The invention discloses a modeling feed for constructing a hyperhomocysteinemia animal model and a preparation method thereof, and relates to the technical field of construction of medicine experimental animal model. The preparation method comprises the steps: according to the proportion, weighing casein, corn starch, sucrose, cellulose, DL-methionine, L-cystine, a composite mineral, a composite vitamin and choline dihydrogen citrate, vegetable oil and water; mixing the weighed materials, stirring uniformly, preparing feed particles by a hoop standard granulator, and drying the feed particles to obtain feed particles; and finally, carrying out irradiation sterilization by using cobalt 60, to obtain the finished product. The product is formed by single stable nutrients, the nutrient composition is not affected by seasons and regions and is stable, and the processing technology at normal temperature is adopted to ensure no change of the nutrient composition of the product. The model construction success rate is high, the model preparation process is simple, and the model formation effect is good.