488 results about "Control release" patented technology

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention discloses a buccal nicotine bag product and a preparation method thereof. The buccal nicotine bag product comprises a content and an outer package, the content is powdery and comprises a nicotine source and an acidic pH regulator; the outer package is a saliva permeable pouch and is used for packaging the content, so that the pH value of the buccal nicotine pouch product in pure water or saliva is smaller than 6.0. Optimizing the pH value to a weakly acidic range (pH lt; a specific buffer system and a slow-release carrier are combined to solve the problems of oral cavity stimulation, flavor limitation and high pH dependence in the using process of an existing nicotine bag, the palatability of the nicotine bag in the using process and the nicotine release efficiency in the mouth consumption process are improved, long-acting and stable nicotine delivery is achieved by controlling release kinetics, the production cost is reduced, and the nicotine bag is suitable for large-scale popularization and application. The consumption experience is improved.

The invention discloses organic nano composite hydrogel as well as a preparation method and application of the organic nano composite hydrogel, and belongs to the technical field of biological medicine delivery. The polysaccharide-based nano prodrug in the composite hydrogel can be subjected to surface protonation under the stimulation of a tumor extracellular slightly acidic environment, so that cellular uptake is promoted, low-pH / high-concentration glutathione in tumor cells is responded, intracellular aggregation and controllable release of the nano drug are realized, the retention time of the drug in the cells is prolonged, and the bioavailability of the drug is improved. The technical effect of killing tumor cells through combined chemotherapy is achieved. According to the preparation method disclosed by the invention, the release of the polysaccharide-based nano prodrug from the hydrogel and the tissue infiltration capacity are accelerated by adopting fluorinated orthoester, the infiltration of the polysaccharide-based nano prodrug to cells is increased, and then the drug-loaded compound is encapsulated by using gellan gum, so that the slow-release effect of the polysaccharide-based nano prodrug is enhanced; therefore, the efficient enrichment of the medicine at the tumor part is realized.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allows for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention belongs to the technical field of biological materials, and particularly relates to nano composite hydrogel as well as a preparation method and application thereof. In the preparation process of the hydrogel, preparation of gelatin hydrazide and preparation of pullulan oxidation are sequentially completed, then preparation of active component loaded PLGA nanoparticles and self-assembly coating with metal-polyphenol are completed, and finally, the metal-polyphenol coated PLGA nanoparticles are mixed with gelatin hydrazide and pullulan oxidation to form gel in situ. The hydrogel has the characteristics of injectability, self-healing, wet adhesion and the like, the metal-polyphenol layer has the effects of resisting inflammation, resisting oxidation and promoting angiogenesis and generates photo-thermal response to near infrared rays, on-demand controllable release of the drug-loaded nanoparticles is achieved, the composite hydrogel can improve the wound surface microenvironment, promote angiogenesis and inhibit inflammation and scar formation, and the drug-loaded nanoparticles can be applied to wound healing. The ointment is suitable for burns, scalds and various complex wounds.

The invention belongs to the technical field of fertilizers, and particularly relates to magnesium-containing controlled-release urea and a preparation method thereof, and the magnesium-containing controlled-release urea is characterized in that magnesium or magnesium-boron, magnesium-zinc and magnesium-boron-zinc medium trace element combinations are added into large-particle urea, and then coating is carried out. According to the controlled-release urea, elements such as magnesium are added into molten urine, then roller granulation and cooling are carried out, and finally coating is carried out. According to the prepared product, urea, magnesium and other elements can be synchronously and slowly released for a long time, nitrogen, magnesium and other nutrients have synergistic benefits, the utilization rate of nitrogen fertilizer, magnesium and other elements can be further increased, robust growth of crops is promoted, the yield is increased, the quality is improved, the stress resistance is enhanced, and labor is saved; and the method is especially suitable for regions with relatively common lack of medium trace elements and high-added-value commercial crops, and has a wide practical application value.

The invention discloses a preparation method of a lignosulfonate controlled-release drug-loaded capsule. The invention constructs a pH controlled release type lignin-based drug-loaded capsule around a three-stage delivery strategy of emulsion construction-electrostatic self-assembly-metal chelation. The preparation method specifically comprises the following steps: dissolving pesticide active ingredients and an emulsifier in an organic solvent to serve as an oil phase; dissolving lignosulfonate and a dispersing agent in water to serve as a water phase; mixing the oil phase and the water phase under stirring and homogenizing conditions to form O / W type emulsion; cationic monomers are added into the O / W type emulsion, a prototype of a shell layer is formed by means of electrostatic acting force, then the shell layer is cured by means of chelation of metal ions, and the lignosulfonate-based drug-loaded capsule loaded with pesticide is formed. The drug-loaded capsule prepared by the invention can shield ultraviolet light through the lignosulfonate metal complexing layer, has sensitive acid-base response performance, can realize the response controlled release process of encapsulated drugs, and effectively reduces the dosage of pesticides.

The invention belongs to the technical field of gel dressings, and particularly relates to a bio-based gel dressing for wound treatment and a preparation method thereof.The bio-based gel dressing is prepared from, by weight, 10-17 parts of mussel mucin, 13-20 parts of silk fibroin, 1-5 parts of plant vesicles, 2-4 parts of traditional Chinese medicine polysaccharide, 0.05 part of antibacterial peptide, 1.5 parts of glycerinum and 0.3 part of cross-linking agent; nano plant vesicles which are extracted from a traditional Chinese medicine prescription and have the effect of promoting wound healing are used as a carrier for encapsulating antibacterial peptide, and then the antibacterial peptide is encapsulated in a three-dimensional gel network formed by natural protein, so that controlled release and slow release of antibacterial and anti-inflammatory components are realized, and efficient wound healing is promoted.

The invention discloses an embolism microsphere and a preparation method thereof.The embolism microsphere is prepared through the following steps that a polycarboxylate microsphere is prepared by combining a free radical polymerization method and an emulsion polymerization method, and the polycarboxylate microsphere is obtained; and saponifying and hydrolyzing the polycarboxylate microspheres to hydrolyze the polycarboxylate microspheres to obtain hydroxyl polymer microspheres, and introducing an acidic group onto the hydroxyl polymer microspheres to obtain the embolism microspheres containing both the hydroxyl group and the acidic group. The embolism microsphere disclosed by the invention realizes high loading capacity and controllable release of the anti-tumor drug, realizes accurate embolism in blood flow, and improves the treatment effect of the drug.

The invention discloses a photocuring microneedle with ginseng exosome loaded berberine, a preparation method of the photocuring microneedle and application of the photocuring microneedle to tissue repair. A ginseng exosome loaded berberine compound is prepared through a microfluidic technology; filling a needle cavity of a microneedle mold with a needle tip layer preparation solution containing the compound, methylacryloylated hyaluronic acid and methylacryloylated gelatin through a centrifugal method; covering a backing layer preparation solution composed of hyaluronic acid and povidone K90, and centrifuging again; and finally, carrying out light curing, drying and demolding. The prepared composite microneedle is complete and sharp in needle shape and high in forming rate; the efficient entrapment of the active medicine is realized; the biocompatibility is good, and the irritation is low; a cross-linked network structure formed by photocuring is beneficial to realizing controlled release of drugs, the targeted repair function of the ginseng exosome is combined with the hypoglycemic effect of berberine, and a new strategy and technical approach with a prospect are provided for painless, efficient and long-acting treatment of diabetes mellitus.

It relates to drug delivery systems and methods for locally delivering therapeutic agents, and methods for using such drug delivery systems for the treatment of diseases.

The invention relates to the technical field of drug-loaded microparticles, in particular to a preparation method and application of medical stone / PLGA composite drug-loaded microparticles, medical stone and PLGA are prepared into a structure with activated nano medical stone as a core and a PLGA polymer as a shell through the processes of ball milling, acid activation, emulsification, solvent volatilization and the like, and the medical stone and the PLGA are synergistically matched, so that the drug-loaded microparticles have the advantages that the drug-loaded microparticles are uniform in particle size distribution, and the drug-loaded microparticles have good drug-loaded performance. Firstly, the hydrogel has intelligent responsiveness, can accelerate degradation in alkaline and enzyme environments of wound surfaces, and realizes accurate release of drugs as required; secondly, the long-acting controlled release property is shown, and a dual sustained release barrier is constructed through medical stone adsorption and PLGA wrapping, so that the medicine is released for more than 72 hours at a constant speed following zero-order dynamics, and burst release is effectively avoided. And thirdly, when the drug-loaded particles are used for hydrogel, the drug-loaded particles in nanoscale are combined with the hydration effect of a hydrogel matrix, so that the efficient permeability of the drug in the cuticle is greatly improved.

The invention provides a seawater soaking wound hydrogel dressing and a preparation method thereof, a drug-loaded nano system 4OI (at) ZIF-8 (at) PAD with a core-shell structure is constructed, an anti-inflammatory drug 4-octyl itaconic acid and zinc ions are jointly encapsulated in a ZIF-8 framework, and a polydopamine coating is wrapped, so that synergistic loading and controllable release of the drug and metal ions are realized. According to the dressing, dopamine modified hyaluronic acid is used as a matrix, a temperature-sensitive material and an enzyme catalysis cross-linking system are combined, stable gel can be rapidly formed in situ within 5 seconds, and the dressing has excellent tissue adhesion performance (the adhesion strength reaches 6.7 kPa). Experiments prove that the hydrogel dressing has the characteristics of broad-spectrum antibiosis, inflammation regulation and control and long-acting release. Animal experiments prove that the healing rate of seawater soaking wounds treated by the dressing on the twelfth day is as high as 95.7% and is remarkably superior to that of a commercial silver ion gel control group, scars are less after healing, and an efficient, safe and easy-to-implement scheme is provided for marine environment wound nursing.

The invention relates to the technical field of fibers, in particular to a controlled-release anti-aging polypropylene fiber and a preparation method thereof. The fiber is prepared from polypropylene homopolymer resin, a reaction type interface layer master batch and a controlled release anti-aging master batch, the reactive interface layer master batch is formed by reacting and extruding maleic anhydride modified polypropylene and 3-aminopropyl terminated polydimethylsiloxane, so that the interface compatibility is enhanced; the controlled-release anti-aging master batch contains hydroxyl and peracetylated cyclodextrin grafted siloxane carriers, and an ultraviolet absorbent, a light stabilizer and an antioxidant are included, so that the controlled release of an anti-aging agent is realized. The preparation method comprises the steps of master batch preparation, final mixing granulation, melt spinning and drafting setting. The fiber strength is remarkably improved, the boiling water shrinkage rate is reduced, the strength retention rate after ultraviolet aging reaches 93% or above, the yellow index change is small, and the outdoor service life is prolonged.

The invention is a method for treating patients with Parkinson's disease by orally administering a controlled release levodopa formulation and the method provides an improvement of a patient's total post-dose “Off” time, total post dose “On” time and total post dose “Good On” time compared to post-dose of treatment regimens with oral immediate release levodopa tablets.

The invention is a method for treating patients with Parkinson's disease by orally administering a controlled release levodopa formulation and the method provides an improvement of a patient's total post-dose “Off” time, total post dose “On” time and total post dose “Good On” time compared to post-dose of treatment regimens with oral immediate release levodopa tablets.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention discloses a pH-responsive drug-loaded microcapsule based on an electrostatic self-assembly technology and a preparation method of the pH-responsive drug-loaded microcapsule. The drug-loaded microcapsule is prepared from the following raw materials in parts by weight: 0.1-1 part of fludioxonil; 1-3 parts of sodium lignin sulfonate; 4-7 parts of an organic solvent; 0.8-2 parts of an emulsifier; 1.0 to 2.0 parts of a colloid protective agent; 4-7 parts of a cationic monomer; 0.4-2 parts of soluble metal salt and 40-70 parts of deionized water; the invention also specifically discloses a preparation method of the drug-loaded microcapsule. The microcapsule is constructed by using a clean, simple, convenient and environment-friendly electrostatic self-assembly technology, and the capsule shell is effectively reinforced through iron ions, so that the effective controlled release of the pesticide is synergistically realized, the use of an organic solvent is remarkably reduced, the production cost is reduced, and the environmental ecological benefits are improved.

The invention is a method for treating patients with Parkinson's disease by orally administering a controlled release levodopa formulation and the method provides an improvement of a patient's total post-dose “Off” time, total post dose “On” time and total post dose “Good On” time compared to post-dose of treatment regimens with oral immediate release levodopa tablets.

The invention relates to the technical field of medicines, in particular to a stable drug-loaded microcapsule and a preparation method thereof. According to the method, A-type gelatin and succinic anhydride modified B-type gelatin are adopted to synergistically construct a layered composite shell layer, genipin is added step by step to realize progressive crosslinking, and the interface structure and the controlled release performance are optimized. The microcapsule prepared by the invention has high encapsulation efficiency, controllable release and excellent storage stability, adopts an innovative multi-molecular-weight gelatin layered design and a step-by-step cross-linking strategy, and takes into account the dual requirements of strong encapsulation and slow release and controlled release, so that the vitamin B6 is prevented from being influenced by environmental degradation, and the efficacy and compliance of a preparation are improved. The invention provides a new technical scheme for development of controlled release preparations of water-soluble vitamins and related drugs.

The invention relates to the technical field of drug sustained release, and discloses a wearable multi-drug sustained release device which comprises a flexible base material, a sustained release drug delivery structure comprises a microneedle array cluster distributed on the inner side of the flexible base material, a modular drug box is arranged on one side of the microneedle array cluster, and a controlled release module is arranged on the inner side of the flexible base material; a snap fastener is fixed on the surface of the friction belt, and a rope binding belt is sewn on the flexible base material. According to the wearable multi-drug sustained release device, when the flexible base material and the flexible cavity tube deform, stress is mainly absorbed and extended by the flexible cavity tube, the rigid convex block bearing the microneedle cluster tube is kept stable, the angle is automatically adjusted to keep vertical puncture force on the skin surface, and the stability of the microneedle puncture state is ensured; different medicine storage boxes have different RFID identifications, and the effect of administration of different medicines at the same affected part can be achieved; for different sizes of binding parts, the binding stability can be improved by adopting snap fasteners or rope binding belts.

The invention relates to the technical field of biological medicines, and discloses an alpha-ketoglutaric acid composite liposome as well as a preparation method and application thereof. Alpha-ketoglutaric acid is preliminarily entrapped by lecithin and cholesterol to prepare a basic liposome, and then enzymolysis silkworm pupa protein is introduced to the surface of the liposome, so that the enzymolysis silkworm pupa protein and a lipid bilayer are subjected to hydrophobic and hydrogen-bond interaction to form a protein-lipid composite layer, and the stability of a membrane structure is enhanced; and the positively charged arginine modified starch is further deposited on the surface of the liposome to form a polysaccharide-protein-lipid composite layer, so that the electrostatic locking of the negatively charged alpha-ketoglutaric acid is realized, and the encapsulation efficiency and the controlled release performance are further improved. The alpha-ketoglutaric acid composite liposome provided by the invention has the advantages of being high in stability, safe to eat, high in encapsulation efficiency, good in gastric acid resistance stability and the like, has a good slow release characteristic, and can be applied to the fields of sports nutritional supplements, antioxidant products or anti-aging products and the like.

Disclosed herein are drug delivery devices and methods for the treatment of ocular disorders requiring targeted and controlled administration of a drug to an interior portion of the eye for reduction or prevention of symptoms of the disorder. The devices are capable of controlled release of one or more drugs and may also include structures which allow for treatment of increased intraocular pressure by permitting aqueous humor to flow out of the anterior chamber of the eye through the device.

The invention provides a thermo-sensitive triblock copolymer with a lateral group containing polyethylene glycol and a preparation method of the thermo-sensitive triblock copolymer, and relates to the field of polymer synthesis. The preparation method comprises the following steps: carrying out a reaction on hydroxyl-terminated polyether PAGE and single carboxyl-terminated polyethylene glycol monomethyl ether (mPEG-COOH) under the action of N-bromosuccinimide to prepare a polymer brush PAGE-g-mPEG; and reacting the polymer brush PAGE-g-mPEG with poly (N-isopropylacrylamide) to generate a thermo-sensitive triblock copolymer of which the side group contains polyethylene glycol. The thermo-sensitive triblock copolymer disclosed by the invention is endowed with good biocompatibility, hydrophilicity and low-temperature performance, has a good thermo-sensitive characteristic, and can be widely applied to the fields of drug-loaded controlled release, sewage treatment and nanoparticles; the invention also provides a preparation method of the thermo-sensitive triblock copolymer, which overcomes the defects of harsh reaction conditions and easy chain extension reaction, and realizes accurate control of the molecular weight of the prepared copolymer.

An oral product includes a filler and an active ingredient. The filler includes a modified agglomerate and a surface modifier. The modified agglomerate includes a porous carrier. The surface modifier coats at least a portion of a surface of the agglomerate, is in pores of the agglomerate, or both coats at least a portion of the surface of the agglomerate and is in pores of the agglomerate. The surface modifier includes a sugar alcohol or a hydrophobic material. The active ingredient is admixed with the filler.

The disclosure relates to microparticles and nanoparticles comprising a polymer matrix comprising an uncapped polymer and a net positively charged therapeutic agent at neutral pH. More particularly the disclosure relates to PLGA and / or PLA particles comprising an uncapped polymer for extended, controlled release of positively charged proteins or peptides at neutral pH. Methods of making the particles and administering the particles are also provided.