting, and the like. During treatment on the adnascent tree, a notch which does not damage a stem cambium is formed in a tree trunk, the tree trunk is coated with a pulpous nutrition medium, and the dendrobium officinale is planted after the tree is planted for 3 to 5 days, wherein the used pulpous medium is prepared from dimethomorph, manganese zinc myclobutanil, ivy extracts, gibberellins, andrographolide, polyvinyl acetate emulsion, sorbitol, potassium nitrate, ammonium nitro-humate and monocalcium phosphate. The tree is treated in advance, so that the varieties of the selectable trees can be increased; the dendrobium officinale domesticated seedlings are soaked with planting fixing nutritional liquid before planting fixing and then is irrigated after planting fixing, so that the root system of the domesticated seedlings is developed quickly, plant diseases and insect pests are few, and the survival rate is above 98 percent.

This invention relates to enhancing sensitivity of cytotoxic drugs by targeting their interfering mechanisms induced in the tumor microenvironment which lead to drug resistance, using combinatorial therapy with carboxyamidotriazole orotate. Specific doses of cytotoxic drugs are titrated with carboxyamidotriazole orotate to improve the sensitivity and anticancer activity of cytotoxic drugs.

Antimicrobial or non-antimicrobial compositions, sanitizing compositions and other compositions combining use of a propoxylated EO / PO block copolymer surfactant and / or propoxylated polymer in combination with at least one additional anionic and / or nonionic surfactant to provide concentrated compositions having a desired viscoelasticity at an active level of at least 18% are disclosed. Non-antimicrobial applications combining use of a propoxylated surfactant and / or propoxylated polymer in combination with at least one additional anionic and / or nonionic surfactant to provide compositions having a desired viscoelasticity are also disclosed. Methods of using concentrated and use compositions having desired foaming enhancement and stabilization are also disclosed.

A method of encoding a digital image signal comprising a plurality of samples. The method comprises the following steps, applied during the encoding of each sample with a view to its storage in a buffer. The level of occupancy of the buffer is determined, and the level of occupancy is compared with a predetermined threshold. An encoding mode is determined from among a plurality of encoding modes when the level of occupancy is above the predetermined threshold, and encoding the sample according to the determined encoding mode, and the sample is encoded according to a default encoding mode when the level of occupancy is below the predetermined threshold.

The present invention discloses a health snakegourd fruit seed processing method, the health snakegourd fruit seed is fried snakegourd fruit seed prepared by adopting snakegourd fruit seed as a raw material, adopting various auxiliary materials as matching materials, and carrying out cleaning, material selection, frying, material dipping, cooling, detection and packaging. The processed snakegourd fruit seed has characteristics of smooth taste, crispy and specific fragrance, full kernel, and easy opening. In addition, nutrition and efficacy of the mongolian snakegourd fruit seed are maintained; and blood glucose reduction materials such as sugarcane leaves and mulberry are added, and blood fat reduction Chinese herbals such as kirilow rhodiola root and rhizome, licorice root and the like are added so as to enhance a health effect of the snakegourd fruit seed.

A method of preventing or treating constipation in a patient who has been chronically taking opioids, the method comprising administering a quaternary derivative of noroxymorphone in an amount sufficient to prevent or treat the side effect in the patient, but which amount would be insufficient to treat a patient with the same opioid-induced side effect who had not chronically been administered opioids.

Surface retarder compositions of the invention comprise at least one surface retarder active suspended in a vegatable oil or derivative thereof, an animal oil or derivative thereof, or mixtures thereof. Methods involving use of the compositions are also described.

The invention relates to a food and in particular relates to a novel method for making marinated eggs. According to the technical problem to be solved by the invention, fresh eggs are taken as raw materials. The marinating method comprises the following specific steps: 1, putting eggs in a food steamer for steaming, and manually removing the shells; 2, adding angelica sinensis, ginseng, the fruit of Chinese wolfberry, astragalus and poria cocos which serve as marinating traditional Chinese medicines, and adding marinating condiments such as edible salt and brown sugar; 3, adding the eggs, marinating traditional Chinese medicines and marinating condiments into a pot, adding water and green tea which are three times that of the weight of the eggs, and marinating and boiling for 3-6 hours; 4, soaking the cooked marinated eggs for 1-2 hours again; and 5, completely cooling the marinated eggs, and packaging the eggs in vacuum packaging bags, thereby obtaining the product. According to the novel marinated eggs made by the method, the egg processing mode is changed, the defects that the nutrition ingredients and medicinal values of eggs are easily damaged in the conventional processing method are overcome, the marinated eggs are marinated and processed by virtue of Chinese herbal medicines and can be eaten by opening the bags on the basis that the original nutritive value and medicinal values of the eggs are not damaged, the marinated eggs are bright in color, delicious in taste, rich in nutrition and wide in application population, the nutrition ingredients and medical effects of the eggs are maintained, and the pharmacological and health effects are outstanding.