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Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. In preferred high-temperature embodiments, the polymer sample is maintained at a temperature of not less than about 75° C. during sample preparation, loading into a liquid chromatography or flow-injection analysis system, injection into a mobile phase of a liquid chromatography or flow-injection analysis system, and/or elution from chromatographic column. The described methods, systems, and device have primary applications in combinatorial polymer research and in industrial process control.

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

This invention relates to reticulated elastomeric matrices, their manufacture, their post-processing, such as their reinforcement, compressive molding or annealing, and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for surgical devices, tissue augmentation, tissue repair, therapeutic, nutritional, or other useful purposes.

A hyaluronic acid (HA) composition includes crosslinked, water-insoluble, hydrated HA gel particles. The HA includes crosslinks represented by the following structural formula:

HA—U—R₂—U—HA

The variables are defined herein. A method of augmenting tissue in a subject includes inserting a needle into a subject at a location in the subject that is in need of tissue augmentation, wherein the needle is coupled to a syringe loaded with the HA composition, and applying force to the syringe, to deliver the HA composition into the subject. A method of preparing the HA composition, includes forming water-insoluble, dehydrated crosslinked HA particles, separating the water-insoluble, dehydrated particles by average diameter, selecting a subset of particles by average diameter, and hydrating the subset of dehydrated particles with a physiologically compatible aqueous solution. Another method of preparing the crosslinked HA composition includes crosslinking a precursor of the crosslinked HA with a biscarbodiimide in the presence of a pH buffer and dehydrating the crosslinked HA. Also included is a method of augmenting tissue in a subject that is in need of tissue augmentation. A method of stabilizing crosslinked HA includes hydrating water-insoluble, dehydrated crosslinked HA with a physiologically compatible aqueous solution that includes a local anesthetic, wherein the value of storage modulus G′ for the stabilized composition is at least about 110% of the value of G′ for a non-stabilized composition,. Also included is the stabilized HA composition.

Rapid characterization and screening of polymer samples to determine average molecular weight, molecular weight distribution and other properties is disclosed. Rapid flow characterization systems and methods, including liquid chromatography and flow-injection analysis systems and methods are preferably employed. High throughput, automated sampling systems and methods, high-temperature characterization systems and methods, and rapid, indirect calibration compositions and methods are also disclosed. The described methods, systems, and devices have primary applications in combinatorial polymer research and in industrial process control.

This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.

A device for treating or preventing a vascular condition at a mammalian vascular site, comprises an implant formed from a compressible, reticulated elastomeric matrix in a shape conducive to delivery through a delivery instrument. One or more implants are delivered in a compressed state to the mammmalian vascular site where each implant recovers substantially to its uncompressed state following deployment from a delivery instrument. In a preferred embodiment the matrix comprises cross-linked polycarbonate polyurethane-urea or cross-linked polycarbonate polyurea-urethane. In another preferred embodiment the matrix comprises a cross-linked polycarbonate polyurethane. In a yet further embodiment, the matrix comprises thermoplastic polycarbonate polyurethane or thermoplastic polycarbonate polyurethane-urea.

A composite implantable device for promoting tissue ingrowth therein comprising a biodurable reticulated elastomeric matrix having a three-dimensional porous structure having a continueous network of interconnected and intercommunicating open pores and a support structure is disclosed. The support structure may be a polymeric surgical mesh comprising a plurality of intersecting one-dimensional reinforcement elements, wherein said mesh is affixed to a face of said first matrix. Methods of making and using the implantable device are also provided.

The present invention is directed toward a method for calibrating a biometric authentication device over time. The method of the present invention involves obtaining an authenticating biometric value from a biometric measurement. The biometric value is then weighted and integrated into the authentication data set or template.

A method of efficiently transmitting streamed data of a program to multiple clients requesting the program at different times ranks the requests in a multilevel hierarchy, which describes merging of data streams servicing the requests. The multilevel hierarchy changes dynamically as new requests arrive or existing data streams are merged to reduce the bandwidth or other costs required to serve the requests. The hierarchy may be established by simple rules or by a modeling of the actual cost of possible hierarchies.

A method encodes and decodes messages between nodes of a wireless communication network. A first node, such as a fob, is mated with a second node, such as a base station, of the wireless communication network. A time duration of the mating is determined in the fob. The time duration of the mating is also determined in the base station. An encryption key is generated based upon the time duration in the fob. The encryption key is also generated based upon the time duration in the base station. Subsequently, communication messages over the wireless communication network are encrypted and decrypted between the fob and the base station employing the encryption key.

This invention relates to biodurable, reticulated elastomeric matrices that are resiliently-compressible, their manufacture and uses including uses for implantable devices into or for topical treatment of patients, such as humans and other animals, for therapeutic, nutritional, or other useful purposes.

Apparatus for remote interaction with an object of interest includes a remote station for obtaining information from the object of interest, a base station for transmitting energy in space to and communicating with the remote station and the remote station having conversion means for energizing the remote station responsive to receipt of the transmitted energy. The energy may be of any suitable type including RF power, light, acoustic, magnetic energy or other form of space transmitted or "radiant" energy. The remote station does not have to contain a source of stored energy or a wired connection to a source of energy. The remote station receives the energy transmission and data transmission from the base station and transmits data to the base station. Microprocessor controllers may be provided for the base station and the remote station. The remote station may receive information from sensors and through one or more transponders sequentially communicate information to the base station. An associated method is provided. In other embodiments which are suited for use in miniaturized electronic chip systems, power enhancement and increased effective antenna size are provided.

Systems and methods for, inter alia, allowing a remote user to access content, such as data or an executable program, on demand from a remoter server. When accessed the content can be delivered on demand to the user's remote workstation for use by the user. As network resources may vary, the systems described herein further include systems that will monitor network resources, and other factors, versus the transfer demands for the content requested by the user. The systems may then determine a schedule, or load map, for transferring blocks of the content in a way that efficiently employs the available resources, and in a way that provides the user with a user-experience that is similar, or substantially similar, to the user-experience that the user would have if the content were stored locally on the user's workstation.

Markers useful for the identification, characterization and, optionally, the enrichment or isolation of tumorigenic cells or cell subpopulations are disclosed.

Markers useful for the identification, characterization and, optionally, the enrichment or isolation of tumorigenic cells or cell subpopulations are disclosed.

A cable-supporting apparatus is disclosed. One embodiment of the invention includes a rigid support member that may be attached to a framework that supports one or more components. At least one cable support member is attached to the rigid support member for receiving a portion of at least one cable therethrough. The cable support members may comprise split rings that each define central cable-receiving area that is surrounded by rigid portions of the split ring.

The invention relates to compounds of the formula (I), in which Ar denotes a mono- or bicyclic aromatic homo- or heterocycle having 1 to 4 N, O and/or S atoms and 5 to 10 skeleton atoms, which may be unsubstituted or mono-, di- or trisubstituted by carbonyl oxygen, Hal, A, OH, OA, NH₂, NHA, NA₂, NO₂, CN, OCN, SCN, COOH, COOA, CONH₂, CONHA, CONA₂, NHCOA, NHCONH₂, NHSO₂A, CHO, COA, SO₂NH₂ and/or S(O)₉A, A denotes unbranched, branched or cyclic alkyl having 1-14 C atoms, in which one or two CH₂ groups may be replaced by O or S atoms and/or by —CR═CH— groups and/or in addition 1-7 H atoms may be replaced by F and/or Cl, Hal: F, Cl, Br or I, D: NH, NH₂, NA₂, NHA, CH₂, CH₃, OH, OA, O or S, E: CH₂, CH, NH or N, Y: E or a saturated or unsaturated bond, X: CH₂, O or NH, Q: Hal, A, OH, OA, NH₂, NHA, NA₂, NO₂, CN, OCN, SCN, COOH, COOA, CONH₂, CONHA, CONA₂, NHCOA, NHCONH₂, NHSO₂A, CHO, COA, SO₂NH₂ or X-M, to the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases in the development or course of which kinases are involved.