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Modeling feed for constructing hyperhomocysteinemia animal model and preparation method thereof

A technology of cysteinemia and animal models, which is applied in the field of building animal models for medical experiments, can solve the problems of animal phenotype changes, unfavorable clarification of experimental results, changes, etc., to achieve increased methionine content, simple production process, and easy modeling good effect

Inactive Publication Date: 2016-11-09
扬州百利吉生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mixed feeds usually cannot meet the needs of toxicology research, because the research is very sensitive to low concentrations of pollutants; mixed feeds usually cannot meet the needs of immunology research, because the research may be affected by antigens in the feed; 4. Mixed feeds are based on grains. Fundamentally, its nutrient composition is likely to change with the different grain production and harvest periods, resulting in changes in animal phenotypes; moreover, the formula of the mixed feed cannot be disclosed, and the nutrient composition cannot be controlled, which is not conducive to the researchers to clarify the experimental results well
In addition, the mixed feed adopts steam granulation technology (102-110°C), and some heat-sensitive substances such as vitamin B 1 , Vitamin C and other ingredients will be destroyed under high temperature

Method used

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  • Modeling feed for constructing hyperhomocysteinemia animal model and preparation method thereof
  • Modeling feed for constructing hyperhomocysteinemia animal model and preparation method thereof
  • Modeling feed for constructing hyperhomocysteinemia animal model and preparation method thereof

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preparation example Construction

[0047] The preparation method includes the following steps:

[0048] 1), raw material pretreatment,

[0049] Weigh casein, corn starch, sucrose, cellulose, DL-methionine, L-cystine, complex minerals, complex vitamins and dihydrocholine citrate in proportion;

[0050] Weigh 6%-10% of the vegetable oil, add water to the vegetable oil, the amount of water added is 2-9% of the total weight of the raw materials, and continue to stir evenly to form a semi-liquid fat;

[0051] 2), prepare the mixture,

[0052] Mix the weighed raw materials, stir evenly, for 1 to 2 minutes, then gradually add the above semi-liquid fat, continue to stir and mix for 3 to 5 minutes;

[0053] 3) Prepare products,

[0054] At 15~30℃, evenly add the above-mentioned mixed materials to the ring die pelletizer, extrude the materials from the ring die aperture through the ring die pelletizer rollers to form the semi-finished feed, and then transfer the semi-finished feed through the blade Cut into feed pellets with a diam...

specific Embodiment 1

[0057] 1), raw material pretreatment,

[0058] Proportionally weigh 20% casein, 40% corn starch, 10% sucrose, 3% cellulose, 1% DL-methionine, 0.1% L-cystine, 2% complex minerals, 0.5% complex vitamins and citric acid Dihydrocholine 0.1%, weigh 6% vegetable oil, add 2% water to the vegetable oil, stir it evenly, and present a semi-liquid fat;

[0059] 2), prepare the mixture,

[0060] Mix the weighed raw materials, stir evenly, for 1 to 2 minutes, then gradually add the above semi-liquid fat, continue to stir and mix for 3 to 5 minutes;

[0061] 3) Prepare products,

[0062] At 15~30℃, evenly add the above-mentioned mixed materials to the ring die pelletizer, extrude the materials from the ring die aperture through the ring die pelletizer rollers to form the semi-finished feed, and then transfer the semi-finished feed through the blade Cut into feed pellets with a diameter of 10-12mm and a length of 15-20mm. Pass the feed pellets through a dehumidifier at a temperature of 18-25°C and t...

specific Embodiment 2

[0065] 1), raw material pretreatment,

[0066] Weigh 30% casein, 50% corn starch, 20% sucrose, 9% cellulose, 3% DL-methionine, 1% L-cystine, 5% complex minerals, 3% complex vitamins and citric acid according to the proportions. Dihydrocholine 1%, weigh 10% of vegetable oil, add 9% of water to the vegetable oil, stir evenly, and become a semi-liquid fat;

[0067] 2), prepare the mixture,

[0068] Mix the weighed raw materials and stir them evenly for 2 minutes, then gradually add the above semi-liquid fats and continue mixing for 3 minutes;

[0069] 2), prepare the mixture,

[0070] Mix the weighed raw materials, stir evenly, for 1 to 2 minutes, then gradually add the above semi-liquid fat, continue to stir and mix for 3 to 5 minutes;

[0071] 3) Prepare products,

[0072] At 15~30℃, evenly add the above-mentioned mixed materials to the ring die pelletizer, extrude the materials from the ring die aperture through the ring die pelletizer rollers to form the semi-finished feed, and then tra...

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Abstract

The invention discloses a modeling feed for constructing a hyperhomocysteinemia animal model and a preparation method thereof, and relates to the technical field of construction of medicine experimental animal model. The preparation method comprises the steps: according to the proportion, weighing casein, corn starch, sucrose, cellulose, DL-methionine, L-cystine, a composite mineral, a composite vitamin and choline dihydrogen citrate, vegetable oil and water; mixing the weighed materials, stirring uniformly, preparing feed particles by a hoop standard granulator, and drying the feed particles to obtain feed particles; and finally, carrying out irradiation sterilization by using cobalt 60, to obtain the finished product. The product is formed by single stable nutrients, the nutrient composition is not affected by seasons and regions and is stable, and the processing technology at normal temperature is adopted to ensure no change of the nutrient composition of the product. The model construction success rate is high, the model preparation process is simple, and the model formation effect is good.

Description

Technical field [0001] The invention relates to the technical field of constructing medical experimental animal models, and relates to a model-making feed for constructing a hyperhomocysteinemia animal model and a preparation method thereof. Background technique [0002] At present, in laboratory biochemical examinations, the normal fasting plasma homocysteine ​​level is 5-15μmol / L. If the fasting plasma homocysteine ​​level is higher than 15.0μmol / L, it is clinically called high homocysteine. Cystinemia. Elevated plasma homocysteine ​​levels are not only closely related to renal function diseases and neurological diseases, but more importantly, independent risk factors for cardiovascular diseases such as atherosclerosis and coronary heart disease. Studies have shown that 10% of patients with coronary heart disease are related to elevated homocysteine, and elevated levels of mild to moderate homocysteine ​​can increase the risk of death from cardiovascular disease by 4 to 6 time...

Claims

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Application Information

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IPC IPC(8): A23K20/105A23K20/142A23K20/147A23K20/158A23K20/163A23K20/174A23K20/20
Inventor 马剑
Owner 扬州百利吉生物医药有限公司
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