109results about How to "Maintain curative effect" patented technology

A modified Fletcher-Suit tandem tube applicator includes a balloon which can be inflated to both positionally secure the applicator within the vaginal canal and to distend the confronting vaginal wall thereby increasing the distance of such tissue from the radioactive source contained in the tandem tube of applicator and correspondingly reducing radiation damage to nearby tissues and organs such as the rectum and bladder.

A composition including small plant or synthetic molecules, such as resveratrol and quercetin, in their biologically active form, is provided. The small molecules may be derived from natural sources such as grapes or Giant Knotweed (botanical name Polygonum). The composition may be processed such that the gene-controlled biological activity of the small molecules is maintained. Specifically, the raw material for encapsulation must exhibit biological activity before and after encapsulation and be processed in an oxygen-free (nitrogen), dim light environment. The composition may further include at least one metal chelating agent as an antioxidant stabilizer, an antioxidant, and an emulsifier. The compositions are useful in the formation of a dietary supplement or drug.

Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time.

Described are injectable formulations of nanoparticulate olanzapine that produce a prolonged duration of action upon administration, and methods of making and using such formulations. The injectable formulations comprise nanoparticulate olanzapine.

A modified Fletcher-Suit tandem tube applicator includes a balloon which can be inflated to both positionally secure the applicator within the vaginal canal and to distend the confronting vaginal wall thereby increasing the distance of such tissue from the radioactive source contained in the tandem tube of applicator and correspondingly reducing radiation damage to nearby tissues and organs such as the rectum and bladder.

Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation with progressively longer delays (off periods) from an initial stimulation. In particular, described herein are supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >48 hours) inhibition of pro-inflammatory cytokines and / or effects of chronic inflammation; the delay between initial doses (which may be single-pulse doses) may be extended for subsequent doses, potentially dramatically enhancing battery and device longevity.

The embodiments disclose means to inhibit the growth and migration of bacteria, mildew and fungus by applying various coatings which contain an inorganic anti-microbial agent onto metal, glass, and plastic substrates. The substrates are used in the manufacture of components for the interior of refrigerators and freezers, which include wire (100) and glass shelving (200, 300), plastic crisper baskets (500) and other articles within the food storage area. The coatings include the inorganic anti-microbial agent combinet with a matrix resin which are applied by electrostatic powder coating (916), roller coating (810), or robotic spraying (710), and then cured.

A modified Fletcher-Suit tandem tube applicator includes a balloon which can be inflated to both positionally secure the applicator within the vaginal canal and to distend the confronting vaginal wall thereby increasing the distance of such tissue from the radioactive source contained in the tandem tube of applicator and correspondingly reducing radiation damage to nearby tissues and organs such as the rectum and bladder.

The present invention is directed to a foaming composition comprising from about 5% to about 13% total surfactant of one or more anionic surfactants; from 0.1% to about 2% of a surfactant soluble antidandruff active; from about 3% to about 15% of a blowing agent, wherein the foaming composition is at a pH of about 3.5 to 6.5

The present invention relates to an apparatus for treating sludge comprising electrodes including at least one anode and at least one cathode. The electrodes define therebetween a space adapted to receive the sludge so as to submit the sludge disposed within the space to an electric current, thereby dehydrating the sludge and generating an effluent. The apparatus also comprises an inlet for receiving the sludge and an outlet for evacuating the treated sludge. The inlet and the outlet are in communication with the space. The apparatus also comprises compression means for compacting the sludge so as to permit a contact substantially constant between the electrodes and the sludge when the sludge is submitted to the electric current and rotated around a rotation axis. The invention also relates to a process for treating sludge. The invention is useful for treating various types of sludge in order to dehydrate and decontaminate the sludge.

Provided are a fusion protein of Exendin-4 and its analog, the preparation method and use thereof. The fusion protein is obtained by fusing of Exendin-4 or its analog to Fc region of human IgG2 via a linking peptide, which has the better stability and prolonged serum half-life, and can be used for treating diabetes and obesity.

An object of the present invention is to provide an agricultural chemical formulation which is able to control release of an agricultural chemical active ingredient. This agricultural chemical formulation includes a composition, containing an agricultural chemical active ingredient, styrene-maleic anhydride copolymer or mixture of styrene-maleic anhydride copolymer and polymer having repeating units derived from rosin or derivative thereof or salicylic acid or derivative thereof, and a release controller (a water-soluble polymer, a hydrophobically-treated silicon oxide, or a surfactant), forming a compatible state or matrix.

The present invention relates to a process for treating sludge by the combined action of electro-osmosis and pressure. This process comprises providing a cell for treating the sludge, the cell comprising at least two electrodes including at least one cathode and at least one anode. At least one of the electrodes is movable, and at least one of the electrodes is perforated so as to drain effluents. Then, the sludge is introduced into the cell between the at least two electrodes, each of the electrodes defining a surface adapted to constantly contact the sludge. Then, the sludge is submitted to an electric current by applying a voltage to the electrodes, and applying a pressure to the sludge. by means of the at least one movable electrode so as to permit a constant contact between the surfaces and the sludge. An apparatus for carrying out such a process is also disclosed.

Catheter advancing devices, systems and methods for advancing a catheter into the urethra of a user are disclosed. The catheter advancement device includes a body portion that couples to a guide portion of the catheter, the guide portion being movably coupled to the proximal end of a catheter. The catheter advancement device further includes a pair of flexible handles extending outwards from the body portion, and a gripping portion extending inwards from each of the flexible handles. A surface of the gripping portion comes in contact with the catheter when the flexible handles are engaged, and the surface of the gripping portion in contact with the catheter applies pressure to the catheter when the handles are engaged to advance the catheter through the guide portion.

Methods for detecting analytes in a sample are provided. A plurality of particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

Methods for therapeutic drug monitoring are provided. A plurality of particles, each of which is coated with a capture agent capable of binding a therapeutic drug of choice is combined with the sample to form a plurality of therapeutic drug-particle complexes. The system also includes a transport arrangement for transporting the sample and / or particles to the sensor surface, and optionally a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of therapeutic drug-particle complexes that are bound to the sensor surface.

The present invention provides a more safe and highly effective stent having functions such as anti-inflammatory action, antithrombotic action, maintenance of tissue restoration response and maintenance of endothelial regeneration. More specifically, the drug / gene eluting stent has a layer containing a gene encoding a hybrid polypeptide on the surface. The hybrid polypeptide is preferably a bound of fibronectin-derived collagen binding domain (FNCBD) polypeptide and an anti-inflammatory factor or an angiogenic factor. The uniform fine particle size capsules can directly deliver the gene encoding the hybrid polypeptide to the lesion and have benefits of reducing the given doses, and thus improving safety and efficacy and further maintaining the efficacy for a long period.

A method for production and storage of hypochlorous acid is disclosed. The method comprises using high purity water achieved by a combination of softening and reverse osmosis steps. The shelf life is further improved by storing the hypochlorous acid in opaque PET bottles or Nylon / PE bags or nylon bags in a box. Solutions stored in opaque PET bottles exhibit the best stability. Anticipated uses of the extended life hypochlorous acid solution include sanitizer for food contact and non-food contact surfaces, a streak-free cleaner for smooth surfaces and a cut flower life extender. Other biocide uses include water treatment in oil and gas production, cooling tower, lazy river and swimming pools, process water distribution systems, drinking water, portable humidifier, fish tanks and treatment of metalworking fluids and lubricants.

Disclosed is an extended release pharmaceutical formulation comprising a muscle relaxant drug, such as tizanidine, in combination with a cyclooxygenase-2 inhibitor, such as valdecoxib. The formulations are useful in the treatment and management of painful inflammatory conditions associated with, for example, skeletal muscle spasms.

Described herein are compositions in nanofibre form including one or more bioactive compounds releasably incorporated thereon. In one embodiment a composition is described comprising at least one nanofibre and at least one bioactive compound. The nanofibres are formed from a base material that is solubilised with the bioactive or bioactives in an aqueous based solvent solution and the base material and bioactives are together spun via electrospinning to form dry fibres with the bioactives chemically bonded to the nanofibres and the bioactives remaining stable during storage of the composition under ambient conditions substantially free of moisture. On exposure to moisture, the nanofibres dissolve, thereby releasing the bioactives.

It is an object of the present invention to provide a rolling bearing in which efficacy provided by an auxiliary agent for grease can be maintained for a long time to extend its life and a seal for the rolling bearing. A rolling bearing (1) has an inner ring (2); an outer ring (3); a plurality of rolling elements (4) interposed between the inner ring (2) and the outer ring (3); a retainer (5) retaining the rolling elements (4); and a seal (6) provided at an open portion, of the inner ring (2) and the outer ring (3), which is disposed at both axial ends thereof. The rolling bearing (1) is lubricated with a grease (8) enclosed in a space, inside the bearing, which is constructed of the inner ring (2), the outer ring (3), the retainer (5), and the seal (6). A mixture (7) of an auxiliary agent for the grease and a resin is fixed to a surface, of the seal (6) (one of the members constructing the space inside the bearing), which is disposed at a side of the space inside the bearing.

The present Invention relates to pharmaceutical compositions of (3S,11aR)-N-[(2,4-difluorophenyl)methyl]-2,3,5,7,11,11a-hexahydro-6-hydroxy-3-methyl-5,7-dioxo-oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide, useful in the treatment or prevention of Human Immunodeficiency Virus (HIV) infections.

The present invention relates to an apparatus for treating sludge comprising electrodes including at least one anode and at least one cathode. The electrodes define therebetween a space adapted to receive the sludge so as to submit the sludge disposed within the space to an electric current, thereby dehydrating the sludge and generating an effluent. The apparatus also comprises an inlet for receiving the sludge and an outlet for evacuating the treated sludge. The inlet and the outlet are in communication with the space. The apparatus also comprises compression means for compacting the sludge so as to permit a contact substantially constant between the electrodes and the sludge when the sludge is submitted to the electric current and rotated around a rotation axis. The invention also relates to a process for treating sludge. The invention is useful for treating various types of sludge in order to dehydrate and decontaminate the sludge.

Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation with progressively longer delays (off periods) from an initial stimulation. In particular, described herein are supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >48 hours) inhibition of pro-inflammatory cytokines and / or effects of chronic inflammation; the delay between initial doses (which may be single-pulse doses) may be extended for subsequent doses, potentially dramatically enhancing battery and device longevity.

A cellulose-based granule that functions as a carrier vehicle for an odor control agent is described. The granule has a relatively porous substrate body having a high-surface area of at least about 200 m2 / gram, and metal-modified silica particles either adhered to or encapsulated within the cellulose-based substrate. Each of the metal-modified particles has adsorbed metallic ions that are adapted to bind a molecule of a gaseous compound, an odorous compound, or combinations thereof. The odor control granule is free-flowing (i.e., do not exhibit a tendency to agglomerate to each other) and exhibit powder-like characteristics, wherein the granules have an average powder density of 30 to 600 g / l according to DIN 53,468.