Use of nitric oxide adducts

a technology of nitric oxide and adducts, which is applied in the direction of powder delivery, packaged goods type, peptide/protein ingredients, etc., can solve the problems of limited clinical usefulness of such devices, frequent exposure of blood to artificial surfaces, serious thromboembolic complications, etc., and achieve the effect of modulating the effects of vascular injury and reducing intimal proliferation
US20070248676A1Inactive Publication Date: 2007-10-25NITROMED
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
NITROMED
Publication Date
2007-10-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. The nitric oxide adduct can be present in a matrix coating on a surface of the medical device; coated per se on a surface of the medical device; directly or indirectly bound to reactive sites on a surface of the medical device; or at least a portion of the medical device can be formed of a material, such as a polymer, which includes the nitric oxide adduct. Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue.
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Description

RELATED APPLICATIONS

[0001] This application is a continuation of U.S. application Ser. No. 10 / 646,713 filed Aug. 25, 2003, which is a continuation of U.S. application Ser. No. 10 / 253,977 filed Sep. 25, 2002, abandoned, which is a continuation of U.S. application Ser. No. 09 / 621,610 filed Jul. 21, 2000, issued as U.S. Pat. No. 6,471,978, which is a continuation of U.S. application Ser. No. 09 / 433,550 filed Nov. 4, 1999, issued as U.S. Pat. No. 6,174,539, which is a continuation of U.S. application Ser. No. 08 / 460,465 filed Jun. 2, 1995, issued as U.S. Pat. No. 6,087,479, which is a continuation-in-part of U.S. application Ser. No. 08 / 123,331 filed Sep. 17, 1993, abandoned. This application is related to U.S. Pat. No. 6,255,277 and U.S. Pat. No. 6,352,709.FIELD OF THE INVENTION

[0002] This invention relates to the use of medical devices and to the treatment of damaged vasculature. More particularly, the invention relates to the use of medical devices which are inserted into a patient...

Claims

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