2924results about How to "Reduce spread" patented technology

The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.

The present invention relates to the automatic detection of sensitive digital information, and the identification methods, application and enforcement of information security policies for digital information controlled through a software permission wrapper throughout the useful life of the information. This invention includes a unique taxonomy that defines the policies and rules regarding how the information is controlled automatically throughout its useful lifecycle based on the type of information, the stage of the information lifecycle, the user / group role accessing the information, the locality of the information, and the expected threats to the information. The taxonomy is maintained in a database that associates information security control policies and actions to sensitive data. These policies are enforced through a software permission wrapper that is used to encapsulate sensitive digital information. The software permission wrapper is used to control access and enforce digital rights to the information based on the taxonomy based policies for that information. The permission wrapper can automatically change the protection of the information based on pre-defined protection states that can automatically enforce discretionary access control rights to the sensitive information controlled in the permission wrapper. The changes to the level of protection occur dynamically based on changes in user locality, stage of information lifecycle, and user / group role and the detection of threats. In addition, there is provided an internal audit capability describing what actions the user has performed, where the data is located, with whom and how the data has been shared.

A system and method for routing a telephone call on a PSTN network to a data device. The present invention utilizes an automatic call processing system that has a one number location service. A called party provides a calling profile that is stored in the automatic call processing (ACP) system. When a call is placed to a telephone number that is assigned to the called party, the call is routed to the ACP system. The ACP system calls each of the numbers of the calling profile for that called party until that party is reached. At least one of the destinations in the calling profile is a logical address for a data network. The automatic call processing system recognizes the logical address and queries a directory to determine if an IP address has been registered in the directory for the logical address of the called party. If the called party is using a data device that is logged on the Internet, an IP telephony agent, such as an IP telephony client running on the data device, registers the IP address of the data device together with the logical address of the caller. If the ACP system determines if an IP address is registered with the directory, the ACP system will direct the call to an Internet telephony gateway. The Internet telephony gateway encodes and packetizes the voice information for transmission over the data network to the data device.

A small percentage of cells within an established solid tumor have the properties of stem cells. These solid tumor stem cells give rise both to more tumor stem cells and to the majority of cells in the tumor that have lost the capacity for extensive proliferation and the ability to give rise to new tumors. Thus, solid tumor heterogeneity reflects the presence of tumor cell progeny arising from a solid tumor stem cell. We have developed a xenograft model in which we have been able to establish tumors from primary tumors via injection of tumor cells in the mammary gland of severely immunodeficient mice. These xenograft assay have allowed us to do biological and molecular assays to characterize clonogenic solid tumor stem cells. We have also developed evidence that strongly implicates the Notch pathway, especially Notch 4, as playing a central pathway in carcinogenesis.

A method and apparatus for focusing ions for delivery to an ion detection device using an aerodynamic ion focusing system that uses a high-velocity converging gas flow at an entrance aperture to focus an ion plume by reducing spreading and increasing desolvation of ions, and wherein a voltage is applied to at least a portion of the aerodynamic ion focusing system to assist in the focusing and delivery of ions to the ion detection device.

A bimetal composite wire including, in cross-section, an outer shell or tube formed of a first biodegradable material and an inner core formed of a second biodegradable material. When formed into a stent, for example, the first and second biodegradable materials may be different, and may have differing biodegradation rates. In a first embodiment, the first biodegradable material of the shell may degrade relatively slowly for retention of the mechanical integrity of a stent during vessel remodeling, and the second biodegradable material of the core may degrade relatively quickly. In a second embodiment, the first biodegradable material of the shell may degrade relatively quickly, leaving a thinner structure of a second biodegradable material of the core that may degrade relatively slowly. The biodegradation rates may be inherently controlled, such as by selection of materials, and also may be mechanically controlled, such as by material thicknesses and the geometric configuration of the shell, core, or overall device. In any embodiment, the metallic scaffold may also be coated with a drug-eluting, biodegradable polymer, to further inhibit neointimal proliferation and / or restenosis.

Content accessible to a variety of client devices from a web page is associated with machine readable labels setting out capabilities required by a client device in order to manifest the content in a meaningful manner. Several versions of the content may be provided by the author, each version of the content being associated with its own specification of client device capabilities required to manifest it. The capabilities required are matched with the technical attributes of a client device, in order to establish which version of the content to provide to a client device.

The invention discloses a head-mounted portable air purifier. An air purification assembly is additionally arranged on a lug; the air purification assembly comprises an air purification device, a fan and a connecting air pipe; the fan is mounted on the lug; the top end of the connecting air pipe is connected with the fan, and the tail end of the connecting air pipe is connected with the air purification device; a microphone is arranged at the part, of the connecting air pipe or the lug, close to the air purification device, so that an earphone is combined with the air purifier and a user can breathe fresh air in time when using the earphone. The human health is effectively maintained, the head-mounted portable air purifier is diversified in function and attractive in appearance, and the use comfort of the air purifier is improved. Moreover, a door body capable of being used for opening a pipe cavity is arranged on the connecting air pipe, so that the connecting air pipe is convenient to clean and maintain; wires are tightly attached to the inner wall of the connecting air pipe, so that the wires are effectively protected by the connecting air pipe, and the service quality of the earphone is improved.

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17, IL-23 via it's p19 subunit or both IL-17 and IL-23 (via p19). IL-17 and IL-23 are cytokines that are involved in inflammatory processes and human disease.